Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3035 | 0.3035 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0028 | 0.0679 | 0.5 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0014 | 0.0006 | 0.0006 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0028 | 0.0679 | 0.2237 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3035 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.9283 | 0.9283 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0069 | 0.0227 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3035 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0069 | 0.0074 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0069 | 0.0227 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3035 | 0.3269 |
Plasmodium vivax | RNA helicase-1, putative | 0.0028 | 0.0679 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0069 | 0.0069 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1046 | 0.1127 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.1046 | 0.1046 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3035 | 0.3269 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0028 | 0.0679 | 0.0679 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3035 | 0.3035 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1046 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0006 | 0.002 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0679 | 0.2237 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3035 | 0.3269 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.9283 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0014 | 0.000000040358 | 0.00000013299 |
Brugia malayi | Death domain containing protein | 0.0014 | 0.000000040358 | 0.00000013299 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0028 | 0.0679 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1046 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3035 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3035 | 1 |
Echinococcus granulosus | Ankyrin | 0.0014 | 0.0006 | 0.0006 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0069 | 0.0069 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0069 | 0.0069 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0028 | 0.0679 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0028 | 0.0679 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0028 | 0.0679 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3035 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0028 | 0.0679 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0028 | 0.0679 | 0.0731 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.9283 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3035 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.1046 | 0.1046 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.1046 | 0.1127 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0014 | 0.000000040358 | 0.000000040358 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0014 | 0.000000040358 | 0.000000040358 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0028 | 0.0679 | 0.0679 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3035 | 0.3269 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0028 | 0.0679 | 0.0731 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0028 | 0.0679 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0028 | 0.0679 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.9283 | 0.9283 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3035 | 0.3269 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0028 | 0.0679 | 1 |
Brugia malayi | Uncoordinated protein 44 | 0.0014 | 0.000000040358 | 0.00000013299 |
Brugia malayi | hypothetical protein | 0.0036 | 0.1046 | 0.3446 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0014 | 0.000000040358 | 0.000000043473 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0028 | 0.0679 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0219 | 1 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0028 | 0.0679 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0069 | 0.0227 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1046 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0069 | 0.0069 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0028 | 0.0679 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0028 | 0.0679 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0028 | 0.0679 | 0.0679 |
Echinococcus multilocularis | Ankyrin | 0.0014 | 0.0006 | 0.0006 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0028 | 0.0679 | 0.0679 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0028 | 0.0679 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1046 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.9953 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.