Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.1143 | 0.8327 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.0242 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0242 | 1 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0108 | 0.0242 | 1 |
Schistosoma mansoni | apoptosis regulator bax | 0.0108 | 0.0242 | 1 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.1143 | 0.8327 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.1143 | 0.8327 | 1 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.1357 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.1143 | 0.8327 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.0242 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.1143 | 0.8327 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0077 | 0 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0089 | 0.0092 | 0.0111 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.1143 | 0.8327 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0089 | 0.0092 | 1 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.1143 | 0.8327 | 1 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0089 | 0.0092 | 0.0111 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.1143 | 0.8327 | 1 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0089 | 0.0092 | 0.0111 |
Onchocerca volvulus | 0.0089 | 0.0092 | 1 | |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0108 | 0.0242 | 0.0242 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0089 | 0.0092 | 0.0111 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0089 | 0.0092 | 0.0111 |
Leishmania major | oxidoreductase-like protein | 0.0089 | 0.0092 | 1 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0108 | 0.0242 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.1143 | 0.8327 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.0242 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0089 | 0.0092 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0089 | 0.0092 | 0.0111 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0108 | 0.0242 | 1 |
Leishmania major | pteridine reductase 1 | 0.0089 | 0.0092 | 1 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0108 | 0.0242 | 0.0242 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0029 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.