Detailed information for compound 1391747

Basic information

Technical information
  • TDR Targets ID: 1391747
  • Name: 2-(3,3,5-trimethyl-2,4-dihydroisoquinolin-1-y lidene)acetamide
  • MW: 230.306 | Formula: C14H18N2O
  • H donors: 2 H acceptors: 1 LogP: 2.02 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)/C=C/1\NC(C)(C)Cc2c1cccc2C
  • InChi: 1S/C14H18N2O/c1-9-5-4-6-10-11(9)8-14(2,3)16-12(10)7-13(15)17/h4-7,16H,8H2,1-3H3,(H2,15,17)/b12-7-
  • InChiKey: DUVCZACXAHCUHM-GHXNOFRVSA-N  


Substructure search Similarity search

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Synonyms

  • (2Z)-2-(3,3,5-trimethyl-2,4-dihydroisoquinolin-1-ylidene)acetamide
  • 2-(3,3,5-trimethyl-2,4-dihydroisoquinolin-1-ylidene)ethanamide
  • (2Z)-2-(3,3,5-trimethyl-2,4-dihydroisoquinolin-1-ylidene)ethanamide
  • SMR000225575
  • ChemDiv1_020378
  • Oprea1_201303
  • A1923/0080861
  • 2-(3,3,5-trimethyl-3,4-dihydro-1(2H)-isoquinolinylidene)acetamide
  • MLS000700074
  • Oprea1_057697
  • AG-205/12234072

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0077
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0177 0.1325 0.1341
Entamoeba histolytica heat shock protein STI1, putative 0.0015 0.0078 0.0078
Plasmodium falciparum Hsp70/Hsp90 organizing protein 0.0015 0.0078 0.0079
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0238 0.0238
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0024 0.0025
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.1284 0.9881 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0008 0.0024 0.0025
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0024 0.0024
Leishmania major stress-inducible protein STI1 homolog 0.0018 0.0102 0.0103
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0008 0.0024 0.0025
Schistosoma mansoni hypothetical protein 0.0177 0.1325 0.1325
Trypanosoma brucei stress-inducible protein STI1-like, putative 0.0015 0.0078 0.0079
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0112 0.0114
Schistosoma mansoni immunophilin 0.1299 1 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0024 0.0025
Onchocerca volvulus 0.018 0.1348 0.6214
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0177 0.1325 1
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0177 0.1325 0.1341
Loa Loa (eye worm) TPR domain-containing protein 0.0015 0.0078 0.0079
Echinococcus multilocularis O glycosyltransferase 0.0015 0.0078 0.0078
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0177 0.1325 0.1338
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0112 0.0114
Echinococcus multilocularis STIP1 y and U box containing protein 1 0.0015 0.0078 0.0078
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0024 0.0025
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0177 0.1325 0.1325
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0966 0.729
Onchocerca volvulus 0.0033 0.0211 0.0973
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7526 0.7526
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0112 0.0114
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0177 0.1325 0.1338
Trypanosoma cruzi N-acetyltransferase subunit Nat1, putative 0.0015 0.0078 0.0079
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0024 0.0184
Onchocerca volvulus 0.0015 0.0078 0.0361
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0211 0.0214
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0192 0.1444 0.1444
Loa Loa (eye worm) hypothetical protein 0.0029 0.0181 0.0183
Echinococcus granulosus small glutamine rich tetratricopeptide 0.0015 0.0078 0.0078
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0177 0.1325 0.1341
Loa Loa (eye worm) TPR Domain containing protein 0.0015 0.0078 0.0079
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0008 0.0024 0.0025
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0181 0.1363
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0078 0.0079
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0177 0.1325 0.1341
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0008 0.0024 0.0025
Echinococcus granulosus intermediate filament protein 0.0033 0.0211 0.0211
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0181 0.1363
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0177 0.1325 0.1325
Brugia malayi TPR Domain containing protein 0.0015 0.0078 0.0079
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0007 0.0015 0.0116
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0112 0.0848
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0181 0.0183
Loa Loa (eye worm) hypothetical protein 0.0033 0.0211 0.0214
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.1284 0.9881 0.9881
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1078 0.8138
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0125 0.0941
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0024 0.0025
Schistosoma mansoni DNAj homolog subfamily C member 0.0018 0.0102 0.0102
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0024 0.0025
Echinococcus multilocularis musashi 0.0033 0.0211 0.0211
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0181 0.0182
Trypanosoma brucei stress-inducible protein STI1-like, putative 0.0015 0.0078 0.0079
Giardia lamblia Hypothetical protein 0.0177 0.1325 0.1341
Echinococcus multilocularis lamin 0.0033 0.0211 0.0211
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0112 0.0114
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0024 0.0184
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0024 0.0025
Trichomonas vaginalis immunophilin, putative 0.1284 0.9881 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.1284 0.9881 1
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0177 0.1325 1
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0078 0.0079
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0177 0.1325 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.1284 0.9881 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0126
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0112 0.0114
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0177 0.1325 0.1341
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0024 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0181 0.0183
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0024 0.0184
Loa Loa (eye worm) hypothetical protein 0.0016 0.0081 0.0082
Trichomonas vaginalis fk506-binding protein, putative 0.0177 0.1325 0.1341
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0112 0.0114
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0024 0.0184
Echinococcus multilocularis Tetratricopeptide repeat protein 1 0.0015 0.0078 0.0078
Echinococcus multilocularis muscleblind protein 0.018 0.1353 0.1353
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0401 0.0401
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0024 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0112 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1325 0.1341
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.1284 0.9881 1
Brugia malayi hypothetical protein 0.0015 0.0078 0.0079
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0024 0.0184
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0181 0.0183
Onchocerca volvulus 0.0008 0.0024 0.0112
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0008 0.0024 0.0025
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0177 0.1325 0.1341
Trypanosoma cruzi N-acetyltransferase subunit Nat1, putative 0.0015 0.0078 0.0079
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0177 0.1325 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0024 0.0184
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0238 0.0238
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0181 0.0182
Echinococcus granulosus STIP1 y and U box containing protein 1 0.0015 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0015 0.0076 0.0077
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0401 0.0405
Loa Loa (eye worm) hypothetical protein 0.111 0.8539 0.8642
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0181 0.1363
Loa Loa (eye worm) glutathione reductase 0.0057 0.0401 0.0405
Leishmania major fk506-binding protein 1-like protein 0.1284 0.9881 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0024 0.0025
Loa Loa (eye worm) TPR Domain containing protein 0.0015 0.0078 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0126
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0126
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0112 0.0114
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0015 0.0078 0.0079
Trypanosoma brucei stress-induced protein sti1, putative 0.0015 0.0078 0.0079
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0078 0.0078
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0094 0.0095
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.1284 0.9881 0.9976
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0024 0.0025
Leishmania major hypothetical protein, conserved 0.0018 0.0102 0.0103
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0024 0.0025
Onchocerca volvulus 0.0015 0.0078 0.0361
Leishmania major trypanothione reductase 0.0057 0.0401 0.0405
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.1299 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0112 0.0114
Trypanosoma cruzi stress-inducible protein STI1-like, putative 0.0015 0.0078 0.0079
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0081 0.0081
Echinococcus granulosus lamin 0.0033 0.0211 0.0211
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0238 0.1796
Leishmania major stress-induced protein sti1 0.0015 0.0078 0.0079
Mycobacterium tuberculosis Probable reductase 0.013 0.0966 0.729
Echinococcus granulosus Tetratricopeptide repeat protein 1 0.0015 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0126
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0078 0.0079
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0024 0.0184
Echinococcus granulosus stress induced phosphoprotein 1 0.0018 0.0102 0.0102
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0112 0.0114
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.1284 0.9881 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0112 0.0112
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0015 0.0078 0.0079
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0238 0.0238
Schistosoma mansoni immunophilin 0.1123 0.8635 0.8635
Plasmodium falciparum thioredoxin reductase 0.0057 0.0401 0.0405
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0401 0.0401
Brugia malayi intermediate filament protein 0.0033 0.0211 0.0213
Onchocerca volvulus 0.0029 0.0181 0.0833
Onchocerca volvulus Tetratricopeptide repeat protein 5 homolog 0.0015 0.0078 0.0361
Trypanosoma brucei stress-inducible protein STI1-like, putative 0.0015 0.0078 0.0079
Treponema pallidum catabolite gene activator 0.0015 0.0078 0.0079
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1078 0.8138
Toxoplasma gondii thioredoxin reductase 0.0057 0.0401 0.3024
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0177 0.1325 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0177 0.1325 0.1341
Plasmodium falciparum glutathione reductase 0.002 0.0112 0.0114
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.1287 0.9904 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0112 0.0114
Trichomonas vaginalis fk506 binding protein, putative 0.0177 0.1325 0.1341
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0116 0.0873
Echinococcus granulosus lamin dm0 0.0033 0.0211 0.0211
Plasmodium falciparum thioredoxin reductase 0.002 0.0112 0.0114
Schistosoma mansoni heat shock protein 70 0.0015 0.0078 0.0078
Echinococcus multilocularis fk506 binding protein 0.1284 0.9881 0.9881
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0015 0.0078 0.0078
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.1284 0.9881 1
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.1284 0.9881 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0181 0.0183
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0112 0.0848
Echinococcus multilocularis 0.0177 0.1325 0.1325
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.1284 0.9881 0.9881
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0112 0.0848
Loa Loa (eye worm) hypothetical protein 0.0029 0.0181 0.0183
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0024 0.0025
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.1299 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0238 0.0238
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0181 0.0181
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0177 0.1325 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0181 0.0181
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0024 0.0184
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0181 0.0182
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0177 0.1325 0.1341
Mycobacterium ulcerans hypothetical protein 0.0029 0.0181 0.0183
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0181 0.0183
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0125 0.0941
Trypanosoma brucei serine/threonine protein phosphatase 5 0.0015 0.0078 0.0079
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0125 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0238 0.0238
Plasmodium falciparum glutathione reductase 0.0057 0.0401 0.0405
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0024 0.0184
Leishmania major peptidylprolyl isomerase-like protein 0.1284 0.9881 1
Entamoeba histolytica TPR repeat protein 0.0015 0.0078 0.0078
Brugia malayi TPR Domain containing protein 0.0015 0.0078 0.0079
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0177 0.1325 0.1341
Mycobacterium ulcerans hypothetical protein 0.0177 0.1325 0.1341
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0177 0.1325 0.1341
Brugia malayi Pre-SET motif family protein 0.0036 0.0238 0.024
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0015 0.0078 0.0079
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0072 0.0072
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0024 0.0025
Onchocerca volvulus 0.0008 0.0024 0.0112
Echinococcus granulosus FK506 binding protein 2 0.0177 0.1325 0.1325
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0401 0.0405
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0112 0.0848
Schistosoma mansoni DNAj homolog subfamily C member 0.0018 0.0102 0.0102
Onchocerca volvulus 0.0286 0.217 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0238 0.0241
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.1123 0.8635 0.8635
Schistosoma mansoni lamin 0.0033 0.0211 0.0211
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0112 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0078 0.0079
Leishmania major small glutamine-rich tetratricopeptide repeat protein, putative 0.0015 0.0078 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0125 0.0126
Trichomonas vaginalis chaperone binding protein, putative 0.0015 0.0078 0.0079
Trichomonas vaginalis chaperone binding protein, putative 0.0015 0.0078 0.0079
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0116 0.0873
Loa Loa (eye worm) hypothetical protein 0.0032 0.0206 0.0209
Loa Loa (eye worm) hypothetical protein 0.0029 0.0181 0.0183
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0024 0.0025
Schistosoma mansoni fk506 binding protein 0.0177 0.1325 0.1325
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.1284 0.9881 1
Loa Loa (eye worm) oxidoreductase 0.0008 0.0024 0.0025
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.1284 0.9881 1
Loa Loa (eye worm) hypothetical protein 0.018 0.1353 0.137
Brugia malayi TPR Domain containing protein 0.0015 0.0078 0.0079
Trypanosoma cruzi small glutamine-rich tetratricopeptide repeat protein, putative 0.0015 0.0078 0.0079
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0112 0.0848
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0024 0.0025
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0081 0.0081
Brugia malayi Muscleblind-like protein 0.018 0.1353 0.1366
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0112 0.0114
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0177 0.1325 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0024 0.0025
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0008 0.0024 0.0025
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1078 0.8138
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0177 0.1325 0.1341
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0177 0.1325 0.1341
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0181 0.1363
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0177 0.1325 0.1341
Trypanosoma brucei small glutamine-rich tetratricopeptide repeat protein, putative 0.0015 0.0078 0.0079
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0177 0.1325 0.1341
Onchocerca volvulus 0.0036 0.0238 0.1097
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0177 0.1325 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0024 0.0025
Toxoplasma gondii tetratricopeptide repeat domain containing protein 0.0015 0.0078 0.0591
Loa Loa (eye worm) hypothetical protein 0.0015 0.0078 0.0079
Brugia malayi glutathione reductase 0.0057 0.0401 0.0404
Treponema pallidum hypothetical protein 0.0015 0.0078 0.0079
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0112 0.0112
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0966 0.729
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0211 0.0214
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0112 0.0114
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0966 0.729
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0024 0.0025
Trypanosoma brucei trypanothione reductase 0.0057 0.0401 0.0405
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0024 0.0025
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0177 0.1325 0.1341
Echinococcus granulosus O glycosyltransferase 0.0015 0.0078 0.0078
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.1284 0.9881 1
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0008 0.0024 0.0184
Onchocerca volvulus 0.0018 0.0102 0.0469
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0125 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0112 0.0114
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0211 0.0213
Loa Loa (eye worm) hypothetical protein 0.018 0.1353 0.137
Loa Loa (eye worm) hypothetical protein 0.0177 0.1325 0.1341
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0024 0.0025
Trypanosoma brucei hypothetical protein, conserved 0.0177 0.1325 0.1341
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0112 0.0114
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0177 0.1325 0.1325
Schistosoma mansoni immunophilin 0.1299 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0112 0.0114
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0008 0.0024 0.0184
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0008 0.0024 0.0184
Schistosoma mansoni heat shock protein 70 0.0015 0.0078 0.0078
Plasmodium vivax Hsp70/Hsp90 organizing protein, putative 0.0015 0.0078 0.0079
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0177 0.1325 0.1341
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0024 0.0025
Brugia malayi Pre-SET motif family protein 0.0251 0.1901 0.192
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.1284 0.9881 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0112 0.0114
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0228 0.0228
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0966 0.729
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.1284 0.9881 1
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0078 0.0079
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0401 0.3024
Giardia lamblia Stress-induced-phosphoprotein 1 0.0015 0.0078 0.0079
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0112 0.0114
Echinococcus multilocularis small glutamine rich tetratricopeptide 0.0015 0.0078 0.0078
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0181 0.0183
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0072 0.0072
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0024 0.0025
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0112 0.0114
Loa Loa (eye worm) FKBP5 protein 0.1284 0.9881 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0024 0.0184
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0112 0.0114
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0024 0.0184
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0008 0.0024 0.0025
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0177 0.1325 0.1338
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0112 0.0113
Echinococcus multilocularis lamin dm0 0.0033 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0018 0.0102 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0238 0.0238
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0024 0.0024
Plasmodium vivax glutathione reductase, putative 0.0057 0.0401 0.0405
Schistosoma mansoni lamin 0.0033 0.0211 0.0211
Treponema pallidum NADH oxidase 0.002 0.0112 0.0114
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0008 0.0024 0.0025
Trypanosoma brucei TPR-repeat-containing chaperone protein DNAJ, putative 0.0018 0.0102 0.0103
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0024 0.0025
Trichomonas vaginalis chaperone binding protein, putative 0.0015 0.0078 0.0079
Onchocerca volvulus 0.0008 0.0024 0.0112
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0025
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0015 0.0078 0.0079
Leishmania major hypothetical protein, conserved 0.0015 0.0078 0.0079
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1078 0.8138
Trichomonas vaginalis O-linked N-acetylglucosamine transferase, ogt, putative 0.0018 0.0102 0.0103
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0177 0.1325 0.1341
Schistosoma mansoni protein phosphatase-5 0.0015 0.0078 0.0078
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0177 0.1325 0.1341
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0024 0.0184
Trichomonas vaginalis set domain proteins, putative 0.0286 0.217 0.2196
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0112 0.0114
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0008 0.0024 0.0025
Echinococcus granulosus mitochondrial import receptor subunit tom34 0.0015 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0241
Brugia malayi Thioredoxin reductase 0.0057 0.0401 0.0404
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0024 0.0025
Onchocerca volvulus 0.0008 0.0024 0.0112
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0401 0.0405
Onchocerca volvulus 0.0177 0.1325 0.6106
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0112 0.0848
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0015 0.0078 0.0078
Trypanosoma cruzi stress-inducible protein STI1-like, putative 0.0015 0.0078 0.0079
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0181 0.0183
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1901 0.1924
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0125 0.0126
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0112 0.0114
Entamoeba histolytica TPR repeat protein 0.0015 0.0078 0.0078
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.1123 0.8635 0.8635
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0112 0.0114
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0024 0.0025
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0112 0.0114
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0015 0.0078 0.0079
Loa Loa (eye worm) TPR Domain containing protein 0.0015 0.0078 0.0079
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0181 0.0183
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0024 0.0184
Onchocerca volvulus Kinesin light chain homolog 0.0015 0.0078 0.0361
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0112 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.1325 0.1341
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.0177 0.1325 0.1341
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0024 0.0025
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0015 0.0078 0.0079
Trichomonas vaginalis chaperone binding protein, putative 0.0015 0.0078 0.0079
Onchocerca volvulus 0.0033 0.0211 0.0973
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0024 0.0025
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0024 0.0024
Echinococcus multilocularis stress induced phosphoprotein 1 0.0018 0.0102 0.0102
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0966 0.729
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0024 0.0184
Trichomonas vaginalis fk506-binding protein, putative 0.1284 0.9881 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0116 0.0873
Trichomonas vaginalis fk506-binding protein, putative 0.0177 0.1325 0.1341
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0181 0.0183
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0094 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0078 0.0079
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0966 0.729
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0024 0.0025
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0177 0.1325 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.1284 0.9881 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0181 0.0181
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0078 0.0079
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.0015 0.0078 0.0591
Echinococcus granulosus muscleblind protein 0.018 0.1353 0.1353
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0238 0.0238
Schistosoma mansoni intermediate filament proteins 0.0033 0.0211 0.0211
Echinococcus multilocularis mitochondrial import receptor subunit tom34 0.0015 0.0078 0.0078
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0177 0.1325 0.1341
Mycobacterium ulcerans acetyl-CoA synthetase 0.0008 0.0024 0.0025
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0112 0.0114
Giardia lamblia O-linked GlcNAc transferase 0.0015 0.0078 0.0079
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0024 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0116 0.0873
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.1299 1 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.1284 0.9881 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.1353 0.1353
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0112 0.0112
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0181 0.0183
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.1284 0.9881 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0067 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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