Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0061 | 0.3346 | 0.3346 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.3346 | 0.3346 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.4582 | 0.4582 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.7692 | 0.7692 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.2299 | 0.2299 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.4582 | 0.4582 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.3346 | 0.3346 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0096 | 0.6143 | 0.6143 |
Schistosoma mansoni | tyrosine kinase | 0.0046 | 0.2129 | 0.2129 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3346 | 0.3346 |
Schistosoma mansoni | tyrosine kinase | 0.0046 | 0.2129 | 0.2129 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3346 | 0.3346 |
Echinococcus multilocularis | 0.0045 | 0.2013 | 0.2013 | |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1223 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0078 | 0.4647 | 0.4647 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.2299 | 0.2299 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.4647 | 0.4647 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0046 | 0.2129 | 0.2129 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1223 | 0.1223 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.3346 | 0.3346 |
Echinococcus multilocularis | insulin receptor | 0.0046 | 0.2129 | 0.2129 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1223 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.4582 | 0.4582 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.2299 | 0.2299 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1075 | 0.1075 |
Schistosoma mansoni | tyrosine kinase | 0.0144 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0107 | 0.6971 | 0.6971 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0046 | 0.2129 | 0.2129 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0144 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1075 | 0.1075 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.3346 | 0.3346 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.7692 | 0.7692 |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.2129 | 0.2129 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3346 | 0.3346 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.3346 | 0.3346 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.6231 | 0.6231 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.3346 | 0.3346 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3346 | 0.3346 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0046 | 0.2129 | 0.2129 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1223 | 0.1223 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0107 | 0.6971 | 0.6971 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1223 | 0.1223 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.7692 | 0.7692 |
Echinococcus granulosus | insulin receptor | 0.0046 | 0.2129 | 0.2129 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2299 | 0.2299 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1223 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1223 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0078 | 0.4647 | 0.4647 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1075 | 0.1075 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0144 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.4647 | 0.4647 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1223 | 0.1223 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1223 | 0.1223 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0107 | 0.6971 | 0.6971 |
Brugia malayi | RNA binding protein | 0.0061 | 0.3346 | 0.3346 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3346 | 0.3346 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0078 | 0.4647 | 0.4647 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.