Detailed information for compound 1391826

Basic information

Technical information
  • TDR Targets ID: 1391826
  • Name: 7-[(4-phenylmethoxyphenyl)methyl]-1-azabicycl o[2.2.2]octan-8-one hydrochloride
  • MW: 357.874 | Formula: C21H24ClNO2
  • H donors: 0 H acceptors: 1 LogP: 4.59 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C2CCN(C1Cc1ccc(cc1)OCc1ccccc1)CC2.Cl
  • InChi: 1S/C21H23NO2.ClH/c23-21-18-10-12-22(13-11-18)20(21)14-16-6-8-19(9-7-16)24-15-17-4-2-1-3-5-17;/h1-9,18,20H,10-15H2;1H
  • InChiKey: XWLBHFZDKQYHRW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[(4-benzyloxyphenyl)methyl]quinuclidin-3-one hydrochloride
  • 2-[(4-benzyloxyphenyl)methyl]-3-quinuclidinone hydrochloride
  • 2-(4-benzoxybenzyl)quinuclidin-3-one hydrochloride
  • 2-[4-(benzyloxy)benzyl]quinuclidin-3-one hydrochloride
  • MLS000624715
  • SMR000295370

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Candida albicans hypothetical protein Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni immunophilin 0.0757 1 1
Trypanosoma cruzi heat shock protein, putative 0.0016 0.0108 0.0109
Onchocerca volvulus 0.0104 0.1276 0.9886
Schistosoma mansoni hypothetical protein 0.0019 0.0147 0.0147
Schistosoma mansoni lamin 0.0033 0.0328 0.0328
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0442 0.0445
Schistosoma mansoni hypothetical protein 0.0019 0.0147 0.0147
Echinococcus granulosus FK506 binding protein 2 0.0104 0.1276 0.1276
Loa Loa (eye worm) hypothetical protein 0.0033 0.0328 0.033
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0104 0.1276 0.1276
Leishmania major fk506-binding protein 1-like protein 0.0753 0.9938 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0753 0.9938 0.9938
Loa Loa (eye worm) hypothetical protein 0.0015 0.0095 0.0096
Schistosoma mansoni hypothetical protein 0.0019 0.0147 0.0147
Echinococcus multilocularis endoplasmin 0.0031 0.031 0.031
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0753 0.9938 0.9985
Loa Loa (eye worm) hypothetical protein 0.0041 0.0442 0.0445
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.1276 0.1284
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0104 0.1276 0.1284
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0104 0.1276 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0147 0.0148
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0417 0.042
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0313 0.2453
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0417 0.042
Loa Loa (eye worm) FKBP5 protein 0.0753 0.9938 1
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0313 0.0315
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Loa Loa (eye worm) heat shock protein 75 0.0016 0.0108 0.0109
Plasmodium vivax heat shock protein 90, putative 0.0016 0.0108 0.0109
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0104 0.1276 0.1276
Echinococcus multilocularis musashi 0.0033 0.0328 0.0328
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.1276 0.1284
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0147 0.0148
Schistosoma mansoni hypothetical protein 0.0019 0.0147 0.0147
Mycobacterium ulcerans heat shock protein 90 0.0031 0.031 0.0312
Trypanosoma brucei heat shock protein 84, putative 0.0016 0.0108 0.0109
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0753 0.9938 1
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0753 0.9938 0.9938
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.1276 0.1284
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0104 0.1276 0.1282
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0147 0.0148
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0104 0.1276 0.1284
Echinococcus granulosus heat shock protein 90 0.0031 0.031 0.031
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0753 0.9938 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0104 0.1276 0.1284
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0104 0.1276 0.1284
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0753 0.9938 1
Echinococcus granulosus heat shock protein 90 0.0039 0.0417 0.0417
Plasmodium falciparum heat shock protein 90 0.0039 0.0417 0.042
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0753 0.9938 1
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0202 0.0204
Schistosoma mansoni intermediate filament proteins 0.0033 0.0328 0.0328
Schistosoma mansoni fk506 binding protein 0.0104 0.1276 0.1276
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0757 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0126 0.0127
Trichomonas vaginalis immunophilin, putative 0.0753 0.9938 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0697 0.0701
Plasmodium vivax heat shock protein, putative 0.0016 0.0108 0.0109
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0104 0.1276 1
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0104 0.1276 0.1284
Echinococcus multilocularis heat shock protein 0.0039 0.0417 0.0417
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.1276 0.1284
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.1276 0.1276
Trichomonas vaginalis heat shock protein, putative 0.0016 0.0108 0.0109
Trypanosoma brucei heat shock protein, putative 0.0039 0.0417 0.042
Loa Loa (eye worm) hypothetical protein 0.0104 0.1276 0.1284
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0016 0.0108 0.0108
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0104 0.1276 1
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0313 0.0313
Trichomonas vaginalis heat shock protein, putative 0.0031 0.031 0.0312
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0753 0.9938 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0417 0.042
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0753 0.9938 1
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Echinococcus multilocularis lamin 0.0033 0.0328 0.0328
Onchocerca volvulus 0.0033 0.0328 0.2541
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0147 0.0147
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0104 0.1276 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.032 0.0322
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0417 0.042
Trypanosoma brucei hypothetical protein, conserved 0.0104 0.1276 0.1284
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.031 0.0312
Loa Loa (eye worm) hypothetical protein 0.006 0.0697 0.0701
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.031 0.2433
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0417 0.0417
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0147 0.0148
Plasmodium vivax endoplasmin, putative 0.0039 0.0417 0.042
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0417 0.042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0103 0.0104
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0104 0.1276 0.1282
Schistosoma mansoni lamin 0.0033 0.0328 0.0328
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0417 0.0417
Trichomonas vaginalis fk506-binding protein, putative 0.0104 0.1276 0.1284
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0104 0.1276 1
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0215 0.0216
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0313 0.0315
Schistosoma mansoni hypothetical protein 0.0104 0.1276 0.1276
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0104 0.1276 1
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0417 0.042
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.1276 0.1284
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0417 0.042
Plasmodium falciparum heat shock protein 90, putative 0.0016 0.0108 0.0109
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0108 0.1338 0.1338
Echinococcus granulosus intermediate filament protein 0.0033 0.0328 0.0328
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0753 0.9938 1
Giardia lamblia Grp94/Hsp90 0.0031 0.031 0.0312
Treponema pallidum heat shock protein 90 0.0031 0.031 0.0312
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0417 0.042
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0104 0.1276 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0754 0.9953 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0697 0.07
Leishmania major heat shock protein, putative 0.0016 0.0108 0.0109
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0147 0.0147
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0104 0.1276 0.1282
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0126 0.0127
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0104 0.1276 1
Echinococcus granulosus lamin 0.0033 0.0328 0.0328
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0016 0.0108 0.0836
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0753 0.9938 1
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0215 0.0216
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0753 0.9938 1
Trichomonas vaginalis fk506-binding protein, putative 0.0104 0.1276 0.1284
Echinococcus granulosus flap endonuclease 1 0.0031 0.0313 0.0313
Onchocerca volvulus 0.0033 0.0328 0.2541
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0016 0.0108 0.0108
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0417 0.042
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0753 0.9938 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0753 0.9938 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0313 0.0315
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0328 0.0329
Echinococcus granulosus lamin dm0 0.0033 0.0328 0.0328
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.031 0.0312
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0654 0.8618 0.8618
Trypanosoma brucei heat shock protein, putative 0.0039 0.0417 0.042
Schistosoma mansoni hypothetical protein 0.0041 0.0442 0.0442
Trypanosoma brucei heat shock protein, putative 0.0039 0.0417 0.042
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.031 0.0312
Mycobacterium ulcerans hypothetical protein 0.0104 0.1276 0.1284
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Trichomonas vaginalis fk506 binding protein, putative 0.0104 0.1276 0.1284
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.1276 0.1284
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0104 0.1276 0.1284
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0753 0.9938 1
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0417 0.3269
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0417 0.042
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0654 0.8618 0.8618
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0328 0.033
Plasmodium falciparum endoplasmin, putative 0.0024 0.0215 0.0216
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.1276 0.1284
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0753 0.9938 1
Onchocerca volvulus 0.0105 0.129 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0753 0.9938 1
Schistosoma mansoni immunophilin 0.0757 1 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0015 0.0095 0.0096
Trypanosoma brucei heat shock protein, putative 0.0039 0.0417 0.042
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0103 0.0103
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0104 0.1276 0.1284
Toxoplasma gondii heat shock protein 75, putative 0.0016 0.0108 0.0846
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.0104 0.1276 0.1284
Echinococcus granulosus heat shock protein 0.0039 0.0417 0.0417
Schistosoma mansoni endoplasmin 0.0039 0.0417 0.0417
Plasmodium falciparum flap endonuclease 1 0.0031 0.0313 0.0315
Trichomonas vaginalis heat shock protein, putative 0.0031 0.031 0.0312
Echinococcus multilocularis lamin dm0 0.0033 0.0328 0.0328
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0104 0.1276 0.1284
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0313 0.0315
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0757 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.1276 0.1284
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.031 0.0312
Giardia lamblia Hypothetical protein 0.0104 0.1276 0.1284
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0313 0.0315
Echinococcus multilocularis heat shock protein 90 0.0031 0.031 0.031
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0313 0.0315
Trichomonas vaginalis heat shock protein, putative 0.0031 0.031 0.0312
Leishmania major peptidylprolyl isomerase-like protein 0.0753 0.9938 1
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.065 0.857 0.8624
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0697 0.07
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0104 0.1276 0.1284
Plasmodium falciparum heat shock protein 90, putative 0.0016 0.0108 0.0109
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0016 0.0108 0.0108
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.031 0.2433
Echinococcus multilocularis heat shock protein 90 0.0039 0.0417 0.0417
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0753 0.9938 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.031 0.031
Schistosoma mansoni heat shock protein 0.0039 0.0417 0.0417
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0417 0.042
Schistosoma mansoni heat shock protein 0.0039 0.0417 0.0417
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0104 0.1276 0.1284
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0147 0.0147
Echinococcus multilocularis 0.0104 0.1276 0.1276
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0104 0.1276 0.1284
Trypanosoma brucei heat shock protein, putative 0.0039 0.0417 0.042
Brugia malayi Hsp90 protein 0.0016 0.0108 0.0108
Schistosoma mansoni flap endonuclease-1 0.0028 0.0273 0.0273
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0328 0.033
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0417 0.042
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0313 0.0315
Echinococcus granulosus GPCR family 2 0.0019 0.0147 0.0147
Trypanosoma brucei heat shock protein, putative 0.0039 0.0417 0.042
Schistosoma mansoni heat shock protein 0.0016 0.0108 0.0108
Brugia malayi heat shock protein 90 0.0039 0.0417 0.0419
Echinococcus granulosus endoplasmin 0.0031 0.031 0.031
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0104 0.1276 0.1284
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Brugia malayi intermediate filament protein 0.0033 0.0328 0.0329
Schistosoma mansoni immunophilin 0.0654 0.8618 0.8618
Echinococcus multilocularis fk506 binding protein 0.0753 0.9938 0.9938
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.031 0.2433
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0147 0.0147
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0757 1 1
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0417 0.3269
Leishmania major heat shock protein 83-1 0.0039 0.0417 0.042
Trichomonas vaginalis fk506-binding protein, putative 0.0753 0.9938 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0016 0.0108 0.0846
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0104 0.1276 0.1284
Brugia malayi Flap endonuclease-1 0.0031 0.0313 0.0314
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0103 0.0103
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0104 0.1276 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0417 0.042
Brugia malayi Endoplasmin precursor 0.0039 0.0417 0.0419
Schistosoma mansoni endoplasmin 0.0039 0.0417 0.0417
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0417 0.042
Loa Loa (eye worm) endoplasmin 0.0039 0.0417 0.042

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2.191 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
Potency (functional) 0.3162 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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