Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0283 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0283 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0283 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0283 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0283 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0283 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0283 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0069 | 0 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0069 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0283 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0283 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0283 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 5 mg kg-1 | Effective dose of the compound for its analgesic activity in nonfasted male mice at 55 degree C using Hot plate assay; inactive up to a dose of 5 mg/Kg | ChEMBL. | 2585442 |
ED50 (functional) | > 5 mg kg-1 | Effective dose of the compound for its analgesic activity in nonfasted male mice at 55 degree C using Hot plate assay; inactive up to a dose of 5 mg/Kg | ChEMBL. | 2585442 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.