Detailed information for compound 1393618

Basic information

Technical information
  • TDR Targets ID: 1393618
  • Name: ethyl 3-[(1-cyclopentylbenzotriazole-5-carbon yl)amino]benzoate
  • MW: 378.424 | Formula: C21H22N4O3
  • H donors: 1 H acceptors: 4 LogP: 3.34 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cccc(c1)NC(=O)c1ccc2c(c1)nnn2C1CCCC1
  • InChi: 1S/C21H22N4O3/c1-2-28-21(27)15-6-5-7-16(12-15)22-20(26)14-10-11-19-18(13-14)23-24-25(19)17-8-3-4-9-17/h5-7,10-13,17H,2-4,8-9H2,1H3,(H,22,26)
  • InChiKey: IOBAGDAYJHNBIR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[(1-cyclopentyl-5-benzotriazolyl)-oxomethyl]amino]benzoic acid ethyl ester
  • 3-[(1-cyclopentylbenzotriazole-5-carbonyl)amino]benzoic acid ethyl ester
  • ethyl 3-[(1-cyclopentylbenzotriazol-5-yl)carbonylamino]benzoate
  • F058-1230
  • NCGC00127994-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.003 0.0087
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.02 0.02
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0108 0.1716
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Toxoplasma gondii beta tubulin 0.0025 0.0063 0.0469
Loa Loa (eye worm) hypothetical protein 0.0072 0.0257 0.0865
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0027 0.0078
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0381
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0043 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.003 0.0099
Schistosoma mansoni inositol monophosphatase 0.0036 0.0108 0.0316
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0199 0.0784 0.2295
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0025 0.0062 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.003 0.0099
Brugia malayi jmjC domain containing protein 0.0063 0.022 0.0738
Schistosoma mansoni nuclear hormone receptor 0.0017 0.003 0.0087
Echinococcus multilocularis acetylcholinesterase 0.0727 0.2976 0.2976
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0099
Echinococcus multilocularis xaa pro aminopeptidase 0.0025 0.0062 0.0062
Mycobacterium ulcerans methionine aminopeptidase 0.0199 0.0784 1
Brugia malayi hypothetical protein 0.0032 0.0088 0.0297
Brugia malayi metallopeptidase family M24 containing protein 0.0025 0.0062 0.0207
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.1843 0.1843
Schistosoma mansoni tubulin subunit beta 0.0025 0.0063 0.0185
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0025 0.0062 0.0508
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0025 0.0062 0.0508
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0199 0.0784 0.0784
Plasmodium vivax methionine aminopeptidase 2, putative 0.0025 0.0062 0.0452
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0025 0.0062 0.0508
Loa Loa (eye worm) hypothetical protein 0.0039 0.012 0.0405
Echinococcus multilocularis zinc finger protein 0.0019 0.0037 0.0037
Brugia malayi MH2 domain containing protein 0.0016 0.0025 0.0086
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.003 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0043 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0089
Mycobacterium tuberculosis Conserved protein 0.0072 0.0257 0.1229
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0043 0.0123
Schistosoma mansoni transcription factor btf3 0.0034 0.0099 0.029
Entamoeba histolytica hypothetical protein 0.007 0.0248 0.7495
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0087 0.032 0.3614
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0025 0.0062 0.0377
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0025 0.0062 0.0508
Giardia lamblia Methionine aminopeptidase 0.0025 0.0062 0.1556
Loa Loa (eye worm) hypothetical protein 0.0072 0.0256 0.0861
Echinococcus granulosus xaa Pro dipeptidase 0.0025 0.0062 0.0181
Toxoplasma gondii creatinase domain-containing protein 0.0025 0.0062 0.0452
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.003 0.0087
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0043 0.0064
Entamoeba histolytica hypothetical protein 0.0087 0.032 1
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0257 0.2897
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0025 0.0062 0.0652
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.003 0.0087
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0025 0.0062 0.0181
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0257 0.1229
Loa Loa (eye worm) hypothetical protein 0.0061 0.0209 0.0702
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0033 0.0168
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0033 0.0112
Plasmodium vivax tubulin beta chain, putative 0.0025 0.0063 0.0469
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0099 0.0957
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0257 0.0754
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0215 0.0851 1
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0099 0.0957
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.022 0.0642
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.032 0.0937
Schistosoma mansoni ets-related 0.0215 0.0851 0.2491
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Loa Loa (eye worm) initiation factor 2-associated protein 0.0025 0.0062 0.0207
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0025 0.0074
Brugia malayi RhoGAP domain containing protein 0.0062 0.0215 0.0723
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0039 0.012 0.0353
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0033 0.0098
Brugia malayi beta-tubulin, identical 0.0025 0.0063 0.0212
Loa Loa (eye worm) carboxylesterase 0.0123 0.0467 0.157
Echinococcus multilocularis tubulin subunit beta 0.0025 0.0063 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0043 0.0143
Brugia malayi metallopeptidase family M24 containing protein 0.0025 0.0062 0.0207
Leishmania major methionine aminopeptidase 2, putative 0.0025 0.0062 0.0508
Brugia malayi beta-NAC-like protein 0.0034 0.0099 0.0333
Loa Loa (eye worm) carboxylesterase 0.0727 0.2976 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0043 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0099
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.003 0.0087
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0199 0.0784 0.2295
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0052 0.0175 0.1561
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.003 0.0087
Giardia lamblia Xaa-Pro dipeptidase 0.0025 0.0062 0.1556
Brugia malayi nuclear receptor NHR-88 0.0017 0.003 0.0099
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0215 0.0851 1
Toxoplasma gondii transcriptional elongation factor FACT140 0.0025 0.0062 0.0452
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0043 0.0279
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0033 0.0096
Loa Loa (eye worm) hypothetical protein 0.0053 0.0178 0.0598
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0108 0.1716
Loa Loa (eye worm) voltage-dependent calcium channel 0.0039 0.012 0.0405
Echinococcus multilocularis muscleblind protein 0.0146 0.0565 0.0565
Brugia malayi Carboxylesterase family protein 0.0123 0.0467 0.157
Brugia malayi AMP-binding enzyme family protein 0.007 0.0248 0.0833
Toxoplasma gondii methionine aminopeptidase 0.0215 0.0851 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0093 0.0343 0.1153
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0215 0.0851 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0343 0.1153
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0093 0.0343 0.0343
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0025 0.0062 0.0452
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0033 0.0168
Echinococcus multilocularis voltage dependent calcium channel 0.0039 0.012 0.012
Brugia malayi steroid hormone receptor 0.0017 0.003 0.0099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0163 0.0715
Brugia malayi MH2 domain containing protein 0.0241 0.0958 0.3217
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0178 0.0178
Toxoplasma gondii ABC1 family protein 0.0072 0.0257 0.2819
Loa Loa (eye worm) hypothetical protein 0.0072 0.0257 0.0865
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0257 0.2984
Schistosoma mansoni hypothetical protein 0.0093 0.0343 0.1004
Brugia malayi beta-lactamase family protein 0.0072 0.0257 0.0865
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0027 0.0078
Schistosoma mansoni hypothetical protein 0.0166 0.0644 0.1886
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0099 0.0957
Echinococcus multilocularis Proliferation associated protein 2G4 0.0025 0.0062 0.0062
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.003 0.0087
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0025 0.0062 0.0652
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.0958 0.3217
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0043 0.0222
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0072 0.0257 0.0865
Echinococcus multilocularis tubulin beta 1 chain 0.0025 0.0063 0.0063
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.003 0.0099
Schistosoma mansoni hypothetical protein 0.007 0.0248 0.0727
Loa Loa (eye worm) BEN-1 protein 0.0025 0.0063 0.0212
Brugia malayi jmjC domain containing protein 0.0016 0.0025 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.003 0.0099
Onchocerca volvulus 0.0072 0.0257 0.3987
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0248 0.277
Brugia malayi Protein kinase domain containing protein 0.0087 0.032 0.1075
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0151 0.0151
Trichomonas vaginalis tubulin gamma chain, putative 0.0025 0.0063 0.0684
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0151 0.0442
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0043 0.0279
Plasmodium falciparum acyl-CoA synthetase 0.0052 0.0175 0.1816
Loa Loa (eye worm) tubulin beta-1 chain 0.0025 0.0063 0.0212
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0063 0.0063
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0043 0.0279
Schistosoma mansoni smad 0.0016 0.0025 0.0074
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0039 0.012 0.1214
Brugia malayi hypothetical protein 0.0123 0.0467 0.157
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0123 0.0467 0.0467
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0025 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.003 0.0099
Entamoeba histolytica protein kinase domain containing protein 0.0087 0.032 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0207 0.2308
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0043 0.0212
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0033 0.011
Brugia malayi beta-lactamase family protein 0.0072 0.0257 0.0865
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.1843 0.1843
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Trichomonas vaginalis tubulin epsilon chain, putative 0.0025 0.0063 0.0684
Giardia lamblia Beta tubulin 0.0025 0.0063 0.1632
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0043 0.0123
Entamoeba histolytica methionine aminopeptidase, putative 0.0025 0.0062 0.0987
Trypanosoma brucei Metallopeptidase family M24, putative 0.0025 0.0062 0.0508
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0093 0.0343 0.1004
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.003 0.0099
Echinococcus granulosus FACT complex subunit SPT16 0.0025 0.0062 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.003 0.0099
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Loa Loa (eye worm) hypothetical protein 0.0052 0.0175 0.0586
Loa Loa (eye worm) Smad1 0.0016 0.0025 0.0086
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0248 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.003 0.0099
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0025 0.0062 0.0652
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Echinococcus granulosus GPCR family 2 0.0093 0.0343 0.1004
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0063 0.0063
Schistosoma mansoni BC026374 protein (S09 family) 0.0123 0.0467 0.1368
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0143
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.1843 0.5393
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.003 0.0087
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0099 0.0904
Schistosoma mansoni bromodomain containing protein 0.0062 0.0215 0.0628
Brugia malayi jmjC domain containing protein 0.0016 0.0025 0.0085
Echinococcus granulosus xaa Pro dipeptidase 0.0025 0.0062 0.0181
Brugia malayi MH1 domain containing protein 0.0016 0.0025 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0257 0.2861
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0025 0.0062 0.0652
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0025 0.0062 0.0508
Loa Loa (eye worm) hypothetical protein 0.0047 0.0151 0.0508
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0025 0.001
Mycobacterium tuberculosis Conserved protein 0.0072 0.0257 0.1229
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0025 0.0062 0.0508
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.016 0.1695
Echinococcus multilocularis beta tubulin 0.0025 0.0063 0.0063
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0025 0.0025
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0025 0.0062 0.0652
Giardia lamblia Rho GAP, putative 0.0062 0.0215 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.003 0.0099
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.003 0.0099
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.003 0.003
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.016 0.1646
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0199 0.0784 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0025 0.0062 0.0508
Leishmania major hypothetical protein, conserved 0.0025 0.0062 0.0508
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0027 0.0078
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0294 0.1177 0.3953
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0025 0.0062 0.0452
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.007 0.0248 0.2858
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0039 0.012 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0099 0.1512
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.007 0.0248 0.2858
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0085
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.02 0.0585
Brugia malayi jmjC domain containing protein 0.0061 0.0212 0.0712
Echinococcus granulosus Rac GTPase activating protein 1 0.0072 0.0256 0.075
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0039 0.012 0.0353
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0033 0.0168
Echinococcus granulosus acetylcholinesterase 0.0727 0.2976 0.871
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.032 0.3614
Echinococcus multilocularis beta tubulin 0.0025 0.0063 0.0063
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0123 0.0467 0.1368
Schistosoma mansoni tubulin subunit beta 0.0025 0.0063 0.0185
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0025 0.0062 0.0652
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.016 0.1646
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0043 0.0123
Entamoeba histolytica tubulin family protein 0.0025 0.0063 0.1035
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0043 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.003 0.0099
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.016 0.1695
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0033 0.0014
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0039 0.012 0.012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.003 0.003
Schistosoma mansoni tubulin subunit beta 0.0025 0.0063 0.0185
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0215 0.0851 0.0851
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0103 0.0103
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.0057
Trypanosoma brucei beta tubulin 0.0025 0.0063 0.0525
Brugia malayi hypothetical protein 0.007 0.0248 0.0834
Toxoplasma gondii methionine aminopeptidase 0.0199 0.0784 0.9189
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0257 0.0754
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.003 0.003
Echinococcus granulosus tubulin beta 4A class IVa 0.0025 0.0063 0.0185
Onchocerca volvulus 0.0072 0.0257 0.3987
Schistosoma mansoni tubulin subunit beta 0.0025 0.0063 0.0185
Echinococcus granulosus dual specificity 0.0087 0.032 0.0937
Onchocerca volvulus Dipeptidase C homolog 0.0025 0.0062 0.0563
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0163 0.0715
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0025 0.0074
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0025 0.0074
Mycobacterium ulcerans hypothetical protein 0.007 0.0248 0.2858
Echinococcus multilocularis voltage dependent calcium channel 0.0039 0.012 0.012
Schistosoma mansoni neuroligin 3 (S09 family) 0.0123 0.0467 0.1368
Loa Loa (eye worm) hypothetical protein 0.0087 0.0318 0.1069
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0043 0.0279
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0025 0.0074
Entamoeba histolytica tubulin family protein 0.0025 0.0063 0.1035
Leishmania major basic transcription factor 3a, putative 0.0034 0.0099 0.0957
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0085
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0043 0.0123
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0108 0.1063
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.022 0.0642
Loa Loa (eye worm) tubulin beta chain 0.0025 0.0063 0.0212
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.0207
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0199 0.0784 0.9189
Loa Loa (eye worm) tubulin beta-2A chain 0.0025 0.0063 0.0212
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0025 0.0025
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0025 0.0062 0.0452
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0025 0.0062 0.0508
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0248 0.2748
Loa Loa (eye worm) hypothetical protein 0.0069 0.0245 0.0822
Loa Loa (eye worm) methionine aminopeptidase type I 0.0215 0.0851 0.286
Entamoeba histolytica hypothetical protein 0.007 0.0248 0.7495
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0108 0.1011
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0123 0.0467 0.2367
Loa Loa (eye worm) hypothetical protein 0.0146 0.0565 0.1897
Echinococcus granulosus zinc finger protein 0.0019 0.0037 0.0108
Trypanosoma brucei methionine aminopeptidase, putative 0.0215 0.0851 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0178 0.0521
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0207 0.0605
Schistosoma mansoni smad1 5 8 and 0.0016 0.0025 0.0074
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0151 0.0442
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0025 0.0062 0.0508
Brugia malayi RhoGAP domain containing protein 0.0072 0.0256 0.0861
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0257 0.2984
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0039 0.012 0.1214
Echinococcus granulosus para nitrobenzyl esterase 0.0123 0.0467 0.1368
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0043 0.0222
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0025 0.0062 0.0508
Brugia malayi Carboxylesterase family protein 0.0727 0.2976 1
Brugia malayi Bromodomain containing protein 0.0037 0.0113 0.038
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.032 0.3614
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0025 0.001
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0025 0.0086
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0151 0.0442
Onchocerca volvulus 0.0072 0.0257 0.3987
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0025 0.0062 0.0508
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0092 0.0667
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0248 0.2858
Leishmania major hypothetical protein, conserved 0.0049 0.016 0.1695
Echinococcus granulosus Proliferation associated protein 2G4 0.0025 0.0062 0.0181
Trypanosoma cruzi beta tubulin, putative 0.0025 0.0063 0.0525
Echinococcus multilocularis carboxylesterase 5A 0.0727 0.2976 0.2976
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0043 0.0222
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0257 0.1229
Brugia malayi Fli-1 protein 0.0215 0.0851 0.2859
Brugia malayi beta-lactamase 0.0072 0.0257 0.0865
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0025 0.0068
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0093 0.0343 0.1153
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0025 0.0062 0.0508
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0043 0.0143
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.003 0.0087
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0207 0.2251
Chlamydia trachomatis methionine aminopeptidase 0.0199 0.0784 1
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0025 0.0062 0.0181
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0178 0.0598
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0043 0.0123
Brugia malayi PHD-finger family protein 0.0024 0.0059 0.0197
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0063 0.0185
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0178 0.0178
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.003 0.003
Treponema pallidum aminopeptidase P 0.0025 0.0062 0.0377
Onchocerca volvulus 0.0021 0.0043 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.003 0.0099
Loa Loa (eye worm) hypothetical protein 0.0049 0.016 0.0539
Brugia malayi Inositol-1 0.0036 0.0108 0.0363
Treponema pallidum methionine aminopeptidase (map) 0.0199 0.0784 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0099
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.003 0.0087
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0108 0.1063
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0025 0.0062 0.0452
Onchocerca volvulus 0.0123 0.0467 0.7659
Brugia malayi Calcitonin receptor-like protein seb-1 0.0294 0.1177 0.3953
Mycobacterium ulcerans hypothetical protein 0.0072 0.0257 0.2984
Loa Loa (eye worm) tubulin beta-4 chain 0.0025 0.0063 0.0212
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0025 0.0062 0.0181
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.007 0.0248 0.277
Schistosoma mansoni tubulin subunit beta 0.0025 0.0063 0.0185
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0199 0.0784 0.4085
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.003 0.003
Loa Loa (eye worm) inositol-1 0.0036 0.0108 0.0363
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0043 0.0143
Brugia malayi Bromodomain containing protein 0.0073 0.0262 0.0881
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0207 0.2308
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0257 0.1229
Leishmania major transcription factor-like protein 0.0025 0.0062 0.0508
Loa Loa (eye worm) hypothetical protein 0.0039 0.012 0.0405
Loa Loa (eye worm) fli-1 protein 0.0215 0.0851 0.2859
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0043 0.0123
Schistosoma mansoni Smad4 0.0016 0.0025 0.0074
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0257 0.5163
Mycobacterium ulcerans beta-lactamase 0.0072 0.0257 0.2984
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0043 0.0064
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0049 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.003 0.0099
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0049 0.0049
Echinococcus multilocularis Rac GTPase activating protein 1 0.0072 0.0256 0.0256
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0043 0.0279
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0029 0.0098
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.003 0.0087
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0151 0.0442
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0063 0.0185
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0207 0.2206
Onchocerca volvulus 0.0123 0.0467 0.7659
Mycobacterium ulcerans dipeptidase 0.0025 0.0062 0.0377
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0043 0.0123
Brugia malayi latrophilin 2 splice variant baaae 0.0201 0.0791 0.2657
Brugia malayi AMP-binding enzyme family protein 0.007 0.0248 0.0833
Echinococcus granulosus Smad4 0.0016 0.0025 0.0074
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0025 0.0074
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0248 0.7487
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0093 0.0343 0.0343
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0025 0.0025
Schistosoma mansoni coup transcription factor 0.0017 0.003 0.0087
Loa Loa (eye worm) hypothetical protein 0.0052 0.0175 0.0586
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0043 0.0064
Loa Loa (eye worm) hypothetical protein 0.0123 0.0467 0.157
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.007 0.0248 0.1178
Brugia malayi mbt repeat family protein 0.0047 0.0151 0.0508
Loa Loa (eye worm) calcium channel 0.0039 0.012 0.0405
Schistosoma mansoni zinc finger protein 0.0019 0.0037 0.0108
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0108 0.0992
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0099 0.2289
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0248 0.2748
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0025 0.0074
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0151 0.0442
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0049 0.0143
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0043 0.0279
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0087 0.032 0.1075
Echinococcus multilocularis FACT complex subunit SPT16 0.0025 0.0062 0.0062
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0093 0.0343 0.1004
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0024 0.0058
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.003 0.0099
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0288 0.1151 0.337
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.003 0.0099
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0039 0.012 0.0405
Schistosoma mansoni gabp alpha 0.0071 0.0252 0.0737
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0212 0.062
Echinococcus multilocularis neuroligin 0.0123 0.0467 0.0467
Echinococcus multilocularis smad 0.0016 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0201 0.0791 0.2314
Loa Loa (eye worm) hypothetical protein 0.007 0.0248 0.0833
Echinococcus granulosus tubulin beta 1 chain 0.0025 0.0063 0.0185
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0025 0.0062 0.0508
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0257 0.1229
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0039 0.012 0.012
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0123 0.0467 0.1368
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0043 0.0212
Loa Loa (eye worm) hypothetical protein 0.0155 0.0601 0.202
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0025 0.0062 0.0257
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0257 0.0754
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0025 0.0062 0.0181
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0248 0.0727
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0043 0.0123
Brugia malayi jmjC domain containing protein 0.0016 0.0025 0.0085
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0063 0.0063
Loa Loa (eye worm) beta-tubulin 0.0025 0.0063 0.0212
Loa Loa (eye worm) hypothetical protein 0.0727 0.2976 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0043 0.0064
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0025 0.0085
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0043 0.0279
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0207 0.0954
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0257 0.1229
Plasmodium vivax acyl-CoA synthetase, putative 0.0052 0.0175 0.1816
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0199 0.0784 1
Entamoeba histolytica protein kinase, putative 0.0087 0.032 1
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0252 0.0252
Onchocerca volvulus 0.0021 0.0043 0.0229
Onchocerca volvulus 0.0021 0.0043 0.0229
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0043 0.0125
Entamoeba histolytica protein kinase, putative 0.0087 0.032 1
Echinococcus granulosus acetylcholinesterase 0.0727 0.2976 0.871
Trypanosoma brucei beta tubulin 0.0025 0.0063 0.0525
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0123 0.0467 0.2367
Echinococcus granulosus transcription factor btf3 0.0034 0.0099 0.029
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0025 0.0062 0.0508
Brugia malayi Carboxylesterase family protein 0.0123 0.0467 0.157
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0063 0.0063
Echinococcus multilocularis Tubulin beta 2C chain 0.0025 0.0063 0.0063
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0178 0.0521
Brugia malayi Ets-domain containing protein 0.0071 0.0252 0.0846
Brugia malayi Muscleblind-like protein 0.0146 0.0565 0.1897
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0099 0.0333
Echinococcus granulosus xaa pro aminopeptidase 0.0025 0.0062 0.0181
Toxoplasma gondii exonuclease III APE 0.0018 0.0033 0.011
Trypanosoma cruzi aminopeptidase P, putative 0.0025 0.0062 0.0508
Toxoplasma gondii transporter, cation channel family protein 0.0039 0.012 0.1163
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0199 0.0784 0.4085
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0178 0.0521
Brugia malayi Tubulin beta-1 chain 0.0025 0.0063 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.003 0.0099
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0025 0.0062 0.0207
Loa Loa (eye worm) hypothetical protein 0.007 0.0248 0.0833
Schistosoma mansoni tubulin subunit beta 0.0025 0.0063 0.0185
Brugia malayi hypothetical protein 0.0049 0.016 0.0539
Loa Loa (eye worm) hypothetical protein 0.0123 0.0467 0.157
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0043 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0257 0.2861
Loa Loa (eye worm) carboxylesterase 0.0123 0.0467 0.157
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0257 0.0865
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0099 0.0904
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0025 0.0068
Brugia malayi Methionine aminopeptidase protein type I 0.0215 0.0851 0.286
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.0737 0.2156
Loa Loa (eye worm) hypothetical protein 0.0123 0.0467 0.157
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0207 0.0207
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.003 0.003
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0212 0.062
Brugia malayi ecdysteroid receptor 0.0017 0.003 0.0099
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0123 0.0467 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.007 0.0248 0.7487
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0043 0.0123
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0151 0.0151
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0123 0.0467 0.1368
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0248 0.0727
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0025 0.0074
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0025 0.0062 0.0377
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0025 0.0062 0.0652
Loa Loa (eye worm) hypothetical protein 0.004 0.0123 0.0413
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0025 0.0062 0.0563
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0043 0.0321
Loa Loa (eye worm) oxidoreductase 0.0021 0.0043 0.0143
Schistosoma mansoni hypothetical protein 0.0093 0.0343 0.1004
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0039 0.012 0.0353
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0103 0.0302
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0085
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0025 0.0062 0.0652
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0048 0.0142
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0212 0.0212
Trypanosoma cruzi aminopeptidase P1, putative 0.0025 0.0062 0.0508
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0043 0.0143
Entamoeba histolytica acyl-coA synthetase, putative 0.007 0.0248 0.7487
Mycobacterium ulcerans dipeptidase PepE 0.0025 0.0062 0.0377
Plasmodium falciparum tubulin beta chain 0.0025 0.0063 0.0469
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0199 0.0784 0.9189
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0207 0.0605
Brugia malayi Carboxylesterase family protein 0.0123 0.0467 0.157
Echinococcus multilocularis BC026374 protein (S09 family) 0.0123 0.0467 0.0467
Schistosoma mansoni hypothetical protein 0.0093 0.0343 0.1004
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0099
Entamoeba histolytica aminopeptidase, putative 0.0025 0.0062 0.0987
Mycobacterium leprae Probable lipase LipE 0.0072 0.0257 0.2897
Loa Loa (eye worm) hypothetical protein 0.0052 0.0175 0.0586
Brugia malayi metallopeptidase family M24 containing protein 0.0025 0.0062 0.0207
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Echinococcus granulosus voltage dependent calcium channel 0.0039 0.012 0.0353
Mycobacterium tuberculosis Conserved protein 0.0072 0.0257 0.1229
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3417 1
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0025 0.0074
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0025 0.0062 0.0508
Schistosoma mansoni rac gtpase activating protein 0.0072 0.0256 0.075
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0025 0.0062 0.0181
Mycobacterium tuberculosis Carboxylesterase LipT 0.0123 0.0467 0.2367
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0043 0.0143
Giardia lamblia Beta tubulin 0.0025 0.0063 0.1632
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0027 0.0027
Leishmania major hypothetical protein, conserved 0.0016 0.0025 0.0068
Echinococcus multilocularis acetylcholinesterase 0.0727 0.2976 0.2976
Trichomonas vaginalis tubulin epsilon chain, putative 0.0025 0.0063 0.0684
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.003 0.0087
Loa Loa (eye worm) beta-lactamase 0.0072 0.0257 0.0865
Loa Loa (eye worm) hypothetical protein 0.0146 0.0565 0.1897
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Loa Loa (eye worm) hypothetical protein 0.0294 0.1177 0.3953
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0025 0.0062 0.0508
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0257 0.2819
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0199 0.0784 1
Echinococcus granulosus carboxylesterase 5A 0.0727 0.2976 0.871
Brugia malayi MH1 domain containing protein 0.0016 0.0025 0.0086
Brugia malayi hypothetical protein 0.0155 0.0601 0.202
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0025 0.0074
Brugia malayi jmjC domain containing protein 0.0016 0.0025 0.0085
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0257 0.5163
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0257 0.1229
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0027 0.0078
Loa Loa (eye worm) hypothetical protein 0.0727 0.2976 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.003 0.0099
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.0207
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0143
Plasmodium vivax JmjC domain containing protein 0.0016 0.0025 0.001
Echinococcus granulosus phd:f box containing protein 0.0016 0.0025 0.0074
Loa Loa (eye worm) hypothetical protein 0.0123 0.0467 0.157
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.003 0.0099
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0043 0.0143
Loa Loa (eye worm) hypothetical protein 0.0072 0.0257 0.0865
Onchocerca volvulus 0.0025 0.0062 0.0563
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0043 0.0279
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.016 0.1695
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0215 0.0851 0.2491
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0025 0.0025
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0025 0.0062 0.0652
Brugia malayi Carboxylesterase family protein 0.0123 0.0467 0.157
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0043 0.0064
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0025 0.0074
Schistosoma mansoni gliotactin 0.0123 0.0467 0.1368
Echinococcus granulosus voltage dependent calcium channel 0.0039 0.012 0.0353
Entamoeba histolytica hypothetical protein 0.007 0.0248 0.7495
Leishmania major hypothetical protein, conserved 0.0016 0.0024 0.0058
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0043 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0163 0.0715
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.022 0.0738
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0027 0.0078
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0087 0.032 0.3614
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.003 0.0087
Loa Loa (eye worm) hypothetical protein 0.0052 0.0175 0.0586
Onchocerca volvulus 0.0047 0.0151 0.2127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.003 0.0099
Loa Loa (eye worm) hypothetical protein 0.0072 0.0257 0.0865
Loa Loa (eye worm) hypothetical protein 0.0042 0.0131 0.0439
Echinococcus granulosus smad 0.0016 0.0025 0.0074
Onchocerca volvulus 0.007 0.0248 0.3822
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0025 0.0062 0.0508
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0025 0.0062 0.0062
Echinococcus granulosus methionine aminopeptidase type I 0.0025 0.0062 0.0181
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0039 0.012 0.0353
Leishmania major 4-coumarate:coa ligase-like protein 0.007 0.0248 0.2748
Loa Loa (eye worm) hypothetical protein 0.0123 0.0467 0.157
Trichomonas vaginalis esterase, putative 0.0072 0.0257 0.5163
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3417 1
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0025 0.0062 0.0181
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0212 0.0212
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0092 0.0332
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.0958 0.3217
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0257 0.0257
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.007 0.0248 0.1178
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0207 0.2308
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0025 0.0062 0.0181
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0215 0.0851 1
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0257 0.1229
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.003 0.0099
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0033 0.0168
Schistosoma mansoni acetylcholinesterase 0.0123 0.0467 0.1368
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0025 0.0062 0.0452
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0025 0.0062 0.0652
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0043 0.0143
Mycobacterium ulcerans carboxylesterase, LipT 0.0123 0.0467 0.578
Giardia lamblia Beta tubulin 0.0025 0.0063 0.1632
Loa Loa (eye worm) hypothetical protein 0.0155 0.0601 0.202
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0099 0.1512
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0041 0.0138
Echinococcus multilocularis GPCR, family 2 0.0093 0.0343 0.0343
Giardia lamblia Xaa-Pro dipeptidase 0.0025 0.0062 0.1556
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.003 0.0099
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0063 0.0185
Toxoplasma gondii beta-tubulin, putative 0.0025 0.0063 0.0469
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0099
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0108 0.1063
Echinococcus granulosus methionyl aminopeptidase 2 0.0025 0.0062 0.0181
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0024 0.0058
Brugia malayi mbt repeat family protein 0.0047 0.0151 0.0508
Schistosoma mansoni smad1 5 8 and 0.0016 0.0025 0.0074
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0043 0.0123
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.003 0.0087
Toxoplasma gondii beta-1 tubulin, putative 0.0025 0.0063 0.0469
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0033 0.0033
Echinococcus multilocularis methionyl aminopeptidase 2 0.0025 0.0062 0.0062
Echinococcus multilocularis xaa Pro dipeptidase 0.0025 0.0062 0.0062
Echinococcus multilocularis Smad4 0.0016 0.0025 0.0025
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0025 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0248 0.2858
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0025 0.0085
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0257 0.5163
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0025 0.0085
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0025 0.0062 0.0452
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.003 0.003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0294 0.1177 0.3953
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0099
Echinococcus granulosus BC026374 protein S09 family 0.0123 0.0467 0.1368
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.016 0.1646
Mycobacterium ulcerans aminopeptidase 0.0025 0.0062 0.0377
Echinococcus granulosus geminin 0.0166 0.0644 0.1886
Loa Loa (eye worm) hypothetical protein 0.0025 0.0062 0.0207
Schistosoma mansoni thyroid hormone receptor 0.0017 0.003 0.0087
Loa Loa (eye worm) DNA-binding protein 0.0025 0.0062 0.0207
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0025 0.0063 0.0063
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0043 0.0125
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0025 0.0062 0.0508
Loa Loa (eye worm) hypothetical protein 0.0035 0.0101 0.0339
Trichomonas vaginalis tubulin beta chain, putative 0.0025 0.0063 0.0684
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0025 0.0062 0.0452
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0252 0.0846
Trichomonas vaginalis spcc417.12 protein, putative 0.0123 0.0467 1
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3417 0.3417
Trypanosoma brucei beta tubulin 0.0025 0.0063 0.0525
Schistosoma mansoni hypothetical protein 0.002 0.0041 0.0121
Loa Loa (eye worm) hypothetical protein 0.0201 0.0791 0.2657
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.0737 0.0737
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0099 0.0904
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0043 0.0064
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0108 0.0316
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.0035 0.0101 0.0339
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0462 0.1875 1
Entamoeba histolytica hypothetical protein 0.007 0.0248 0.7495
Schistosoma mansoni hypothetical protein 0.0022 0.0048 0.0142
Brugia malayi AMP-binding enzyme family protein 0.007 0.0248 0.0833
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0063 0.0185
Onchocerca volvulus 0.0123 0.0467 0.7659
Schistosoma mansoni hypothetical protein 0.0093 0.0343 0.1004
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0043 0.0123
Echinococcus multilocularis para nitrobenzyl esterase 0.0123 0.0467 0.0467
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.003 0.0099
Loa Loa (eye worm) BEN-1 protein 0.0025 0.0063 0.0212
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.003 0.003
Loa Loa (eye worm) MBCTL1 0.0053 0.0178 0.0598
Echinococcus granulosus FTZ F1 alpha 0.0017 0.003 0.0087
Echinococcus granulosus neuroligin 0.0123 0.0467 0.1368
Schistosoma mansoni smad1 5 8 and 0.0016 0.0025 0.0074
Echinococcus granulosus muscleblind protein 0.0146 0.0565 0.1652
Loa Loa (eye worm) hypothetical protein 0.0052 0.0175 0.0586
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0025 0.0062 0.0207
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0025 0.0062 0.0652
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Brugia malayi Latrophilin receptor protein 2 0.0093 0.0343 0.1153
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0257 0.2861
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0043 0.0222
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0199 0.0784 0.9189
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0025 0.0068
Entamoeba histolytica hypothetical protein 0.0034 0.0099 0.2289
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0025 0.0086
Echinococcus multilocularis geminin 0.0166 0.0644 0.0644
Toxoplasma gondii hypothetical protein 0.0035 0.0101 0.0925
Trypanosoma brucei beta tubulin 0.0025 0.0063 0.0525
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0727 0.2976 0.871
Echinococcus granulosus tubulin subunit beta 0.0025 0.0063 0.0185
Brugia malayi Smad1 0.0016 0.0025 0.0086
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0025 0.0062 0.0987
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0025 0.0062 0.0652
Mycobacterium ulcerans lipase LipD 0.0072 0.0257 0.2984
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0043 0.0222
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.003 0.0087
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0175 0.1879
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0257 0.5163
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0052 0.0175 0.0779
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0027 0.0078
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0033 0.011
Trichomonas vaginalis tubulin, putative 0.0025 0.0063 0.0684
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0025 0.0062 0.0652
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0108 0.1063
Brugia malayi Ets-domain containing protein 0.0071 0.0252 0.0846
Echinococcus granulosus neuropeptide s receptor 0.0454 0.1843 0.5393
Plasmodium falciparum methionine aminopeptidase 2 0.0025 0.0062 0.0452
Brugia malayi Carboxylesterase family protein 0.0727 0.2976 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0043 0.0064
Loa Loa (eye worm) hypothetical protein 0.0087 0.0318 0.1069
Trichomonas vaginalis tubulin alpha chain, putative 0.0025 0.0063 0.0684
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.003 0.0087
Loa Loa (eye worm) acetylcholinesterase 1 0.0727 0.2976 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0257 0.0865
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.003 0.0087
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0043 0.0064
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0215 0.0851 1
Entamoeba histolytica hypothetical protein, conserved 0.0025 0.0062 0.0987
Echinococcus multilocularis methionine aminopeptidase, type I 0.0025 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0166 0.0644 0.1886
Leishmania major hypothetical protein, conserved 0.0072 0.0257 0.2861
Mycobacterium ulcerans acyl-CoA synthetase 0.007 0.0248 0.2858
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0043 0.0123
Loa Loa (eye worm) hypothetical protein 0.0123 0.0467 0.157
Echinococcus multilocularis xaa Pro dipeptidase 0.0025 0.0062 0.0062
Onchocerca volvulus 0.0021 0.0043 0.0229
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0025 0.0062 0.0508
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0033 0.0112
Schistosoma mansoni zinc finger protein 0.0015 0.0019 0.0057
Schistosoma mansoni ap endonuclease 0.0018 0.0033 0.0098
Loa Loa (eye worm) hypothetical protein 0.007 0.0248 0.0833
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0039 0.012 0.0353
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0043 0.0064
Onchocerca volvulus 0.0123 0.0467 0.7659
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.022 0.0642
Entamoeba histolytica peptidase, putative 0.0025 0.0062 0.0987
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0043 0.0279
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0163 0.0715
Brugia malayi nuclear hormone receptor 0.0017 0.003 0.0099
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.003 0.0087
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0108 0.1716
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0099
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0207 0.0605
Echinococcus granulosus beta tubulin 0.0025 0.0063 0.0185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.003 0.0099
Loa Loa (eye worm) hypothetical protein 0.0062 0.0215 0.0723
Toxoplasma gondii peptidase D, putative 0.0025 0.0062 0.0452
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0025 0.0062 0.0181
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0108 0.0992
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0257 0.0865
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0215 0.0851 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.007 0.0248 0.2858
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0043 0.0123
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0043 0.0143
Leishmania major beta tubulin 0.0025 0.0063 0.0525
Plasmodium vivax peptidase, putative 0.0025 0.0062 0.0452
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0024 0.0058
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0151 0.2127
Brugia malayi MH2 domain containing protein 0.0016 0.0025 0.0086
Echinococcus multilocularis transcription factor btf3 0.0034 0.0099 0.0099
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0025 0.0025
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0039 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0123 0.0467 0.157
Echinococcus granulosus Tubulin beta 2C chain 0.0025 0.0063 0.0185
Schistosoma mansoni thyroid hormone receptor 0.0017 0.003 0.0087
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0215 0.0851 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0108 0.0316
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0108 0.0108
Plasmodium vivax FACT complex subunit SPT16, putative 0.0025 0.0062 0.0452
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0151 0.0508
Brugia malayi initiation factor 2-associated protein. 0.0025 0.0062 0.0207
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0025 0.0062 0.0563
Onchocerca volvulus 0.0155 0.0601 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0123 0.0467 0.1368
Schistosoma mansoni voltage-gated cation channel 0.0039 0.012 0.0353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.003 0.0099
Schistosoma mansoni peptidase 0.0025 0.0062 0.0181
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0108 0.2597
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.016 0.1646
Onchocerca volvulus 0.0123 0.0467 0.7659
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0099
Echinococcus multilocularis dual specificity 0.0087 0.032 0.032
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0257 0.5163
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0025 0.0062 0.0508
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0199 0.0784 1
Mycobacterium tuberculosis Dipeptidase PepE 0.0025 0.0062 0.0168
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0252 0.0737
Echinococcus granulosus beta tubulin 0.0025 0.0063 0.0185
Schistosoma mansoni ap endonuclease 0.0018 0.0033 0.0098
Plasmodium falciparum aminopeptidase P 0.0025 0.0062 0.0452
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0099 0.1512
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.007 0.0248 0.2858

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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