Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0109 | 0.4205 | 0.4036 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0109 | 0.4205 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0109 | 0.4205 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0109 | 0.4205 | 0.4036 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0109 | 0.4205 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0109 | 0.4205 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0109 | 0.4205 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.2028 | 0.4447 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0109 | 0.4205 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.2028 | 0.1795 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0109 | 0.4205 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0109 | 0.4205 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2028 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0109 | 0.4205 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0109 | 0.4205 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.2028 | 0.1795 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.0284 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2028 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0109 | 0.4205 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0109 | 0.4205 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2028 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0109 | 0.4205 | 0.4036 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 0.0284 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0109 | 0.4205 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0109 | 0.4205 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0109 | 0.4205 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.2028 | 0.1795 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0109 | 0.4205 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0109 | 0.4205 | 0.4036 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.2028 | 0.4447 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0109 | 0.4205 | 0.4036 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.2028 | 0.1795 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.2028 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.1582 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.1582 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.3323 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.