Detailed information for compound 13925

Basic information

Technical information
  • TDR Targets ID: 13925
  • Name: 4-[4-[5-(4-fluorophenyl)-3-piperidin-4-ylimid azol-4-yl]pyrimidin-2-yl]oxyphenol
  • MW: 431.462 | Formula: C24H22FN5O2
  • H donors: 2 H acceptors: 4 LogP: 3.29 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)Oc1nccc(n1)c1n(cnc1c1ccc(cc1)F)C1CCNCC1
  • InChi: 1S/C24H22FN5O2/c25-17-3-1-16(2-4-17)22-23(30(15-28-22)18-9-12-26-13-10-18)21-11-14-27-24(29-21)32-20-7-5-19(31)6-8-20/h1-8,11,14-15,18,26,31H,9-10,12-13H2
  • InChiKey: GXLHMZKUDLOKOT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[4-[5-(4-fluorophenyl)-3-(4-piperidyl)imidazol-4-yl]pyrimidin-2-yl]oxyphenol
  • 4-[[4-[5-(4-fluorophenyl)-3-(4-piperidinyl)-4-imidazolyl]-2-pyrimidinyl]oxy]phenol
  • 4-[4-[5-(4-fluorophenyl)-3-piperidin-4-yl-imidazol-4-yl]pyrimidin-2-yl]oxyphenol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Brugia malayi hypothetical protein 0.0133 0.657 0.3509
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0133 0.657 0.3509
Echinococcus granulosus neuropeptides capa receptor 0.0133 0.657 0.657
Brugia malayi Serotonin receptor 0.0133 0.657 0.3509
Echinococcus granulosus mitogen activated protein kinase 14 0.0152 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0133 0.657 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0133 0.657 1
Brugia malayi Dopamine receptor 0.0133 0.657 0.3509
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0133 0.657 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0133 0.657 0.657
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.657 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0152 1 0.5
Brugia malayi AKH receptor 0.0133 0.657 0.3509
Schistosoma mansoni neuropeptide F-like receptor 0.0133 0.657 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Onchocerca volvulus 0.0133 0.657 1
Echinococcus multilocularis serotonin receptor 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0133 0.657 0.657
Echinococcus multilocularis g protein coupled receptor 0.0133 0.657 0.657
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0133 0.657 0.657
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0123 0.4716 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0133 0.657 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0133 0.657 0.657
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Brugia malayi GnHR receptor homolog 0.0133 0.657 0.3509
Schistosoma mansoni biogenic amine (5HT) receptor 0.0133 0.657 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.657 0.657
Echinococcus granulosus 7TM GPCR rhodopsin 0.0133 0.657 0.657
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.657 0.657
Onchocerca volvulus 0.0133 0.657 1
Echinococcus granulosus fmrfamide receptor 0.0133 0.657 0.657
Echinococcus granulosus serotonin receptor 0.0133 0.657 0.657
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0133 0.657 0.3509
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0133 0.657 1
Schistosoma mansoni neuropeptide F-like receptor 0.0133 0.657 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus multilocularis G protein coupled receptor 139 0.0133 0.657 0.657
Echinococcus multilocularis neuropeptide Y receptor 0.0133 0.657 0.657
Echinococcus multilocularis somatostatin receptor 0.0133 0.657 0.657
Echinococcus multilocularis serotonin receptor 0.0133 0.657 0.657
Schistosoma mansoni hypothetical protein 0.0133 0.657 1
Schistosoma mansoni histamine h1 receptor 0.0133 0.657 1
Schistosoma mansoni neuropeptide receptor 0.0133 0.657 1
Brugia malayi sulfakinin receptor protein 0.0133 0.657 0.3509
Echinococcus multilocularis fmrfamide receptor 0.0133 0.657 0.657
Echinococcus multilocularis neuropeptide FF receptor 2 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Onchocerca volvulus 0.0133 0.657 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.657 1
Schistosoma mansoni amine GPCR 0.0133 0.657 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.657 0.657
Echinococcus multilocularis neuropeptide s receptor 0.0133 0.657 0.657
Loa Loa (eye worm) G-protein coupled receptor 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Schistosoma mansoni biogenic amine receptor 0.0133 0.657 1
Echinococcus multilocularis neuropeptides capa receptor 0.0133 0.657 0.657
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0133 0.657 0.657
Echinococcus multilocularis fmrfamide receptor 0.0133 0.657 0.657
Echinococcus multilocularis dro:myosuppressin receptor 0.0133 0.657 0.657
Echinococcus granulosus dro:myosuppressin receptor 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Schistosoma mansoni neuropeptide receptor 0.0133 0.657 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.657 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Brugia malayi ORL1-like opioid receptor 0.0133 0.657 0.3509
Echinococcus granulosus hypothetical protein 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 1 0.5
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0133 0.657 0.657
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.657 1
Echinococcus granulosus neuropeptide receptor 0.0133 0.657 0.657
Brugia malayi G-protein coupled receptor 0.0133 0.657 0.3509
Echinococcus multilocularis g protein coupled receptor 0.0133 0.657 0.657
Schistosoma mansoni biogenic amine receptor 0.0133 0.657 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0123 0.4716 0.5
Echinococcus granulosus neuropeptide receptor 0.0133 0.657 0.657
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0133 0.657 0.657
Echinococcus granulosus neuropeptide FF receptor 2 0.0133 0.657 0.657
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0133 0.657 0.657
Schistosoma mansoni myosin xvIII 0.0133 0.657 1
Brugia malayi hypothetical protein 0.0133 0.657 0.3509
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0133 0.657 0.3509
Brugia malayi hypothetical protein 0.0133 0.657 0.3509
Schistosoma mansoni opsin-like receptor 0.0133 0.657 1
Schistosoma mansoni amine GPCR 0.0133 0.657 1
Onchocerca volvulus 0.0133 0.657 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0133 0.657 0.657
Schistosoma mansoni amine GPCR 0.0133 0.657 1
Brugia malayi Serotonin receptor 0.0133 0.657 0.3509
Brugia malayi hypothetical protein 0.0133 0.657 0.3509
Echinococcus granulosus neuropeptides capa receptor 0.0133 0.657 0.657
Brugia malayi Tachykinin-like peptides receptor 99D 0.0133 0.657 0.3509
Onchocerca volvulus 0.0133 0.657 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 1 1
Echinococcus multilocularis allatostatin A receptor 0.0133 0.657 0.657
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0133 0.657 0.657
Brugia malayi putative neuropeptide receptor NPR1 0.0133 0.657 0.3509
Onchocerca volvulus 0.0133 0.657 1
Echinococcus multilocularis neuropeptide receptor 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0133 0.657 0.657
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus granulosus 7tm_1 domain containing protein 0.0133 0.657 0.657
Echinococcus multilocularis g-protein coupled receptor 0.0133 0.657 0.657
Loa Loa (eye worm) neuropeptide F receptor 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Brugia malayi Dopamine receptor protein 2 0.0133 0.657 0.3509
Brugia malayi hypothetical protein 0.0133 0.657 0.3509
Echinococcus granulosus tachykinin peptides receptor 99D 0.0133 0.657 0.657
Brugia malayi larval opioid receptor 0.0133 0.657 0.3509
Schistosoma mansoni growth hormone secretagogue receptor 0.0133 0.657 1
Onchocerca volvulus 0.0133 0.657 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.657 0.657
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0133 0.657 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0133 0.657 0.657
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.657 0.657
Echinococcus granulosus peptide allatostatin:somatostatin 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0123 0.4716 0.5
Brugia malayi hypothetical protein 0.0133 0.657 0.3509
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0133 0.657 0.657
Onchocerca volvulus 0.0133 0.657 1
Echinococcus granulosus neuropeptide receptor A26 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Schistosoma mansoni alpha-1 adrenergic receptor 0.0133 0.657 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0133 0.657 0.3509
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0133 0.657 0.3509
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.657 1
Onchocerca volvulus 0.0133 0.657 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0133 0.657 0.657
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Schistosoma mansoni opsin-like receptor 0.0133 0.657 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.657 0.657
Loa Loa (eye worm) melatonin receptor type 1A 0.0133 0.657 0.657
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0133 0.657 1
Schistosoma mansoni biogenic amine receptor 0.0133 0.657 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Brugia malayi hypothetical protein 0.0133 0.657 0.3509
Onchocerca volvulus 0.0133 0.657 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus granulosus g-protein coupled receptor 0.0133 0.657 0.657
Onchocerca volvulus 0.0133 0.657 1
Brugia malayi hypothetical protein 0.0133 0.657 0.3509
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Onchocerca volvulus 0.0133 0.657 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus granulosus g protein coupled receptor 0.0133 0.657 0.657
Schistosoma mansoni amine GPCR 0.0133 0.657 1
Echinococcus multilocularis neuropeptide Y receptor 0.0133 0.657 0.657
Echinococcus granulosus tm gpcr rhodopsin 0.0133 0.657 0.657
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0133 0.657 0.657
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0133 0.657 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0133 0.657 1
Schistosoma mansoni hypothetical protein 0.0133 0.657 1
Schistosoma mansoni hypothetical protein 0.0133 0.657 1
Schistosoma mansoni hypothetical protein 0.0133 0.657 1
Schistosoma mansoni adenoreceptor 0.0133 0.657 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0133 0.657 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.657 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0133 0.657 0.657
Echinococcus granulosus sex peptide receptor 0.0133 0.657 0.657
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0152 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0133 0.657 0.3509
Loa Loa (eye worm) TYRA-2 protein 0.0133 0.657 0.657
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.657 0.657
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0133 0.657 0.657
Onchocerca volvulus 0.0133 0.657 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Loa Loa (eye worm) neuropeptide F receptor 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0123 0.4716 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0133 0.657 1
Echinococcus multilocularis orexin receptor type 2 0.0133 0.657 0.657
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Brugia malayi follicle stimulating hormone receptor 0.0133 0.657 0.3509
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.657 0.657
Schistosoma mansoni amine GPCR 0.0133 0.657 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0133 0.657 0.657
Echinococcus granulosus mitogen activated protein kinase 11 0.0152 1 1
Onchocerca volvulus 0.0133 0.657 1
Echinococcus granulosus neuropeptide s receptor 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus granulosus tm gpcr rhodopsin 0.0133 0.657 0.657
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.657 0.657
Echinococcus multilocularis neuropeptide receptor 0.0133 0.657 0.657
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Brugia malayi G protein-coupled receptor 0.0133 0.657 0.3509
Onchocerca volvulus 0.0133 0.657 1
Brugia malayi neuropeptide F receptor 0.0133 0.657 0.3509
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus multilocularis g protein coupled receptor 0.0133 0.657 0.657
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Schistosoma mansoni neuropeptide receptor 0.0133 0.657 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Loa Loa (eye worm) G-protein coupled receptor 0.0133 0.657 0.657
Onchocerca volvulus 0.0133 0.657 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0133 0.657 0.657
Echinococcus granulosus orexin receptor type 2 0.0133 0.657 0.657
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus granulosus G protein coupled receptor 139 0.0133 0.657 0.657
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.657 0.657
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0133 0.657 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0133 0.657 1
Echinococcus granulosus somatostatin receptor 0.0133 0.657 0.657
Brugia malayi putative neuropeptide receptor 0.0133 0.657 0.3509
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0133 0.657 0.657
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0133 0.657 1
Echinococcus multilocularis neuropeptide receptor A26 0.0133 0.657 0.657
Echinococcus granulosus neuropeptide Y receptor 0.0133 0.657 0.657
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0133 0.657 0.657
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0133 0.657 0.657
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0152 1 0.5
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0133 0.657 0.657
Echinococcus granulosus allatostatin A receptor 0.0133 0.657 0.657
Echinococcus granulosus rhodopsin orphan GPCR 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0133 0.657 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.657 1
Brugia malayi Dopamine receptor protein 1 0.0133 0.657 0.3509
Echinococcus multilocularis G-protein coupled receptor, putative 0.0133 0.657 0.657
Brugia malayi hypothetical protein 0.0133 0.657 0.3509
Schistosoma mansoni neuropeptide receptor 0.0133 0.657 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.657 0.657
Brugia malayi Melatonin receptor type 1A 0.0133 0.657 0.3509
Echinococcus granulosus g protein coupled receptor 0.0133 0.657 0.657
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0123 0.4716 0.5
Echinococcus granulosus purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Brugia malayi neuropeptide F receptor 0.0133 0.657 0.3509
Echinococcus multilocularis rhodopsin orphan GPCR 0.0133 0.657 0.657
Schistosoma mansoni opsin-like receptor 0.0133 0.657 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Brugia malayi G-protein coupled receptor 0.0133 0.657 0.3509
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.657 1
Echinococcus granulosus g protein coupled receptor 0.0133 0.657 0.657
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus granulosus tm gpcr rhodopsin 0.0133 0.657 0.657
Echinococcus granulosus neuropeptide Y receptor 0.0133 0.657 0.657
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0133 0.657 1
Brugia malayi RE15519p 0.0133 0.657 0.3509
Onchocerca volvulus 0.0133 0.657 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Echinococcus multilocularis sex peptide receptor 0.0133 0.657 0.657
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0133 0.657 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0123 0.4716 0.4716
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0133 0.657 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.657 0.657
Brugia malayi hypothetical protein 0.0133 0.657 0.3509

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.85 Inhibition of p38alpha ChEMBL. 17706839
IC50 (binding) = 14 nM Inhibitory concentration against mitogen-activated protein kinase p38 alpha ChEMBL. 11354358
IC50 (binding) = 14 nM Inhibitory concentration against mitogen-activated protein kinase p38 alpha ChEMBL. 11354358
IC50 (binding) = 14 nM Inhibition of p38alpha ChEMBL. 17706839

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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