Detailed information for compound 1394405

Basic information

Technical information
  • TDR Targets ID: 1394405
  • Name: [2-[[6-amino-2,4-dioxo-1-(phenylmethyl)pyrimi din-5-yl]-(2-methoxyethyl)amino]-2-oxoethyl] 2-(1H-indol-3-yl)acetate
  • MW: 505.522 | Formula: C26H27N5O6
  • H donors: 3 H acceptors: 4 LogP: 1.3 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: COCCN(c1c(=O)[nH]c(=O)n(c1N)Cc1ccccc1)C(=O)COC(=O)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C26H27N5O6/c1-36-12-11-30(21(32)16-37-22(33)13-18-14-28-20-10-6-5-9-19(18)20)23-24(27)31(26(35)29-25(23)34)15-17-7-3-2-4-8-17/h2-10,14,28H,11-13,15-16,27H2,1H3,(H,29,34,35)
  • InChiKey: KZZHRHPEQJKPGL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[[6-amino-2,4-dioxo-1-(phenylmethyl)pyrimidin-5-yl]-(2-methoxyethyl)amino]-2-oxo-ethyl] 2-(1H-indol-3-yl)acetate
  • 2-(1H-indol-3-yl)acetic acid [2-[[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-(2-methoxyethyl)amino]-2-oxoethyl] ester
  • 2-(1H-indol-3-yl)acetic acid [2-[[6-amino-1-(benzyl)-2,4-diketo-pyrimidin-5-yl]-(2-methoxyethyl)amino]-2-keto-ethyl] ester
  • [2-[[6-amino-2,4-dioxo-1-(phenylmethyl)pyrimidin-5-yl]-(2-methoxyethyl)amino]-2-oxo-ethyl] 2-(1H-indol-3-yl)ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi nucleobase transporter, putative 0.0043 0.048 0.0794
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0123 0.0188
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1292 0.2479
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0069 0.0803 0.1505
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0782 0.1458
Echinococcus granulosus alpha 1A adrenergic receptor 0.0069 0.0803 0.15
Brugia malayi Adenosine kinase-like 0.026 0.3201 0.6301
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0069 0.0803 0.15
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Schistosoma mansoni neuropeptide F-like receptor 0.0069 0.0803 0.15
Brugia malayi hypothetical protein 0.0069 0.0803 0.1505
Echinococcus granulosus neuropeptide Y receptor 0.0069 0.0803 0.15
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0194 0.0482
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.0803 0.15
Schistosoma mansoni amine GPCR 0.0069 0.0803 0.15
Toxoplasma gondii nucleoside transporter protein 0.0043 0.048 0.0951
Trypanosoma cruzi nucleoside transporter-like, putative 0.0043 0.048 0.0794
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0069 0.0803 0.0753
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.0803 0.0753
Onchocerca volvulus 0.0069 0.0803 0.2525
Brugia malayi Nucleoside transporter family protein 0.0246 0.3029 0.5958
Schistosoma mansoni amine GPCR 0.0069 0.0803 0.15
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.003 0.0315 0.0263
Mycobacterium ulcerans fructokinase, PfkB 0.003 0.0315 0.0529
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.0803 0.15
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0069 0.0803 0.0753
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1292 0.2483
Loa Loa (eye worm) TYRA-2 protein 0.0069 0.0803 0.1965
Brugia malayi putative neuropeptide receptor 0.0069 0.0803 0.1505
Brugia malayi Dopamine receptor 0.0069 0.0803 0.1505
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0043 0.048 0.0794
Echinococcus multilocularis allatostatin A receptor 0.0069 0.0803 0.0753
Trypanosoma cruzi adenosine kinase, putative 0.003 0.0315 0.0463
Giardia lamblia Ribokinase 0.003 0.0315 0.0529
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1292 0.3244
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0572 0.1037
Echinococcus granulosus tm gpcr rhodopsin 0.0069 0.0803 0.15
Entamoeba histolytica kinase, PfkB family 0.003 0.0315 0.0625
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.0803 0.15
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.0803 0.15
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Schistosoma mansoni biogenic amine (5HT) receptor 0.0069 0.0803 0.15
Trypanosoma brucei adenosine transporter 2, putative 0.0043 0.048 0.0794
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0069 0.0803 0.0753
Echinococcus granulosus tm gpcr rhodopsin 0.0069 0.0803 0.15
Echinococcus granulosus peptide allatostatin:somatostatin 0.0069 0.0803 0.15
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.1292 0.2479
Echinococcus multilocularis neuropeptide s receptor 0.0069 0.0803 0.0753
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0407 0.505 1
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1292 0.2559
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.0803 0.15
Trypanosoma brucei purine nucleoside transporter 0.0043 0.048 0.0794
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0069 0.0803 0.15
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0069 0.0803 0.1505
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0069 0.0803 0.0753
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0782 0.1402
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0203 0.2494 0.2453
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0043 0.048 0.0859
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0209 0.0316
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0407 0.505 1
Entamoeba histolytica ribokinase, putative 0.003 0.0315 0.0625
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0123 0.0138
Echinococcus multilocularis orexin receptor type 2 0.0069 0.0803 0.0753
Onchocerca volvulus 0.0069 0.0803 0.2525
Onchocerca volvulus 0.0069 0.0803 0.2525
Onchocerca volvulus 0.0069 0.0803 0.2525
Onchocerca volvulus 0.0069 0.0803 0.2525
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0123 0.0138
Schistosoma mansoni ribokinase 0.003 0.0315 0.0524
Brugia malayi Serotonin receptor 0.0069 0.0803 0.1505
Leishmania major ribokinase, putative 0.003 0.0315 0.0463
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0407 0.505 1
Entamoeba histolytica nucleoside transporter, putative 0.0043 0.048 0.0951
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0308 0.0376
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0407 0.505 1
Brugia malayi Ribokinase 0.003 0.0315 0.0529
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0407 0.505 1
Echinococcus granulosus somatostatin receptor 0.0069 0.0803 0.15
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0308 0.0516
Trypanosoma brucei unspecified product 0.0043 0.048 0.0794
Brugia malayi 6-phosphofructokinase 0.0108 0.1292 0.2483
Echinococcus granulosus sex peptide receptor 0.0069 0.0803 0.15
Loa Loa (eye worm) hypothetical protein 0.002 0.0194 0.0375
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.0803 0.0753
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Trypanosoma brucei adenosine transporter, putative 0.0043 0.048 0.0794
Echinococcus granulosus dro:myosuppressin receptor 0.0069 0.0803 0.15
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0076 0.0895 0.4629
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0407 0.505 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0782 0.1402
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0069 0.0803 0.1505
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Trypanosoma brucei adenosine kinase, putative 0.026 0.3201 0.6275
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0069 0.0803 0.15
Mycobacterium ulcerans carbohydrate kinase CbhK 0.003 0.0315 0.0529
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0407 0.505 1
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0267 0.3286 0.6473
Mycobacterium tuberculosis Ribokinase RbsK 0.003 0.0315 0.1597
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0123 0.0241
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1292 0.2559
Brugia malayi hypothetical protein 0.0069 0.0803 0.1505
Trypanosoma brucei adenosine transporter, putative 0.0043 0.048 0.0794
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0069 0.0803 0.0753
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0069 0.0803 0.15
Brugia malayi G-protein coupled receptor 0.0069 0.0803 0.1505
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.003 0.0315 0.1597
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0069 0.0803 0.15
Schistosoma mansoni equilibrative nucleoside transporter 0.0043 0.048 0.0854
Schistosoma mansoni myosin xvIII 0.0069 0.0803 0.15
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0782 0.1402
Onchocerca volvulus 0.003 0.0315 0.0888
Onchocerca volvulus 0.023 0.283 0.933
Echinococcus multilocularis neuropeptide receptor A26 0.0069 0.0803 0.0753
Brugia malayi AKH receptor 0.0069 0.0803 0.1505
Echinococcus granulosus neuropeptide FF receptor 2 0.0069 0.0803 0.15
Brugia malayi hypothetical protein 0.003 0.0315 0.0529
Onchocerca volvulus 0.0069 0.0803 0.2525
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0308 0.0516
Echinococcus multilocularis neuropeptides capa receptor 0.0069 0.0803 0.0753
Trypanosoma brucei nucleoside transporter 1, putative 0.0043 0.048 0.0794
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0308 0.051
Trypanosoma brucei ribokinase, putative 0.003 0.0315 0.0463
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0123 0.0069
Mycobacterium ulcerans endonuclease IV 0.0076 0.0895 0.1688
Echinococcus granulosus g protein coupled receptor 0.0069 0.0803 0.15
Echinococcus multilocularis serotonin receptor 0.0069 0.0803 0.0753
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0126 0.1526 0.2951
Trichomonas vaginalis ribokinase, putative 0.003 0.0315 0.0529
Loa Loa (eye worm) hypothetical protein 0.003 0.0315 0.0691
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0069 0.0803 0.0753
Echinococcus multilocularis fmrfamide receptor 0.0069 0.0803 0.0753
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0407 0.505 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.1292 0.7255
Loa Loa (eye worm) hypothetical protein 0.0246 0.3029 0.7782
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0086 0.017
Loa Loa (eye worm) neuropeptide F receptor 0.0069 0.0803 0.1965
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0043 0.048 0.0859
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0246 0.3029 0.5958
Onchocerca volvulus 0.0069 0.0803 0.2525
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0209 0.0316
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0895 0.1684
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0069 0.0803 0.15
Brugia malayi Melatonin receptor type 1A 0.0069 0.0803 0.1505
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0308 0.0611
Echinococcus multilocularis g protein coupled receptor 0.0069 0.0803 0.0753
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0054 0.0007
Trypanosoma cruzi ribokinase, putative 0.003 0.0315 0.0463
Echinococcus multilocularis fmrfamide receptor 0.0069 0.0803 0.0753
Brugia malayi RE15519p 0.0069 0.0803 0.1505
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0069 0.0803 0.15
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0069 0.0803 0.15
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0407 0.505 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.014 0.1705 0.3309
Loa Loa (eye worm) RecQ helicase 0.0021 0.0209 0.0413
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0267 0.3289 0.6478
Schistosoma mansoni adenosine kinase 0.026 0.3201 0.6299
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0308 0.0516
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0407 0.505 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0069 0.0803 0.15
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.1292 0.2075
Brugia malayi hypothetical protein 0.0069 0.0803 0.1505
Leishmania major nucleobase transporter 0.0043 0.048 0.0794
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0188
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0043 0.048 0.0859
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Schistosoma mansoni neuropeptide receptor 0.0069 0.0803 0.15
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0069 0.0803 0.15
Brugia malayi sulfakinin receptor protein 0.0069 0.0803 0.1505
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0069 0.0803 0.1965
Trypanosoma cruzi nucleoside transporter 1, putative 0.0043 0.048 0.0794
Leishmania major tagatose-6-phosphate kinase-like protein 0.003 0.0315 0.0463
Leishmania major nucleoside transporter 1, putative 0.0043 0.048 0.0794
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0069 0.0803 0.1505
Leishmania major nucleoside transporter 1, putative 0.0043 0.048 0.0794
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1292 0.2483
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0407 0.505 0.5
Schistosoma mansoni hypothetical protein 0.0069 0.0803 0.15
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Brugia malayi 6-phosphofructokinase 0.0108 0.1292 0.2483
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.0803 0.0753
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.0803 0.15
Schistosoma mansoni opsin-like receptor 0.0069 0.0803 0.15
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0407 0.505 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.0192
Schistosoma mansoni amine GPCR 0.0069 0.0803 0.15
Leishmania major tagatose-6-phosphate kinase-like protein 0.003 0.0315 0.0463
Toxoplasma gondii kinase, pfkB family protein 0.003 0.0315 0.0625
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0246 0.3029 1
Echinococcus granulosus G protein coupled receptor 139 0.0069 0.0803 0.15
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0069 0.0803 0.0753
Echinococcus granulosus serotonin receptor 0.0069 0.0803 0.15
Loa Loa (eye worm) hypothetical protein 0.0017 0.0155 0.0273
Schistosoma mansoni biogenic amine receptor 0.0069 0.0803 0.15
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.1292 0.2483
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0069 0.0803 0.0753
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.0803 0.0753
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.0803 0.15
Brugia malayi hypothetical protein 0.0069 0.0803 0.1505
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0308 0.0516
Onchocerca volvulus 0.0069 0.0803 0.2525
Echinococcus granulosus neuropeptide receptor A26 0.0069 0.0803 0.15
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0407 0.505 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0069 0.0803 0.1965
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0069 0.0803 0.0753
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0209 0.0316
Schistosoma mansoni growth hormone secretagogue receptor 0.0069 0.0803 0.15
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0246 0.3029 0.5956
Trypanosoma cruzi adenosine kinase, putative 0.003 0.0315 0.0463
Echinococcus multilocularis g-protein coupled receptor 0.0069 0.0803 0.0753
Brugia malayi putative neuropeptide receptor NPR1 0.0069 0.0803 0.1505
Loa Loa (eye worm) melatonin receptor type 1A 0.0069 0.0803 0.1965
Toxoplasma gondii nucleoside transporter protein 0.0043 0.048 0.0951
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.0803 0.15
Entamoeba histolytica nucleoside transporter, putative 0.0246 0.3029 0.5999
Echinococcus granulosus fmrfamide receptor 0.0069 0.0803 0.15
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0407 0.505 0.5023
Echinococcus multilocularis sex peptide receptor 0.0069 0.0803 0.0753
Leishmania major putative PfkB family sugar kinase 0.003 0.0315 0.0463
Trypanosoma brucei purine nucleoside transporter 0.0043 0.048 0.0794
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0194 0.0866
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0069 0.0803 0.15
Echinococcus granulosus Ankyrin 0.0014 0.0124 0.0141
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0281 0.3468 0.8928
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0782 0.0732
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0126 0.1526 0.2901
Trypanosoma brucei adenosine transporter 2, putative 0.0043 0.048 0.0794
Schistosoma mansoni neuropeptide f receptor 76f 0.0069 0.0803 0.15
Leishmania major adenosine kinase, putative 0.026 0.3201 0.6275
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0076 0.0895 0.1688
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0429 0.0378
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0153 0.02
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0407 0.505 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0069 0.0803 0.15
Trypanosoma brucei unspecified product 0.0043 0.048 0.0794
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0054 0.0006
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0267 0.3289 0.6476
Trichomonas vaginalis ribokinase, putative 0.003 0.0315 0.0529
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.1292 0.1245
Echinococcus granulosus biogenic amine 5HT receptor 0.0069 0.0803 0.15
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0209 0.0156
Trypanosoma brucei adenosine transporter 2, putative 0.0043 0.048 0.0794
Schistosoma mansoni neuropeptide receptor 0.0069 0.0803 0.15
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0124 0.0141
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0069 0.0803 0.15
Loa Loa (eye worm) hypothetical protein 0.0043 0.048 0.1122
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0407 0.505 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Brugia malayi hypothetical protein 0.0069 0.0803 0.1505
Onchocerca volvulus 0.0069 0.0803 0.2525
Mycobacterium tuberculosis Adenosine kinase 0.003 0.0315 0.1597
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.1292 0.2559
Onchocerca volvulus 0.0069 0.0803 0.2525
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0296 0.3655 0.9418
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0782 0.1402
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0407 0.505 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0407 0.505 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Echinococcus granulosus neuropeptide s receptor 0.0069 0.0803 0.15
Brugia malayi GnHR receptor homolog 0.0069 0.0803 0.1505
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Schistosoma mansoni amine GPCR 0.0069 0.0803 0.15
Echinococcus granulosus neuropeptide receptor 0.0069 0.0803 0.15
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0123 0.0144
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Brugia malayi hypothetical protein 0.012 0.1454 0.2807
Echinococcus multilocularis adenosine kinase 0.026 0.3201 0.3164
Schistosoma mansoni hypothetical protein 0.0014 0.0123 0.0138
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0407 0.505 1
Echinococcus granulosus death domain containing protein 0.0014 0.0123 0.0138
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0043 0.048 0.0794
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Trichomonas vaginalis ribokinase, putative 0.003 0.0315 0.0529
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1292 0.2483
Echinococcus granulosus allatostatin A receptor 0.0069 0.0803 0.15
Echinococcus granulosus biogenic amine 5HT receptor 0.0069 0.0803 0.15
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0407 0.505 1
Echinococcus multilocularis neuropeptide receptor 0.0069 0.0803 0.0753
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0069 0.0803 0.2525
Schistosoma mansoni amine GPCR 0.0069 0.0803 0.15
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0407 0.505 1
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.1292 0.2479
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0246 0.3029 0.2992
Schistosoma mansoni adenoreceptor 0.0069 0.0803 0.15
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0054 0.0106
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0267 0.3289 0.8461
Leishmania major nucleobase transporter 0.0043 0.048 0.0794
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0308 0.051
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0407 0.505 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Onchocerca volvulus 0.0069 0.0803 0.2525
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0407 0.505 1
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.014 0.1705 0.3309
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0069 0.0803 0.0753
Brugia malayi Uncoordinated protein 44 0.0014 0.0123 0.0144
Trypanosoma brucei adenosine transporter 2, putative 0.0043 0.048 0.0794
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Loa Loa (eye worm) G-protein coupled receptor 0.0069 0.0803 0.1965
Brugia malayi hypothetical protein 0.0069 0.0803 0.1505
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0123 0.0138
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0141 0.1708 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0308 0.0516
Brugia malayi STAT protein, DNA binding domain containing protein 0.013 0.1575 0.305
Echinococcus granulosus g protein coupled receptor 0.0069 0.0803 0.15
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0429 0.0752
Mycobacterium ulcerans epimerase 0.002 0.0194 0.0287
Trypanosoma cruzi adenosine kinase, putative 0.026 0.3201 0.6275
Brugia malayi Tachykinin-like peptides receptor 99D 0.0069 0.0803 0.1505
Loa Loa (eye worm) phosphofructokinase 0.0108 0.1292 0.3244
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0407 0.505 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0407 0.505 0.5023
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0043 0.048 0.0794
Loa Loa (eye worm) hypothetical protein 0.026 0.3201 0.823
Brugia malayi hypothetical protein 0.0069 0.0803 0.1505
Brugia malayi phosphofructokinase 0.0108 0.1292 0.2483
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0043 0.048 0.0794
Echinococcus multilocularis G-protein coupled receptor, putative 0.0069 0.0803 0.0753
Schistosoma mansoni hypothetical protein 0.0069 0.0803 0.15
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0407 0.505 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0054 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.0803 0.15
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Onchocerca volvulus 0.0069 0.0803 0.2525
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Loa Loa (eye worm) hypothetical protein 0.0076 0.0895 0.2205
Loa Loa (eye worm) STAT protein 0.013 0.1575 0.3983
Trypanosoma cruzi nucleobase transporter, putative 0.0043 0.048 0.0794
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.1292 0.7493
Schistosoma mansoni hypothetical protein 0.0168 0.2046 0.3987
Leishmania major adenosine kinase-like protein 0.003 0.0315 0.0463
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.0803 0.0753
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.0803 0.15
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0043 0.048 0.0794
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0054 0.0106
Leishmania major adenosine kinase-like protein 0.003 0.0315 0.0463
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0069 0.0803 0.15
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0407 0.505 1
Echinococcus granulosus neuropeptide Y receptor 0.0069 0.0803 0.15
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0246 0.3029 0.2992
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0069 0.0803 0.0753
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0267 0.3289 0.8461
Schistosoma mansoni alpha-1 adrenergic receptor 0.0069 0.0803 0.15
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Toxoplasma gondii kinase, pfkB family protein 0.026 0.3201 0.6339
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.0803 0.0753
Brugia malayi Death domain containing protein 0.0014 0.0123 0.0144
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0069 0.0803 0.15
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0407 0.505 1
Echinococcus multilocularis g protein coupled receptor 0.0069 0.0803 0.0753
Mycobacterium ulcerans hypothetical protein 0.002 0.0194 0.0287
Brugia malayi hypothetical protein 0.0069 0.0803 0.1505
Echinococcus multilocularis Ankyrin 0.0014 0.0124 0.0071
Brugia malayi G protein-coupled receptor F59B2.13 0.0069 0.0803 0.1505
Giardia lamblia Hypothetical protein 0.0246 0.3029 0.5958
Loa Loa (eye worm) hypothetical protein 0.0314 0.3878 1
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0267 0.3286 0.6448
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0054 0.0006
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1292 0.2431
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0126 0.1526 0.2901
Onchocerca volvulus 0.005 0.0572 0.1749
Loa Loa (eye worm) hypothetical protein 0.005 0.0572 0.1361
Echinococcus multilocularis g protein coupled receptor 0.0069 0.0803 0.0753
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.0803 0.15
Echinococcus multilocularis G protein coupled receptor 139 0.0069 0.0803 0.0753
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0858 0.1609
Echinococcus granulosus neuropeptide receptor 0.0069 0.0803 0.15
Echinococcus granulosus ribokinase 0.003 0.0315 0.0524
Brugia malayi Protein kinase domain containing protein 0.0014 0.0123 0.0144
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0281 0.3468 0.8928
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0141 0.1708 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.0803 0.0753
Onchocerca volvulus 0.0069 0.0803 0.2525
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0194 0.0287
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.003 0.0315 0.0625
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.1292 0.2483
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.1292 0.2431
Brugia malayi neuropeptide F receptor 0.0069 0.0803 0.1505
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0194 0.0287
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0782 0.1458
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.1292 0.3244
Echinococcus granulosus tm gpcr rhodopsin 0.0069 0.0803 0.15
Echinococcus multilocularis dro:myosuppressin receptor 0.0069 0.0803 0.0753
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Trypanosoma brucei ribokinase, putative 0.003 0.0315 0.0463
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0407 0.505 1
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0895 0.1566
Loa Loa (eye worm) hypothetical protein 0.003 0.0315 0.0691
Brugia malayi hypothetical protein 0.0246 0.3029 0.5958
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0407 0.505 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Toxoplasma gondii endonuclease IV APN 0.0076 0.0895 0.1772
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0315 0.0529
Echinococcus granulosus tumor protein p63 0.0342 0.4231 0.8362
Loa Loa (eye worm) hypothetical protein 0.0267 0.3289 0.8461
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0246 0.3029 0.5958
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0069 0.0803 0.1505
Trypanosoma brucei adenosine transporter 2 0.0043 0.048 0.0794
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0407 0.505 1
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0246 0.3029 0.5958
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0043 0.048 0.0794
Echinococcus multilocularis rhodopsin orphan GPCR 0.0069 0.0803 0.0753
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0054 0.0006
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Trypanosoma cruzi adenosine kinase, putative 0.026 0.3201 0.6275
Schistosoma mansoni neuropeptide F-like receptor 0.0069 0.0803 0.15
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0043 0.048 0.0794
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0308 0.0376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.0803 0.15
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0267 0.3286 0.6448
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.003 0.0315 0.0625
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.1292 0.2431
Onchocerca volvulus 0.0069 0.0803 0.2525
Brugia malayi hypothetical protein 0.0069 0.0803 0.1505
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Schistosoma mansoni opsin-like receptor 0.0069 0.0803 0.15
Echinococcus multilocularis somatostatin receptor 0.0069 0.0803 0.0753
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0177 0.0247
Echinococcus granulosus 7TM GPCR rhodopsin 0.0069 0.0803 0.15
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0123 0.0069
Echinococcus granulosus 7tm_1 domain containing protein 0.0069 0.0803 0.15
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0069 0.0803 0.15
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0782 0.1548
Brugia malayi larval opioid receptor 0.0069 0.0803 0.1505
Echinococcus granulosus orexin receptor type 2 0.0069 0.0803 0.15
Echinococcus granulosus adenosine kinase 0.026 0.3201 0.6299
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0407 0.505 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.0803 0.15
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0246 0.3029 0.5958
Echinococcus granulosus neuropeptides capa receptor 0.0069 0.0803 0.15
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0076 0.0895 0.5094
Schistosoma mansoni hypothetical protein 0.0069 0.0803 0.15
Chlamydia trachomatis endonuclease IV 0.0076 0.0895 0.1237
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.0803 0.15
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0267 0.3289 0.3253
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Trypanosoma cruzi nucleobase transporter, putative 0.0043 0.048 0.0794
Echinococcus multilocularis neuropeptide Y receptor 0.0069 0.0803 0.0753
Schistosoma mansoni biogenic amine (5HT) receptor 0.0069 0.0803 0.15
Echinococcus granulosus bloom syndrome protein 0.0021 0.0209 0.0311
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0069 0.0803 0.0753
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Trypanosoma cruzi nucleoside transporter 1, putative 0.0043 0.048 0.0794
Echinococcus multilocularis neuropeptide Y receptor 0.0069 0.0803 0.0753
Trypanosoma brucei nucleoside transporter 1, putative 0.0043 0.048 0.0794
Trypanosoma cruzi nucleoside transporter 1, putative 0.0043 0.048 0.0794
Brugia malayi Dopamine receptor protein 2 0.0069 0.0803 0.1505
Onchocerca volvulus Putative pyridoxal kinase 0.003 0.0315 0.0888
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0069 0.0803 0.15
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0308 0.0516
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0407 0.505 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0069 0.0803 0.2525
Trypanosoma brucei adenosine transporter 2 0.0043 0.048 0.0794
Brugia malayi follicle stimulating hormone receptor 0.0296 0.3655 0.7211
Echinococcus granulosus rhodopsin orphan GPCR 0.0069 0.0803 0.15
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0407 0.505 1
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0267 0.3286 0.6448
Brugia malayi G-protein coupled receptor 0.0069 0.0803 0.1505
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Brugia malayi Dopamine receptor protein 1 0.0069 0.0803 0.1505
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0043 0.048 0.0794
Trypanosoma cruzi nucleoside transporter-like, putative 0.0043 0.048 0.0794
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0126 0.1526 0.2901
Brugia malayi G protein-coupled receptor 0.0069 0.0803 0.1505
Loa Loa (eye worm) G-protein coupled receptor 0.0069 0.0803 0.1965
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.003 0.0315 0.0524
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0308 0.0611
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0308 0.0611
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0069 0.0803 0.15
Onchocerca volvulus Ribokinase homolog 0.003 0.0315 0.0888
Loa Loa (eye worm) neuropeptide F receptor 0.0069 0.0803 0.1965
Entamoeba histolytica nucleoside transporter, putative 0.0043 0.048 0.0951
Schistosoma mansoni adenosine kinase 0.026 0.3201 0.6299
Brugia malayi hypothetical protein 0.0043 0.048 0.0859
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0308 0.0516
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0043 0.048 0.0859
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0069 0.0803 0.15
Loa Loa (eye worm) hypothetical protein 0.0246 0.3029 0.7782
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0407 0.505 1
Loa Loa (eye worm) hypothetical protein 0.0246 0.3029 0.7782
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0407 0.505 1
Schistosoma mansoni netrin receptor unc5 0.0014 0.0123 0.0138
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0043 0.048 0.0859
Entamoeba histolytica fructokinase, putative 0.003 0.0315 0.0625
Brugia malayi neuropeptide F receptor 0.0069 0.0803 0.1505
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Echinococcus granulosus g-protein coupled receptor 0.0069 0.0803 0.15
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0782 0.191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0069 0.0803 0.15
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0069 0.0803 0.1965
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0121 0.024
Schistosoma mansoni biogenic amine receptor 0.0069 0.0803 0.15
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0308 0.0611
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0267 0.3289 0.6478
Onchocerca volvulus 0.0069 0.0803 0.2525
Toxoplasma gondii nucleoside transporter protein 0.0043 0.048 0.0951
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0126 0.1526 0.2901
Echinococcus multilocularis neuropeptides capa receptor 0.0069 0.0803 0.0753
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0069 0.0803 0.0753
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0126 0.1526 0.2901
Echinococcus multilocularis ribokinase 0.003 0.0315 0.0263
Echinococcus granulosus hypothetical protein 0.0069 0.0803 0.15
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0782 0.1462
Schistosoma mansoni histamine h1 receptor 0.0069 0.0803 0.15
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0069 0.0803 0.15
Onchocerca volvulus 0.0069 0.0803 0.2525
Echinococcus multilocularis geminin 0.0168 0.2046 0.2003
Schistosoma mansoni hypothetical protein 0.0069 0.0803 0.15
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0246 0.3029 1
Trypanosoma brucei adenosine kinase, putative 0.026 0.3201 0.6275
Loa Loa (eye worm) hypothetical protein 0.0069 0.0803 0.1965
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0407 0.505 1
Mycobacterium leprae Probable adenosine kinase adk 0.003 0.0315 0.08
Echinococcus multilocularis serotonin receptor 0.0069 0.0803 0.0753
Echinococcus granulosus neuropeptides capa receptor 0.0069 0.0803 0.15
Echinococcus multilocularis neuropeptide FF receptor 2 0.0069 0.0803 0.0753
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0069 0.0803 0.1965
Brugia malayi ORL1-like opioid receptor 0.0069 0.0803 0.1505
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0308 0.0516
Echinococcus multilocularis neuropeptide receptor 0.0069 0.0803 0.0753
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0069 0.0803 0.0753
Schistosoma mansoni neuropeptide receptor 0.0069 0.0803 0.15
Echinococcus multilocularis tumor protein p63 0.0342 0.4231 0.42
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0858 0.0808
Echinococcus granulosus geminin 0.0168 0.2046 0.3987
Schistosoma mansoni neuropeptide receptor 0.0069 0.0803 0.15
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0086 0.007
Schistosoma mansoni protein kinase 0.0043 0.048 0.0854
Echinococcus granulosus g protein coupled receptor 0.0069 0.0803 0.15
Echinococcus granulosus equilibrative nucleoside transporter 0.0246 0.3029 0.5956
Schistosoma mansoni biogenic amine receptor 0.0069 0.0803 0.15
Brugia malayi Serotonin receptor 0.0069 0.0803 0.1505
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0267 0.3286 0.6448
Trypanosoma brucei adenosine transporter 2, putative 0.0043 0.048 0.0794
Brugia malayi hypothetical protein 0.0069 0.0803 0.1505
Schistosoma mansoni opsin-like receptor 0.0069 0.0803 0.15
Onchocerca volvulus 0.0069 0.0803 0.2525
Schistosoma mansoni hypothetical protein 0.0168 0.2046 0.3987
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0407 0.505 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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