Detailed information for compound 1391339

Basic information

Technical information
  • TDR Targets ID: 1391339
  • Name: 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfan yl]-N-(5-fluoro-2-methylphenyl)acetamide
  • MW: 308.371 | Formula: C15H17FN2O2S
  • H donors: 1 H acceptors: 2 LogP: 2.99 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cc(F)ccc1C)CSCc1c(C)noc1C
  • InChi: 1S/C15H17FN2O2S/c1-9-4-5-12(16)6-14(9)17-15(19)8-21-7-13-10(2)18-20-11(13)3/h4-6H,7-8H2,1-3H3,(H,17,19)
  • InChiKey: NBRMTDHKRAAHGJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(3,5-dimethylisoxazol-4-yl)methylsulfanyl]-N-(5-fluoro-2-methyl-phenyl)acetamide
  • 2-[(3,5-dimethyl-4-isoxazolyl)methylthio]-N-(5-fluoro-2-methylphenyl)acetamide
  • 2-[(3,5-dimethylisoxazol-4-yl)methylthio]-N-(5-fluoro-2-methyl-phenyl)acetamide
  • 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]-N-(5-fluoro-2-methyl-phenyl)ethanamide
  • T5381068
  • ZINC06510329

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi neuropeptide F receptor 0.0296 0.5348 0.5307
Onchocerca volvulus 0.0296 0.5348 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Schistosoma mansoni regulator of G protein signaling 0.002 0.0283 0.0529
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0276 0.1299
Echinococcus granulosus biogenic amine 5HT receptor 0.0296 0.5348 0.7415
Schistosoma mansoni biogenic amine receptor 0.0296 0.5348 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Schistosoma mansoni lamin 0.003 0.0455 0.085
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Onchocerca volvulus 0.0296 0.5348 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.2121 0.2121
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0507 0.1063
Schistosoma mansoni neuropeptide F-like receptor 0.0296 0.5348 1
Echinococcus granulosus O glycosyltransferase 0.0046 0.0746 0.0928
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.2121 0.468
Echinococcus granulosus orexin receptor type 2 0.0296 0.5348 0.7415
Loa Loa (eye worm) hypothetical protein 0.0014 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Brugia malayi DNA polymerase alpha catalytic subunit 0.0044 0.0724 0.0642
Echinococcus granulosus 6 phosphofructokinase 0.012 0.2121 0.2866
Echinococcus granulosus 7tm_1 domain containing protein 0.0296 0.5348 0.7415
Plasmodium falciparum glutathione reductase 0.0052 0.0871 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Onchocerca volvulus Neuropeptide F receptor homolog 0.0296 0.5348 1
Mycobacterium tuberculosis Probable reductase 0.012 0.2104 0.8837
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0276 0.13
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0007 0.0033 0.0033
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0283 0.0529
Echinococcus granulosus hypothetical protein 0.0296 0.5348 0.7415
Entamoeba histolytica thymidine kinase, putative 0.025 0.4495 1
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0283 0.0275
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0296 0.5348 0.7415
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0283 0.0529
Echinococcus granulosus g protein coupled receptor 0.0296 0.5348 0.7415
Loa Loa (eye worm) hypothetical protein 0.001 0.0086 0.0086
Echinococcus multilocularis neuropeptide FF receptor 2 0.0296 0.5348 0.7415
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0055 0.0914 0.1708
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0283 0.0275
Schistosoma mansoni DNA helicase recq5 0.001 0.0087 0.0163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0924 0.1178
Echinococcus multilocularis neuropeptide Y receptor 0.0296 0.5348 0.7415
Echinococcus multilocularis neuropeptides capa receptor 0.0296 0.5348 0.7415
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0296 0.5348 0.7415
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0283 0.0529
Echinococcus granulosus neuropeptide Y receptor 0.0296 0.5348 0.7415
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Toxoplasma gondii exonuclease III APE 0.002 0.0276 0.3164
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0243 0.2503
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0455 0.0455
Toxoplasma gondii DNA polymerase 0.0015 0.0187 0.2143
Onchocerca volvulus 0.0296 0.5348 1
Schistosoma mansoni neuropeptide receptor 0.0296 0.5348 1
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0015 0.0187 0.014
Echinococcus granulosus dro:myosuppressin receptor 0.0296 0.5348 0.7415
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0015 0.0187 0.1837
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0243 0.0471
Schistosoma mansoni opsin-like receptor 0.0296 0.5348 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0296 0.5348 0.7415
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0087 0.0087
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0276 0.0312
Schistosoma mansoni ap endonuclease 0.002 0.0276 0.0515
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0288 0.3048
Loa Loa (eye worm) hypothetical protein 0.002 0.0283 0.0283
Echinococcus multilocularis g protein coupled receptor 0.0296 0.5348 0.7415
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.2121 0.468
Schistosoma mansoni axis inhibition protein axin 0.002 0.0283 0.0529
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0243 0.0352
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0296 0.5348 0.5307
Schistosoma mansoni 6-phosphofructokinase 0.012 0.2121 0.3966
Schistosoma mansoni regulator of G protein signaling 0.002 0.0283 0.0529
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0243 0.2784
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0198 0.2267
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.2121 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0296 0.5348 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0924 0.0844
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0243 0.054
Brugia malayi Dopamine receptor protein 2 0.0296 0.5348 0.5307
Schistosoma mansoni regulator of G protein signaling 0.002 0.0283 0.0529
Brugia malayi G protein-coupled receptor 0.0296 0.5348 0.5307
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0243 0.0236
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0283 0.0275
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0283 0.0197
Schistosoma mansoni growth hormone secretagogue receptor 0.0296 0.5348 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0243 0.0431
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0243 0.0454
Onchocerca volvulus 0.0296 0.5348 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.2104 0.8837
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0507 0.5653
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0507 0.5816
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0087 0.1002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.5348 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0507 0.5816
Brugia malayi Cytochrome P450 family protein 0.0014 0.0158 0.0071
Echinococcus multilocularis lamin 0.003 0.0455 0.0518
Echinococcus multilocularis neuropeptide Y receptor 0.0296 0.5348 0.7415
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Brugia malayi hypothetical protein 0.0296 0.5348 0.5307
Loa Loa (eye worm) hypothetical protein 0.0007 0.0033 0.0033
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0341 0.069
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0296 0.5348 0.5307
Loa Loa (eye worm) hypothetical protein 0.0014 0.0172 0.0172
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0015 0.0194 0.0431
Plasmodium falciparum thioredoxin reductase 0.0018 0.0243 0.2503
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0015 0.0187 0.014
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0296 0.5348 0.7415
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0018 0.0237 0.0008
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0243 0.1572
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0283 0.0197
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0187 0.0415
Echinococcus granulosus bloom syndrome protein 0.0023 0.0341 0.0357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.5348 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0276 0.0613
Giardia lamblia DNA polymerase alpha subunit A 0.0046 0.076 0.1525
Echinococcus granulosus intermediate filament protein 0.003 0.0455 0.0518
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0296 0.5348 0.5348
Brugia malayi Dopamine receptor protein 1 0.0296 0.5348 0.5307
Echinococcus granulosus tachykinin peptides receptor 99D 0.0296 0.5348 0.7415
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0296 0.5348 1
Plasmodium falciparum thioredoxin reductase 0.0052 0.0871 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0243 0.054
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0276 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0243 0.0219
Brugia malayi PXA domain containing protein 0.002 0.0283 0.0197
Brugia malayi Dopamine receptor 0.0296 0.5348 0.5307
Echinococcus multilocularis G-protein coupled receptor, putative 0.0296 0.5348 0.7415
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0243 0.054
Echinococcus granulosus allatostatin A receptor 0.0296 0.5348 0.7415
Brugia malayi Melatonin receptor type 1A 0.0296 0.5348 0.5307
Trichomonas vaginalis DNA polymerase II, putative 0.0024 0.0348 0.0706
Loa Loa (eye worm) hypothetical protein 0.002 0.0283 0.0283
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0276 0.0545
Schistosoma mansoni regulator of G protein signaling 0.002 0.0283 0.0529
Onchocerca volvulus 0.0296 0.5348 1
Loa Loa (eye worm) RecQ helicase 0.0023 0.0341 0.0341
Echinococcus granulosus sex peptide receptor 0.0296 0.5348 0.7415
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0283 0.0529
Schistosoma mansoni amine GPCR 0.0296 0.5348 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.2121 0.4719
Treponema pallidum hypothetical protein 0.0018 0.0237 0.1115
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0087 0.0652
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0243 0.0471
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0243 0.0431
Brugia malayi intermediate filament protein 0.003 0.0455 0.037
Schistosoma mansoni amine GPCR 0.0296 0.5348 1
Leishmania major cytochrome p450-like protein 0.0014 0.0158 0.0281
Brugia malayi DNA polymerase family B containing protein 0.0015 0.0187 0.01
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0007 0.0033 0.0073
Entamoeba histolytica phosphofructokinase, putative 0.012 0.2121 0.4719
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0158 0.0042
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.2104 0.8837
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0187 0.0108
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.5348 1
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0507 0.5816
Schistosoma mansoni 6-phosphofructokinase 0.012 0.2121 0.3966
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0243 0.2784
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0296 0.5348 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0296 0.5348 0.7415
Echinococcus granulosus neuropeptide FF receptor 2 0.0296 0.5348 0.7415
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0348 0.0706
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0296 0.5348 0.7415
Loa Loa (eye worm) hypothetical protein 0.0075 0.129 0.129
Brugia malayi DNA polymerase delta catalytic subunit 0.0015 0.0187 0.01
Schistosoma mansoni neuropeptide F-like receptor 0.0296 0.5348 1
Trypanosoma brucei thymidine kinase 0.025 0.4495 1
Echinococcus granulosus tm gpcr rhodopsin 0.0296 0.5348 0.7415
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0243 0.0236
Loa Loa (eye worm) hypothetical protein 0.001 0.0087 0.0087
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0044 0.0724 0.8307
Trypanosoma brucei RNA helicase, putative 0.0138 0.2445 0.5293
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.056
Onchocerca volvulus 0.0296 0.5348 1
Brugia malayi hypothetical protein 0.0296 0.5348 0.5307
Brugia malayi putative neuropeptide receptor 0.0296 0.5348 0.5307
Echinococcus granulosus neuropeptides capa receptor 0.0296 0.5348 0.7415
Loa Loa (eye worm) hypothetical protein 0.0007 0.0033 0.0033
Echinococcus granulosus neuropeptide receptor 0.0296 0.5348 0.7415
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Brugia malayi hypothetical protein 0.002 0.0283 0.0197
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0507 1
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0015 0.0187 0.0226
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0296 0.5348 0.7415
Toxoplasma gondii DNA polymerase family B protein 0.0015 0.0187 0.2143
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0015 0.0187 0.0108
Brugia malayi G-protein coupled receptor 0.0296 0.5348 0.5307
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.5348 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0507 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0063 0.0063
Echinococcus multilocularis serotonin receptor 0.0296 0.5348 0.7415
Brugia malayi Serotonin receptor 0.0296 0.5348 0.5307
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0283 0.0283
Echinococcus granulosus alpha 1A adrenergic receptor 0.0296 0.5348 0.7415
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0296 0.5348 0.5307
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0007 0.0033 0.0073
Plasmodium vivax glutathione reductase, putative 0.0052 0.0871 1
Entamoeba histolytica recQ family helicase, putative 0.0013 0.014 0.0311
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0154 0.0067
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0015 0.0187 0.0345
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.2349 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0507 0.2389
Echinococcus multilocularis dro:myosuppressin receptor 0.0296 0.5348 0.7415
Loa Loa (eye worm) hypothetical protein 0.0029 0.0445 0.0445
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0172 0.012
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0871 0.1939
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus granulosus serotonin receptor 0.0296 0.5348 0.7415
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0283 0.0275
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0924 0.1727
Entamoeba histolytica phosphofructokinase, putative 0.012 0.2121 0.4719
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Onchocerca volvulus 0.0296 0.5348 1
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0045 0.0743 0.0662
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus granulosus axis inhibition protein axin 0.002 0.0283 0.0275
Entamoeba histolytica hypothetical protein 0.002 0.0283 0.0629
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0158 0.0158
Toxoplasma gondii DNA polymerase family B protein 0.0007 0.0033 0.0375
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.2121 0.8918
Schistosoma mansoni amine GPCR 0.0296 0.5348 1
Loa Loa (eye worm) G-protein coupled receptor 0.0296 0.5348 0.5348
Echinococcus granulosus axis inhibition protein axin 0.002 0.0283 0.0275
Brugia malayi glutathione reductase 0.0052 0.0871 0.0791
Schistosoma mansoni histamine h1 receptor 0.0296 0.5348 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.056
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0154 0.0067
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.2121 0.2866
Giardia lamblia O-linked GlcNAc transferase 0.0045 0.0737 0.1473
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0024 0.0348 0.0706
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0243 0.054
Echinococcus multilocularis neuropeptide s receptor 0.0296 0.5348 0.7415
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.2349 1
Echinococcus granulosus tm gpcr rhodopsin 0.0296 0.5348 0.7415
Brugia malayi Tachykinin-like peptides receptor 99D 0.0296 0.5348 0.5307
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0871 0.2985
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0296 0.5348 0.5307
Onchocerca volvulus 0.0296 0.5348 1
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0015 0.0187 0.0349
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0296 0.5348 0.7415
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0243 0.0236
Echinococcus granulosus tm gpcr rhodopsin 0.0296 0.5348 0.7415
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0283 0.0275
Onchocerca volvulus 0.0296 0.5348 1
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0075 0.129 0.2137
Loa Loa (eye worm) hypothetical protein 0.003 0.0455 0.0455
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0276 0.0545
Echinococcus multilocularis fmrfamide receptor 0.0296 0.5348 0.7415
Echinococcus multilocularis sex peptide receptor 0.0296 0.5348 0.7415
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0158 0.0351
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0283 0.0275
Plasmodium falciparum glutathione reductase 0.0018 0.0243 0.2503
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0276 0.2897
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0201 0.0208
Schistosoma mansoni opsin-like receptor 0.0296 0.5348 1
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0283 0.0197
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0015 0.0187 0.0349
Echinococcus granulosus lamin 0.003 0.0455 0.0518
Leishmania major trypanothione reductase 0.0052 0.0871 0.188
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus granulosus fmrfamide receptor 0.0296 0.5348 0.7415
Brugia malayi GnHR receptor homolog 0.0296 0.5348 0.5307
Brugia malayi PXA domain containing protein 0.002 0.0283 0.0197
Loa Loa (eye worm) hypothetical protein 0.0008 0.0063 0.0063
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0507 0.1128
Echinococcus granulosus neuropeptides capa receptor 0.0296 0.5348 0.7415
Echinococcus granulosus neuropeptide Y receptor 0.0296 0.5348 0.7415
Trypanosoma brucei trypanothione reductase 0.0052 0.0871 0.168
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0296 0.5348 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0507 0.1063
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0015 0.0187 0.0108
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0924 0.1178
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.056
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0243 0.2503
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0055 0.0914 0.1165
Onchocerca volvulus 0.0296 0.5348 1
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0283 0.0275
Echinococcus granulosus biogenic amine 5HT receptor 0.0296 0.5348 0.7415
Onchocerca volvulus 0.0296 0.5348 1
Schistosoma mansoni neuropeptide receptor 0.0296 0.5348 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0507 0.5653
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Schistosoma mansoni myosin xvIII 0.0296 0.5348 1
Onchocerca volvulus 0.0296 0.5348 1
Brugia malayi hypothetical protein 0.0296 0.5348 0.5307
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.2121 0.2121
Schistosoma mansoni hypothetical protein 0.0138 0.2445 0.4571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.5348 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0283 0.0283
Onchocerca volvulus 0.0296 0.5348 1
Loa Loa (eye worm) phosphofructokinase 0.012 0.2121 0.2121
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0283 0.0275
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0243 0.0817
Brugia malayi Thioredoxin reductase 0.0052 0.0871 0.0791
Brugia malayi G protein-coupled receptor F59B2.13 0.0296 0.5348 0.5307
Echinococcus granulosus expressed protein 0.0396 0.7183 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0243 0.0817
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0243 0.0236
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0296 0.5348 0.7415
Brugia malayi G-protein coupled receptor 0.0296 0.5348 0.5307
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0276 0.0276
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0015 0.0187 0.0226
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0008 0.0063 0.0365
Schistosoma mansoni biogenic amine receptor 0.0296 0.5348 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0296 0.5348 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.2349 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0296 0.5348 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0296 0.5348 0.7415
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0283 0.0197
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0283 0.0529
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Loa Loa (eye worm) hypothetical protein 0.002 0.0283 0.0283
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0243 0.054
Schistosoma mansoni amine GPCR 0.0296 0.5348 1
Loa Loa (eye worm) TYRA-2 protein 0.0296 0.5348 0.5348
Loa Loa (eye worm) neuropeptide F receptor 0.0296 0.5348 0.5348
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0276 0.0265
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus multilocularis allatostatin A receptor 0.0296 0.5348 0.7415
Brugia malayi larval opioid receptor 0.0296 0.5348 0.5307
Echinococcus multilocularis fmrfamide receptor 0.0296 0.5348 0.7415
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0296 0.5348 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0296 0.5348 0.7415
Schistosoma mansoni biogenic amine (5HT) receptor 0.0296 0.5348 1
Brugia malayi neuropeptide F receptor 0.0296 0.5348 0.5307
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.2121 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0924 0.0924
Onchocerca volvulus 0.0296 0.5348 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.2104 0.8837
Brugia malayi AKH receptor 0.0296 0.5348 0.5307
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0283 0.0283
Toxoplasma gondii thioredoxin reductase 0.0052 0.0871 1
Echinococcus granulosus g-protein coupled receptor 0.0296 0.5348 0.7415
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0015 0.0187 0.0415
Loa Loa (eye worm) follicle stimulating hormone receptor 0.055 1 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus multilocularis g-protein coupled receptor 0.0296 0.5348 0.7415
Echinococcus multilocularis g protein coupled receptor 0.0296 0.5348 0.7415
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0871 0.0871
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0158 0.0158
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0296 0.5348 0.7415
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0283 0.0197
Entamoeba histolytica hypothetical protein 0.002 0.0283 0.0629
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Brugia malayi 6-phosphofructokinase 0.012 0.2121 0.2052
Echinococcus multilocularis somatostatin receptor 0.0296 0.5348 0.7415
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.0045 0.0737 0.8454
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.014 0.0311
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0283 0.0529
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0341 0.069
Schistosoma mansoni hypothetical protein 0.0296 0.5348 1
Onchocerca volvulus 0.003 0.0455 0.0519
Echinococcus multilocularis neuropeptide receptor 0.0296 0.5348 0.7415
Giardia lamblia Thymidine kinase 0.025 0.4495 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0276 0.0427
Loa Loa (eye worm) hypothetical protein 0.0019 0.0253 0.0253
Trichomonas vaginalis thymidine kinase, putative 0.025 0.4495 1
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0341 0.0256
Echinococcus granulosus neuropeptide s receptor 0.0296 0.5348 0.7415
Echinococcus multilocularis G protein coupled receptor 139 0.0296 0.5348 0.7415
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0015 0.0187 0.0415
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.056
Brugia malayi RE15519p 0.0296 0.5348 0.5307
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0046 0.0746 0.1395
Loa Loa (eye worm) melatonin receptor type 1A 0.0296 0.5348 0.5348
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0015 0.0187 0.014
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Echinococcus multilocularis neuropeptide receptor 0.0296 0.5348 0.7415
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0087 0.1002
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0341 0.0357
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0296 0.5348 0.7415
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0243 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0015 0.0187 0.0345
Plasmodium vivax DNA polymerase alpha, putative 0.0044 0.0724 0.7845
Echinococcus granulosus 7TM GPCR rhodopsin 0.0296 0.5348 0.7415
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0158 0.0158
Brugia malayi ORL1-like opioid receptor 0.0296 0.5348 0.5307
Echinococcus multilocularis neuropeptide receptor A26 0.0296 0.5348 0.7415
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0283 0.056
Trypanosoma cruzi thymidine kinase, putative 0.025 0.4495 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0296 0.5348 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.025 0.0467
Echinococcus granulosus lamin dm0 0.003 0.0455 0.0518
Echinococcus granulosus g protein coupled receptor 0.0296 0.5348 0.7415
Loa Loa (eye worm) neuropeptide F receptor 0.0296 0.5348 0.5348
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0276 0.0545
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.5348 1
Brugia malayi hypothetical protein 0.0296 0.5348 0.5307
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0283 0.0275
Schistosoma mansoni regulator of G protein signaling 0.002 0.0283 0.0529
Leishmania major ATP-dependent phosphofructokinase 0.012 0.2121 0.468
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.2349 1
Schistosoma mansoni adenoreceptor 0.0296 0.5348 1
Brugia malayi hypothetical protein 0.002 0.0283 0.0197
Brugia malayi hypothetical protein 0.0296 0.5348 0.5307
Echinococcus granulosus neuropeptide receptor 0.0296 0.5348 0.7415
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.2121 0.455
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0296 0.5348 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0243 0.0471
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0283 0.0283
Onchocerca volvulus 0.0296 0.5348 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0243 0.054
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Brugia malayi phosphofructokinase 0.012 0.2121 0.2052
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus granulosus neuropeptide receptor A26 0.0296 0.5348 0.7415
Echinococcus multilocularis neuropeptides capa receptor 0.0296 0.5348 0.7415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.5348 1
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0015 0.0187 0.0345
Giardia lamblia O-linked GlcNAc transferase 0.0026 0.0394 0.0695
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.2104 0.8837
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0243 0.054
Loa Loa (eye worm) glutathione reductase 0.0052 0.0871 0.0871
Schistosoma mansoni neuropeptide f receptor 76f 0.0296 0.5348 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0007 0.0033 0.0073
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0871 0.1105
Echinococcus multilocularis lamin dm0 0.003 0.0455 0.0518
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0871 1
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0283 0.0275
Schistosoma mansoni axis inhibition protein axin 0.002 0.0283 0.0529
Brugia malayi Cytochrome P450 family protein 0.0014 0.0158 0.0071
Trichomonas vaginalis thymidine kinase, putative 0.025 0.4495 1
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0243 0.0471
Trichomonas vaginalis thymidine kinase, putative 0.025 0.4495 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0296 0.5348 0.7415
Loa Loa (eye worm) intermediate filament protein 0.003 0.0455 0.0455
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0296 0.5348 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Trypanosoma cruzi thymidine kinase, putative 0.025 0.4495 1
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0283 0.0275
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0276 0.019
Onchocerca volvulus 0.0296 0.5348 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0924 0.1727
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0296 0.5348 0.5307
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0296 0.5348 0.7415
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0276 0.0265
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0172 0.012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.5348 1
Brugia malayi sulfakinin receptor protein 0.0296 0.5348 0.5307
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0296 0.5348 0.5348
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0283 0.0275
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0008 0.0063 0.0069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0243 0.054
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0296 0.5348 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Brugia malayi hypothetical protein 0.0296 0.5348 0.5307
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0296 0.5348 0.7415
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0015 0.0194 0.1919
Schistosoma mansoni hypothetical protein 0.0296 0.5348 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0296 0.5348 1
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0283 0.0275
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0507 0.1063
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0296 0.5348 0.7415
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.002 0.0285 0.0534
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0296 0.5348 0.7415
Leishmania major thymidine kinase, putative 0.025 0.4495 1
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0015 0.0187 0.014
Treponema pallidum hypothetical protein 0.0018 0.0236 0.1115
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0015 0.0187 0.01
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0507 0.1063
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0296 0.5348 0.7415
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0871 0.1105
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0924 0.1178
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0507 0.1063
Loa Loa (eye worm) G-protein coupled receptor 0.0296 0.5348 0.5348
Onchocerca volvulus 0.0296 0.5348 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0015 0.0187 0.0187
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0348 0.0774
Echinococcus multilocularis O glycosyltransferase 0.0046 0.0746 0.0928
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0924 0.1727
Schistosoma mansoni hypothetical protein 0.0296 0.5348 1
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0507 0.1063
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0507 0.1063
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0243 0.054
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0296 0.5348 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus multilocularis g protein coupled receptor 0.0296 0.5348 0.7415
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.014 0.024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0924 0.1178
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0243 0.0157
Entamoeba histolytica hypothetical protein 0.002 0.0283 0.0629
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0243 0.0471
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus granulosus g protein coupled receptor 0.0296 0.5348 0.7415
Echinococcus multilocularis serotonin receptor 0.0296 0.5348 0.7415
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0276 0.0613
Brugia malayi putative neuropeptide receptor NPR1 0.0296 0.5348 0.5307
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0455 0.037
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0187 0.0345
Schistosoma mansoni hypothetical protein 0.0296 0.5348 1
Brugia malayi hypothetical protein 0.0296 0.5348 0.5307
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0158 0.0351
Treponema pallidum NADH oxidase 0.0018 0.0243 0.1144
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0045 0.0743 0.0743
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0243 0.0471
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0507 0.4674
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.056
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.2121 0.0695
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0243 0.0431
Schistosoma mansoni opsin-like receptor 0.0296 0.5348 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0296 0.5348 0.5348
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0296 0.5348 0.7415
Schistosoma mansoni biogenic amine (5HT) receptor 0.0296 0.5348 1
Brugia malayi 6-phosphofructokinase 0.012 0.2121 0.2052
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0283 0.0283
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0187 0.0415
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0015 0.0187 0.014
Loa Loa (eye worm) RGS-3 protein 0.002 0.0283 0.0283
Treponema pallidum hypothetical protein 0.0018 0.0236 0.1115
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0507 0.4674
Treponema pallidum hypothetical protein 0.0018 0.0236 0.1115
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0283 0.0275
Loa Loa (eye worm) hypothetical protein 0.002 0.0283 0.0283
Brugia malayi Serotonin receptor 0.0296 0.5348 0.5307
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0055 0.0914 0.1165
Schistosoma mansoni DNA helicase recq1 0.001 0.0087 0.0163
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0296 0.5348 1
Echinococcus multilocularis musashi 0.003 0.0455 0.0518
Schistosoma mansoni neuropeptide receptor 0.0296 0.5348 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0162 0.0162
Schistosoma mansoni lamin 0.003 0.0455 0.085
Echinococcus granulosus somatostatin receptor 0.0296 0.5348 0.7415
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0507 0.0952
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0296 0.5348 1
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0201 0.0115
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0276 0.06
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0008 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0283 0.056
Schistosoma mansoni intermediate filament proteins 0.003 0.0455 0.085
Mycobacterium ulcerans hypothetical protein 0.0018 0.0236 0.04
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0283 0.0275
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0283 0.0197
Echinococcus multilocularis expressed protein 0.0396 0.7183 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0296 0.5348 0.7415
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0276 0.0157
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.2104 0.8837
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0243 0.1572
Schistosoma mansoni biogenic amine receptor 0.0296 0.5348 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0283 0.0529
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0243 0.0219
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0296 0.5348 0.7415
Brugia malayi hypothetical protein 0.0296 0.5348 0.5307
Schistosoma mansoni amine GPCR 0.0296 0.5348 1
Brugia malayi hypothetical protein 0.0296 0.5348 0.5307
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0015 0.0187 0.014
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Echinococcus granulosus G protein coupled receptor 139 0.0296 0.5348 0.7415
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.014 0.024
Loa Loa (eye worm) hypothetical protein 0.0296 0.5348 0.5348
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0296 0.5348 0.5348
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0276 0.0613
Entamoeba histolytica phosphofructokinase, putative 0.012 0.2121 0.4719
Schistosoma mansoni ap endonuclease 0.002 0.0276 0.0515
Echinococcus multilocularis orexin receptor type 2 0.0296 0.5348 0.7415
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.2121 0.468
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0283 0.0275
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.2121 0.468
Brugia malayi hypothetical protein 0.0296 0.5348 0.5307
Schistosoma mansoni neuropeptide receptor 0.0296 0.5348 1
Onchocerca volvulus 0.003 0.0455 0.0519
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0015 0.0187 0.0349
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0024 0.0348 0.0478
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0283 0.0275
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0015 0.0187 0.0345
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0296 0.5348 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4654 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2238.7211 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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