Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin | 0.0033 | 0.2706 | 0.2491 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.2706 | 0.2491 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0287 | 0.0375 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.4242 | 0.5545 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.2706 | 0.5 | |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2706 | 0.3537 |
Schistosoma mansoni | lamin | 0.0033 | 0.2706 | 0.2491 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2706 | 0.2491 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0287 | 0.0375 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2706 | 0.2491 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2706 | 0.3537 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2706 | 0.3537 |
Echinococcus granulosus | lamin | 0.0033 | 0.2706 | 0.2491 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2706 | 0.2491 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7651 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0287 | 0.0375 |
Onchocerca volvulus | 0.0033 | 0.2706 | 0.5 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 1 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2706 | 0.3537 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0287 | 0.0375 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7651 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2599 | 0.3397 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7651 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.2706 | 0.2491 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7651 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.4242 | 0.4073 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2706 | 0.3537 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2706 | 0.2491 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4242 | 0.5545 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.