Detailed information for compound 1395257

Basic information

Technical information
  • TDR Targets ID: 1395257
  • Name: phenyl 2-ethylsulfanylbenzimidazole-1-carboxy late
  • MW: 298.36 | Formula: C16H14N2O2S
  • H donors: 0 H acceptors: 2 LogP: 4.49 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSc1nc2c(n1C(=O)Oc1ccccc1)cccc2
  • InChi: 1S/C16H14N2O2S/c1-2-21-15-17-13-10-6-7-11-14(13)18(15)16(19)20-12-8-4-3-5-9-12/h3-11H,2H2,1H3
  • InChiKey: RPBVJCLGQZERQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(ethylthio)-1-benzimidazolecarboxylic acid phenyl ester
  • 2-(ethylthio)benzimidazole-1-carboxylic acid phenyl ester
  • ZINC00088271
  • A2497/0106194
  • MLS000549104
  • SMR000114230
  • phenyl 2-(ethylsulfanyl)-1H-benzimidazole-1-carboxylate
  • 2-Ethylsulfanyl-benzimidazole-1-carboxylic acid, phenyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2951 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0226 0.3008 0.9109
Brugia malayi steroid hormone receptor 0.0226 0.3008 0.9109
Loa Loa (eye worm) nuclear hormone receptor 0.0107 0.1151 0.3418
Loa Loa (eye worm) hypothetical protein 0.0119 0.1349 0.4026
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0107 0.1151 0.3513
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0226 0.3008 0.9109
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.017 0.042
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0279 0.5
Loa Loa (eye worm) hypothetical protein 0.0119 0.1349 0.4026
Brugia malayi MH2 domain containing protein 0.0117 0.131 0.3967
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0226 0.3008 0.2985
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0226 0.3008 0.2985
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0226 0.3008 0.9109
Brugia malayi latrophilin 2 splice variant baaae 0.0168 0.2097 0.6349
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0107 0.1151 0.1121
Brugia malayi nuclear receptor RXR 0.0107 0.1151 0.3484
Echinococcus multilocularis tumor protein p63 0.0331 0.4639 0.4621
Brugia malayi hypothetical protein 0.0107 0.1151 0.3484
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0226 0.3008 0.9353
Brugia malayi nuclear receptor NHR-67 0.0107 0.1151 0.3484
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0697 0.0667
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0107 0.1151 0.1121
Echinococcus granulosus nuclear receptor nhr 48 0.0107 0.1151 0.1121
Echinococcus granulosus Nuclear hormone receptor HR96 0.0107 0.1151 0.1121
Schistosoma mansoni hypothetical protein 0.0078 0.0697 0.0667
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0226 0.3008 0.2985
Brugia malayi hypothetical protein 0.0071 0.0603 0.1824
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0226 0.3008 0.2985
Loa Loa (eye worm) hypothetical protein 0.0107 0.1151 0.3418
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0697 0.2032
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0245 0.3303 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0279 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0226 0.3008 0.2985
Schistosoma mansoni nuclear receptor 0.0107 0.1151 0.1121
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0226 0.3008 0.9109
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0279 1
Schistosoma mansoni nuclear hormone receptor 0.0226 0.3008 0.2985
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0226 0.3008 0.91
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0697 0.0667
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0226 0.3008 0.9109
Brugia malayi nuclear hormone receptor family member nhr-6 0.0107 0.1151 0.3484
Brugia malayi beta-lactamase 0.0035 0.0033 0.01
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0107 0.1151 0.3513
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0107 0.1151 0.1121
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0119 0.1349 0.1321
Schistosoma mansoni hypothetical protein 0.0168 0.2097 0.2071
Loa Loa (eye worm) TAR-binding protein 0.0126 0.1452 0.4339
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0574 0.1653
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.017 0.0432
Loa Loa (eye worm) hypothetical protein 0.0226 0.3008 0.91
Loa Loa (eye worm) hypothetical protein 0.0107 0.1151 0.3418
Brugia malayi hypothetical protein 0.0119 0.1349 0.4086
Loa Loa (eye worm) hypothetical protein 0.0119 0.1349 0.4026
Schistosoma mansoni hypothetical protein 0.0078 0.0697 0.0667
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0226 0.3008 0.2985
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0119 0.1349 0.4026
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0144 0.0349
Echinococcus multilocularis microtubule associated protein 2 0.0676 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0603 0.0571
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.017 0.0432
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.017 0.0432
Schistosoma mansoni RAR-like nuclear receptor 0.0226 0.3008 0.2985
Loa Loa (eye worm) hypothetical protein 0.0107 0.1151 0.3418
Schistosoma mansoni hypothetical protein 0.0078 0.0697 0.0667
Loa Loa (eye worm) RNA binding protein 0.0126 0.1452 0.4339
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.017 0.0432
Loa Loa (eye worm) hypothetical protein 0.0107 0.1151 0.3418
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0119 0.1349 0.1321
Brugia malayi hypothetical protein 0.0107 0.1151 0.3484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0226 0.3008 0.91
Mycobacterium ulcerans lipase LipD 0.0035 0.0033 0.5
Brugia malayi hypothetical protein 0.0051 0.0279 0.0845
Loa Loa (eye worm) hypothetical protein 0.0039 0.0098 0.0199
Loa Loa (eye worm) hypothetical protein 0.0226 0.3008 0.91
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0697 0.2112
Brugia malayi Nuclear hormone receptor E75 0.0107 0.1151 0.3484
Schistosoma mansoni nuclear hormone receptor 0.0107 0.1151 0.1121
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0226 0.3008 0.9109
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0226 0.3008 0.9109
Onchocerca volvulus 0.0042 0.0138 0.0329
Brugia malayi nuclear receptor RXR 0.0119 0.1349 0.4086
Brugia malayi tailless protein 0.0107 0.1151 0.3484
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0279 1
Echinococcus granulosus FTZ F1 alpha 0.0226 0.3008 0.2985
Echinococcus granulosus chromobox protein 1 0.007 0.0574 0.0542
Loa Loa (eye worm) hypothetical protein 0.0119 0.1349 0.4026
Schistosoma mansoni retinoic acid receptor RXR 0.0226 0.3008 0.2985
Brugia malayi beta-lactamase family protein 0.0035 0.0033 0.01
Schistosoma mansoni nuclear hormone receptor 0.0107 0.1151 0.1121
Brugia malayi Steroid receptor seven-up type 2 0.0226 0.3008 0.9109
Echinococcus granulosus chromobox protein 1 0.007 0.0574 0.0542
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0226 0.3008 0.9109
Onchocerca volvulus 0.0239 0.3214 1
Echinococcus multilocularis FTZ F1 alpha 0.0226 0.3008 0.2985
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0697 0.0667
Schistosoma mansoni alpha glucosidase 0.0044 0.017 0.0138
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2762 0.8348
Brugia malayi nuclear receptor NHR-88 0.0107 0.1151 0.3484
Trichomonas vaginalis chromobox protein, putative 0.007 0.0574 0.1699
Schistosoma mansoni zinc finger protein 0.0107 0.1151 0.1121
Loa Loa (eye worm) hypothetical protein 0.0107 0.1151 0.3418
Schistosoma mansoni coup transcription factor 0.0226 0.3008 0.2985
Onchocerca volvulus Bile acid receptor homolog 0.0226 0.3008 0.9353
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0033 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0245 0.3303 1
Brugia malayi Nuclear hormone receptor-like 1 0.0226 0.3008 0.9109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0107 0.1151 0.1121
Echinococcus multilocularis chromobox protein 1 0.007 0.0574 0.0542
Schistosoma mansoni alpha-glucosidase 0.0169 0.2125 0.2099
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.017 0.0432
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0107 0.1151 0.1121
Onchocerca volvulus 0.0107 0.1151 0.3513
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1452 0.1423
Echinococcus granulosus thyroid hormone receptor alpha 0.0107 0.1151 0.1121
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0226 0.3008 0.2985
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.0204
Brugia malayi nuclear hormone receptor family member odr-7 0.0107 0.1151 0.3484
Brugia malayi nuclear hormone receptor 0.0107 0.1151 0.3484
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0226 0.3008 0.9109
Brugia malayi ecdysone receptor 0.0107 0.1151 0.3484
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0226 0.3008 0.9109
Loa Loa (eye worm) hypothetical protein 0.0107 0.1151 0.3418
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2551 0.2526
Brugia malayi RNA binding protein 0.0126 0.1452 0.4396
Loa Loa (eye worm) hypothetical protein 0.0107 0.1151 0.3418
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0144 0.0349
Entamoeba histolytica hypothetical protein 0.0071 0.0603 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0226 0.3008 0.91
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.017 0.5584
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0107 0.1151 0.1121
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0279 1
Loa Loa (eye worm) steroid hormone receptor 0.0226 0.3008 0.91
Brugia malayi TAR-binding protein 0.0126 0.1452 0.4396
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2551 0.7724
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.017 0.5584
Echinococcus granulosus tumor protein p63 0.0331 0.4639 0.4621
Schistosoma mansoni chromobox protein 0.007 0.0574 0.0542
Brugia malayi Pre-SET motif family protein 0.021 0.2762 0.8364
Mycobacterium ulcerans hypothetical protein 0.0035 0.0033 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0226 0.3008 0.2985
Echinococcus granulosus ecdysone induced protein 78C 0.0226 0.3008 0.2985
Brugia malayi beta-lactamase family protein 0.0035 0.0033 0.01
Echinococcus granulosus tar DNA binding protein 0.0126 0.1452 0.1423
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.0204
Loa Loa (eye worm) hypothetical protein 0.0226 0.3008 0.91
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.131 0.3906
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0226 0.3008 0.2985
Echinococcus multilocularis thyroid hormone receptor alpha 0.0226 0.3008 0.2985
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0033 0.5
Loa Loa (eye worm) hypothetical protein 0.0107 0.1151 0.3418
Loa Loa (eye worm) hypothetical protein 0.0107 0.1151 0.3418
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0603 0.0571
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0603 0.0571
Loa Loa (eye worm) hypothetical protein 0.0226 0.3008 0.91
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0226 0.3008 0.91
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0107 0.1151 0.1121
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0226 0.3008 0.2985
Loa Loa (eye worm) hypothetical protein 0.0245 0.3303 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0279 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0226 0.3008 0.9109
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1452 0.1423
Brugia malayi ecdysteroid receptor 0.0226 0.3008 0.9109
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.017 0.0432
Schistosoma mansoni nuclear receptor nhr-48 0.0107 0.1151 0.1121
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0226 0.3008 0.91
Brugia malayi orphan nuclear receptor NR2E1 0.0107 0.1151 0.3484
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0226 0.3008 0.2985
Echinococcus multilocularis nuclear receptor nhr 48 0.0107 0.1151 0.1121
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0226 0.3008 0.2985
Echinococcus multilocularis chromobox protein 1 0.007 0.0574 0.0542
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2551 0.7701
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0138 0.0105
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0697 0.0667
Loa Loa (eye worm) hypothetical protein 0.0226 0.3008 0.91
Echinococcus multilocularis tar DNA binding protein 0.0126 0.1452 0.1423
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.017 0.0138
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0697 0.2112
Echinococcus multilocularis GPCR, family 2 0.0078 0.0697 0.0667
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0226 0.3008 0.91
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0098 0.0204
Mycobacterium ulcerans beta-lactamase 0.0035 0.0033 0.5
Mycobacterium leprae Probable lipase LipE 0.0035 0.0033 0.5
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0107 0.1151 0.3484
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0033 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0226 0.3008 0.2985
Echinococcus granulosus Nuclear hormone receptor HR96 0.0107 0.1151 0.1121
Schistosoma mansoni nuclear receptor 0.0107 0.1151 0.1121
Onchocerca volvulus 0.0048 0.0245 0.0666
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.131 0.3906
Loa Loa (eye worm) hypothetical protein 0.0226 0.3008 0.91
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.017 0.0432
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0119 0.1349 0.1321
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.017 0.5584
Schistosoma mansoni thyroid hormone receptor 0.0226 0.3008 0.2985
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0119 0.1349 0.1321
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2551 0.2526
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0226 0.3008 0.9109
Trypanosoma brucei glucosidase, putative 0.0044 0.017 0.5584
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1452 0.1423
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.017 0.0432
Onchocerca volvulus 0.0107 0.1151 0.3513
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0107 0.1151 0.1121
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0226 0.3008 0.2985
Trichomonas vaginalis chromobox protein, putative 0.007 0.0574 0.1699
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.017 0.5584
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0107 0.1151 0.3418
Brugia malayi hypothetical protein 0.0119 0.1349 0.4086
Echinococcus granulosus GPCR family 2 0.0078 0.0697 0.0667
Loa Loa (eye worm) hypothetical protein 0.0048 0.0245 0.0648
Brugia malayi chromobox protein homolog 3 0.0039 0.0098 0.0297
Loa Loa (eye worm) nuclear receptor NHR-67 0.0107 0.1151 0.3418
Brugia malayi Heterochromatin protein 1 0.007 0.0574 0.1737
Loa Loa (eye worm) hypothetical protein 0.0226 0.3008 0.91
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.017 0.0516
Onchocerca volvulus 0.0226 0.3008 0.9353
Loa Loa (eye worm) hypothetical protein 0.0226 0.3008 0.91
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1452 0.1423
Brugia malayi Nuclear hormone receptor-like 1 0.0119 0.1349 0.4086
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0226 0.3008 0.9109
Loa Loa (eye worm) hypothetical protein 0.0107 0.1151 0.3418
Schistosoma mansoni steroid hormone receptor ad4bp 0.0226 0.3008 0.2985
Schistosoma mansoni hypothetical protein 0.0071 0.0603 0.0571
Brugia malayi nuclear receptor NHR-88 0.0226 0.3008 0.9109
Schistosoma mansoni microtubule-associated protein tau 0.0676 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0279 0.0753
Entamoeba histolytica hypothetical protein 0.0071 0.0603 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.2125 0.2099
Schistosoma mansoni thyroid hormone receptor 0.0226 0.3008 0.2985
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.017 0.0138
Echinococcus multilocularis ecdysone induced protein 78C 0.0226 0.3008 0.2985
Entamoeba histolytica hypothetical protein 0.0071 0.0603 1
Loa Loa (eye worm) DR-78 0.0107 0.1151 0.3418
Schistosoma mansoni hypothetical protein 0.0078 0.0697 0.0667
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0226 0.3008 0.9109
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0226 0.3008 0.2985
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0144 0.0349
Brugia malayi Nuclear hormone receptor-like 1 0.0119 0.1349 0.4086
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2551 0.2526
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1452 0.1423
Schistosoma mansoni chromobox protein 0.007 0.0574 0.0542
Loa Loa (eye worm) hypothetical protein 0.0119 0.1349 0.4026
Leishmania major hypothetical protein, conserved 0.0051 0.0279 1
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.1452 0.4396
Loa Loa (eye worm) hypothetical protein 0.0107 0.1151 0.3418
Brugia malayi conserved hypotetical protein 0.0107 0.1151 0.3484
Brugia malayi nuclear hormone receptor 0.0226 0.3008 0.9109
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0226 0.3008 0.2985
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0226 0.3008 0.2985
Onchocerca volvulus 0.0114 0.1261 0.386
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0033 0.01
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0226 0.3008 0.2985
Trichomonas vaginalis set domain proteins, putative 0.0239 0.3214 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0226 0.3008 0.91
Onchocerca volvulus Protein ultraspiracle homolog 0.0226 0.3008 0.9353
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0279 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0226 0.3008 0.2985
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.1452 0.4339
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0245 0.0213
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.017 0.0432
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0107 0.1151 0.1121
Loa Loa (eye worm) hypothetical protein 0.0078 0.0697 0.2032
Loa Loa (eye worm) hypothetical protein 0.0107 0.1151 0.3418
Brugia malayi Nuclear hormone receptor E75 0.0107 0.1151 0.3484
Loa Loa (eye worm) hypothetical protein 0.0107 0.1151 0.3418
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0245 0.3303 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.2097 0.6312
Entamoeba histolytica hypothetical protein 0.0071 0.0603 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1778 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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