Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | hydroxysteroid (17-beta) dehydrogenase 10 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | hydroxysteroid (17-beta) dehydrogenase 10 | 252 aa | 251 aa | 24.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pyridoxal-dependent decarboxylase | 0.0122 | 0.3144 | 0.26 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0108 | 0.2553 | 0.1963 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0122 | 0.3144 | 1 |
Giardia lamblia | Ornithine decarboxylase | 0.0122 | 0.3144 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0121 | 0.3079 | 0.246 |
Trichomonas vaginalis | pyridoxal-dependent decarboxylase, putative | 0.0122 | 0.3144 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0108 | 0.2553 | 0.1887 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0084 | 0.1558 | 0.4582 |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0122 | 0.3144 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0108 | 0.2553 | 0.8128 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0108 | 0.2553 | 0.1887 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0067 | 0.0821 | 0.1957 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.2553 | 0.1963 |
Brugia malayi | MH2 domain containing protein | 0.0245 | 0.8298 | 0.8214 |
Brugia malayi | FAD binding domain containing protein | 0.0067 | 0.0821 | 0.0371 |
Onchocerca volvulus | 0.0122 | 0.3144 | 1 | |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0108 | 0.2553 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0108 | 0.2553 | 0.7333 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0245 | 0.8298 | 0.8163 |
Plasmodium vivax | S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative | 0.0122 | 0.3144 | 1 |
Toxoplasma gondii | diaminopimelate decarboxylase | 0.0122 | 0.3144 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0108 | 0.2553 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0245 | 0.8298 | 0.8163 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0067 | 0.0821 | 0.0094 |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0122 | 0.3144 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0067 | 0.0821 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0467 | 0.0697 |
Leishmania major | cytochrome P450 reductase, putative | 0.0096 | 0.2038 | 0.5007 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0069 | 0.093 | 0.2345 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0108 | 0.2553 | 0.4658 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0108 | 0.2553 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0108 | 0.2553 | 0.1887 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0122 | 0.3144 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0108 | 0.2553 | 0.1887 |
Schistosoma mansoni | lipoxygenase | 0.0121 | 0.3079 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0069 | 0.093 | 0.0119 |
Mycobacterium ulcerans | diaminopimelate decarboxylase LysA | 0.0122 | 0.3144 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0054 | 0.0306 | 0.0123 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0108 | 0.2553 | 0.8122 |
Leishmania major | ornithine decarboxylase, putative | 0.0122 | 0.3144 | 1 |
Mycobacterium tuberculosis | Diaminopimelate decarboxylase LysA (DAP decarboxylase) | 0.0122 | 0.3144 | 1 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0069 | 0.093 | 0.0485 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0467 | 0.0697 |
Leishmania major | p450 reductase, putative | 0.0108 | 0.2553 | 0.7333 |
Brugia malayi | Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein | 0.0122 | 0.3144 | 0.2808 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0069 | 0.093 | 0.0119 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0121 | 0.3079 | 0.246 |
Trypanosoma brucei | ornithine decarboxylase | 0.0122 | 0.3144 | 1 |
Plasmodium falciparum | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 0.0122 | 0.3144 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0096 | 0.2038 | 0.6484 |
Entamoeba histolytica | ornithine decarboxylase, putative | 0.0122 | 0.3144 | 0.5 |
Brugia malayi | flavodoxin family protein | 0.0108 | 0.2553 | 0.2188 |
Mycobacterium leprae | PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP DECARBOXYLASE) | 0.0047 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0108 | 0.2553 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0108 | 0.2553 | 0.7333 |
Brugia malayi | FAD binding domain containing protein | 0.0108 | 0.2553 | 0.2188 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.1585 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.