Detailed information for compound 1394058

Basic information

Technical information
  • TDR Targets ID: 1394058
  • Name: 1-ethyl-7-methyl-3-(4-phenyl3,6-dihydro-2H-py ridine-1-carbonyl)-1,8-naphthyridin-4-one
  • MW: 373.448 | Formula: C23H23N3O2
  • H donors: 0 H acceptors: 3 LogP: 3.27 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1cc(C(=O)N2CCC(=CC2)c2ccccc2)c(=O)c2c1nc(C)cc2
  • InChi: 1S/C23H23N3O2/c1-3-25-15-20(21(27)19-10-9-16(2)24-22(19)25)23(28)26-13-11-18(12-14-26)17-7-5-4-6-8-17/h4-11,15H,3,12-14H2,1-2H3
  • InChiKey: MOOZWTRXZAGZGI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-ethyl-7-methyl-3-[oxo-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]-1,8-naphthyridin-4-one
  • 1-ethyl-7-methyl-3-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)carbonyl]-1,8-naphthyridin-4-one
  • EU-0029254
  • 1-ethyl-7-methyl-3-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)carbonyl]-1,8-naphthyridin-4(1H)-one
  • MLS000095754
  • SMR000031302
  • Oprea1_447836

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0046 1 1
Plasmodium vivax vivapain-2 0.0046 1 1
Brugia malayi Cathepsin L-like precursor 0.0046 1 1
Plasmodium vivax unspecified product 0.0024 0.2757 0.2757
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 1 1
Plasmodium vivax vivapain-1 0.0024 0.2757 0.2757
Schistosoma mansoni cathepsin F (C01 family) 0.0031 0.5061 0.5061
Trypanosoma cruzi cysteine peptidase, putative 0.0024 0.2757 0.2757
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 1 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.9572 0.9409
Onchocerca volvulus 0.0046 1 1
Echinococcus multilocularis cysteine protease 0.0046 1 1
Plasmodium vivax vivapain-3 0.0024 0.2757 0.2757
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 1 1
Onchocerca volvulus Cathepsin L homolog 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0046 1 1
Leishmania major cathepsin L-like protease 0.0046 1 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.9572 0.9409
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.9572 0.9409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0024 0.2757 0.2757
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 1 1
Echinococcus multilocularis cysteine protease 0.0046 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0046 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0046 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0046 1 1
Leishmania major cathepsin L-like protease 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 1 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.9572 0.9409
Onchocerca volvulus 0.0046 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.5061 0.5061
Plasmodium vivax vivapain-2 0.0046 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.9572 0.9572
Onchocerca volvulus 0.0046 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0046 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.2757 0.2757
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.9572 0.9409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.5061 0.3182
Echinococcus granulosus cathepsin L cysteine proteinase 0.0046 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0046 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0031 0.5061 0.5061
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0031 0.5061 0.5061
Onchocerca volvulus 0.0046 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0046 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0024 0.2757 0.2757
Brugia malayi Cathepsin L-like precursor 0.0031 0.5061 0.5061
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 1 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.9572 0.9409
Loa Loa (eye worm) hypothetical protein 0.0031 0.5061 0.5061
Brugia malayi Cathepsin L-like precursor 0.0031 0.5061 0.5061
Onchocerca volvulus 0.0046 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0046 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 1 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.9572 0.5
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0024 0.2757 0.2757
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.2757 0.2757
Trypanosoma cruzi cysteine protease, putative 0.0024 0.2757 0.2757
Trypanosoma cruzi cruzipain precursor, putative 0.0046 1 1
Brugia malayi Cathepsin L-like precursor 0.0046 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0046 1 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.9572 0.9572
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.5061 0.3182
Loa Loa (eye worm) fibroinase 0.0046 1 1
Brugia malayi cathepsin L-like precursor 0.0031 0.5061 0.5061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0046 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 1 1
Onchocerca volvulus Cathepsin L homolog 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 1 1
Leishmania major cathepsin L-like protease 0.0046 1 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.9572 0.9572
Plasmodium falciparum cysteine proteinase falcipain 3 0.0046 1 1
Echinococcus granulosus cathepsin l1 0.0031 0.5061 0.3182
Entamoeba histolytica cysteine protease, putative 0.0046 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.2757 0.2757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Leishmania major cathepsin L-like protease 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Loa Loa (eye worm) cysteine protease 0.0046 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 1 1
Onchocerca volvulus 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0046 1 1
Echinococcus granulosus cathepsin l1 0.0046 1 1
Leishmania major cathepsin L-like protease 0.0046 1 1
Toxoplasma gondii cathepsin CPL 0.0046 1 0.5
Brugia malayi Cathepsin L-like precursor 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.9572 0.9572
Loa Loa (eye worm) hypothetical protein 0.0031 0.5061 0.5061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 1 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.9572 0.9409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.5061 0.3182
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.9572 0.9572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 1 1
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.9572 0.9409
Leishmania major cathepsin L-like protease 0.0046 1 1
Loa Loa (eye worm) ctsf protein 0.0046 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 1 1
Onchocerca volvulus Cathepsin F homolog 0.0046 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.2757 0.2757
Onchocerca volvulus 0.0046 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.9572 0.9572
Brugia malayi Cathepsin L-like precursor 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Leishmania major cathepsin L-like protease 0.0046 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0046 1 1
Leishmania major cysteine peptidase A (CPA) 0.0046 1 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.9572 0.9409
Brugia malayi Cathepsin L-like precursor 0.0046 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0046 1 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.9572 0.9409
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0046 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.2757 0.2757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 1 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.9572 0.9409
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0046 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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