Detailed information for compound 1390975

Basic information

Technical information
  • TDR Targets ID: 1390975
  • Name: 2-(4-methylphenyl)sulfanyl-1-(5-phenyl-4,5-di hydropyrazol-1-yl)ethanone
  • MW: 310.413 | Formula: C18H18N2OS
  • H donors: 0 H acceptors: 1 LogP: 3.33 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)SCC(=O)N1N=CCC1c1ccccc1
  • InChi: 1S/C18H18N2OS/c1-14-7-9-16(10-8-14)22-13-18(21)20-17(11-12-19-20)15-5-3-2-4-6-15/h2-10,12,17H,11,13H2,1H3
  • InChiKey: XKOSPQCGTDSZJZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-methylphenyl)thio]-1-(5-phenyl-4,5-dihydropyrazol-1-yl)ethanone
  • 1-{[(4-methylphenyl)thio]acetyl}-5-phenyl-4,5-dihydro-1H-pyrazole
  • MLS000624870
  • SMR000293623
  • STOCK4S-78025

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) animal heme peroxidase 0.1704 0.3697 1
Echinococcus granulosus sex peptide receptor 0.0024 0.0022 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0108 0.0108
Trypanosoma brucei pyruvate kinase 1 0.0032 0.004 0.0276
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0011 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0022 0.0022
Echinococcus multilocularis neuropeptide receptor A26 0.1541 0.3341 0.3341
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.0099 0.0099
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0439 0.093 0.2515
Echinococcus granulosus pyruvate kinase 0.0032 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0051
Brugia malayi Calcium binding EGF domain containing protein 0.0371 0.0781 0.2113
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0389 0.0389
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Echinococcus multilocularis cysteine protease 0.0054 0.0086 0.0086
Echinococcus multilocularis histone deacetylase 6 0.0053 0.0084 0.0084
Loa Loa (eye worm) glutathione reductase 0.0056 0.0091 0.0245
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0086 0.0799
Plasmodium vivax multidomain scavenger receptor, putative 0.006 0.0099 0.3508
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0017 0.0017
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0019 0.0045
Brugia malayi Cathepsin L-like precursor 0.0054 0.0086 0.0233
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0017 0.0762
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0035 0.0095
Echinococcus multilocularis pyruvate kinase 0.0017 0.0006 0.0006
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0053 0.0084 0.0228
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0029 0.0029
Trypanosoma brucei cytochrome P450, putative 0.003 0.0035 0.0238
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0011 0.003
Mycobacterium leprae conserved hypothetical protein 0.0055 0.0088 0.2765
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0024 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0022 0.0022
Schistosoma mansoni amine GPCR 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.016
Plasmodium vivax glutathione reductase, putative 0.0056 0.0091 0.3183
Echinococcus granulosus g protein coupled receptor 0.0024 0.0022 0.0022
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0064 0.0586
Brugia malayi G-protein coupled receptor 0.0024 0.0022 0.0059
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0022 0.0022
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0022 0.0059
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0029 0.0976
Echinococcus granulosus cathepsin l1 0.0054 0.0086 0.0086
Entamoeba histolytica cysteine protease, putative 0.0028 0.0029 0.0976
Echinococcus multilocularis 0.0022 0.0016 0.0016
Echinococcus granulosus orexin receptor type 2 0.0024 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0016 0.0095
Onchocerca volvulus 0.0024 0.0022 0.0052
Brugia malayi Calcitonin receptor-like protein seb-1 0.0439 0.093 0.2515
Brugia malayi hypothetical protein 0.006 0.0099 0.0269
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0011 0.0063
Onchocerca volvulus 0.006 0.0099 0.0262
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0016 0.0016
Onchocerca volvulus 0.0023 0.0019 0.0045
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0022 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0053
Schistosoma mansoni pyruvate kinase 0.0032 0.004 0.004
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0635 0.1359 1
Echinococcus granulosus histone deacetylase 6 0.0053 0.0084 0.0084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0022 0.0022
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0022 0.0022
Echinococcus granulosus protein jagged 1 0.0371 0.0781 0.0781
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0029 0.0197
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0035 0.0238
Echinococcus granulosus protein jagged 2 0.0371 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0021
Trypanosoma brucei histone deacetylase, putative 0.0053 0.0084 0.0603
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0064 0.0586
Onchocerca volvulus 0.0063 0.0108 0.0285
Trichomonas vaginalis histone deacetylase, putative 0.0141 0.0277 0.2622
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Plasmodium falciparum cysteine proteinase falcipain 1 0.0028 0.0029 0.095
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0019 0.0019
Echinococcus multilocularis pyruvate kinase 0.0026 0.0025 0.0025
Brugia malayi EGF-like domain containing protein 0.0371 0.0781 0.2113
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0019 0.0019
Leishmania major cytochrome p450-like protein 0.003 0.0035 0.0238
Onchocerca volvulus 0.0089 0.0163 0.0433
Schistosoma mansoni hypothetical protein 0.0038 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0019 0.0053
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0017 0.0044
Loa Loa (eye worm) hypothetical protein 0.0439 0.093 0.2515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0048 0.0428
Toxoplasma gondii histone deacetylase HDAC3 0.0141 0.0277 0.3519
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0043 0.0063 0.0063
Loa Loa (eye worm) animal heme peroxidase 0.1704 0.3697 1
Echinococcus multilocularis somatostatin receptor 0.0024 0.0022 0.0022
Leishmania major pyruvate kinase 0.0032 0.004 0.0276
Onchocerca volvulus 0.0024 0.0022 0.0052
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0074 0.0074
Schistosoma mansoni peroxidasin 0.1704 0.3697 0.3697
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0019 0.0053
Plasmodium vivax SET domain protein, putative 0.0063 0.0108 0.3813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Brugia malayi AKH receptor 0.0024 0.0022 0.0059
Toxoplasma gondii histone deacetylase HDAC2 0.0141 0.0277 0.3519
Loa Loa (eye worm) hypothetical protein 0.006 0.0099 0.0269
Schistosoma mansoni hypothetical protein 0.0523 0.1114 0.1114
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0011 0.0282
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Schistosoma mansoni histone deacetylase hda2 0.0053 0.0084 0.0084
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0016 0.0038
Echinococcus granulosus notch 0.0371 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Trypanosoma cruzi cysteine peptidase, putative 0.0204 0.0416 0.3044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Loa Loa (eye worm) hypothetical protein 0.0063 0.0108 0.0292
Trypanosoma cruzi cysteine protease, putative 0.0028 0.0029 0.0197
Onchocerca volvulus 0.0024 0.0022 0.0052
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0019 0.0019
Brugia malayi EGF-like domain containing protein 0.0371 0.0781 0.2113
Toxoplasma gondii histone deacetylase HDAC4 0.0053 0.0084 0.1041
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0006 0.0077
Loa Loa (eye worm) hypothetical protein 0.0095 0.0176 0.0477
Onchocerca volvulus Chorion peroxidase homolog 0.1704 0.3697 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0108 0.0108
Plasmodium falciparum LCCL domain-containing protein 0.006 0.0099 0.3508
Plasmodium vivax unspecified product 0.0028 0.0029 0.095
Onchocerca volvulus 0.006 0.0099 0.0262
Echinococcus granulosus lamin 0.0089 0.0163 0.0163
Plasmodium falciparum glutathione reductase 0.0019 0.0011 0.0282
Schistosoma mansoni cytochrome P450 0.0022 0.0016 0.0016
Schistosoma mansoni neuropeptide receptor 0.0024 0.0022 0.0022
Brugia malayi Cathepsin L-like precursor 0.0036 0.0048 0.0129
Leishmania major histone deacetylase, putative 0.0053 0.0084 0.0603
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.0416 0.3044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0059 0.0541
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0008 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.0389 0.0389
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0022 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0055 0.0088 0.3104
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0371 0.0781 0.2113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0086 0.3046
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0063
Onchocerca volvulus 0.0054 0.0086 0.0226
Schistosoma mansoni notch 0.0371 0.0781 0.0781
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.004 0.0109
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0371 0.0781 0.2107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0063
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0011 0.0011
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0022 0.0022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0019 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0016 0.0095
Brugia malayi Animal haem peroxidase family protein 0.1704 0.3697 1
Plasmodium vivax vivapain-2 0.0054 0.0086 0.3026
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0003 0.0009
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.084 0.084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.013 0.0878
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0063
Brugia malayi EGF-like domain containing protein 0.0371 0.0781 0.2113
Echinococcus multilocularis neural cadherin 0.0371 0.0781 0.0781
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0022 0.0022
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0059 0.0718
Brugia malayi N-terminal motif family protein 0.0175 0.0351 0.095
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0022 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.0389 0.0389
Loa Loa (eye worm) histone deacetylase 3 0.0141 0.0277 0.075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0022 0.0022
Echinococcus multilocularis neuropeptide s receptor 0.1541 0.3341 0.3341
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0022 0.0022
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0022 0.0022
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0017 0.0497
Loa Loa (eye worm) pyruvate kinase 0.0032 0.004 0.0109
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Loa Loa (eye worm) animal heme peroxidase 0.1704 0.3697 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0054 0.0086 0.0086
Leishmania major cytochrome p450-like protein 0.0022 0.0016 0.01
Plasmodium falciparum thioredoxin reductase 0.0019 0.0011 0.0282
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0022 0.0022
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0063
Brugia malayi Cathepsin L-like precursor 0.0036 0.0048 0.0129
Giardia lamblia High cysteine protein 0.0371 0.0781 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0003
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0055 0.0088 1
Leishmania major cysteine peptidase A (CPA) 0.0054 0.0086 0.0616
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0063
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0022 0.0022
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0017 0.0137
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0032 0.0214
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.01 0.01
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0016 0.0095
Schistosoma mansoni septate junction protein 0.0371 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Brugia malayi EGF-like domain containing protein 0.0371 0.0781 0.2113
Echinococcus granulosus L aminoadipate semialdehyde 0.0194 0.0393 0.0393
Brugia malayi histone deacetylase 11 0.0053 0.0084 0.0228
Schistosoma mansoni thyroid hormone receptor 0.0163 0.0326 0.0326
Entamoeba histolytica hypothetical protein 0.0055 0.0088 0.3124
Brugia malayi neuropeptide F receptor 0.0024 0.0022 0.0059
Leishmania major histone deacetylase, putative 0.0053 0.0084 0.0603
Schistosoma mansoni notch 0.0371 0.0781 0.0781
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0229 0.0619
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0019 0.0019
Echinococcus multilocularis geminin 0.0523 0.1114 0.1114
Leishmania major cytochrome p450-like protein 0.0022 0.0016 0.01
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0019 0.0053
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.0073 0.0197
Leishmania major pyruvate kinase 0.0032 0.004 0.0276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0086 0.0799
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0029 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0019 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0045 0.0406
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0022 0.0059
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0019 0.0019
Trypanosoma cruzi cruzipain precursor, putative 0.0018 0.0008 0.0038
Brugia malayi Dopamine receptor protein 1 0.0024 0.0022 0.0059
Echinococcus granulosus cathepsin L 0.0028 0.0029 0.0029
Brugia malayi GnHR receptor homolog 0.0024 0.0022 0.0059
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0022 0.0022
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0011 0.0063
Trypanosoma brucei histone deacetylase 4 0.0053 0.0084 0.0603
Loa Loa (eye worm) blistered cuticle protein 3 0.1704 0.3697 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0032 0.1031
Schistosoma mansoni notch 0.0371 0.0781 0.0781
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.0048 0.0129
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0091 0.0245
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.013 0.093
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.4459 0.9725 0.9725
Onchocerca volvulus 0.0054 0.0086 0.0226
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0022 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0022 0.0022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0019 0.0019
Onchocerca volvulus 0.0024 0.0022 0.0052
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0091 0.3183
Echinococcus multilocularis histone deacetylase 6 0.0053 0.0084 0.0084
Brugia malayi notch-like transmembrane receptor 0.0371 0.0781 0.2113
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.014 0.0275 0.0275
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0022 0.0059
Brugia malayi Cadherin domain containing protein 0.0371 0.0781 0.2113
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0022 0.0022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0022 0.0022
Schistosoma mansoni histamine h1 receptor 0.0024 0.0022 0.0022
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0065 0.0764
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0022 0.0022
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0011 0.0063
Schistosoma mansoni rab6-interacting 0.006 0.0099 0.0099
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0059 0.0541
Schistosoma mansoni hypothetical protein 0.0371 0.0781 0.0781
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0022 0.0059
Echinococcus granulosus neurogenic locus notch protein 0.0371 0.0781 0.0781
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0016 0.0095
Brugia malayi latrophilin 2 splice variant baaae 0.03 0.0626 0.1693
Echinococcus multilocularis thyroid hormone receptor alpha 0.0163 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0141 0.0277 1
Plasmodium falciparum thioredoxin reductase 0.0056 0.0091 0.3183
Trichomonas vaginalis histone deacetylase, putative 0.0141 0.0277 0.2622
Loa Loa (eye worm) hypothetical protein 0.0087 0.0159 0.0431
Echinococcus granulosus neurogenic locus notch protein 0.0371 0.0781 0.0781
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0127 0.0246 0.179
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0003 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.0416 0.3044
Brugia malayi hypothetical protein 0.0024 0.0022 0.0059
Schistosoma mansoni histone deacetylase 0.0141 0.0277 0.0277
Brugia malayi histone deacetylase 3 (HD3) 0.0141 0.0277 0.0749
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0022 0.0022
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0045 0.1548
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Plasmodium vivax vivapain-2 0.0054 0.0086 0.3026
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0054 0.0086 0.0233
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0022 0.0022
Brugia malayi Serotonin receptor 0.0024 0.0022 0.0059
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Brugia malayi sulfakinin receptor protein 0.0024 0.0022 0.0059
Trypanosoma cruzi histone deacetylase 1, putative 0.0141 0.0277 0.2023
Onchocerca volvulus 0.0107 0.0204 0.0545
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.0416 0.3044
Onchocerca volvulus 0.0054 0.0086 0.0226
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0389 0.0389
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0055 0.0088 0.1092
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0022 0.0022
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0022 0.0022
Onchocerca volvulus 0.0024 0.0022 0.0052
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0017 0.0497
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0022 0.0022
Echinococcus granulosus g protein coupled receptor 0.0024 0.0022 0.0022
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0011 0.0063
Loa Loa (eye worm) hypothetical protein 0.0526 0.112 0.303
Schistosoma mansoni thyroid hormone receptor 0.0163 0.0326 0.0326
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0008 0.0008
Schistosoma mansoni alpha glucosidase 0.0041 0.0059 0.0059
Schistosoma mansoni neuropeptide receptor 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Schistosoma mansoni polycystin 1-related 0.006 0.0099 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0017 0.0524
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0086 0.0799
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0035 0.0095
Brugia malayi follicle stimulating hormone receptor 0.0024 0.0022 0.0059
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0059 0.0541
Schistosoma mansoni cellular tumor antigen P53 0.0107 0.0203 0.0203
Schistosoma mansoni notch 0.0371 0.0781 0.0781
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0016 0.0095
Echinococcus multilocularis cysteine protease 0.0054 0.0086 0.0086
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0064 0.0064
Entamoeba histolytica hypothetical protein 0.0038 0.0052 0.1795
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0019 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0019 0.0053
Loa Loa (eye worm) Notch2 0.0371 0.0781 0.2113
Leishmania major cathepsin L-like protease 0.0054 0.0086 0.0616
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0019 0.0053
Schistosoma mansoni cathepsin s 0.0018 0.0008 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.013 0.013
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0022 0.0022
Schistosoma mansoni biogenic amine receptor 0.0024 0.0022 0.0022
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0126 0.0126
Plasmodium falciparum histone deacetylase 1 0.0141 0.0277 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0016 0.0095
Loa Loa (eye worm) hypothetical protein 0.0095 0.0176 0.0477
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.0416 0.3044
Leishmania major cathepsin L-like protease 0.0054 0.0086 0.0616
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0022 0.0022
Echinococcus multilocularis protein jagged 1 0.0371 0.0781 0.0781
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0011 0.0099
Plasmodium vivax pyruvate kinase, putative 0.0032 0.004 0.1341
Brugia malayi Animal haem peroxidase family protein 0.1704 0.3697 1
Echinococcus multilocularis histone deacetylase 0.0053 0.0084 0.0084
Schistosoma mansoni lamin 0.0089 0.0163 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0139 0.0273 0.0273
Brugia malayi nuclear receptor NHR-88 0.0023 0.0019 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Brugia malayi steroid hormone receptor 0.0023 0.0019 0.0053
Echinococcus granulosus neuropeptide receptor A26 0.1541 0.3341 0.3341
Echinococcus granulosus neuropeptide s receptor 0.1541 0.3341 0.3341
Schistosoma mansoni amine GPCR 0.0024 0.0022 0.0022
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.0324 0.0324
Brugia malayi EGF-like domain containing protein 0.0371 0.0781 0.2113
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0003
Brugia malayi hypothetical protein 0.0018 0.001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0022 0.0059
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0016 0.0095
Schistosoma mansoni histone deacetylase 4 5 0.0053 0.0084 0.0084
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0019 0.0019
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0022 0.0022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0024 0.0022 0.0059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0019 0.0053
Brugia malayi Cathepsin L-like precursor 0.0054 0.0086 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0019 0.0053
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0022 0.0022
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0019 0.0582
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0022 0.0059
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0022 0.0022
Schistosoma mansoni cell polarity protein 0.0371 0.0781 0.0781
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0019 0.0045
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0022 0.0022
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0022 0.0022
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0022 0.0022
Echinococcus granulosus pyruvate kinase 0.0017 0.0006 0.0006
Schistosoma mansoni cpg binding protein 0.0065 0.0111 0.0111
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0019 0.0019
Schistosoma mansoni pyruvate kinase 0.0032 0.004 0.004
Echinococcus multilocularis protein jagged 1 0.0371 0.0781 0.0781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0074 0.0901
Echinococcus multilocularis lysosomal alpha glucosidase 0.0186 0.0376 0.0376
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0022 0.0059
Loa Loa (eye worm) CYP4Cod1 0.003 0.0035 0.0095
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0008 0.0008
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0194 0.0393 0.1064
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Brugia malayi Cathepsin L-like precursor 0.0054 0.0086 0.0233
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0022 0.0022
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0108 0.0108
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0064 0.0452
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0016 0.0038
Onchocerca volvulus 0.0061 0.0104 0.0273
Brugia malayi hypothetical protein 0.0526 0.112 0.303
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0003 0.0009
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.004 0.0276
Leishmania major hypothetical protein, conserved 0.0029 0.0032 0.0214
Trypanosoma brucei glucosidase, putative 0.0041 0.0059 0.0417
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0139 0.0273 0.0273
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0052 0.0052
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0019 0.0019
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0074 0.0901
Entamoeba histolytica cysteine protease, putative 0.0028 0.0029 0.0976
Echinococcus multilocularis histone deacetylase 3 0.0141 0.0277 0.0277
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0016 0.01
Schistosoma mansoni biogenic amine receptor 0.0024 0.0022 0.0022
Onchocerca volvulus 0.0054 0.0086 0.0226
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0059 0.0541
Brugia malayi Animal haem peroxidase family protein 0.1704 0.3697 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0045 0.1524
Onchocerca volvulus Peroxidase homolog 0.1704 0.3697 1
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0022 0.0022
Plasmodium falciparum glutathione reductase 0.0056 0.0091 0.3183
Echinococcus multilocularis lysosomal alpha glucosidase 0.0186 0.0376 0.0376
Onchocerca volvulus 0.0107 0.0204 0.0545
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0053
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0064 0.6836
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0019 0.0053
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0016 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0019 0.0019
Toxoplasma gondii exonuclease III APE 0.0022 0.0017 0.0175
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0022 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0059 0.0541
Onchocerca volvulus 0.0024 0.0022 0.0052
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0022 0.0022
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0127 0.0246 0.179
Plasmodium falciparum pyruvate kinase 0.0032 0.004 0.1341
Trypanosoma brucei histone deacetylase 1 0.0141 0.0277 0.2023
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0022 0.0022
Brugia malayi Serotonin receptor 0.0024 0.0022 0.0059
Brugia malayi hypothetical protein 0.0024 0.0022 0.0059
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.0314 0.0314
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0052 0.0052
Schistosoma mansoni alpha-glucosidase 0.016 0.0319 0.0319
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0055 0.0088 0.0573
Schistosoma mansoni pyruvate kinase 0.0017 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.014 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0019 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0029 0.0197
Brugia malayi glutathione reductase 0.0056 0.0091 0.0245
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0016 0.0038
Onchocerca volvulus Histone deacetylase 10 homolog 0.0053 0.0084 0.0221
Echinococcus granulosus RUN 0.006 0.0099 0.0099
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0022 0.0022
Brugia malayi Histone deacetylase 1 0.0141 0.0277 0.0749
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0019 0.0053
Entamoeba histolytica hypothetical protein 0.0038 0.0052 0.1795
Brugia malayi hypothetical protein 0.0024 0.0022 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.0416 0.3044
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0022 0.0022
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0064 0.0064
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0635 0.1359 1
Toxoplasma gondii histone deacetylase HDAC1 0.0053 0.0084 0.1041
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0022 0.0022
Echinococcus granulosus pyruvate kinase 0.0017 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Plasmodium vivax vivapain-1 0.0028 0.0029 0.095
Plasmodium falciparum histone deacetylase 2 0.0053 0.0084 0.2959
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0091 0.0091
Echinococcus multilocularis pyruvate kinase 0.0017 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.016
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0019 0.0019
Echinococcus multilocularis cpg binding protein 0.0065 0.0111 0.0111
Echinococcus granulosus histone deacetylase 6 0.0053 0.0084 0.0084
Onchocerca volvulus 0.0371 0.0781 0.2107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0139 0.0273 0.0739
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0019 0.0019
Onchocerca volvulus 0.0024 0.0022 0.0052
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.004 0.0271
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Echinococcus granulosus histone deacetylase 7 0.0053 0.0084 0.0084
Brugia malayi ORL1-like opioid receptor 0.0024 0.0022 0.0059
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0635 0.1359 1
Loa Loa (eye worm) cytochrome P450 0.0022 0.0016 0.0044
Echinococcus granulosus cysteine protease 0.0028 0.0029 0.0029
Loa Loa (eye worm) histone deacetylase 0.0053 0.0084 0.0228
Loa Loa (eye worm) doublecortin family protein 0.006 0.0099 0.0269
Brugia malayi hypothetical protein 0.1704 0.3697 1
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0019 0.0019
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0011 0.0057
Onchocerca volvulus 0.0024 0.0022 0.0052
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0003 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0016 0.0095
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0084 0.0603
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.004 0.0915
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Plasmodium falciparum cysteine proteinase falcipain 3 0.0054 0.0086 0.3026
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0016 0.0038
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0021
Brugia malayi Cathepsin L-like precursor 0.0054 0.0086 0.0233
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Echinococcus granulosus histone deacetylase 3 0.0141 0.0277 0.0277
Onchocerca volvulus 0.1704 0.3697 1
Echinococcus multilocularis pyruvate kinase 0.0032 0.004 0.004
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.004 0.0101
Echinococcus multilocularis RUN 0.006 0.0099 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Schistosoma mansoni hypothetical protein 0.03 0.0626 0.0626
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0084 0.0603
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0053
Echinococcus multilocularis slit 2 protein 0.0371 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0022 0.0022
Brugia malayi Dopamine receptor protein 2 0.0024 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.0089 0.0163 0.044
Toxoplasma gondii EGF family domain-containing protein 0.0371 0.0781 1
Echinococcus granulosus protein jagged 2 0.0371 0.0781 0.0781
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0016 0.0095
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0011 0.0063
Echinococcus multilocularis GPCR, family 2 0.0139 0.0273 0.0273
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0022 0.0022
Schistosoma mansoni intermediate filament proteins 0.0089 0.0163 0.0163
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0016 0.0095
Echinococcus multilocularis L aminoadipate semialdehyde 0.0194 0.0393 0.0393
Schistosoma mansoni adenoreceptor 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0048 0.0129
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0017 0.0046
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0003
Echinococcus multilocularis serotonin receptor 0.0024 0.0022 0.0022
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0008 0.0008
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0029 0.0197
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0016 0.0095
Entamoeba histolytica cysteine protease, putative 0.0028 0.0029 0.0976
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0016 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.0416 0.3044
Schistosoma mansoni lipoxygenase 0.0249 0.0514 0.0514
Onchocerca volvulus 0.0371 0.0781 0.2107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0019 0.0053
Echinococcus granulosus fibropellin Ia 0.0371 0.0781 0.0781
Schistosoma mansoni survival motor neuron protein 0.0107 0.0204 0.0204
Onchocerca volvulus 0.1704 0.3697 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0108 0.1342
Brugia malayi EGF-like domain containing protein 0.0371 0.0781 0.2113
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.013 0.0878
Brugia malayi Histone deacetylase family protein 0.0053 0.0084 0.0228
Echinococcus multilocularis histone deacetylase 8 0.0053 0.0084 0.0084
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0011 0.0011
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0022 0.0059
Onchocerca volvulus 0.0024 0.0022 0.0052
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0035 0.0238
Toxoplasma gondii histone lysine methyltransferase SET1 0.0123 0.0238 0.301
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0141 0.0277 0.2622
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0022 0.0022
Onchocerca volvulus Putative cubilin 0.0371 0.0781 0.2107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Brugia malayi cytochrome P450 0.0022 0.0016 0.0044
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0016 0.0038
Brugia malayi hypothetical protein 0.0024 0.0022 0.0059
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0019 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0019 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.0416 0.3044
Echinococcus granulosus Polycystic kidney disease protein 0.006 0.0099 0.0099
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0064 0.2234
Brugia malayi Dopamine receptor 0.0024 0.0022 0.0059
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0141 0.0277 0.2622
Leishmania major basic transcription factor 3a, putative 0.0035 0.0045 0.0313
Onchocerca volvulus 0.0024 0.0022 0.0052
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0032 0.1031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0011 0.0063
Schistosoma mansoni hypothetical protein 0.0371 0.0781 0.0781
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0022 0.0022
Echinococcus granulosus lysosomal alpha glucosidase 0.0186 0.0376 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0029 0.0256
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0019 0.0019
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0074 0.0677
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0019 0.0019
Trypanosoma brucei histone deacetylase 2 0.0053 0.0084 0.0603
Trypanosoma cruzi cysteine peptidase, putative 0.0204 0.0416 0.3044
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0055 0.0088 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0017 0.0106
Loa Loa (eye worm) cysteine protease 0.0054 0.0086 0.0233
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0086 0.0799
Brugia malayi Cytochrome P450 family protein 0.004 0.0057 0.0154
Schistosoma mansoni rab6-interacting 0.006 0.0099 0.0099
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0022 0.0022
Brugia malayi Delta serrate ligand family protein 0.0371 0.0781 0.2113
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0017 0.0106
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0059 0.0417
Brugia malayi Cathepsin L-like precursor 0.0018 0.0008 0.0021
Echinococcus multilocularis microtubule associated protein 2 0.4584 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0052 0.0052
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0011 0.0282
Loa Loa (eye worm) histone deacetylase 11 0.0053 0.0084 0.0228
Trypanosoma cruzi cysteine peptidase, putative 0.0054 0.0086 0.0616
Entamoeba histolytica cysteine protease, putative 0.0028 0.0029 0.0976
Brugia malayi Pre-SET motif family protein 0.0434 0.0919 0.2485
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0107 0.0204 0.0551
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0055 0.0088 1
Onchocerca volvulus 0.0024 0.0022 0.0052
Plasmodium falciparum histone deacetylase, putative 0.0053 0.0084 0.2959
Echinococcus granulosus neurogenic locus notch protein 4 0.0371 0.0781 0.0781
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0032 0.0214
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0011 0.0282
Loa Loa (eye worm) hypothetical protein 0.0194 0.0393 0.1064
Schistosoma mansoni neuropeptide receptor 0.0024 0.0022 0.0022
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0055 0.0088 0.0627
Trypanosoma cruzi major cysteine proteinase, putative 0.016 0.032 0.2339
Schistosoma mansoni hypothetical protein 0.0022 0.0016 0.0016
Brugia malayi Phospholipase A2 family protein 0.0095 0.0176 0.0477
Brugia malayi hypothetical protein 0.0024 0.0022 0.0059
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0064 0.0452
Onchocerca volvulus 0.0024 0.0022 0.0052
Echinococcus granulosus histone deacetylase 8 0.0053 0.0084 0.0084
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0108 0.0108
Entamoeba histolytica cysteine protease, putative 0.0028 0.0029 0.0976
Mycobacterium tuberculosis Probable reductase 0.0127 0.0246 0.179
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0017 0.0106
Echinococcus multilocularis pyruvate kinase 0.0032 0.004 0.004
Leishmania major cathepsin L-like protease 0.0204 0.0416 0.3044
Loa Loa (eye worm) hypothetical protein 0.0139 0.0273 0.0739
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.004 0.0276
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.0389 0.1052
Brugia malayi Melatonin receptor type 1A 0.0024 0.0022 0.0059
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0055 0.0088 0.1092
Brugia malayi Animal haem peroxidase family protein 0.1704 0.3697 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0065 0.2264
Loa Loa (eye worm) hypothetical protein 0.0043 0.0063 0.0169
Schistosoma mansoni hypothetical protein 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Schistosoma mansoni hypothetical protein 0.0024 0.0022 0.0022
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0022 0.0059
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0356 0.0749 0.0749
Brugia malayi Calcium binding EGF domain containing protein 0.0371 0.0781 0.2113
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0127 0.0246 0.179
Plasmodium vivax histone deacetylase, putative 0.0053 0.0084 0.2959
Echinococcus granulosus cathepsin L cysteine proteinase 0.0054 0.0086 0.0086
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Brugia malayi Cadherin domain containing protein 0.0371 0.0781 0.2113
Brugia malayi hypothetical protein 0.0024 0.0022 0.0059
Brugia malayi Cathepsin L-like precursor 0.0054 0.0086 0.0233
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0139 0.0273 0.0273
Brugia malayi Glycosyl hydrolases family 31 protein 0.0186 0.0376 0.1016
Schistosoma mansoni notch 0.0371 0.0781 0.0781
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0064 0.0392
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.0175 0.0351 0.095
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0059 0.0541
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0016 0.0038
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0019 0.0019
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0029 0.008
Loa Loa (eye worm) histone deacetylase 1 0.0141 0.0277 0.075
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0064 0.0778
Onchocerca volvulus 0.0107 0.0203 0.0542
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0022 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0108 0.0108
Entamoeba histolytica histone deacetylase, putative 0.0141 0.0277 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.004 0.0109
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0088 0.0632
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0035 0.0045 0.1548
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0022 0.0022
Schistosoma mansoni opsin-like receptor 0.0024 0.0022 0.0022
Leishmania major histone deacetylase, putative 0.0141 0.0277 0.2023
Schistosoma mansoni slit 0.0371 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Leishmania major cathepsin L-like protease 0.0054 0.0086 0.0616
Brugia malayi Histone deacetylase family protein 0.0053 0.0084 0.0228
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.004 0.0109
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0053
Echinococcus multilocularis fibropellin Ia 0.0371 0.0781 0.0781
Onchocerca volvulus 0.1704 0.3697 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0055 0.0088 0.3104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0019 0.0053
Onchocerca volvulus 0.0371 0.0781 0.2107
Entamoeba histolytica cysteine protease, putative 0.0028 0.0029 0.0976
Echinococcus multilocularis transcription factor btf3 0.0035 0.0045 0.0045
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Entamoeba histolytica cysteine proteinase 1, putative 0.0028 0.0029 0.0976
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0022 0.0052
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Echinococcus granulosus neuropeptide receptor 0.0024 0.0022 0.0022
Schistosoma mansoni cathepsin F (C01 family) 0.0054 0.0086 0.0086
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0074 0.0677
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0022 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.0389 0.1052
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0059 0.0417
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0022 0.0022
Mycobacterium ulcerans pyruvate kinase 0.0032 0.004 0.0215
Brugia malayi hypothetical protein 0.0024 0.0022 0.0059
Schistosoma mansoni hypothetical protein 0.0107 0.0204 0.0204
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0022 0.0022
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0434 0.0919 0.2485
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0019 0.0019
Echinococcus granulosus histone deacetylase 0.0053 0.0084 0.0084
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.013 0.013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0063
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0019 0.0045
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0084 0.0603
Echinococcus granulosus neurogenic locus protein delta 0.0371 0.0781 0.0781
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Schistosoma mansoni inositol monophosphatase 0.0043 0.0064 0.0064
Brugia malayi hypothetical protein 0.0024 0.0022 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.013 0.013
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0016 0.0095
Loa Loa (eye worm) ctsf protein 0.0054 0.0086 0.0233
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0016 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0022 0.0022
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0008 0.0021
Onchocerca volvulus Peroxidasin homolog 0.1704 0.3697 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.0324 0.0324
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0063
Onchocerca volvulus 0.0024 0.0022 0.0052
Schistosoma mansoni hypothetical protein 0.0139 0.0273 0.0273
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0045 0.0406
Brugia malayi beta-NAC-like protein 0.0035 0.0045 0.0122
Loa Loa (eye worm) notch protein 0.0371 0.0781 0.2113
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0086 0.0799
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.0389 0.0389
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.0259 0.0259
Echinococcus multilocularis tumor protein p63 0.0731 0.1568 0.1568
Brugia malayi isocitrate dehydrogenase 0.0016 0.0003 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0053
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0045 0.0313
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0045 0.0313
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.014 0.0275 0.0275
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0011 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.0389 0.0389
Trypanosoma brucei trypanothione reductase 0.0056 0.0091 0.0648
Schistosoma mansoni amine GPCR 0.0024 0.0022 0.0022
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0057 0.0154
Loa Loa (eye worm) histone deacetylase 7A 0.0053 0.0084 0.0228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.0416 0.3044
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0065 0.2242
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0022 0.0022
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0045 0.1524
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0064 0.0586
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0016 0.0038
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0086 0.0799
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0019 0.0019
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0016 0.0038
Giardia lamblia NADH oxidase lateral transfer candidate 0.0019 0.0011 0.0072
Echinococcus granulosus delta-like protein 1 0.0371 0.0781 0.0781
Brugia malayi hypothetical protein 0.0029 0.0032 0.0086
Schistosoma mansoni cpg binding protein 0.0065 0.0111 0.0111
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0032 0.0363
Trichomonas vaginalis histone deacetylase, putative 0.0141 0.0277 0.2622
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0059 0.0541
Schistosoma mansoni histone deacetylase hda2 0.0053 0.0084 0.0084
Onchocerca volvulus 0.0036 0.0048 0.0121
Brugia malayi hypothetical protein 0.006 0.0099 0.0269
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0019 0.0053
Onchocerca volvulus 0.0089 0.0163 0.0433
Onchocerca volvulus 0.0024 0.0022 0.0052
Loa Loa (eye worm) intermediate filament protein 0.0089 0.0163 0.044
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0016 0.0095
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0016 0.0038
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0055 0.0088 0.0573
Loa Loa (eye worm) hypothetical protein 0.0036 0.0048 0.0129
Leishmania major histone deacetylase, putative 0.0141 0.0277 0.2023
Brugia malayi EGF-like domain containing protein 0.0371 0.0781 0.2113
Onchocerca volvulus Phospholipase A2 homolog 0.0095 0.0176 0.047
Schistosoma mansoni amine GPCR 0.0024 0.0022 0.0022
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0186 0.0376 0.1016
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0017 0.0137
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0022 0.0022
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0141 0.0277 0.2622
Brugia malayi Calcium binding EGF domain containing protein 0.0371 0.0781 0.2113
Brugia malayi putative neuropeptide receptor 0.0024 0.0022 0.0059
Onchocerca volvulus Peroxidasin homolog 0.1704 0.3697 1
Schistosoma mansoni hypothetical protein 0.0024 0.0022 0.0022
Onchocerca volvulus 0.0494 0.105 0.2834
Echinococcus multilocularis histone deacetylase 1 0.0141 0.0277 0.0277
Echinococcus multilocularis protein jagged 2 0.0371 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.0036 0.0048 0.0129
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0016 0.0038
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0022 0.0022
Loa Loa (eye worm) latrophilin receptor protein 2 0.0139 0.0273 0.0739
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0084 0.0603
Echinococcus multilocularis lamin 0.0089 0.0163 0.0163
Plasmodium vivax unspecified product 0.0018 0.0008 0.0159
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0019 0.0019
Brugia malayi GCC2 and GCC3 family protein 0.0371 0.0781 0.2113
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0008 0.0021
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.0099 0.0099
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.004 0.0101
Echinococcus multilocularis neurogenic locus notch protein 0.0371 0.0781 0.0781
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0022 0.0059
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0371 0.0781 0.0781
Brugia malayi Papain family cysteine protease containing protein 0.0054 0.0086 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.0416 0.3044
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0029 0.0976
Echinococcus granulosus peroxidasin 0.1704 0.3697 0.3697
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0635 0.1359 1
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0022 0.0022
Brugia malayi Blistered cuticle protein 3 0.1704 0.3697 1
Echinococcus granulosus dnaJ subfamily B 0.0398 0.084 0.084
Trypanosoma cruzi cysteine peptidase, putative 0.0204 0.0416 0.3044
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0016 0.0038
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0086 0.0086
Echinococcus multilocularis neurogenic locus notch protein 0.0371 0.0781 0.0781
Schistosoma mansoni opsin-like receptor 0.0024 0.0022 0.0022
Brugia malayi Peroxidasin 0.1704 0.3697 1
Schistosoma mansoni neuropeptide receptor 0.0024 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0022 0.0059
Echinococcus multilocularis neurogenic locus notch protein 4 0.0371 0.0781 0.0781
Entamoeba histolytica cysteine protease, putative 0.0028 0.0029 0.0976
Brugia malayi Muscle positioning protein 4 0.0371 0.0781 0.2113
Onchocerca volvulus Cathepsin F homolog 0.0054 0.0086 0.0226
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0356 0.0749 0.0749
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0086 0.0226
Onchocerca volvulus 0.0371 0.0781 0.2107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0022 0.0022
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0011 0.0099
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0019 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.0416 0.3044
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0127 0.0246 0.179
Echinococcus granulosus geminin 0.0523 0.1114 0.1114
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0029 0.0197
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0022 0.0022
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.0351 0.0944
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0054 0.0086 0.3026
Brugia malayi hypothetical protein 0.0038 0.0052 0.014
Echinococcus granulosus pyruvate kinase 0.0032 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Leishmania major trypanothione reductase 0.0056 0.0091 0.0648
Schistosoma mansoni hypothetical protein 0.0398 0.084 0.084
Onchocerca volvulus 0.0024 0.0022 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0019 0.0053
Entamoeba histolytica cysteine proteinase, putative 0.0054 0.0086 0.3046
Chlamydia trachomatis pyruvate kinase 0.0032 0.004 0.3752
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.0073 0.0197
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Echinococcus multilocularis peroxidasin 0.1704 0.3697 0.3697
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0019 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0016 0.0095
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0011 0.0282
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 0.0086 0.0086
Onchocerca volvulus 0.0054 0.0086 0.0226
Loa Loa (eye worm) animal heme peroxidase 0.1704 0.3697 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0204 0.0416 0.3044
Leishmania major phosphopantetheinyl transferase-like protein 0.0055 0.0088 0.0632
Brugia malayi histone deacetylase 1 (HD1) 0.0141 0.0277 0.0749
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0064 0.0452
Schistosoma mansoni microtubule-associated protein tau 0.4584 1 1
Onchocerca volvulus 0.0194 0.0393 0.1057
Plasmodium vivax histone deacetylase 1, putative 0.0141 0.0277 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0089 0.0163 0.044
Brugia malayi larval opioid receptor 0.0024 0.0022 0.0059
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0022 0.0022
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0019 0.0019
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0059 0.0059
Entamoeba histolytica cysteine protease, putative 0.0028 0.0029 0.0976
Brugia malayi Intermediate filament tail domain containing protein 0.0089 0.0163 0.044
Mycobacterium tuberculosis Probable dehydrogenase 0.0127 0.0246 0.179
Entamoeba histolytica cysteine proteinase 2 0.0028 0.0029 0.0976
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0022 0.0022
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0022 0.0059
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0126 0.0126
Echinococcus granulosus fmrfamide receptor 0.0024 0.0022 0.0022
Echinococcus granulosus protein jagged 1 0.0371 0.0781 0.0781
Schistosoma mansoni hypothetical protein 0.0371 0.0781 0.0781
Schistosoma mansoni transcription factor btf3 0.0035 0.0045 0.0045
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0045 0.0122
Brugia malayi MH2 domain containing protein 0.0119 0.0229 0.0619
Schistosoma mansoni coup transcription factor 0.0023 0.0019 0.0019
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0016 0.0038
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0022 0.0059
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0032 0.0214
Brugia malayi Inositol-1 0.0043 0.0064 0.0173
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0011 0.0081
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0022 0.0022
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0018 0.0008 0.0021
Brugia malayi ecdysteroid receptor 0.0023 0.0019 0.0053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0053
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0016 0.0038
Loa Loa (eye worm) pyruvate kinase 0.0032 0.004 0.0109
Echinococcus multilocularis musashi 0.0089 0.0163 0.0163
Onchocerca volvulus Peroxidase homolog 0.1704 0.3697 1
Schistosoma mansoni ap endonuclease 0.0022 0.0017 0.0017
Echinococcus granulosus hypothetical protein 0.0024 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0086 0.0799
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0127 0.0246 0.8814
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0017 0.01
Loa Loa (eye worm) pyruvate kinase 0.0032 0.004 0.0109
Schistosoma mansoni peroxidasin 0.1704 0.3697 0.3697
Echinococcus granulosus pyruvate kinase 0.0017 0.0006 0.0006
Trichomonas vaginalis histone deacetylase, putative 0.0141 0.0277 0.2622
Echinococcus multilocularis notch 0.0371 0.0781 0.0781
Brugia malayi Latrophilin receptor protein 2 0.0139 0.0273 0.0739
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0186 0.0377 0.2758
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0084 0.0603
Brugia malayi neuropeptide F receptor 0.0024 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Schistosoma mansoni myosin xvIII 0.0024 0.0022 0.0022
Echinococcus multilocularis neurogenic locus protein delta 0.0371 0.0781 0.0781
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.013 0.0935
Schistosoma mansoni hypothetical protein 0.0371 0.0781 0.0781
Brugia malayi Pre-SET motif family protein 0.0063 0.0108 0.0292
Schistosoma mansoni opsin-like receptor 0.0024 0.0022 0.0022
Plasmodium vivax histone deacetylase, putative 0.0053 0.0084 0.2959
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0016 0.0095
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0141 0.0277 0.2019
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.004 0.0358
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0022 0.0022
Brugia malayi Doublecortin family protein 0.006 0.0099 0.0269
Schistosoma mansoni notch 0.0371 0.0781 0.0781
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0019 0.0053
Brugia malayi nuclear hormone receptor 0.0023 0.0019 0.0053
Schistosoma mansoni alpha-glucosidase 0.016 0.0319 0.0319
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0019 0.0019
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0016 0.0042
Schistosoma mansoni histone deacetylase 0.0141 0.0277 0.0277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0022 0.0022
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0086 0.0086
Echinococcus multilocularis histone deacetylase 7 0.0053 0.0084 0.0084
Echinococcus granulosus survival motor neuron protein 1 0.0526 0.112 0.112
Brugia malayi Cathepsin L-like precursor 0.0054 0.0086 0.0233
Echinococcus multilocularis sex peptide receptor 0.0024 0.0022 0.0022
Leishmania major cathepsin L-like protease 0.0054 0.0086 0.0616
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0035 0.0176
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Giardia lamblia Histone deacetylase 0.0141 0.0277 0.3501
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0104 0.028
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0054 0.0373
Loa Loa (eye worm) inositol-1 0.0043 0.0064 0.0173
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.006 0.0099 0.0269
Echinococcus multilocularis lamin dm0 0.0089 0.0163 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0045 0.0406
Schistosoma mansoni biogenic amine receptor 0.0024 0.0022 0.0022
Leishmania major cathepsin L-like protease 0.0204 0.0416 0.3044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Echinococcus granulosus transcription factor btf3 0.0035 0.0045 0.0045
Leishmania major cathepsin L-like protease 0.0204 0.0416 0.3044
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Entamoeba histolytica hypothetical protein 0.0038 0.0052 0.1795
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0022 0.0022
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0141 0.0277 0.2019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0086 0.0799
Onchocerca volvulus Slit protein homolog 0.0371 0.0781 0.2107
Schistosoma mansoni ap endonuclease 0.0022 0.0017 0.0017
Schistosoma mansoni inositol monophosphatase 0.0043 0.0064 0.0064
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0635 0.1359 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0108 0.0108
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0016 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0019 0.0053
Schistosoma mansoni hypothetical protein 0.0371 0.0781 0.0781
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0029 0.008
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0029 0.0976
Echinococcus multilocularis pyruvate kinase 0.0017 0.0006 0.0006
Brugia malayi hypothetical protein 0.0024 0.0022 0.0059
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0229 0.0619
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0064 0.0452
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0006 0.0027
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0059 0.2062
Echinococcus granulosus GPCR family 2 0.0139 0.0273 0.0273
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0011 0.0063
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0022 0.0022
Echinococcus multilocularis survival motor neuron protein 1 0.0526 0.112 0.112
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0006 0.0077
Brugia malayi Cytochrome P450 family protein 0.0022 0.0016 0.0044
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0016 0.0038
Toxoplasma gondii histone deacetylase HDAC5 0.0053 0.0085 0.1044
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0194 0.0393 0.0393
Echinococcus multilocularis neurogenic locus protein delta 0.0371 0.0781 0.0781
Echinococcus granulosus cathepsin l1 0.0036 0.0048 0.0048
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Brugia malayi CXXC zinc finger family protein 0.0061 0.0104 0.028
Mycobacterium tuberculosis Probable oxidoreductase 0.0141 0.0277 0.2019
Echinococcus multilocularis Polycystic kidney disease protein 0.006 0.0099 0.0099
Echinococcus granulosus lamin dm0 0.0089 0.0163 0.0163
Giardia lamblia Pyruvate kinase 0.0032 0.004 0.0446
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0022 0.0059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.013 0.0878
Onchocerca volvulus 0.0024 0.0022 0.0052
Echinococcus granulosus allatostatin A receptor 0.0024 0.0022 0.0022
Brugia malayi intermediate filament protein 0.0089 0.0163 0.044
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0053
Schistosoma mansoni hypothetical protein 0.0371 0.0781 0.0781
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0022 0.0022
Echinococcus granulosus neural cadherin 0.0371 0.0781 0.0781
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0017 0.0762
Echinococcus granulosus neuropeptide receptor 0.0024 0.0022 0.0022
Echinococcus granulosus tumor protein p63 0.0731 0.1568 0.1568
Echinococcus granulosus slit 2 protein 0.0371 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0074 0.256
Echinococcus granulosus g protein coupled receptor 0.0024 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0038 0.0052 0.1795
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0019 0.0019
Echinococcus multilocularis fat cadherin tumor suppressor 0.0371 0.0781 0.0781
Entamoeba histolytica cysteine protease, putative 0.0028 0.0029 0.0976
Plasmodium vivax vivapain-3 0.0028 0.0029 0.095
Echinococcus granulosus intermediate filament protein 0.0089 0.0163 0.0163
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0059 0.0541
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0059 0.0541
Onchocerca volvulus 0.0371 0.0781 0.2107
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0059 0.0417
Schistosoma mansoni histone deacetylase 4 5 0.0053 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0022 0.0022
Brugia malayi Cytochrome P450 family protein 0.003 0.0035 0.0095
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.004 0.0358
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0048 0.1634
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0019 0.0053
Onchocerca volvulus Cathepsin L homolog 0.0054 0.0086 0.0226
Loa Loa (eye worm) hypothetical protein 0.0054 0.0086 0.0233
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0091 0.0642
Echinococcus multilocularis histone deacetylase 6 0.0053 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 0.0086 0.0086
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0017 0.0017
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0054 0.0086 0.3026
Schistosoma mansoni hypothetical protein 0.0523 0.1114 0.1114
Brugia malayi Animal haem peroxidase family protein 0.1704 0.3697 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0032 0.0086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0017 0.0106
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0017 0.0148
Brugia malayi G-protein coupled receptor 0.0024 0.0022 0.0059
Echinococcus granulosus histone deacetylase 1 0.0141 0.0277 0.0277
Schistosoma mansoni cpg binding protein 0.0061 0.0104 0.0104
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0029 0.0976
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0635 0.1359 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0029 0.0029
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0059 0.2062
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Echinococcus granulosus histone deacetylase 6 0.0053 0.0084 0.0084
Brugia malayi Cytochrome P450 family protein 0.003 0.0035 0.0095
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0108 0.0108
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0045 0.0536
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0016 0.0016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0019 0.0019
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0091 0.0648
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0011 0.0063
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0032 0.1031
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0086 0.0799
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0022 0.0022
Entamoeba histolytica cysteine protease, putative 0.0028 0.0029 0.0976
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0139 0.0273 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0048 0.0428
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0054 0.1447
Plasmodium vivax histone deacetylase 2, putative 0.0053 0.0084 0.2959
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.013 0.1621
Schistosoma mansoni laminin gamma-3 chain 0.0371 0.0781 0.0781
Onchocerca volvulus 0.0054 0.0086 0.0226
Trichomonas vaginalis histone deacetylase, putative 0.0141 0.0277 0.2622
Brugia malayi hypothetical protein 0.0024 0.0022 0.0059
Schistosoma mansoni hypothetical protein 0.006 0.0099 0.0099
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0011 0.0011
Onchocerca volvulus Dual oxidase homolog 0.1704 0.3697 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0006
Trichomonas vaginalis histone deacetylase, putative 0.0141 0.0277 0.2622
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0022 0.0022
Loa Loa (eye worm) fibroinase 0.0054 0.0086 0.0233
Onchocerca volvulus Neurogenic locus notch homolog 0.0371 0.0781 0.2108
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0086 0.0233
Entamoeba histolytica cysteine protease, putative 0.0028 0.0029 0.0976
Schistosoma mansoni lipoxygenase 0.0356 0.0749 0.0749
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0003 0.0003
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.004 0.0472
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Entamoeba histolytica cysteine protease, putative 0.0028 0.0029 0.0976
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0022 0.0059
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0141 0.0277 0.075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0019 0.0053
Toxoplasma gondii cathepsin CPL 0.0054 0.0086 0.1065
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 0.0086 0.0799
Brugia malayi cathepsin L-like precursor 0.0036 0.0048 0.0129
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0022 0.0022
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0019 0.0053
Toxoplasma gondii thioredoxin reductase 0.0056 0.0091 0.112
Schistosoma mansoni lamin 0.0089 0.0163 0.0163
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0059 0.016
Brugia malayi RE15519p 0.0024 0.0022 0.0059
Echinococcus multilocularis serotonin receptor 0.0024 0.0022 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0016 0.0095
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.0324 0.0877
Entamoeba histolytica cysteine protease, putative 0.0028 0.0029 0.0976
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0017 0.0046
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0011 0.0063
Loa Loa (eye worm) acetyltransferase 0.0162 0.0324 0.0877
Leishmania major cathepsin L-like protease 0.0054 0.0086 0.0616
Brugia malayi G protein-coupled receptor 0.0024 0.0022 0.0059
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0059 0.0059
Trypanosoma cruzi cruzipain precursor, putative 0.0204 0.0416 0.3044
Entamoeba histolytica cysteine protease, putative 0.0054 0.0086 0.3046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0439 0.093 0.2515
Loa Loa (eye worm) hypothetical protein 0.03 0.0626 0.1693
Schistosoma mansoni loxhd1 0.006 0.0099 0.0099
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0022 0.0059
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0016 0.0038
Schistosoma mansoni hypothetical protein 0.0139 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.004 0.0276
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0059 0.016
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0019 0.0053
Echinococcus granulosus cpg binding protein 0.0065 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0022 0.0059
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0022 0.0059
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0003 0.0003
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0371 0.0781 0.0781
Trypanosoma cruzi histone deacetylase 1, putative 0.0141 0.0277 0.2023
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Schistosoma mansoni hypothetical protein 0.0139 0.0273 0.0273
Echinococcus granulosus somatostatin receptor 0.0024 0.0022 0.0022
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0028 0.0029 0.0197
Trichomonas vaginalis set domain proteins, putative 0.0494 0.1049 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0022 0.0022
Echinococcus multilocularis cathepsin L 0.0028 0.0029 0.0029
Schistosoma mansoni histone deacetylase 1 2 3 0.0053 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0107 0.0203 0.0549
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0015 0.0041
Onchocerca volvulus Phospholipase A2 homolog 0.0095 0.0176 0.047
Trypanosoma brucei histone deacetylase 3 0.0053 0.0084 0.0603
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 0.0086 0.0799
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0022 0.0022
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0016 0.0095
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 0.0086 0.0799
Echinococcus granulosus serotonin receptor 0.0024 0.0022 0.0022
Onchocerca volvulus 0.0054 0.0086 0.0226
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0139 0.0273 0.0273
Schistosoma mansoni amine GPCR 0.0024 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0371 0.0781 0.2113
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0043 0.0063 0.0063
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0016 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0029 0.0256
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0029 0.0029
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.004 0.0101
Onchocerca volvulus 0.0024 0.0022 0.0052
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0045 0.0313
Loa Loa (eye worm) hypothetical protein 0.1704 0.3697 1
Brugia malayi Thioredoxin reductase 0.0056 0.0091 0.0245

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: Confirmation Assay for Identification of Novel General Anesthetics. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2323, AID2385, AID485281] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 42.5615 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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