TDR Targets

Basic information

Technical information

TDR Targets ID: 1392022
Name: 3-phenyl-1-[1-(2,4,6-trioxo-1,3-diazinan-5-yl idene)propylamino]thiourea
MW: 333.366 | Formula: C14H15N5O3S
H donors: 4 H acceptors: 3 LogP: 2.39 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCC(=C1C(=O)NC(=O)NC1=O)NN=C(Nc1ccccc1)S
InChi: 1S/C14H15N5O3S/c1-2-9(10-11(20)16-13(22)17-12(10)21)18-19-14(23)15-8-6-4-3-5-7-8/h3-7,18H,2H2,1H3,(H2,15,19,23)(H2,16,17,20,21,22)
InChiKey: RCCZNSVIPYBENB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-phenyl-1-[1-(2,4,6-trioxohexahydropyrimidin-5-ylidene)propylamino]thiourea
3-phenyl-1-[1-(2,4,6-trioxo-5-hexahydropyrimidinylidene)propylamino]thiourea
3-phenyl-1-[1-(2,4,6-triketohexahydropyrimidin-5-ylidene)propylamino]thiourea
MLS000332442
SMR000221644
STOCK4S-30383
ZINC05119873

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Giardia intestinalis	Putative fructose-1,6-bisphosphate aldolase	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Giardia lamblia	Fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Treponema pallidum	fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.5 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium ulcerans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	26.9 %
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0022	0.0167
Loa Loa (eye worm)	FKBP5 protein	0.1027	0.9919	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0022
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33	0.0141	0.1281	0.127
Trichomonas vaginalis	fk506-binding protein, putative	0.0141	0.1281	0.1292
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0022	0.0022
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3346	0.3373
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0172	0.1585	1
Echinococcus multilocularis		0.0141	0.1281	0.1281
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0043	0.0326	0.0326
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.1281	0.1292
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-30	0.0141	0.1281	0.1292
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0022	0.0022
Leishmania major	peptidylprolyl isomerase-like protein	0.1027	0.9919	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0022	0.0022
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.1027	0.9919	1
Echinococcus multilocularis	FK506 binding protein 8, 38 kDa	0.015	0.1362	0.1362
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0022	0.0022
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0022	0.0022
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.3346	0.3121
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0141	0.1281	0.5
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0894	0.8622	0.8622
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0141	0.1281	0.5
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0022	0.0022
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.1027	0.9919	1
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.1035	1	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1281	0.1292
Schistosoma mansoni	fk506 binding protein	0.0141	0.1281	0.1281
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.1027	0.9919	0.9919
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0172	0.1585	1
Trypanosoma brucei	hypothetical protein, conserved	0.0141	0.1281	0.1292
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3346	0.3373
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0022
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.1027	0.9919	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.3346	0.3121
Trichomonas vaginalis	fk506-binding protein, putative	0.0141	0.1281	0.1292
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30	0.0141	0.1281	0.127
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.1027	0.9919	1
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0887	0.8557	0.8627
Echinococcus multilocularis	fk506 binding protein	0.1027	0.9919	0.9919
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0022	0.0022
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.0141	0.1281	0.1292
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0141	0.1281	0.1281
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13	0.0141	0.1281	0.127
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.1027	0.9919	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0022	0.0022
Toxoplasma gondii	peptidyl-prolyl isomerase FKBP12, putative	0.0141	0.1281	0.5
Leishmania major	fk506-binding protein 1-like protein	0.1027	0.9919	1
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.1027	0.9919	1
Leishmania major	peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative	0.0141	0.1281	0.1292
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0022	0.0022
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0326	0.0326
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.1027	0.9919	0.9983
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3346	0.3373
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0022	0.0022
Onchocerca volvulus		0.0143	0.1298	1
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0326	0.0326
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.1028	0.9936	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0022	0.0022
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3346	0.3373
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3346	0.3373
Schistosoma mansoni	coup transcription factor	0.0012	0.0022	0.0022
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0022	0.0022
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0022	0.0022
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0022	0.0022
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3346	0.3373
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0022
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0022	0.0022
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-13	0.0141	0.1281	0.1292
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0141	0.1281	0.0987
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.1027	0.9919	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0022	0.0022
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0022	0.0022
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3346	0.3373
Schistosoma mansoni	immunophilin	0.1035	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0022	0.0022
Schistosoma mansoni	immunophilin	0.0894	0.8622	0.8622
Onchocerca volvulus		0.0012	0.0022	0.0167
Trypanosoma brucei	macrophage infectivity potentiator, precursor, putative	0.0141	0.1281	0.1292
Treponema pallidum	fructose-bisphosphate aldolase	0.0353	0.3346	0.2391
Echinococcus granulosus	FK506 binding protein 8 38 kDa	0.0141	0.1281	0.1281
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0022	0.0022
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0141	0.1281	0.1292
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0022
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0022	0.0022
Chlamydia trachomatis	peptidyl-prolyl cis-trans isomerase	0.0141	0.1281	0.5
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.1027	0.9919	1
Trypanosoma brucei	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0141	0.1281	0.1292
Onchocerca volvulus		0.0141	0.1281	0.9873
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0022	0.0022
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.1027	0.9919	1
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-33	0.0141	0.1281	0.1292
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.1027	0.9919	1
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0894	0.8622	0.8622
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0022	0.0022
Leishmania major	FKBP-type peptidyl-prolyl cis-trans isomerase, putative	0.0141	0.1281	0.1292
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0022
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0172	0.1585	0.0352
Echinococcus granulosus	FK506 binding protein 2	0.0141	0.1281	0.1281
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0022	0.0022
Trichomonas vaginalis	immunophilin, putative	0.1027	0.9919	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0022	0.0022
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.3346	0.3373
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.1027	0.9919	0.9919
Trichomonas vaginalis	fk506-binding protein, putative	0.1027	0.9919	1
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0141	0.1281	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0022	0.0022
Leishmania major	hypothetical protein, conserved	0.001	0.0000087146	0.0000087857
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0022
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.1027	0.9919	1
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0022	0.0022
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0022	0.0022
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0022	0.0022
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0141	0.1281	0.5
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.1035	1	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.1027	0.9919	1
Trichomonas vaginalis	conserved hypothetical protein	0.0141	0.1281	0.1292
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0022	0.0022
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0022	0.0022
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0022	0.0022
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0141	0.1281	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0022	0.0022
Schistosoma mansoni	immunophilin	0.1035	1	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0022	0.0022
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0022	0.0167
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.1035	1	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0141	0.1281	0.0987
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0022	0.0022
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.1027	0.9919	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0022	0.0167
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.1027	0.9919	1
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.1027	0.9919	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0326	0.0326
Giardia lamblia	Fructose-bisphosphate aldolase	0.0353	0.3346	0.2391
Brugia malayi	hypothetical protein	0.0043	0.0326	0.0307
Trichomonas vaginalis	fk506 binding protein, putative	0.0141	0.1281	0.1292
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0022	0.0022

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 17.7407 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	21.3313 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1531848

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1392022