Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0285 | 0.1077 | 0.1077 |
Schistosoma mansoni | protein kinase C | 0.0285 | 0.1077 | 0.1077 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0236 | 0.0844 | 0.0924 |
Brugia malayi | Protein kinase domain containing protein | 0.0335 | 0.1316 | 0.1559 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0368 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.1538 | 0.7048 | 0.8609 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0244 | 0.0885 | 0.0975 |
Trichomonas vaginalis | cyclin B, putative | 0.0136 | 0.0368 | 0.2796 |
Echinococcus granulosus | unc 13 munc13 | 0.0285 | 0.1077 | 0.1077 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.1538 | 0.7048 | 0.7048 |
Echinococcus granulosus | protein kinase C gamma type | 0.1921 | 0.8877 | 0.8877 |
Brugia malayi | Protein kinase c protein 2 | 0.1831 | 0.8446 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1773 | 0.8171 | 1 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0236 | 0.0844 | 0.0844 |
Onchocerca volvulus | 0.0285 | 0.1077 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0844 | 0.0924 |
Schistosoma mansoni | rac gtpase activating protein | 0.0236 | 0.0844 | 0.0844 |
Echinococcus granulosus | myotubularin protein 13 | 0.0236 | 0.0844 | 0.0844 |
Brugia malayi | diacylglycerol kinase | 0.0236 | 0.0844 | 0.0999 |
Echinococcus granulosus | protein kinase c iota type | 0.0571 | 0.2439 | 0.2439 |
Brugia malayi | protein kinase C3,putative | 0.0244 | 0.0885 | 0.1048 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0136 | 0.0368 | 0.0436 |
Brugia malayi | RhoGAP domain containing protein | 0.0236 | 0.0844 | 0.0999 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0335 | 0.1316 | 0.1559 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0136 | 0.0368 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0543 | 0.2307 | 0.2307 |
Trichomonas vaginalis | cyclins, putative | 0.0136 | 0.0368 | 0.2796 |
Brugia malayi | diacylglycerol kinase | 0.0236 | 0.0844 | 0.0999 |
Trichomonas vaginalis | AGC family protein kinase | 0.0335 | 0.1316 | 1 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0236 | 0.0844 | 0.0844 |
Schistosoma mansoni | atypical protein kinase C | 0.0571 | 0.2439 | 0.2439 |
Schistosoma mansoni | protein kinase C mu | 0.0236 | 0.0844 | 0.0844 |
Trichomonas vaginalis | AGC family protein kinase | 0.0335 | 0.1316 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0571 | 0.2439 | 0.2439 |
Schistosoma mansoni | serine/threonine kinase | 0.0335 | 0.1316 | 0.1316 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0844 | 0.0924 |
Brugia malayi | Variant SH3 domain containing protein | 0.0236 | 0.0844 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0368 | 0.0334 |
Echinococcus multilocularis | cyclin B | 0.0136 | 0.0368 | 0.0368 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2157 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0244 | 0.0885 | 0.0885 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0335 | 0.1316 | 0.1316 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.1538 | 0.7048 | 0.7048 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0335 | 0.1316 | 0.1316 |
Brugia malayi | Hr1 repeat family protein | 0.0335 | 0.1316 | 0.1559 |
Brugia malayi | Protein kinase domain containing protein | 0.0244 | 0.0885 | 0.1048 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.062 | 0.2673 | 0.2673 |
Trypanosoma cruzi | cyclin, putative | 0.0136 | 0.0368 | 0.5 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0236 | 0.0844 | 0.0844 |
Toxoplasma gondii | AGC kinase | 0.0335 | 0.1316 | 1 |
Brugia malayi | protein kinase C II. | 0.062 | 0.2673 | 0.3165 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0236 | 0.0844 | 0.641 |
Brugia malayi | RhoGEF domain containing protein | 0.0236 | 0.0844 | 0.0999 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.1538 | 0.7048 | 0.7048 |
Trichomonas vaginalis | AGC family protein kinase | 0.0335 | 0.1316 | 1 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0335 | 0.1316 | 0.1316 |
Trichomonas vaginalis | AGC family protein kinase | 0.0335 | 0.1316 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0136 | 0.0368 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.1921 | 0.8877 | 0.8877 |
Trichomonas vaginalis | AGC family protein kinase | 0.0335 | 0.1316 | 1 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0236 | 0.0844 | 0.0844 |
Trichomonas vaginalis | AGC family protein kinase | 0.0335 | 0.1316 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0335 | 0.1316 | 0.1509 |
Trichomonas vaginalis | cyclins, putative | 0.0093 | 0.0163 | 0.124 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0136 | 0.0368 | 0.5 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0335 | 0.1316 | 0.1509 |
Trichomonas vaginalis | cyclin B, putative | 0.0136 | 0.0368 | 0.2796 |
Onchocerca volvulus | 0.0236 | 0.0844 | 0.671 | |
Trichomonas vaginalis | cyclin B, putative | 0.0136 | 0.0368 | 0.2796 |
Schistosoma mansoni | unc-13 (munc13) | 0.0285 | 0.1077 | 0.1077 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0236 | 0.0844 | 0.0844 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.062 | 0.2673 | 0.3189 |
Trichomonas vaginalis | cyclin B, putative | 0.0136 | 0.0368 | 0.2796 |
Brugia malayi | Protein kinase domain containing protein | 0.0335 | 0.1316 | 0.1559 |
Schistosoma mansoni | cyclin B | 0.0136 | 0.0368 | 0.0368 |
Trichomonas vaginalis | AGC family protein kinase | 0.0335 | 0.1316 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0335 | 0.1316 | 1 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.0593 | 0.2545 | 0.3014 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0285 | 0.1077 | 0.1077 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0236 | 0.0844 | 0.0844 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0335 | 0.1316 | 0.1316 |
Entamoeba histolytica | protein kinase, putative | 0.0335 | 0.1316 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0244 | 0.0885 | 0.0885 |
Brugia malayi | Protein kinase domain containing protein | 0.0335 | 0.1316 | 0.1559 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0326 | 0.1275 | 0.9685 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0335 | 0.1316 | 0.1316 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0244 | 0.0885 | 0.0975 |
Echinococcus multilocularis | N chimaerin | 0.0236 | 0.0844 | 0.0844 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0335 | 0.1316 | 0.1316 |
Loa Loa (eye worm) | Ras association domain family 1 isoform A | 0.0236 | 0.0844 | 0.0924 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0335 | 0.1316 | 0.1509 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0335 | 0.1316 | 0.1316 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0236 | 0.0844 | 0.0844 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0236 | 0.0844 | 0.0924 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0244 | 0.0885 | 0.0885 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0844 | 0.0924 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0236 | 0.0844 | 0.0844 |
Echinococcus granulosus | Diacylglycerol kinase theta | 0.0236 | 0.0844 | 0.0844 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0136 | 0.0368 | 0.0436 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.1595 | 0.7323 | 0.8949 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0844 | 0.0924 |
Trichomonas vaginalis | AGC family protein kinase | 0.0335 | 0.1316 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.0136 | 0.0368 | 0.5 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0335 | 0.1316 | 0.1316 |
Echinococcus multilocularis | protein kinase c eta type | 0.0236 | 0.0844 | 0.0844 |
Brugia malayi | RhoGAP domain containing protein | 0.0236 | 0.0844 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0844 | 0.0924 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0236 | 0.0844 | 0.0924 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0244 | 0.0885 | 0.1048 |
Loa Loa (eye worm) | raf kinase | 0.0236 | 0.0844 | 0.0924 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0844 | 0.0924 |
Trichomonas vaginalis | cyclin A, putative | 0.0136 | 0.0368 | 0.2796 |
Echinococcus multilocularis | Diacylglycerol kinase theta | 0.0236 | 0.0844 | 0.0844 |
Echinococcus granulosus | cyclin B | 0.0136 | 0.0368 | 0.0368 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2157 | 1 | 1 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0244 | 0.0885 | 0.0885 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.1077 | 0.1213 |
Echinococcus granulosus | protein kinase c eta type | 0.0236 | 0.0844 | 0.0844 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0335 | 0.1316 | 0.1316 |
Leishmania major | cyclin | 0.0136 | 0.0368 | 0.5 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0236 | 0.0844 | 0.0844 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0335 | 0.1316 | 0.1509 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.0593 | 0.2545 | 0.3032 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0335 | 0.1316 | 0.1316 |
Echinococcus granulosus | protein kinase c epsilon type | 0.062 | 0.2673 | 0.2673 |
Entamoeba histolytica | cyclin, putative | 0.0136 | 0.0368 | 0.2796 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0335 | 0.1316 | 0.1316 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0844 | 0.0924 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0844 | 0.0924 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0335 | 0.1316 | 0.1509 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0335 | 0.1316 | 0.1509 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0285 | 0.1077 | 0.1077 |
Entamoeba histolytica | protein kinase, putative | 0.0335 | 0.1316 | 1 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0236 | 0.0844 | 0.641 |
Schistosoma mansoni | unc-13 (munc13) | 0.0285 | 0.1077 | 0.1077 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0335 | 0.1316 | 0.1316 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0335 | 0.1316 | 0.1509 |
Brugia malayi | Ras association domain family 1 isoform A | 0.0236 | 0.0844 | 0.0999 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0236 | 0.0844 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0844 | 0.0924 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.2157 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0335 | 0.1316 | 0.1316 |
Brugia malayi | C1-like domain containing protein | 0.0244 | 0.0885 | 0.1048 |
Onchocerca volvulus | 0.0236 | 0.0844 | 0.671 | |
Trichomonas vaginalis | cyclins, putative | 0.0136 | 0.0368 | 0.2796 |
Entamoeba histolytica | hypothetical protein | 0.0236 | 0.0844 | 0.641 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0543 | 0.2307 | 0.2307 |
Trichomonas vaginalis | cyclins, putative | 0.0136 | 0.0368 | 0.2796 |
Trichomonas vaginalis | AGC family protein kinase | 0.0335 | 0.1316 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0335 | 0.1316 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0136 | 0.0368 | 0.5 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0335 | 0.1316 | 0.1509 |
Schistosoma mansoni | hypothetical protein | 0.0236 | 0.0844 | 0.0844 |
Schistosoma mansoni | serine/threonine protein kinase | 0.062 | 0.2673 | 0.2673 |
Brugia malayi | Pleckstrin Homology Domain | 0.0236 | 0.0844 | 0.0999 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0335 | 0.1316 | 1 |
Schistosoma mansoni | vav2 | 0.0236 | 0.0844 | 0.0844 |
Trichomonas vaginalis | cyclins, putative | 0.0136 | 0.0368 | 0.2796 |
Echinococcus granulosus | N chimaerin | 0.0236 | 0.0844 | 0.0844 |
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0236 | 0.0844 | 0.0844 |
Schistosoma mansoni | protein kinase C mu | 0.0244 | 0.0885 | 0.0885 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0335 | 0.1316 | 0.1316 |
Trichomonas vaginalis | AGC family protein kinase | 0.0335 | 0.1316 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0335 | 0.1316 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0844 | 0.0924 |
Echinococcus granulosus | NDR protein kinase | 0.0335 | 0.1316 | 0.1316 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0236 | 0.0844 | 0.0844 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.