Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.2562 | 0.2175 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.876 | 0.8696 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0494 | 0.0564 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.13 | 0.1484 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0494 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.876 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2343 | 0.2674 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.876 | 0.8696 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.3198 | 0.2844 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.876 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.876 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.0564 |
Echinococcus multilocularis | lamin | 0.0033 | 0.876 | 0.8696 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.13 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0494 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.0564 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0494 | 0.0564 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0012 | 0.13 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.0564 |
Schistosoma mansoni | lamin | 0.0033 | 0.876 | 0.8696 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.13 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.0564 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.876 | 0.8696 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0494 | 0.0564 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.13 | 0.0848 |
Onchocerca volvulus | 0.0033 | 0.876 | 1 | |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.13 | 0.1484 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.876 | 0.8696 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.2562 | 0.2175 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2343 | 0.2674 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.876 | 0.8696 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.3198 | 0.3651 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.13 | 0.0848 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0.13 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0494 | 0.0564 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.13 | 0.1484 |
Schistosoma mansoni | lamin | 0.0033 | 0.876 | 0.8696 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0494 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.0564 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.876 | 0.8696 |
Echinococcus multilocularis | musashi | 0.0033 | 0.876 | 0.8696 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0012 | 0.13 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.876 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0494 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2562 | 0.2925 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.8541 | 0.975 |
Echinococcus granulosus | lamin | 0.0033 | 0.876 | 0.8696 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.0564 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0224 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.