TDR Targets

Basic information

Technical information

TDR Targets ID: 1393285
Name: 1-(2,5-diethoxy-4-morpholin-4-ylphenyl)-3-pro pylurea
MW: 351.441 | Formula: C18H29N3O4
H donors: 2 H acceptors: 1 LogP: 2.25 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCNC(=O)Nc1cc(OCC)c(cc1OCC)N1CCOCC1
InChi: 1S/C18H29N3O4/c1-4-7-19-18(22)20-14-12-17(25-6-3)15(13-16(14)24-5-2)21-8-10-23-11-9-21/h12-13H,4-11H2,1-3H3,(H2,19,20,22)
InChiKey: IWDFEMNNLZERCC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2,5-diethoxy-4-morpholino-phenyl)-3-propyl-urea
1-(2,5-diethoxy-4-morpholinophenyl)-3-propylurea
1-(2,5-diethoxy-4-morpholin-4-yl-phenyl)-3-propyl-urea
ZINC03002950
MLS000110618
SMR000106547
BAS 02988382

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4E	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0093	0.0186
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.01	0.0352	0.1004
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1118	0.2636
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0147	0.0366
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.01	0.0352	0.1004
Brugia malayi	Presenilin spe-4	0.007	0.0202	0.0482
Schistosoma mansoni	jumonji domain containing protein	0.0071	0.0207	0.0593
Brugia malayi	Presenilin-like protein At2g29900	0.007	0.0202	0.0482
Schistosoma mansoni	coup transcription factor	0.0251	0.1118	0.341
Loa Loa (eye worm)	DR-78	0.01	0.0352	0.0805
Trichomonas vaginalis	Nicastrin precursor, putative	0.0097	0.0341	0.3441
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0071	0.0207	0.0554
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0477	0.2262	0.537
Brugia malayi	N-terminal motif family protein	0.0176	0.0737	0.1756
Brugia malayi	jmjC domain containing protein	0.0071	0.0207	0.0494
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0251	0.1118	0.341
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1118	0.2636
Brugia malayi	ecdysteroid receptor	0.0859	0.4199	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0251	0.1118	0.3383
Trypanosoma cruzi	Aph-1 protein, putative	0.0186	0.0788	0.9136
Brugia malayi	jmjC domain containing protein	0.0073	0.0219	0.0522
Entamoeba histolytica	presenilin 1 peptidase, putative	0.02	0.086	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.01	0.0352	0.1004
Echinococcus multilocularis	presenilin	0.02	0.086	0.2582
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0251	0.1118	0.2663
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.01	0.0352	0.1041
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0251	0.1118	0.341
Loa Loa (eye worm)	hypothetical protein	0.01	0.0352	0.0805
Brugia malayi	hypothetical protein	0.007	0.0202	0.0482
Echinococcus multilocularis	presenilin enhancer 2	0.0188	0.0798	0.2389
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0097	0.0194
Brugia malayi	hypothetical protein	0.007	0.0202	0.0482
Loa Loa (eye worm)	nuclear hormone receptor	0.01	0.0352	0.0805
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.0844	0.2533
Schistosoma mansoni	nuclear receptor	0.01	0.0352	0.1041
Echinococcus granulosus	Nuclear hormone receptor HR96	0.01	0.0352	0.1004
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0069	0.0479
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.0844	0.2011
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0614	0.1429
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0044	0.0069	0.0164
Mycobacterium ulcerans	short chain dehydrogenase	0.2004	1	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.01	0.0352	0.0839
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.0468	0.1364
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0093	0.0222
Brugia malayi	conserved hypotetical protein	0.01	0.0352	0.0839
Brugia malayi	Nuclear hormone receptor-like 1	0.0151	0.0614	0.1461
Onchocerca volvulus	Bile acid receptor homolog	0.0859	0.4199	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0251	0.1118	0.2636
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.0844	0.2533
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0072	0.0213	0.0571
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.02	0.086	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0251	0.1118	0.3383
Echinococcus granulosus	thyroid hormone receptor alpha	0.0389	0.1821	0.5564
Loa Loa (eye worm)	steroid hormone receptor	0.0541	0.2586	0.6145
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0093	0.0222
Schistosoma mansoni	bromodomain containing protein	0.0076	0.0235	0.0678
Schistosoma mansoni	hypothetical protein	0.0122	0.0468	0.14
Brugia malayi	hypothetical protein	0.01	0.0352	0.0839
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0251	0.1118	0.3383
Trypanosoma brucei	presenilin-like aspartic peptidase, putative	0.02	0.086	1
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.0468	0.1364
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0219	0.0487
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0071	0.0207	0.0554
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0251	0.1118	0.2663
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.0067	0.012
Brugia malayi	ecdysone receptor	0.01	0.0352	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0176	0.0737	0.1725
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0347	0.1604	0.4892
Schistosoma mansoni	microtubule-associated protein tau	0.0671	0.3249	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.01	0.0352	0.1004
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0044	0.0069	0.0124
Loa Loa (eye worm)	presenilin spe-4	0.007	0.0202	0.0446
Brugia malayi	Nuclear hormone receptor-like 1	0.0151	0.0614	0.1461
Schistosoma mansoni	zinc finger protein	0.01	0.0352	0.1041
Trypanosoma brucei	glucosidase, putative	0.0044	0.0069	0.0479
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0477	0.2262	0.6935
Leishmania major	presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative	0.02	0.086	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0069	0.0479
Brugia malayi	photoreceptor-specific nuclear receptor	0.0251	0.1118	0.2663
Brugia malayi	Bromodomain containing protein	0.0046	0.0082	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0109	0.0222
Schistosoma mansoni	RAR-like nuclear receptor	0.0251	0.1118	0.341
Brugia malayi	hypothetical protein	0.0151	0.0614	0.1461
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0614	0.1429
Echinococcus multilocularis	Nicastrin	0.0097	0.0341	0.097
Loa Loa (eye worm)	hypothetical protein	0.01	0.0352	0.0805
Brugia malayi	nuclear receptor NHR-67	0.01	0.0352	0.0839
Brugia malayi	tailless protein	0.01	0.0352	0.0839
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0251	0.1118	0.2663
Echinococcus granulosus	FTZ F1 alpha	0.0251	0.1118	0.3383
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0251	0.1118	0.2663
Schistosoma mansoni	alpha glucosidase	0.0044	0.0069	0.0165
Schistosoma mansoni	nuclear receptor nhr-48	0.01	0.0352	0.1041
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.0844	0.1981
Brugia malayi	Nuclear hormone receptor-like 1	0.0251	0.1118	0.2663
Loa Loa (eye worm)	hypothetical protein	0.01	0.0352	0.0805
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0069	0.0479
Echinococcus multilocularis	lysine specific demethylase 5A	0.0071	0.0207	0.0554
Brugia malayi	nuclear receptor NHR-88	0.01	0.0352	0.0839
Loa Loa (eye worm)	hypothetical protein	0.01	0.0352	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1118	0.2636
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1118	0.2636
Schistosoma mansoni	thyroid hormone receptor	0.0373	0.1739	0.5329
Schistosoma mansoni	nuclear hormone receptor	0.01	0.0352	0.1041
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.01	0.0352	0.1004
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0044	0.0069	0.0127
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0073	0.0219	0.063
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0176	0.0737	0.1001
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0251	0.1118	0.3383
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0614	0.1429
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0251	0.1118	0.1991
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.0844	0.2533
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0251	0.1118	0.2636
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0614	0.1429
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0251	0.1118	0.2663
Brugia malayi	hypothetical protein	0.0097	0.0341	0.0812
Brugia malayi	nuclear receptor RXR	0.0151	0.0614	0.1461
Loa Loa (eye worm)	hypothetical protein	0.01	0.0352	0.0805
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0251	0.1118	0.3383
Brugia malayi	Steroid receptor seven-up type 2	0.0251	0.1118	0.2663
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0147	0.0366
Toxoplasma gondii	hypothetical protein	0.0056	0.0134	0.4855
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0477	0.2262	0.6948
Schistosoma mansoni	thyroid hormone receptor	0.0373	0.1739	0.5329
Trichomonas vaginalis	Nicastrin precursor, putative	0.0097	0.0341	0.3441
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0251	0.1118	0.2636
Brugia malayi	hypothetical protein	0.007	0.0202	0.0482
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0069	0.0479
Schistosoma mansoni	retinoic acid receptor RXR	0.0347	0.1604	0.4913
Loa Loa (eye worm)	gamma-secretase subunit pen-2	0.0188	0.0798	0.187
Loa Loa (eye worm)	hypothetical protein	0.01	0.0352	0.0805
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0251	0.1118	0.3383
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0251	0.1118	0.2663
Schistosoma mansoni	nuclear hormone receptor	0.01	0.0352	0.1041
Brugia malayi	nuclear hormone receptor family member nhr-6	0.01	0.0352	0.0839
Trypanosoma cruzi	presenilin-like aspartic peptidase, putative	0.02	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.028	0.0633
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0251	0.1118	0.3383
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.01	0.0352	0.1004
Brugia malayi	Nuclear hormone receptor E75	0.01	0.0352	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0614	0.1429
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0373	0.1739	0.531
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0251	0.1118	0.2663
Brugia malayi	Presenilin spe-4	0.007	0.0202	0.0482
Brugia malayi	hypothetical protein	0.0151	0.0614	0.1461
Echinococcus granulosus	nuclear receptor nhr 48	0.01	0.0352	0.1004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0251	0.1118	0.2636
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1118	0.2636
Echinococcus granulosus	neutral alpha glucosidase AB	0.0044	0.0069	0.0124
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0251	0.1118	0.2636
Onchocerca volvulus		0.0114	0.0424	0.0187
Echinococcus multilocularis	microtubule associated protein 2	0.0671	0.3249	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0251	0.1118	0.3383
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.02	0.086	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0251	0.1118	0.2663
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0251	0.1118	0.2663
Trypanosoma cruzi	Aph-1 protein, putative	0.0186	0.0788	0.9136
Echinococcus granulosus	microtubule associated protein 2	0.0671	0.3249	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0147	0.5851
Trypanosoma brucei	Presenilin enhancer-2 subunit of gamma secretase, putative	0.0056	0.0134	0.1259
Brugia malayi	Presenilin spe-4	0.007	0.0202	0.0482
Loa Loa (eye worm)	hypothetical protein	0.01	0.0352	0.0805
Brugia malayi	Presenilin family protein	0.02	0.086	0.2049
Loa Loa (eye worm)	hypothetical protein	0.01	0.0352	0.0805
Schistosoma mansoni	alpha-glucosidase	0.0169	0.0706	0.2134
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0251	0.1118	0.341
Loa Loa (eye worm)	hypothetical protein	0.01	0.0352	0.0805
Trypanosoma cruzi	presenilin-like aspartic peptidase, putative	0.02	0.086	1
Schistosoma mansoni	alpha-glucosidase	0.0169	0.0706	0.2134
Loa Loa (eye worm)	nuclear receptor NHR-67	0.01	0.0352	0.0805
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0151	0.0614	0.1849
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0016	0.0037
Brugia malayi	hypothetical protein	0.01	0.0352	0.0839
Schistosoma mansoni	nuclear hormone receptor	0.0251	0.1118	0.341
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0251	0.1118	0.3383
Schistosoma mansoni	hypothetical protein	0.0097	0.0341	0.1007
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0147	0.0406
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0147	0.0987
Toxoplasma gondii	hypothetical protein	0.007	0.0202	1
Schistosoma mansoni	subfamily A22A unassigned peptidase (A22 family)	0.02	0.086	0.2612
Brugia malayi	Nuclear hormone receptor E75	0.01	0.0352	0.0839
Leishmania major	hypothetical protein, conserved	0.0056	0.0134	0.0819
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0251	0.1118	0.341
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0251	0.1118	0.3383
Echinococcus granulosus	presenilin	0.02	0.086	0.2582
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0151	0.0614	0.1815
Trypanosoma brucei	Aph-1 protein, putative	0.0186	0.0788	0.9136
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0151	0.0614	0.1849
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0251	0.1118	0.341
Loa Loa (eye worm)	hypothetical protein	0.01	0.0352	0.0805
Onchocerca volvulus		0.0251	0.1118	0.1991
Echinococcus multilocularis	ecdysone induced protein 78C	0.0251	0.1118	0.3383
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.02	0.086	1
Brugia malayi	hypothetical protein	0.0097	0.0341	0.0812
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0251	0.1118	0.2636
Echinococcus granulosus	presenilin enhancer 2	0.0188	0.0798	0.2389
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0251	0.1118	0.3383
Echinococcus multilocularis	FTZ F1 alpha	0.0251	0.1118	0.3383
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.01	0.0352	0.1041
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0196	0.0838	0.2513
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.01	0.0352	0.1004
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0151	0.0614	0.1429
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0251	0.1118	0.2663
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0147	0.0406
Brugia malayi	nuclear receptor RXR	0.01	0.0352	0.0839
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0073	0.0219	0.063
Brugia malayi	gamma-secretase subunit aph-1	0.0477	0.2262	0.5387
Brugia malayi	nuclear receptor NHR-88	0.0251	0.1118	0.2663
Onchocerca volvulus	Protein ultraspiracle homolog	0.0251	0.1118	0.1991
Loa Loa (eye worm)	hypothetical protein	0.01	0.0352	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0859	0.4199	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.01	0.0352	0.0805
Brugia malayi	Bromodomain containing protein	0.0091	0.0306	0.073
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0082	0.016
Loa Loa (eye worm)	hypothetical protein	0.01	0.0352	0.0805
Echinococcus multilocularis	Nicastrin	0.0097	0.0341	0.097
Echinococcus granulosus	Nicastrin	0.0097	0.0341	0.097
Brugia malayi	steroid hormone receptor	0.0541	0.2586	0.6159
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0251	0.1118	0.2636
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0341	0.0778
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0251	0.1118	0.3383
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0251	0.1118	0.341
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0151	0.0614	0.1815
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0251	0.1118	0.2663
Loa Loa (eye worm)	hypothetical protein	0.01	0.0352	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1118	0.2636
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0251	0.1118	0.341
Echinococcus granulosus	gamma secretase subunit aph 1	0.0477	0.2262	0.6935
Echinococcus granulosus	lysine specific demethylase 5A	0.0073	0.0219	0.0591
Brugia malayi	nuclear hormone receptor family member odr-7	0.01	0.0352	0.0839
Brugia malayi	gamma-secretase subunit pen-2	0.0188	0.0798	0.19
Brugia malayi	nuclear hormone receptor	0.01	0.0352	0.0839
Brugia malayi	orphan nuclear receptor NR2E1	0.01	0.0352	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0251	0.1118	0.2636
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0251	0.1118	0.2663
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0093	0.0186
Echinococcus multilocularis	nuclear receptor nhr 48	0.01	0.0352	0.1004
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0251	0.1118	0.2663
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0251	0.1118	0.3383
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.0067	0.012
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0072	0.0213	0.0571
Brugia malayi	nuclear hormone receptor	0.0251	0.1118	0.2663
Schistosoma mansoni	nuclear receptor	0.01	0.0352	0.1041

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.1259 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.631 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	0.7079 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	0.9285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1525331

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1393285