Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.2244 | 0.1969 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0272 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2244 | 0.5 |
Echinococcus multilocularis | geminin | 0.0166 | 0.5854 | 0.4655 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1283 | 0.1283 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0341 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0272 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.2244 | 0.1677 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0272 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.2244 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.5854 | 0.5551 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0341 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0272 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0272 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2244 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0272 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0272 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.5854 | 0.5551 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0341 | 0.0341 |
Trypanosoma brucei | protein kinase, putative | 0.0272 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1283 | 0.1283 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.2244 | 0.1969 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2244 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1283 | 0.0975 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0272 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0272 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1283 | 0.0975 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.068 | 0.0351 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0272 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0272 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0341 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0272 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0272 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0272 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0272 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0272 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0272 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0272 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.068 | 0.068 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.2244 | 0.1677 |
Echinococcus granulosus | geminin | 0.0166 | 0.5854 | 0.4655 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0272 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.