Detailed information for compound 1394793
Basic information
Technical information
- TDR Targets ID: 1394793
- Name: 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetami de
- MW: 197.257 | Formula: C8H11N3OS
-
H donors: 1
H acceptors: 3
LogP: 0.79
Rotable bonds: 3
Rule of 5 violations (Lipinski): 1 - SMILES: NC(=O)CSc1nc(C)cc(n1)C
- InChi: 1S/C8H11N3OS/c1-5-3-6(2)11-8(10-5)13-4-7(9)12/h3H,4H2,1-2H3,(H2,9,12)
- InChiKey: CYWIRZGTWFPTMH-UHFFFAOYSA-N
Network
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Synonyms
- 2-[(4,6-dimethyl-2-pyrimidinyl)thio]acetamide
- 2-[(4,6-dimethylpyrimidin-2-yl)thio]acetamide
- 2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanamide
- MLS000693131
- SMR000284759
- ZINC00370350
- STOCK2S-90040
- 2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetamide
- BAS 03014660
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Possible short-chain dehydrogenase EphD | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | estradiol 17 beta-dehydrogenase, putative | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | retinal dehydrogenase | 0.0113 | 1 | 1 |
| Leishmania major | pteridine reductase 1 | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Plasmodium falciparum | heat shock protein 90 | 0.0099 | 0.7408 | 0.7295 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | conserved hypothetical protein | 0.0113 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0113 | 1 | 0.5 |
| Echinococcus multilocularis | estradiol 17 beta dehydrogenase 12 | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Echinococcus granulosus | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | epidermal retinal dehydrogenase 2 | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Schistosoma mansoni | oxidoreductase short chain dehydrogenase/reductase family | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | heat shock protein, putative | 0.0079 | 0.3726 | 0.3452 |
| Echinococcus granulosus | hypothetical protein | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 90, putative | 0.0079 | 0.3726 | 0.3726 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Toxoplasma gondii | 3-ketoacyl-CoA reductase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Plasmodium falciparum | steroid dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Brugia malayi | Retinol dehydrogenase 12 | 0.0113 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0113 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | Dehydrogenase:reductase SDR family | 0.0113 | 1 | 1 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 3, putative | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Entamoeba histolytica | oxidoreductase, short chain dehydrogenase/reductase family | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0099 | 0.7408 | 0.5869 |
| Treponema pallidum | heat shock protein 90 | 0.0079 | 0.3726 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0113 | 1 | 1 |
| Trypanosoma brucei | 3-keto-dihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma brucei | 3-ketoacyl-CoA reductase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Plasmodium falciparum | oxidoreductase, short-chain dehydrogenase family, putative | 0.0113 | 1 | 1 |
| Brugia malayi | D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0113 | 1 | 0.5 |
| Echinococcus granulosus | Dehydrogenase:reductase SDR family | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short chain alcohol dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | heat shock protein, putative | 0.0099 | 0.7408 | 0.7295 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Trypanosoma cruzi | heat shock protein 85, putative | 0.0079 | 0.3726 | 0.3726 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | oxidoreductase | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Possible ketoacyl reductase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain membrane-associated dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | quinonoid dihydropteridine reductase, putative | 0.0113 | 1 | 1 |
| Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | heat shock protein, putative | 0.0079 | 0.3726 | 0.3452 |
| Brugia malayi | dehydrogenases, short chain protein 9 | 0.0113 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | oxidoreductase | 0.0113 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Echinococcus granulosus | heat shock protein | 0.0099 | 0.7408 | 0.5869 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Leishmania major | oxidoreductase-like protein | 0.0113 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Possible fatty acyl-CoA reductase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | steroid dehydrogenase, putative | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Schistosoma mansoni | 3-keto-dihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | oxidoreductase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Entamoeba histolytica | 3-ketodihydrosphingosine reductase protein, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Decaprenylphosphoryl-D-2-keto erythro pentose reductase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0113 | 1 | 1 |
| Giardia lamblia | Oxidoreductase, short chain dehydrogenase/reductase family | 0.0113 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0113 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0113 | 1 | 1 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0113 | 1 | 1 |
| Trypanosoma brucei | oxidoreductase-like protein | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 85, putative | 0.0099 | 0.7408 | 0.7408 |
| Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Mycobacterium ulcerans | dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 90, putative | 0.0099 | 0.7408 | 0.7408 |
| Toxoplasma gondii | carbonyl reductase 1, putative | 0.0113 | 1 | 1 |
| Echinococcus granulosus | epidermal retinal dehydrogenase 2 | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus granulosus | heat shock protein 90 | 0.0099 | 0.7408 | 0.5869 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short-chain dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Mycobacterium leprae | PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Giardia lamblia | Reductase, putative | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0113 | 1 | 1 |
| Echinococcus granulosus | WW domain containing oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 13 | 0.0113 | 1 | 1 |
| Leishmania major | short chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trypanosoma brucei | beta-D-hydroxybutyrate dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | carveol-like dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | transient receptor potential cation channel | 0.0113 | 1 | 1 |
| Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0113 | 1 | 1 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0113 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | heat shock protein, putative | 0.0079 | 0.3726 | 0.3452 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Mycobacterium leprae | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Mycobacterium tuberculosis | Probable short-chain dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.0113 | 1 | 1 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0113 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0113 | 1 | 1 |
| Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0113 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Brugia malayi | Hypothetical oxidoreductase F56D1.5 | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Brugia malayi | dehydrogenases, short chain protein 2 | 0.0113 | 1 | 1 |
| Mycobacterium leprae | Possible short-chain dehydrogenase EphD | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0113 | 1 | 1 |
| Brugia malayi | Dehydrogenases, short chain protein 2 | 0.0113 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | hydroxyacyl dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Possible iron-regulated short-chain dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0113 | 1 | 1 |
| Plasmodium vivax | steroid dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable shortchain dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0113 | 1 | 1 |
| Leishmania major | short chain dehydrogenase-like protein | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | Heat shock protein 83, putative | 0.0099 | 0.7408 | 0.7408 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 2 | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 85, putative | 0.0099 | 0.7408 | 0.7408 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Giardia lamblia | Short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.0113 | 1 | 1 |
| Giardia lamblia | Hypothetical protein | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Leishmania major | 3-keto-dihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Mycobacterium leprae | ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 85, putative | 0.0099 | 0.7408 | 0.7408 |
| Echinococcus multilocularis | 3 ketodihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Brugia malayi | Dehydrogenases, short chain protein 30 | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | heat shock protein 90 | 0.0099 | 0.7408 | 0.5869 |
| Echinococcus granulosus | oxidoreductase | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 1 homolog | 0.0113 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type oxidoreductase | 0.0113 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase/decarboxylase protein | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | heat shock protein | 0.0099 | 0.7408 | 0.5869 |
| Brugia malayi | oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus granulosus | 3 ketodihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Onchocerca volvulus | Sepiapterin reductase homolog | 0.0113 | 1 | 0.5 |
| Leishmania major | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Plasmodium vivax | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Leishmania major | short chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Trichomonas vaginalis | short-chain dehydrogenases/reductase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0113 | 1 | 1 |
| Leishmania major | dehydrogenase-like protein | 0.0113 | 1 | 1 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0113 | 1 | 1 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| Inhibition (binding) | < 10 % | Inhibition of GST-tagged human SIRT1 (133 to 747 amino acids) using ZMAL as substrate at 200 uM after 4 hrs by fluorescence-based microplate reader method | ChEMBL. | 26696402 |
| Inhibition (binding) | < 10 % | Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate at 50 uM after 4 hrs by fluorescence-based microplate reader method | ChEMBL. | 26696402 |
| Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL1526762
Bibliographic References
1 literature reference was collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.