TDR Targets

Basic information

Technical information

TDR Targets ID: 1391483
Name: phenylmethyl 5-(4-methylphenyl)-4,6-dioxo-3a, 6a-dihydro-1H-pyrrolo[3,4-d]pyrazole-3-carbox ylate
MW: 363.367 | Formula: C20H17N3O4
H donors: 1 H acceptors: 3 LogP: 2.86 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)N1C(=O)C2C(C1=O)NN=C2C(=O)OCc1ccccc1
InChi: 1S/C20H17N3O4/c1-12-7-9-14(10-8-12)23-18(24)15-16(19(23)25)21-22-17(15)20(26)27-11-13-5-3-2-4-6-13/h2-10,15-16,21H,11H2,1H3
InChiKey: YASHCXBRCRLSEF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-(4-methylphenyl)-4,6-dioxo-3a,6a-dihydro-1H-pyrrolo[3,4-d]pyrazole-3-carboxylic acid phenylmethyl ester
4,6-diketo-5-(4-methylphenyl)-3a,6a-dihydro-1H-pyrrolo[3,4-d]pyrazole-3-carboxylic acid benzyl ester
STOCK4S-60210
4,6-Dioxo-5-p-tolyl-1,3a,4,5,6,6a-hexahydro-pyrrolo[3,4-c]pyrazole-3-carboxylic acid benzyl ester
MLS000588210
SMR000220200

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0531	0	0.5
Brugia malayi	hypothetical protein	0.0531	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0531	0	0.5
Brugia malayi	G-protein coupled receptor	0.0531	0	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0531	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0531	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0531	0	0.5
Echinococcus multilocularis	somatostatin receptor	0.0531	0	0.5
Brugia malayi	Dopamine receptor protein 2	0.0531	0	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0531	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0531	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.0531	0	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0531	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0531	0	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0531	0	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0531	0	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0531	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0531	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0531	0	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0531	0	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0531	0	0.5
Brugia malayi	ORL1-like opioid receptor	0.0531	0	0.5
Echinococcus granulosus	orexin receptor type 2	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0531	0	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0531	0	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0531	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0531	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0531	0	0.5
Echinococcus multilocularis	sex peptide receptor	0.0531	0	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0531	0	0.5
Brugia malayi	G-protein coupled receptor	0.0531	0	0.5
Echinococcus granulosus	serotonin receptor	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0531	0	0.5
Brugia malayi	hypothetical protein	0.0531	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0531	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0531	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0531	0	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0531	0	0.5
Schistosoma mansoni	adenoreceptor	0.0531	0	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.0531	0	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0531	0	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0531	0	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0531	0	0.5
Schistosoma mansoni	amine GPCR	0.0531	0	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0531	0	0.5
Brugia malayi	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0531	0	0.5
Brugia malayi	putative neuropeptide receptor	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0531	0	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0531	0	0.5
Brugia malayi	Serotonin receptor	0.0531	0	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0531	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0531	0	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0531	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0531	0	0.5
Brugia malayi	Dopamine receptor protein 1	0.0531	0	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0531	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0531	0	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0531	0	0.5
Brugia malayi	G protein-coupled receptor	0.0531	0	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0531	0	0.5
Brugia malayi	hypothetical protein	0.0531	0	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0531	0	0.5
Brugia malayi	hypothetical protein	0.0531	0	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0531	0	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Brugia malayi	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Schistosoma mansoni	amine GPCR	0.0531	0	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Schistosoma mansoni	histamine h1 receptor	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Brugia malayi	GnHR receptor homolog	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Mycobacterium tuberculosis	Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)	0.0827	1	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0531	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0531	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0531	0	0.5
Schistosoma mansoni	myosin xvIII	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0531	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0531	0	0.5
Brugia malayi	neuropeptide F receptor	0.0531	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0531	0	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0531	0	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0531	0	0.5
Schistosoma mansoni	amine GPCR	0.0531	0	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0531	0	0.5
Echinococcus granulosus	sex peptide receptor	0.0531	0	0.5
Echinococcus granulosus	somatostatin receptor	0.0531	0	0.5
Brugia malayi	AKH receptor	0.0531	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0531	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0531	0	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0531	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus granulosus	neuropeptide receptor	0.0531	0	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0531	0	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0531	0	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0531	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Brugia malayi	neuropeptide F receptor	0.0531	0	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0531	0	0.5
Brugia malayi	follicle stimulating hormone receptor	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0531	0	0.5
Brugia malayi	Melatonin receptor type 1A	0.0531	0	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0531	0	0.5
Brugia malayi	sulfakinin receptor protein	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0531	0	0.5
Echinococcus granulosus	neuropeptide receptor	0.0531	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0531	0	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0531	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0531	0	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0531	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.0531	0	0.5
Brugia malayi	Serotonin receptor	0.0531	0	0.5
Echinococcus granulosus	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0531	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0531	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Brugia malayi	larval opioid receptor	0.0531	0	0.5
Brugia malayi	hypothetical protein	0.0531	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0531	0	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0531	0	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0531	0	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0531	0	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0531	0	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0531	0	0.5
Echinococcus granulosus	allatostatin A receptor	0.0531	0	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0531	0	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0531	0	0.5
Brugia malayi	hypothetical protein	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0531	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.0531	0	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0531	0	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0531	0	0.5
Schistosoma mansoni	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Schistosoma mansoni	amine GPCR	0.0531	0	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0531	0	0.5
Brugia malayi	hypothetical protein	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0531	0	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0531	0	0.5
Mycobacterium ulcerans	secreted antigen 85-C FbpC	0.0827	1	0.5
Onchocerca volvulus		0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Echinococcus multilocularis	serotonin receptor	0.0531	0	0.5
Schistosoma mansoni	hypothetical protein	0.0531	0	0.5
Brugia malayi	hypothetical protein	0.0531	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0531	0	0.5
Brugia malayi	RE15519p	0.0531	0	0.5
Schistosoma mansoni	amine GPCR	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0531	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0531	0	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0531	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0531	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0531	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0531	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0531	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0531	0	0.5
Schistosoma mansoni	hypothetical protein	0.0531	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0531	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0531	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0531	0	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0531	0	0.5
Echinococcus multilocularis	serotonin receptor	0.0531	0	0.5
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Schistosoma mansoni	hypothetical protein	0.0531	0	0.5
Onchocerca volvulus		0.0531	0	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0531	0	0.5
Brugia malayi	Dopamine receptor	0.0531	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0531	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0531	0	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0531	0	0.5
Echinococcus granulosus	fmrfamide receptor	0.0531	0	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0531	0	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0531	0	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0531	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.7943 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1530022

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1391483