Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glutathione reductase, putative | 0.0422 | 0.4101 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0662 | 0.6785 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0136 | 0.09 | 0.2195 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0055 | 0.0135 |
Brugia malayi | glutathione reductase | 0.0422 | 0.4101 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0136 | 0.09 | 0.2187 |
Treponema pallidum | thioredoxin reductase (trxB) | 0.019 | 0.1508 | 1 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.019 | 0.1508 | 1 |
Chlamydia trachomatis | thioredoxin reductase | 0.019 | 0.1508 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0422 | 0.4101 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0422 | 0.4101 | 1 |
Giardia lamblia | Thioredoxin reductase | 0.019 | 0.1508 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0422 | 0.4101 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0055 | 0.0135 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0422 | 0.4101 | 0.5439 |
Brugia malayi | Thioredoxin reductase | 0.0422 | 0.4101 | 1 |
Leishmania major | trypanothione reductase | 0.0422 | 0.4101 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0136 | 0.09 | 0.2187 |
Mycobacterium ulcerans | thioredoxin reductase TrxB2 | 0.019 | 0.1508 | 1 |
Trichomonas vaginalis | dihydrolipoamide dehydrogenase, putative | 0.019 | 0.1508 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0423 | 0.4116 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0422 | 0.4101 | 1 |
Wolbachia endosymbiont of Brugia malayi | thioredoxin reductase | 0.019 | 0.1508 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0576 | 0.5819 | 0.8359 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0576 | 0.5819 | 0.8359 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0576 | 0.5819 | 0.8359 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0662 | 0.6785 | 1 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.019 | 0.1508 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0576 | 0.5819 | 0.8359 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0662 | 0.6785 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0055 | 0.0135 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0576 | 0.5819 | 0.8359 |
Plasmodium falciparum | glutathione reductase | 0.0422 | 0.4101 | 1 |
Mycobacterium tuberculosis | Probable thioredoxin reductase TrxB2 (TRXR) (TR) | 0.019 | 0.1508 | 0.1033 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0136 | 0.09 | 0.09 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0576 | 0.5819 | 0.8359 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.019 | 0.1508 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0662 | 0.6785 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0055 | 0.0135 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0576 | 0.5819 | 0.817 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0086 | 0.0348 | 0.0848 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0086 | 0.0348 | 0.0848 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.019 | 0.1508 | 1 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.019 | 0.1508 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0422 | 0.4101 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0423 | 0.4116 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0422 | 0.4101 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0422 | 0.4101 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3162 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 75.193 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.