Detailed information for compound 1394793

Basic information

Technical information
  • TDR Targets ID: 1394793
  • Name: 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetami de
  • MW: 197.257 | Formula: C8H11N3OS
  • H donors: 1 H acceptors: 3 LogP: 0.79 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)CSc1nc(C)cc(n1)C
  • InChi: 1S/C8H11N3OS/c1-5-3-6(2)11-8(10-5)13-4-7(9)12/h3H,4H2,1-2H3,(H2,9,12)
  • InChiKey: CYWIRZGTWFPTMH-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[(4,6-dimethyl-2-pyrimidinyl)thio]acetamide
  • 2-[(4,6-dimethylpyrimidin-2-yl)thio]acetamide
  • 2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanamide
  • MLS000693131
  • SMR000284759
  • ZINC00370350
  • STOCK2S-90040
  • 2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetamide
  • BAS 03014660

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Echinococcus granulosus steroid dehydrogenase 0.0113 1 1
Echinococcus granulosus heat shock protein 90 0.0099 0.7408 0.5869
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0113 1 1
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Mycobacterium ulcerans dehydrogenase 0.0113 1 1
Echinococcus multilocularis carbonyl reductase 1 0.0113 1 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0099 0.7408 0.7408
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0113 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0099 0.7408 0.7408
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Trichomonas vaginalis heat shock protein, putative 0.0099 0.7408 0.7295
Entamoeba histolytica hypothetical protein, conserved 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Schistosoma mansoni steroid dehydrogenase 0.0113 1 1
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0113 1 1
Schistosoma mansoni carbonyl reductase 0.0113 1 1
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0113 1 1
Echinococcus granulosus carbonyl reductase 1 0.0113 1 1
Echinococcus granulosus carbonyl reductase 1 0.0113 1 1
Entamoeba histolytica hypothetical protein 0.0113 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0113 1 1
Onchocerca volvulus 0.0113 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0113 1 1
Onchocerca volvulus 0.0113 1 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0113 1 1
Loa Loa (eye worm) oxidoreductase 0.0113 1 1
Schistosoma mansoni steroid dehydrogenase 0.0113 1 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0113 1 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0113 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0113 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0113 1 1
Loa Loa (eye worm) oxidoreductase 0.0113 1 1
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0113 1 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0113 1 1
Onchocerca volvulus 0.0113 1 0.5
Schistosoma mansoni steroid dehydrogenase 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0113 1 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0113 1 1
Plasmodium falciparum steroid dehydrogenase, putative 0.0113 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 1 1
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0113 1 1
Leishmania major hypothetical protein, conserved 0.0113 1 1
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0113 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 1 1
Onchocerca volvulus 0.0113 1 0.5
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0113 1 1
Trichomonas vaginalis steroid dehydrogenase, putative 0.0113 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0099 0.7408 0.7408
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Brugia malayi Retinol dehydrogenase 12 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Mycobacterium ulcerans oxidoreductase 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Loa Loa (eye worm) oxidoreductase 0.0113 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 1 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0113 1 1
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0113 1 1
Leishmania major oxidoreductase-like protein 0.0113 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0113 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0113 1 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0113 1 1
Echinococcus multilocularis oxidoreductase 0.0113 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Echinococcus multilocularis heat shock protein 0.0099 0.7408 0.5869
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0113 1 1
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0113 1 1
Echinococcus multilocularis conserved hypothetical protein 0.0113 1 1
Plasmodium falciparum heat shock protein 90 0.0099 0.7408 0.7295
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0113 1 1
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0113 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0113 1 1
Plasmodium vivax steroid dehydrogenase, putative 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0113 1 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0113 1 1
Onchocerca volvulus 0.0113 1 0.5
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Trichomonas vaginalis heat shock protein, putative 0.0079 0.3726 0.3452
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Giardia lamblia Short-chain dehydrogenase, putative 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0113 1 0.5
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0113 1 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0113 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0113 1 1
Leishmania major short chain dehydrogenase-like protein 0.0113 1 1
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0113 1 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Leishmania major hypothetical protein, conserved 0.0113 1 1
Mycobacterium ulcerans oxidoreductase 0.0113 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0113 1 1
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0113 1 1
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0113 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Leishmania major short chain dehydrogenase, putative 0.0113 1 1
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Schistosoma mansoni steroid dehydrogenase 0.0113 1 1
Leishmania major hypothetical protein, conserved 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Loa Loa (eye worm) oxidoreductase 0.0113 1 1
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0113 1 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0113 1 1
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Entamoeba histolytica short chain dehydrogenase family protein 0.0113 1 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0113 1 1
Leishmania major hypothetical protein, conserved 0.0113 1 1
Schistosoma mansoni steroid dehydrogenase 0.0113 1 1
Brugia malayi dehydrogenases, short chain protein 2 0.0113 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0113 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 1 1
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0113 1 1
Loa Loa (eye worm) dehydrogenase 0.0113 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0113 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Loa Loa (eye worm) oxidoreductase 0.0113 1 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0113 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 1 1
Onchocerca volvulus 0.0113 1 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0113 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0113 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0099 0.7408 0.7408
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Echinococcus multilocularis steroid dehydrogenase 0.0113 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0113 1 1
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Echinococcus granulosus oxidoreductase 0.0113 1 1
Brugia malayi hypothetical protein 0.0113 1 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0113 1 1
Schistosoma mansoni steroid dehydrogenase 0.0113 1 1
Giardia lamblia Hypothetical protein 0.0113 1 1
Echinococcus granulosus carbonyl reductase 1 0.0113 1 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0113 1 1
Treponema pallidum heat shock protein 90 0.0079 0.3726 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Echinococcus multilocularis heat shock protein 90 0.0099 0.7408 0.5869
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0113 1 1
Schistosoma mansoni retinal dehydrogenase 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 1 1
Brugia malayi Dehydrogenases, short chain protein 30 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0113 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0099 0.7408 0.5869
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0113 1 1
Loa Loa (eye worm) oxidoreductase 0.0113 1 1
Mycobacterium ulcerans short-chain type oxidoreductase 0.0113 1 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0113 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0113 1 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0113 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 1 1
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0113 1 1
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Loa Loa (eye worm) dehydrogenase 0.0113 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 1 1
Echinococcus granulosus carbonyl reductase 1 0.0113 1 1
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0113 1 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0113 1 1
Trichomonas vaginalis heat shock protein, putative 0.0079 0.3726 0.3452
Onchocerca volvulus 0.0113 1 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Leishmania major short chain dehydrogenase, putative 0.0113 1 1
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 1 1
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0113 1 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0113 1 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Schistosoma mansoni carbonyl reductase 0.0113 1 1
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0079 0.3726 0.3726
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0113 1 1
Brugia malayi oxidoreductase 0.0113 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 1 1
Mycobacterium ulcerans ketoacyl reductase 0.0113 1 1
Mycobacterium ulcerans ketoacyl reductase 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Onchocerca volvulus 0.0113 1 0.5
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Echinococcus multilocularis carbonyl reductase 1 0.0113 1 1
Mycobacterium leprae Probable oxidoreductase 0.0113 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0099 0.7408 0.7408
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Brugia malayi dehydrogenases, short chain protein 9 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0113 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 1 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 1 1
Onchocerca volvulus Sepiapterin reductase homolog 0.0113 1 0.5
Mycobacterium ulcerans dehydrogenase/reductase 0.0113 1 1
Leishmania major pteridine reductase 1 0.0113 1 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Echinococcus multilocularis steroid dehydrogenase 0.0113 1 1
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Schistosoma mansoni steroid dehydrogenase 0.0113 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 1 1
Brugia malayi hypothetical protein 0.0113 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0113 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 1 1
Trichomonas vaginalis heat shock protein, putative 0.0079 0.3726 0.3452
Mycobacterium ulcerans short-chain dehydrogenase 0.0113 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0113 1 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 1 1
Echinococcus granulosus hypothetical protein 0.0113 1 1
Leishmania major dehydrogenase-like protein 0.0113 1 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0113 1 1
Leishmania major hypothetical protein, conserved 0.0113 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0113 1 0.5
Plasmodium vivax hypothetical protein, conserved 0.0113 1 1
Echinococcus multilocularis carbonyl reductase 1 0.0113 1 1
Schistosoma mansoni steroid dehydrogenase 0.0113 1 1
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0113 1 1
Echinococcus granulosus heat shock protein 0.0099 0.7408 0.5869
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0113 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0113 1 0.5
Toxoplasma gondii oxidoreductase, putative 0.0113 1 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0113 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 1 1
Mycobacterium ulcerans carveol-like dehydrogenase 0.0113 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 1 1
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0079 0.3726 0.3726
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Echinococcus multilocularis carbonyl reductase 1 0.0113 1 1
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0113 1 1
Schistosoma mansoni carbonyl reductase 0.0113 1 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0113 1 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0113 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0113 1 1
Onchocerca volvulus 0.0113 1 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0113 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0113 1 1
Leishmania major 3-keto-dihydrosphingosine reductase 0.0113 1 1
Schistosoma mansoni steroid dehydrogenase 0.0113 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0113 1 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0113 1 1
Mycobacterium ulcerans ketoacyl reductase 0.0113 1 1
Toxoplasma gondii carbonyl reductase 1, putative 0.0113 1 1
Schistosoma mansoni short chain dehydrogenase 0.0113 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Loa Loa (eye worm) oxidoreductase 0.0113 1 1
Loa Loa (eye worm) oxidoreductase 0.0113 1 1
Echinococcus granulosus hypothetical protein 0.0113 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 1 1
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0113 1 1
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0113 1 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0113 1 1
Onchocerca volvulus 0.0113 1 0.5
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Echinococcus multilocularis transient receptor potential cation channel 0.0113 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0113 1 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0113 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Loa Loa (eye worm) hypothetical protein 0.0113 1 1
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Schistosoma mansoni steroid dehydrogenase 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0113 1 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Echinococcus granulosus retinol dehydrogenase 11 0.0113 1 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0113 1 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0113 1 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0113 1 1
Toxoplasma gondii oxidoreductase, putative 0.0113 1 1
Onchocerca volvulus 0.0113 1 0.5
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0113 1 1
Onchocerca volvulus 0.0113 1 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0113 1 1
Echinococcus granulosus WW domain containing oxidoreductase 0.0113 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0113 1 1
Trypanosoma brucei oxidoreductase-like protein 0.0113 1 1
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0113 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0113 1 1
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0113 1 1
Loa Loa (eye worm) oxidoreductase 0.0113 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0113 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 1 1
Leishmania major heat shock protein 83-1 0.0099 0.7408 0.5869
Giardia lamblia Reductase, putative 0.0113 1 1
Echinococcus multilocularis retinol dehydrogenase 13 0.0113 1 1
Onchocerca volvulus 0.0113 1 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0113 1 1
Leishmania major quinonoid dihydropteridine reductase 0.0113 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 1 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0113 1 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0113 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 1 1
Mycobacterium ulcerans short chain dehydrogenase 0.0113 1 1
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0113 1 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) < 10 % Inhibition of GST-tagged human SIRT1 (133 to 747 amino acids) using ZMAL as substrate at 200 uM after 4 hrs by fluorescence-based microplate reader method ChEMBL. 26696402
Inhibition (binding) < 10 % Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate at 50 uM after 4 hrs by fluorescence-based microplate reader method ChEMBL. 26696402
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.