Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | Smad1 | 0.0043 | 0.0429 | 0.0429 |
Brugia malayi | MH1 domain containing protein | 0.0024 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0019 | 0.0042 | 0.0042 |
Schistosoma mansoni | lamin | 0.0031 | 0.0235 | 0.048 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0235 | 0.0235 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0274 | 0.0577 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0235 | 0.0235 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0274 | 0.0577 |
Trichomonas vaginalis | set domain proteins, putative | 0.0267 | 0.4047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0235 | 0.0235 |
Schistosoma mansoni | smad1 5 8 and | 0.0043 | 0.0429 | 0.0965 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0515 | 0.0515 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 0.4054 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 0.4054 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0267 | 0.4054 | 0.4054 |
Brugia malayi | TAR-binding protein | 0.0267 | 0.4054 | 0.4054 |
Echinococcus granulosus | tar DNA binding protein | 0.0267 | 0.4054 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0274 | 0.0577 |
Echinococcus granulosus | lamin | 0.0031 | 0.0235 | 0.048 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0043 | 0.0429 | 0.0965 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0043 | 0.0429 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0116 | 0.0116 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0515 | 0.0515 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0234 | 0.3523 | 0.3523 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0235 | 0.0235 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0235 | 0.048 |
Echinococcus multilocularis | tar DNA binding protein | 0.0267 | 0.4054 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.0235 | 0.048 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0634 | 1 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0024 | 0.0116 | 0.0116 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0235 | 0.048 |
Schistosoma mansoni | smad | 0.0043 | 0.0429 | 0.0965 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0515 | 0.0515 |
Brugia malayi | MH2 domain containing protein | 0.0043 | 0.0429 | 0.0429 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0274 | 0.0577 |
Onchocerca volvulus | 0.0267 | 0.4047 | 1 | |
Loa Loa (eye worm) | nuclear factor I | 0.0024 | 0.0116 | 0.0116 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0235 | 0.048 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0267 | 0.4054 | 0.4054 |
Echinococcus granulosus | Smad4 | 0.0043 | 0.0429 | 0.0965 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0267 | 0.4054 | 0.4054 |
Loa Loa (eye worm) | RNA binding protein | 0.0267 | 0.4054 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0042 | 0.0042 |
Echinococcus granulosus | smad | 0.0043 | 0.0429 | 0.0965 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 0.4054 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0043 | 0.0429 | 0.0429 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0266 | 0.0266 |
Schistosoma mansoni | smad1 5 8 and | 0.0043 | 0.0429 | 0.0965 |
Schistosoma mansoni | Smad4 | 0.0043 | 0.0429 | 0.0965 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0019 | 0.0042 | 0.0042 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0235 | 0.048 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 0.4054 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0019 | 0.0042 | 0.0042 |
Brugia malayi | Smad1 | 0.0043 | 0.0429 | 0.0429 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0274 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0274 | 0.0274 |
Brugia malayi | MH1 domain containing protein | 0.0043 | 0.0429 | 0.0429 |
Schistosoma mansoni | smad1 5 8 and | 0.0043 | 0.0429 | 0.0965 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0253 | 0.0527 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0274 | 0.0577 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0634 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0043 | 0.0429 | 0.0429 |
Onchocerca volvulus | 0.0034 | 0.0274 | 0.0578 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0235 | 0.0235 |
Echinococcus multilocularis | Smad4 | 0.0043 | 0.0429 | 0.0965 |
Schistosoma mansoni | tar DNA-binding protein | 0.0267 | 0.4054 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0043 | 0.0429 | 0.0965 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0515 | 0.0515 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0274 | 0.5 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0043 | 0.0429 | 0.0965 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0235 | 0.048 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0274 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0274 | 0.0577 |
Brugia malayi | Pre-SET motif family protein | 0.0234 | 0.3523 | 0.3523 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0043 | 0.0429 | 0.0965 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0266 | 0.0266 |
Brugia malayi | mothers against decapentaplegic homolog 3 | 0.0019 | 0.0042 | 0.0042 |
Echinococcus multilocularis | smad | 0.0043 | 0.0429 | 0.0965 |
Onchocerca volvulus | 0.0031 | 0.0235 | 0.0481 | |
Onchocerca volvulus | 0.0031 | 0.0235 | 0.0481 | |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0274 | 0.0274 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0235 | 0.048 |
Brugia malayi | RNA binding protein | 0.0267 | 0.4054 | 0.4054 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0043 | 0.0429 | 0.0965 |
Brugia malayi | MH1 domain containing protein | 0.0043 | 0.0429 | 0.0429 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0266 | 0.0559 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.125 ug ml-1 | Minimum Inhibitory concentration measured against S. aureus ATCC 29213 | ChEMBL. | 7629792 |
MIC (functional) | = 0.125 ug ml-1 | Minimum Inhibitory concentration measured against E. coli ATCC 1-25922 | ChEMBL. | 7629792 |
MIC (functional) | = 0.125 ug ml-1 | Minimum Inhibitory concentration measured against E. coli ATCC 1-25922 | ChEMBL. | 7629792 |
MIC (functional) | = 1 ug ml-1 | Minimum Inhibitory concentration measured against S. faecalis ATCC 29212 | ChEMBL. | 7629792 |
MIC (functional) | = 1 ug ml-1 | Minimum Inhibitory concentration measured against S. pyogenes ATCC 6301 | ChEMBL. | 7629792 |
MIC (functional) | = 1 ug ml-1 | Minimum Inhibitory concentration measured against B. fragilis ATCC 25285 | ChEMBL. | 7629792 |
MIC (functional) | = 4 ug ml-1 | Minimum Inhibitory concentration measured against P. aeruginosa ATCC 27853 | ChEMBL. | 7629792 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.