Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 15-lipoxygenase | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | arachidonate 5 lipoxygenase | arachidonate 15-lipoxygenase | 662 aa | 590 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.3072 | 0.2043 |
Brugia malayi | hypothetical protein | 0.0024 | 0.1293 | 0.4209 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.3072 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.3072 | 0.2043 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0024 | 0.1293 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1293 | 0.4209 |
Brugia malayi | Doublecortin family protein | 0.0024 | 0.1293 | 0.4209 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0024 | 0.1293 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1293 | 0.4209 |
Onchocerca volvulus | 0.0033 | 0.3072 | 1 | |
Loa Loa (eye worm) | doublecortin family protein | 0.0024 | 0.1293 | 0.4209 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0067 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.3072 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.3072 | 0.2043 |
Echinococcus multilocularis | musashi | 0.0033 | 0.3072 | 0.2043 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.3072 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.3072 | 0.2043 |
Brugia malayi | hypothetical protein | 0.0024 | 0.1293 | 0.4209 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.3072 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.3072 | 0.2043 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.3072 | 0.2043 |
Schistosoma mansoni | lipoxygenase | 0.0067 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.3072 | 0.2043 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2951 | 0.9606 |
Onchocerca volvulus | 0.0033 | 0.3072 | 1 | |
Echinococcus multilocularis | lamin | 0.0033 | 0.3072 | 0.2043 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.