Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | EYA transcriptional coactivator and phosphatase 2 | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2529 | 0.2529 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.3208 | 0.3208 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0613 | 0.0613 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.1124 | 0.2714 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.0613 | 0.0613 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.3208 | 0.3208 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.3208 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.0613 | 0.0613 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.3208 | 0.3208 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.3105 | 0.5782 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.3208 | 0.3208 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.1124 | 0.7399 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.3208 | 0.5653 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.0613 | 0.0887 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.2773 | 0.2773 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1124 | 0.1221 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1072 | 0.179 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0911 | 0.0911 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1368 | 0.1741 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.1326 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.3105 | 0.5434 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1238 | 0.1465 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3279 | 0.5805 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.3208 | 0.3208 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.0613 | 0.0887 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.1124 | 0.2714 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.0613 | 0.0613 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.3208 | 0.5985 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1077 | 0.1122 |
Brugia malayi | chromobox protein homolog 3 | 0.0047 | 0.1124 | 0.1891 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 0.5252 | 1 |
Schistosoma mansoni | eyes absent homolog | 0.0106 | 0.4464 | 0.4464 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.012 | 0.5252 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 0.5252 | 1 |
Brugia malayi | hypothetical protein | 0.0106 | 0.4464 | 0.8451 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.0613 | 0.0135 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0613 | 0.0613 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0613 | 0.0135 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.3208 | 0.3208 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.1326 | 0.3419 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.3571 | 0.6697 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.3105 | 0.3105 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.3208 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.4464 | 0.8323 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2529 | 0.2529 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.4464 | 0.8323 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.0613 | 0.0613 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0911 | 0.0911 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.1326 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0613 | 0.0613 |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.0613 | 0.0613 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3264 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.2944 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 8.4936 uM | PubChem BioAssay. qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Saccharomyces cerevisiae | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.