Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | polymerase (DNA directed), beta | 335 aa | 303 aa | 32.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.1053 | 0.528 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.027 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0908 | 0.4432 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.1053 | 0.528 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1788 | 0.9552 | 0.995 |
Schistosoma mansoni | hypothetical protein | 0.0908 | 0.4432 | 0.8394 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.1796 | 0.96 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1796 | 0.96 | 0.96 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.1053 | 0.528 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0146 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0146 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0146 | 0 | 0.5 |
Onchocerca volvulus | 0.0146 | 0 | 0.5 | |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0908 | 0.4432 | 0.8394 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1796 | 0.96 | 0.96 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.1274 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.027 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.1274 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0365 | 0.1274 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 0.1274 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.