Detailed information for compound 1393313

Basic information

Technical information
  • TDR Targets ID: 1393313
  • Name: 1,6-dimethyl-3-pyridin-3-ylpyrimido[5,6-e][1, 2,4]triazine-5,7-dione
  • MW: 270.247 | Formula: C12H10N6O2
  • H donors: 0 H acceptors: 3 LogP: -0.09 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1nc(nc2c1nc(=O)n(c2=O)C)c1cccnc1
  • InChi: 1S/C12H10N6O2/c1-17-11(19)8-10(15-12(17)20)18(2)16-9(14-8)7-4-3-5-13-6-7/h3-6H,1-2H3
  • InChiKey: MRMHYQXWTYCMFU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1,6-dimethyl-3-(3-pyridyl)pyrimido[5,6-e][1,2,4]triazine-5,7-dione
  • 1,6-dimethyl-3-(3-pyridyl)pyrimido[5,6-e][1,2,4]triazine-5,7-quinone
  • 1,6-dimethyl-3-pyridin-3-yl-pyrimido[5,6-e][1,2,4]triazine-5,7-dione
  • Oprea1_605946
  • ZINC00267654
  • Oprea1_193319

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis fmrfamide receptor 0.0199 0.1229 0.1229
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0058 0.0058
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.2744 0.7366
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0281 0.177 0.3452
Echinococcus granulosus tm gpcr rhodopsin 0.0199 0.1229 0.1229
Trypanosoma brucei adenosine transporter 2 0.01 0.0585 0.1136
Toxoplasma gondii endonuclease IV APN 0.008 0.0449 0.0842
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0071 0.0183
Echinococcus granulosus neuropeptide FF receptor 2 0.0199 0.1229 0.1229
Toxoplasma gondii kinase, pfkB family protein 0.009 0.0517 0.0975
Entamoeba histolytica hypothetical protein 0.0043 0.021 0.0557
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0669 0.0669
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0023 0.0023
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0669 0.0669
Schistosoma mansoni DNA polymerase eta 0.0077 0.0433 0.0433
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0022 0.0005
Leishmania major DNA polymerase eta, putative 0.0045 0.0222 0.0428
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0082 0.0466 0.1245
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0199 0.1229 0.1229
Echinococcus granulosus 7tm_1 domain containing protein 0.0199 0.1229 0.1229
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0669 0.1789
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0058 0.0147
Brugia malayi hypothetical protein 0.0043 0.021 0.0384
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0429 0.2744 0.5353
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0199 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Brugia malayi hypothetical protein 0.0579 0.3724 0.7261
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Loa Loa (eye worm) hypothetical protein 0.0281 0.1772 0.3441
Loa Loa (eye worm) prolyl oligopeptidase 0.0056 0.0291 0.0543
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0231 0.0613
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0063 0.0158
Echinococcus granulosus neuropeptide s receptor 0.0199 0.1229 0.1229
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0669 0.1789
Echinococcus granulosus geminin 0.0348 0.221 0.221
Brugia malayi isocitrate dehydrogenase 0.0016 0.003 0.0032
Brugia malayi hypothetical protein 0.0199 0.1229 0.2378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Echinococcus granulosus orexin receptor type 2 0.0199 0.1229 0.1229
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0199 0.1229 0.2378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Schistosoma mansoni hypothetical protein 0.0199 0.1229 0.1229
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0429 0.2744 0.2744
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0281 0.1772 0.4754
Brugia malayi Tachykinin-like peptides receptor 99D 0.0199 0.1229 0.2378
Leishmania major DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0429 0.2744 0.7366
Schistosoma mansoni adenosine kinase 0.0792 0.5123 0.5123
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0199 0.1229 0.2378
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0281 0.177 0.3452
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0092 0.0142
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0058 0.0058
Trypanosoma brucei unspecified product 0.01 0.0585 0.1136
Brugia malayi hypothetical protein 0.0199 0.1229 0.2378
Echinococcus multilocularis g protein coupled receptor 0.0199 0.1229 0.1229
Echinococcus multilocularis G protein coupled receptor 139 0.0199 0.1229 0.1229
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.2744 0.7366
Echinococcus multilocularis neuropeptide s receptor 0.0199 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Onchocerca volvulus 0.0702 0.4531 0.9972
Echinococcus multilocularis rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Echinococcus multilocularis dna polymerase eta 0.0077 0.0433 0.0433
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0222 0.0396
Echinococcus multilocularis neuropeptides capa receptor 0.0199 0.1229 0.1229
Trypanosoma cruzi nucleoside transporter 1, putative 0.01 0.0585 0.1136
Onchocerca volvulus 0.0082 0.0466 0.0999
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0704 0.4543 0.4543
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0133 0.0798 0.1553
Mycobacterium ulcerans epimerase 0.0021 0.0063 0.0158
Loa Loa (eye worm) hypothetical protein 0.009 0.0517 0.0985
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.2744 0.5353
Echinococcus multilocularis g protein coupled receptor 0.0199 0.1229 0.1229
Onchocerca volvulus 0.0199 0.1229 0.2683
Echinococcus granulosus biogenic amine 5HT receptor 0.0199 0.1229 0.1229
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0669 0.1282
Onchocerca volvulus Putative pyridoxal kinase 0.009 0.0517 0.1111
Echinococcus multilocularis GPCR, family 2 0.0016 0.003 0.003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0256 0.0474
Echinococcus multilocularis neuropeptide receptor A26 0.0199 0.1229 0.1229
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.0585 0.1136
Brugia malayi G protein-coupled receptor F59B2.13 0.0199 0.1229 0.2378
Schistosoma mansoni hypothetical protein 0.0348 0.221 0.221
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0272 0.0272
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0237 0.1478 0.288
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0199 0.1229 0.1229
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.2744 0.7366
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0056 0.0291 0.3006
Echinococcus granulosus G protein coupled receptor 139 0.0199 0.1229 0.1229
Echinococcus granulosus g-protein coupled receptor 0.0199 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0231 0.0613
Toxoplasma gondii cathepsin CPL 0.002 0.0058 0.0074
Loa Loa (eye worm) hypothetical protein 0.0082 0.0466 0.0886
Schistosoma mansoni myosin xvIII 0.0199 0.1229 0.1229
Onchocerca volvulus Neuropeptide F receptor homolog 0.0199 0.1229 0.2683
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.002 0.0033
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.2744 0.7366
Onchocerca volvulus Cathepsin L homolog 0.002 0.0058 0.0097
Loa Loa (eye worm) hypothetical protein 0.008 0.0449 0.0853
Brugia malayi larval opioid receptor 0.0199 0.1229 0.2378
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0082 0.0466 0.1245
Schistosoma mansoni neuropeptide F-like receptor 0.0199 0.1229 0.1229
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0256 0.0474
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.003 0.002
Echinococcus granulosus neuropeptide receptor 0.0199 0.1229 0.1229
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.0449 0.4626
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.003 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0136 0.026
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.0585 0.1563
Trypanosoma cruzi nucleoside transporter 1, putative 0.01 0.0585 0.1136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0058 0.0147
Onchocerca volvulus 0.0199 0.1229 0.2683
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0579 0.3724 1
Schistosoma mansoni netrin receptor unc5 0.0015 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0579 0.3724 0.7261
Trypanosoma brucei adenosine transporter, putative 0.01 0.0585 0.1136
Echinococcus multilocularis rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0517 0.1382
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0231 0.0231
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0058 0.0086
Schistosoma mansoni protein kinase 0.01 0.0585 0.0585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0431 0.0835
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.0585 0.1563
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0199 0.1229 0.1229
Brugia malayi Serine protease Z688.6 precursor 0.0082 0.0466 0.0886
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0429 0.2744 1
Echinococcus granulosus neuropeptide Y receptor 0.0199 0.1229 0.1229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0388 0.0751
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Mycobacterium ulcerans endonuclease IV 0.008 0.0449 0.1577
Leishmania major cathepsin L-like protease 0.0077 0.0431 0.0835
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0231 0.2314
Schistosoma mansoni opsin-like receptor 0.0199 0.1229 0.1229
Onchocerca volvulus 0.0199 0.1229 0.2683
Brugia malayi Melatonin receptor type 1A 0.0199 0.1229 0.2378
Schistosoma mansoni hypothetical protein 0.0199 0.1229 0.1229
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0199 0.1229 0.1229
Loa Loa (eye worm) ctsf protein 0.002 0.0058 0.0086
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0199 0.1229 0.2378
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.003 0.0053
Echinococcus multilocularis tumor protein p63 0.0361 0.2293 0.2293
Echinococcus granulosus allatostatin A receptor 0.0199 0.1229 0.1229
Entamoeba histolytica nucleoside transporter, putative 0.0579 0.3724 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0133 0.0798 0.1553
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0058 0.0139
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0429 0.2744 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0388 0.0388
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Brugia malayi 6-phosphofructokinase 0.0113 0.0669 0.1282
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0669 0.725
Echinococcus multilocularis geminin 0.0348 0.221 0.221
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.002 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0431 0.0835
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0199 0.1229 0.1229
Onchocerca volvulus 0.0199 0.1229 0.2683
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0429 0.2744 0.5353
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Brugia malayi Latrophilin receptor protein 2 0.0016 0.003 0.0031
Entamoeba histolytica nucleoside transporter, putative 0.01 0.0585 0.1563
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0199 0.1229 0.1229
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0199 0.1229 0.1229
Echinococcus granulosus GPCR family 2 0.0016 0.003 0.003
Brugia malayi Nucleoside transporter family protein 0.0579 0.3724 0.7261
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0126 0.033
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0388 0.0732
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0092 0.0175
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0669 0.13
Loa Loa (eye worm) hypothetical protein 0.01 0.0585 0.1117
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0388 0.1034
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0429 0.2744 0.5353
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0429 0.2744 0.5353
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0231 0.0445
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0237 0.1478 0.1478
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.009 0.0517 0.1382
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.0585 0.1136
Echinococcus granulosus sex peptide receptor 0.0199 0.1229 0.1229
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0199 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0056 0.0291 0.0563
Brugia malayi ORL1-like opioid receptor 0.0199 0.1229 0.2378
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0056 0.0291 0.0774
Brugia malayi Death domain containing protein 0.0015 0.0023 0.0019
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0579 0.3724 0.3724
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0466 0.1245
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0058 0.0086
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.003 0.003
Mycobacterium tuberculosis Probable peptidase 0.0056 0.0291 0.3006
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.1535 1 1
Leishmania major DNA damage repair protein, putative 0.0014 0.002 0.0033
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0388 0.0388
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0092 0.0266
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0704 0.4543 0.4543
Trypanosoma brucei adenosine transporter, putative 0.01 0.0585 0.1136
Schistosoma mansoni growth hormone secretagogue receptor 0.0199 0.1229 0.1229
Echinococcus granulosus neuropeptide Y receptor 0.0199 0.1229 0.1229
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0704 0.4543 0.4543
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0126 0.033
Trypanosoma cruzi nucleobase transporter, putative 0.01 0.0585 0.1136
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Loa Loa (eye worm) hypothetical protein 0.009 0.0517 0.0985
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0078 0.0437 0.0934
Brugia malayi Dopamine receptor 0.0199 0.1229 0.2378
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0056 0.0291 0.0774
Leishmania major nucleoside transporter 1, putative 0.01 0.0585 0.1136
Brugia malayi STAT protein, DNA binding domain containing protein 0.0137 0.0825 0.1587
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.002 0.0033
Echinococcus granulosus neuropeptide receptor 0.0199 0.1229 0.1229
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.003 0.002
Trichomonas vaginalis ribokinase, putative 0.009 0.0517 0.1382
Echinococcus multilocularis rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Trypanosoma brucei ribokinase, putative 0.009 0.0517 0.1005
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0148 0.0897 0.1728
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0199 0.1229 0.2378
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.003 0.003
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0126 0.0286
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0449 0.1577
Loa Loa (eye worm) hypothetical protein 0.0579 0.3724 0.7261
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0056 0.0291 0.0563
Onchocerca volvulus 0.009 0.0517 0.1111
Brugia malayi neuropeptide F receptor 0.0199 0.1229 0.2378
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.0585 0.1136
Entamoeba histolytica ribokinase, putative 0.009 0.0517 0.1382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0431 0.0835
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0071 0.0112
Onchocerca volvulus 0.002 0.0058 0.0097
Onchocerca volvulus Prolyl endopeptidase homolog 0.0056 0.0291 0.0612
Leishmania major hypothetical protein, conserved 0.0026 0.0092 0.0175
Leishmania major cathepsin L-like protease 0.002 0.0058 0.0107
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0199 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0058 0.0058
Trypanosoma cruzi nucleoside transporter-like, putative 0.01 0.0585 0.1136
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.003
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0071 0.0183
Trypanosoma brucei unspecified product 0.0032 0.0136 0.026
Leishmania major cathepsin L-like protease 0.002 0.0058 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0431 0.0835
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.009 0.0517 0.5611
Brugia malayi hypothetical protein 0.0199 0.1229 0.2378
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0151 0.0269
Giardia lamblia Alanyl dipeptidyl peptidase 0.0056 0.0291 0.0732
Plasmodium falciparum peptidase, putative 0.0056 0.0291 0.0995
Brugia malayi Adenylyl cyclase protein 0.0078 0.0437 0.0828
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0199 0.1229 0.1229
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0669 0.1789
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0056 0.0291 0.0774
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0082 0.0466 0.0905
Leishmania major tagatose-6-phosphate kinase-like protein 0.009 0.0517 0.1005
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0231 0.0231
Leishmania major ribokinase, putative 0.009 0.0517 0.1005
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0053 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0199 0.1229 0.1229
Mycobacterium ulcerans hypothetical protein 0.0021 0.0063 0.0158
Trypanosoma brucei nucleoside transporter 1, putative 0.01 0.0585 0.1136
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.0449 0.4829
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0199 0.1229 0.1229
Echinococcus multilocularis neuropeptide receptor 0.0199 0.1229 0.1229
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.0585 0.1563
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0058 0.0147
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.0585 0.1136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0092 0.0154
Brugia malayi Adenosine kinase-like 0.0792 0.5123 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0199 0.1229 0.1229
Brugia malayi follicle stimulating hormone receptor 0.0438 0.2803 0.5459
Echinococcus multilocularis prolyl endopeptidase 0.0056 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0082 0.0466 0.1245
Echinococcus multilocularis rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Brugia malayi hypothetical protein 0.0127 0.0758 0.1456
Echinococcus granulosus neuropeptides capa receptor 0.0199 0.1229 0.1229
Brugia malayi Serine protease Z688.6 precursor 0.0082 0.0466 0.0886
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Brugia malayi Cathepsin L-like precursor 0.002 0.0058 0.0086
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0071 0.0071
Brugia malayi MH2 domain containing protein 0.0144 0.0871 0.1678
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.003 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0126 0.033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0199 0.1229 0.1229
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0082 0.0466 0.1245
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Echinococcus granulosus serotonin receptor 0.0199 0.1229 0.1229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0058 0.0147
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.1535 1 1
Brugia malayi G-protein coupled receptor 0.0199 0.1229 0.2378
Trichomonas vaginalis ribokinase, putative 0.009 0.0517 0.1382
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0199 0.1229 0.1229
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.002 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0136 0.026
Trypanosoma cruzi nucleobase transporter, putative 0.01 0.0585 0.1136
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.01 0.0585 0.1136
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0237 0.1478 0.288
Plasmodium vivax vivapain-2 0.002 0.0058 0.0139
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0704 0.4543 1
Trypanosoma brucei purine nucleoside transporter 0.01 0.0585 0.1136
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0438 0.2803 0.5459
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0669 0.1282
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0669 0.7354
Mycobacterium tuberculosis Adenosine kinase 0.009 0.0517 0.5611
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0199 0.1229 0.1229
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0126 0.033
Trypanosoma cruzi adenosine kinase, putative 0.0792 0.5123 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0082 0.0466 0.1245
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0056 0.0291 0.0995
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.003 0.0032
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0082 0.0466 0.1245
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0429 0.2744 0.5353
Echinococcus granulosus rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Onchocerca volvulus 0.0199 0.1229 0.2683
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0431 0.0835
Echinococcus multilocularis fmrfamide receptor 0.0199 0.1229 0.1229
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0199 0.1229 0.1229
Schistosoma mansoni biogenic amine receptor 0.0199 0.1229 0.1229
Echinococcus granulosus tm gpcr rhodopsin 0.0199 0.1229 0.1229
Echinococcus granulosus Ankyrin 0.0015 0.0024 0.0024
Onchocerca volvulus Ribokinase homolog 0.009 0.0517 0.1111
Trypanosoma brucei ribokinase, putative 0.009 0.0517 0.1005
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.003
Brugia malayi Cathepsin L-like precursor 0.002 0.0058 0.0086
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0281 0.1772 0.4754
Brugia malayi Uncoordinated protein 44 0.0015 0.0023 0.0019
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0388 0.0751
Echinococcus granulosus peptide allatostatin:somatostatin 0.0199 0.1229 0.1229
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0281 0.177 0.3452
Echinococcus granulosus adenosine kinase 0.0792 0.5123 0.5123
Loa Loa (eye worm) fibroinase 0.002 0.0058 0.0086
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0056 0.0291 0.0563
Echinococcus multilocularis orexin receptor type 2 0.0199 0.1229 0.1229
Trypanosoma cruzi oligopeptidase b 0.0056 0.0291 0.0563
Loa Loa (eye worm) hypothetical protein 0.0034 0.0151 0.0269
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.0585 0.1563
Brugia malayi hypothetical protein 0.0199 0.1229 0.2378
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0231 0.2314
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0845 0.5473 0.5473
Echinococcus granulosus Dipeptidyl peptidase 9 0.0237 0.1478 0.1478
Onchocerca volvulus 0.0078 0.0437 0.0934
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0478 0.3064 0.3064
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0126 0.0389
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0023 0.0023
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.0585 0.1136
Echinococcus granulosus rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Brugia malayi Cathepsin L-like precursor 0.002 0.0058 0.0086
Brugia malayi hypothetical protein 0.0016 0.0033 0.0038
Loa Loa (eye worm) hypothetical protein 0.005 0.0256 0.0474
Loa Loa (eye worm) G-protein coupled receptor 0.0199 0.1229 0.2378
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0056 0.0291 0.273
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.0585 0.1136
Trypanosoma cruzi prolyl endopeptidase 0.0056 0.0291 0.0563
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0199 0.1229 0.1229
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0056 0.0291 0.0543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0014 0.0029
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Schistosoma mansoni ribokinase 0.009 0.0517 0.0517
Giardia lamblia Ribokinase 0.009 0.0517 0.1343
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0231 0.0445
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0031
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0092 0.0175
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trypanosoma brucei purine nucleoside transporter 0.01 0.0585 0.1136
Brugia malayi G-protein coupled receptor 0.0199 0.1229 0.2378
Trypanosoma cruzi nucleoside transporter-like, putative 0.01 0.0585 0.1136
Leishmania major cathepsin L-like protease 0.002 0.0058 0.0107
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0126 0.0208
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0082 0.0466 0.1245
Echinococcus multilocularis cysteine protease 0.002 0.0058 0.0058
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0126 0.0389
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0291 0.0563
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0429 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0388 0.0732
Schistosoma mansoni opsin-like receptor 0.0199 0.1229 0.1229
Echinococcus multilocularis adenylate cyclase 9 0.0078 0.0437 0.0437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0431 0.0835
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0014 0.0029
Schistosoma mansoni hypothetical protein 0.0199 0.1229 0.1229
Brugia malayi Dopamine receptor protein 2 0.0199 0.1229 0.2378
Schistosoma mansoni hypothetical protein 0.0043 0.021 0.021
Echinococcus multilocularis neuropeptides capa receptor 0.0199 0.1229 0.1229
Echinococcus granulosus tumor protein p63 0.0361 0.2293 0.2293
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0296 0.187 0.3634
Echinococcus multilocularis rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0579 0.3724 1
Loa Loa (eye worm) cysteine protease 0.002 0.0058 0.0086
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0669 0.0669
Entamoeba histolytica prolyl oligopeptidase family protein 0.0056 0.0291 0.0774
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0126 0.0389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0429 0.0429
Brugia malayi hypothetical protein 0.0199 0.1229 0.2378
Echinococcus granulosus equilibrative nucleoside transporter 0.0579 0.3724 0.3724
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0431 0.0835
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0082 0.0466 0.1245
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0669 0.13
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0058 0.0058
Loa Loa (eye worm) RecQ helicase 0.0022 0.0071 0.0112
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0056 0.0291 0.0774
Echinococcus multilocularis neuropeptide FF receptor 2 0.0199 0.1229 0.1229
Brugia malayi neuropeptide F receptor 0.0199 0.1229 0.2378
Trypanosoma brucei unspecified product 0.0032 0.0136 0.026
Trypanosoma cruzi adenosine kinase, putative 0.009 0.0517 0.1005
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0431 0.0835
Loa Loa (eye worm) hypothetical protein 0.0053 0.0272 0.0505
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0199 0.1229 0.1229
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0429 0.2744 0.5337
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.004 0.004
Echinococcus multilocularis neuropeptide receptor 0.0199 0.1229 0.1229
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0082 0.0466 0.1245
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0054
Onchocerca volvulus 0.0199 0.1229 0.2683
Leishmania major adenosine kinase-like protein 0.009 0.0517 0.1005
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.003
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0231 0.0425
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0433 0.084
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0579 0.3724 0.3724
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0056 0.0291 0.0563
Brugia malayi Cathepsin L-like precursor 0.002 0.0058 0.0086
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0136 0.026
Trypanosoma cruzi oligopeptidase b 0.0056 0.0291 0.0563
Chlamydia trachomatis endonuclease IV 0.008 0.0449 0.1236
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0058 0.0147
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0199 0.1229 0.1229
Brugia malayi prolyl oligopeptidase family protein 0.0056 0.0291 0.0543
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0431 0.0835
Toxoplasma gondii nucleoside transporter protein 0.01 0.0585 0.1107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Brugia malayi 6-phosphofructokinase 0.0113 0.0669 0.1282
Trypanosoma cruzi adenosine kinase, putative 0.0792 0.5123 1
Brugia malayi hypothetical protein 0.0181 0.1112 0.2149
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.003 0.003
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0199 0.1229 0.1229
Brugia malayi GnHR receptor homolog 0.0199 0.1229 0.2378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.01 0.0585 0.1136
Loa Loa (eye worm) hypothetical protein 0.0078 0.0437 0.0828
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0669 0.1282
Leishmania major nucleobase transporter 0.01 0.0585 0.1136
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0431 0.0835
Schistosoma mansoni neuropeptide receptor 0.0199 0.1229 0.1229
Brugia malayi Serine carboxypeptidase S28 family protein 0.0082 0.0466 0.0886
Toxoplasma gondii hypothetical protein 0.0056 0.0291 0.0531
Toxoplasma gondii nucleoside transporter protein 0.01 0.0585 0.1107
Schistosoma mansoni amine GPCR 0.0199 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.003 0.003
Trypanosoma brucei adenosine kinase, putative 0.0792 0.5123 1
Brugia malayi hypothetical protein 0.0026 0.0092 0.0154
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0058 0.0058
Onchocerca volvulus 0.0199 0.1229 0.2683
Echinococcus multilocularis dro:myosuppressin receptor 0.0199 0.1229 0.1229
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0281 0.1772 0.1772
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Echinococcus granulosus rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0126 0.033
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0056 0.0291 0.0291
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.002 0.0033
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0429 0.2744 0.5343
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.002 0.0033
Loa Loa (eye worm) pax transcription factor protein 2 0.0244 0.1524 0.2956
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0429 0.2744 0.5337
Onchocerca volvulus 0.0199 0.1229 0.2683
Echinococcus granulosus death domain containing protein 0.0015 0.0023 0.0023
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0231 0.0231
Schistosoma mansoni histamine h1 receptor 0.0199 0.1229 0.1229
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0579 0.3724 0.819
Echinococcus granulosus alpha 1A adrenergic receptor 0.0199 0.1229 0.1229
Onchocerca volvulus 0.0199 0.1229 0.2683
Trypanosoma brucei prolyl oligopeptidase, putative 0.0056 0.0291 0.0563
Brugia malayi putative neuropeptide receptor 0.0199 0.1229 0.2378
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0056 0.0291 0.0563
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0148 0.0897 0.2403
Echinococcus multilocularis g-protein coupled receptor 0.0199 0.1229 0.1229
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0231 0.0231
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0199 0.1229 0.1229
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0082 0.0466 0.0466
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0199 0.1229 0.2378
Schistosoma mansoni neuropeptide receptor 0.0199 0.1229 0.1229
Brugia malayi Cathepsin L-like precursor 0.002 0.0058 0.0086
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0126 0.0208
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0082 0.0466 0.0886
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0082 0.0466 0.1245
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0237 0.1478 0.1478
Entamoeba histolytica cysteine protease, putative 0.002 0.0058 0.0147
Brugia malayi prolyl oligopeptidase family protein 0.0704 0.4543 0.8866
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0199 0.1229 0.1229
Echinococcus granulosus bloom syndrome protein 0.0022 0.0071 0.0071
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0388 0.0388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0431 0.0835
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0433 0.084
Toxoplasma gondii kinase, pfkB family protein 0.0792 0.5123 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.1112 0.2149
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.002 0.0033
Onchocerca volvulus 0.0075 0.0415 0.0886
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0669 0.1789
Brugia malayi Protein kinase domain containing protein 0.0015 0.0023 0.0019
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0281 0.1772 0.3441
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0082 0.0466 0.0875
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Echinococcus multilocularis adenosine kinase 0.0792 0.5123 0.5123
Onchocerca volvulus Cathepsin F homolog 0.002 0.0058 0.0097
Entamoeba histolytica hypothetical protein 0.0043 0.021 0.0557
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0058 0.0107
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0199 0.1229 0.1229
Leishmania major cysteine peptidase A (CPA) 0.002 0.0058 0.0107
Loa Loa (eye worm) neuropeptide F receptor 0.0199 0.1229 0.2378
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0199 0.1229 0.1229
Onchocerca volvulus Cathepsin L homolog 0.002 0.0058 0.0097
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0082 0.0466 0.1245
Schistosoma mansoni biogenic amine (5HT) receptor 0.0199 0.1229 0.1229
Schistosoma mansoni amine GPCR 0.0199 0.1229 0.1229
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.003 0.0031
Brugia malayi hypothetical protein 0.01 0.0585 0.1117
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0669 0.13
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.2744 0.5353
Schistosoma mansoni adenoreceptor 0.0199 0.1229 0.1229
Onchocerca volvulus 0.0199 0.1229 0.2683
Onchocerca volvulus 0.0199 0.1229 0.2683
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0133 0.0798 0.1535
Echinococcus granulosus prolyl endopeptidase 0.0056 0.0291 0.0291
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0199 0.1229 0.1229
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.021 0.021
Trypanosoma cruzi nucleobase transporter, putative 0.01 0.0585 0.1136
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0222 0.0428
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0871 0.1678
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0429 0.2744 0.7366
Schistosoma mansoni amine GPCR 0.0199 0.1229 0.1229
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0669 0.1789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.2744 0.7366
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0281 0.177 0.3452
Leishmania major nucleoside transporter 1, putative 0.01 0.0585 0.1136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0431 0.0835
Echinococcus multilocularis g protein coupled receptor 0.0199 0.1229 0.1229
Brugia malayi prolyl oligopeptidase family protein 0.0237 0.1478 0.2865
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0237 0.1478 0.2857
Onchocerca volvulus 0.0199 0.1229 0.2683
Loa Loa (eye worm) hypothetical protein 0.0014 0.002 0.0012
Echinococcus multilocularis sex peptide receptor 0.0199 0.1229 0.1229
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0429 0.2744 0.5353
Mycobacterium ulcerans carbohydrate kinase CbhK 0.009 0.0517 0.1826
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.0449 0.0853
Schistosoma mansoni adenosine kinase 0.0792 0.5123 0.5123
Echinococcus granulosus rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.003 0.0037
Schistosoma mansoni hypothetical protein 0.0015 0.0023 0.0023
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.01 0.0585 0.1136
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0056 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0082 0.0466 0.0886
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0199 0.1229 0.1229
Onchocerca volvulus 0.0199 0.1229 0.2683
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0023 0.0021
Entamoeba histolytica prolyl oligopeptidase family protein 0.0056 0.0291 0.0774
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0429 0.0429
Echinococcus granulosus tm gpcr rhodopsin 0.0199 0.1229 0.1229
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0199 0.1229 0.1229
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0199 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Brugia malayi Dopamine receptor protein 1 0.0199 0.1229 0.2378
Trypanosoma brucei adenosine kinase, putative 0.0792 0.5123 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.002
Loa Loa (eye worm) neuropeptide F receptor 0.0199 0.1229 0.2378
Loa Loa (eye worm) TYRA-2 protein 0.0199 0.1229 0.2378
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0331 0.2096 0.4074
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0429 0.2744 0.5353
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0231 0.0445
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.003 0.0053
Echinococcus multilocularis allatostatin A receptor 0.0199 0.1229 0.1229
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0082 0.0466 0.0466
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0281 0.177 0.4726
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.003 0.0037
Echinococcus granulosus cathepsin l1 0.0014 0.0014 0.0014
Giardia lamblia DINP protein human, muc B family 0.0047 0.0231 0.057
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.0585 0.1136
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.021 0.021
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0296 0.187 0.3634
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.002 0.0033
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0669 0.2382
Brugia malayi prolyl oligopeptidase family protein 0.0056 0.0291 0.0543
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0199 0.1229 0.1229
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.01 0.0585 0.1136
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0579 0.3724 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.0585 0.1136
Echinococcus granulosus dna polymerase eta 0.0077 0.0433 0.0433
Schistosoma mansoni hypothetical protein 0.0199 0.1229 0.1229
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Entamoeba histolytica fructokinase, putative 0.009 0.0517 0.1382
Onchocerca volvulus 0.0053 0.0272 0.0569
Leishmania major adenosine kinase-like protein 0.009 0.0517 0.1005
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0231 0.0775
Echinococcus multilocularis Ankyrin 0.0015 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0431 0.0835
Brugia malayi hypothetical protein 0.0199 0.1229 0.2378
Entamoeba histolytica hypothetical protein, conserved 0.0056 0.0291 0.0774
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0199 0.1229 0.2378
Schistosoma mansoni neuropeptide receptor 0.0199 0.1229 0.1229
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0126 0.0389
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0388 0.0751
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0056 0.0291 0.0543
Echinococcus multilocularis serotonin receptor 0.0199 0.1229 0.1229
Trypanosoma brucei adenosine transporter 2, putative 0.01 0.0585 0.1136
Brugia malayi hypothetical protein 0.0199 0.1229 0.2378
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0216 0.1343 0.2935
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0023 0.0019
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0082 0.0466 0.1245
Echinococcus granulosus adenylate cyclase 9 0.0078 0.0437 0.0437
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0082 0.0466 0.1245
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0429 0.2744 0.5353
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0058 0.0086
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0058 0.0058
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0148 0.0898 1
Loa Loa (eye worm) adenylyl cyclase 3 0.0078 0.0437 0.0828
Leishmania major cathepsin L-like protease 0.002 0.0058 0.0107
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0092 0.0266
Onchocerca volvulus 0.0199 0.1229 0.2683
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0193 0.0193
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.009 0.0517 0.0517
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.002 0.0033
Leishmania major cathepsin L-like protease 0.002 0.0058 0.0107
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0669 0.2073
Brugia malayi Ribokinase 0.009 0.0517 0.0985
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0056 0.0291 0.0531
Loa Loa (eye worm) STAT protein 0.0137 0.0825 0.1587
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0199 0.1229 0.1229
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.002 0.0033
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0231 0.0425
Giardia lamblia Alanyl dipeptidyl peptidase 0.0056 0.0291 0.0732
Trypanosoma brucei nucleoside transporter 1, putative 0.01 0.0585 0.1136
Entamoeba histolytica hypothetical protein 0.0043 0.021 0.0557
Mycobacterium ulcerans fructokinase, PfkB 0.009 0.0517 0.1826
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0199 0.1229 0.2378
Echinococcus multilocularis neuropeptide Y receptor 0.0199 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0126 0.033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0058 0.0147
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0231 0.0775
Echinococcus granulosus g protein coupled receptor 0.0199 0.1229 0.1229
Onchocerca volvulus 0.002 0.0058 0.0097
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0199 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0058 0.0147
Echinococcus granulosus tachykinin peptides receptor 99D 0.0199 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Echinococcus multilocularis ribokinase 0.009 0.0517 0.0517
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0199 0.1229 0.1229
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0669 0.1789
Trypanosoma cruzi ribokinase, putative 0.009 0.0517 0.1005
Onchocerca volvulus 0.002 0.0058 0.0097
Onchocerca volvulus 0.0199 0.1229 0.2683
Leishmania major DNA polymerase kappa, putative 0.0014 0.002 0.0033
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0429 0.2744 0.5
Brugia malayi Serotonin receptor 0.0199 0.1229 0.2378
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.2744 0.5353
Brugia malayi phosphofructokinase 0.0113 0.0669 0.1282
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0429 0.2744 0.2744
Toxoplasma gondii prolyl endopeptidase 0.0056 0.0291 0.0531
Onchocerca volvulus 0.002 0.0058 0.0097
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0058 0.0147
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0092 0.0175
Schistosoma mansoni biogenic amine (5HT) receptor 0.0199 0.1229 0.1229
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0126 0.033
Brugia malayi Isocitrate dehydrogenase 0.0016 0.003 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0126 0.033
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.003 0.003
Trypanosoma cruzi adenosine kinase, putative 0.009 0.0517 0.1005
Brugia malayi polk-prov protein 0.0014 0.002 0.0012
Echinococcus granulosus neuropeptide receptor A26 0.0199 0.1229 0.1229
Echinococcus granulosus fmrfamide receptor 0.0199 0.1229 0.1229
Entamoeba histolytica kinase, PfkB family 0.009 0.0517 0.1382
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0056 0.0291 0.0291
Toxoplasma gondii nucleoside transporter protein 0.01 0.0585 0.1107
Loa Loa (eye worm) G-protein coupled receptor 0.0199 0.1229 0.2378
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Echinococcus granulosus rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0014 0.0029
Mycobacterium tuberculosis Ribokinase RbsK 0.009 0.0517 0.5611
Onchocerca volvulus 0.0199 0.1229 0.2683
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0063 0.0108
Brugia malayi hypothetical protein 0.0199 0.1229 0.2378
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0082 0.0466 0.1245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0466 0.1245
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.021 0.021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0063 0.0379
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0291 0.0563
Trypanosoma brucei oligopeptidase b 0.0056 0.0291 0.0563
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.009 0.0517 0.1382
Giardia lamblia Hypothetical protein 0.0579 0.3724 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0199 0.1229 0.1229
Leishmania major oligopeptidase b 0.0056 0.0291 0.0563
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0058 0.0139
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.009 0.0517 0.0517
Leishmania major cathepsin L-like protease 0.0077 0.0431 0.0835
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0199 0.1229 0.1229
Leishmania major nucleobase transporter 0.01 0.0585 0.1136
Echinococcus granulosus g protein coupled receptor 0.0199 0.1229 0.1229
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0092 0.0266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0199 0.1229 0.1229
Brugia malayi sulfakinin receptor protein 0.0199 0.1229 0.2378
Echinococcus granulosus 7TM GPCR rhodopsin 0.0199 0.1229 0.1229
Brugia malayi Serotonin receptor 0.0199 0.1229 0.2378
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0199 0.1229 0.2378
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.01 0.0585 0.1563
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0058 0.0147
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.003 0.003
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0063 0.0096
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0231 0.0445
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0431 0.0835
Trypanosoma brucei prolyl endopeptidase 0.0056 0.0291 0.0563
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0082 0.0466 0.1245
Leishmania major putative PfkB family sugar kinase 0.009 0.0517 0.1005
Echinococcus granulosus cathepsin l1 0.002 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0056 0.0291 0.0543
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0256 0.0474
Schistosoma mansoni neuropeptide f receptor 76f 0.0199 0.1229 0.1229
Brugia malayi hypothetical protein 0.009 0.0517 0.0985
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0433 0.082
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Schistosoma mansoni opsin-like receptor 0.0199 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.0082 0.0466 0.0886
Schistosoma mansoni biogenic amine receptor 0.0199 0.1229 0.1229
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0429 0.2744 0.7354
Leishmania major DNA polymerase eta, putative 0.0077 0.0433 0.084
Schistosoma mansoni alpha-1 adrenergic receptor 0.0199 0.1229 0.1229
Leishmania major adenosine kinase, putative 0.0792 0.5123 1
Loa Loa (eye worm) hypothetical protein 0.0579 0.3724 0.7261
Entamoeba histolytica hypothetical protein 0.0043 0.021 0.0557
Schistosoma mansoni neuropeptide F-like receptor 0.0199 0.1229 0.1229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0058 0.0147
Echinococcus granulosus g protein coupled receptor 0.0199 0.1229 0.1229
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.002 0.0033
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.003 0.003
Echinococcus granulosus ribokinase 0.009 0.0517 0.0517
Brugia malayi RE15519p 0.0199 0.1229 0.2378
Brugia malayi Cathepsin L-like precursor 0.002 0.0058 0.0086
Loa Loa (eye worm) hypothetical protein 0.0021 0.0063 0.0096
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.003 0.0031
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0429 0.2744 0.2744
Echinococcus multilocularis cysteine protease 0.002 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0213 0.1321 0.2559
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.003
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0126 0.0208
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0133 0.0798 0.1553
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0388 0.0751
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0082 0.0466 0.1245
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Echinococcus granulosus neuropeptides capa receptor 0.0199 0.1229 0.1229
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0133 0.0798 0.1553
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0199 0.1229 0.2683
Brugia malayi G protein-coupled receptor 0.0199 0.1229 0.2378
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.003 0.0053
Schistosoma mansoni neuropeptide receptor 0.0199 0.1229 0.1229
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0024 0.0024
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0449 0.1577
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0429 0.2744 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0231 0.0445
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0387 0.075
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.002 0.002
Schistosoma mansoni biogenic amine receptor 0.0199 0.1229 0.1229
Schistosoma mansoni equilibrative nucleoside transporter 0.01 0.0585 0.0585
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0133 0.0798 0.1553
Trypanosoma brucei adenosine transporter 2 0.01 0.0585 0.1136
Schistosoma mansoni hypothetical protein 0.0348 0.221 0.221
Onchocerca volvulus 0.0244 0.1524 0.3334
Brugia malayi Pax transcription factor protein 2 0.0244 0.1524 0.2956
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0082 0.0466 0.0905
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0082 0.0466 0.0466
Echinococcus multilocularis rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Echinococcus granulosus hypothetical protein 0.0199 0.1229 0.1229
Echinococcus multilocularis serotonin receptor 0.0199 0.1229 0.1229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0058 0.0147
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0429 0.2744 0.2744
Echinococcus granulosus biogenic amine 5HT receptor 0.0199 0.1229 0.1229
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0429 0.2744 0.2744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0429 0.2744 0.2744
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0669 0.0669
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0014 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0291 0.0995
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0322 0.0624
Plasmodium vivax vivapain-2 0.002 0.0058 0.0139
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0056 0.0291 0.0563
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0024 0.0014
Onchocerca volvulus 0.002 0.0058 0.0097
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0199 0.1229 0.1229
Echinococcus granulosus dna polymerase kappa 0.0047 0.0231 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0058 0.0147
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0231 0.0613
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0193 0.0193
Echinococcus multilocularis acylamino acid releasing enzyme 0.0056 0.0291 0.0291
Brugia malayi putative neuropeptide receptor NPR1 0.0199 0.1229 0.2378
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0082 0.0466 0.1245
Schistosoma mansoni hypothetical protein 0.0034 0.0151 0.0151
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0579 0.3724 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0058 0.0147
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0429 0.2744 1
Trypanosoma cruzi nucleoside transporter 1, putative 0.01 0.0585 0.1136
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0237 0.1478 0.288
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.003 0.003
Brugia malayi AKH receptor 0.0199 0.1229 0.2378
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0082 0.0466 0.0905
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.003 0.003
Trichomonas vaginalis ribokinase, putative 0.009 0.0517 0.1382
Giardia lamblia Thymus-specific serine protease precursor 0.0082 0.0466 0.1205
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0237 0.1478 0.288
Entamoeba histolytica nucleoside transporter, putative 0.01 0.0585 0.1563
Entamoeba histolytica prolyl oligopeptidase family protein 0.0056 0.0291 0.0774
Brugia malayi hypothetical protein 0.0199 0.1229 0.2378
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0199 0.1229 0.1229
Echinococcus multilocularis neuropeptide Y receptor 0.0199 0.1229 0.1229
Schistosoma mansoni amine GPCR 0.0199 0.1229 0.1229
Echinococcus granulosus somatostatin receptor 0.0199 0.1229 0.1229
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0148 0.0898 1
Schistosoma mansoni amine GPCR 0.0199 0.1229 0.1229
Brugia malayi prolyl oligopeptidase family protein 0.0056 0.0291 0.0543
Loa Loa (eye worm) hypothetical protein 0.0077 0.0433 0.082
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0429 0.2744 0.2744
Mycobacterium leprae Probable adenosine kinase adk 0.009 0.0517 0.5438
Onchocerca volvulus 0.0199 0.1229 0.2683
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0056 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0281 0.1772 0.3441
Loa Loa (eye worm) prolyl oligopeptidase 0.0704 0.4543 0.8866
Trypanosoma brucei unspecified product 0.01 0.0585 0.1136
Echinococcus granulosus acylamino acid releasing enzyme 0.0056 0.0291 0.0291
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0199 0.1229 0.2378
Trypanosoma brucei unspecified product 0.0047 0.0231 0.0445
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0199 0.1229 0.1229
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0023 0.0019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0199 0.1229 0.1229
Onchocerca volvulus 0.002 0.0058 0.0097
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0237 0.1478 0.288
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0199 0.1229 0.2378
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0579 0.3724 0.819
Loa Loa (eye worm) hypothetical protein 0.0792 0.5123 1
Onchocerca volvulus 0.002 0.0058 0.0097
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0579 0.3724 0.3724
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0669 0.1789
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0058 0.0139
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0429 0.2744 0.7366
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0871 0.1678
Leishmania major cathepsin L-like protease 0.0077 0.0431 0.0835
Echinococcus granulosus rhodopsin orphan GPCR 0.0199 0.1229 0.1229
Echinococcus multilocularis somatostatin receptor 0.0199 0.1229 0.1229
Giardia lamblia Serine peptidase, putative 0.0082 0.0466 0.1205
Leishmania major tagatose-6-phosphate kinase-like protein 0.009 0.0517 0.1005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0431 0.0835
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0058 0.0147
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0023 0.0023
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0281 0.1772 0.1772
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0199 0.1229 0.1229
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0086
Echinococcus granulosus dro:myosuppressin receptor 0.0199 0.1229 0.1229
Echinococcus multilocularis G-protein coupled receptor, putative 0.0199 0.1229 0.1229
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0291 0.0774
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0082 0.0466 0.1245
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0429 0.2744 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0199 0.1229 0.2378
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0429 0.2744 0.5353
Brugia malayi hypothetical protein 0.0199 0.1229 0.2378

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)] ChEMBL. No reference
Potency (functional) 1.6834 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 2.3934 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 3.6898 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) 4.0995 uM PUBCHEM_BIOASSAY: qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540272] ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Giardia lamblia

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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