Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1584 | 0.2254 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.2012 | 0.1897 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1584 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0135 | 0.4049 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.2012 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0135 | 0.4049 | 0.3485 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0135 | 0.4049 | 0.3705 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0986 | 0.0375 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0688 | 0.3419 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.0546 | 0.2714 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0135 | 0.4049 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0688 | 0.3419 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.2012 | 0.1255 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.2012 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.1584 | 0.0785 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0986 | 0.0375 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0866 | 0.0339 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0135 | 0.4049 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0111 | 0.309 | 0.2435 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0135 | 0.4049 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.1584 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.0546 | 0.2714 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0135 | 0.4049 | 1 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.2012 | 0.3601 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0866 | 0.0735 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0135 | 0.4049 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1584 | 0.2254 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.1584 | 0.0785 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.2012 | 0.1551 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.0688 | 0.6473 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0107 | 0.2924 | 0.2252 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0135 | 0.4049 | 0.3485 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.2012 | 0.1255 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0546 | 0.041 |
Onchocerca volvulus | 0.0058 | 0.0986 | 1 | |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0078 | 0.1786 | 0.1007 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.2012 | 0.3601 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1584 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0111 | 0.309 | 0.6987 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.2012 | 0.1255 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 1 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0078 | 0.1786 | 0.1007 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.1584 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.0546 | 0.479 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.1584 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.2012 | 0.1255 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0135 | 0.4049 | 0.3963 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0986 | 0.0465 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0891 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.3162 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.