Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.8288 | 0.8262 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0169 | 0.1542 | 0.141 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1542 | 0.1542 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0169 | 0.1542 | 0.5 |
Onchocerca volvulus | 0.0169 | 0.1542 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0169 | 0.1542 | 0.1542 |
Brugia malayi | hypothetical protein | 0.0169 | 0.1542 | 0.1542 |
Echinococcus granulosus | neuroligin | 0.0169 | 0.1542 | 0.141 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1542 | 0.1542 |
Echinococcus multilocularis | acetylcholinesterase | 0.1002 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1002 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0169 | 0.1542 | 0.141 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0154 | 0.0154 |
Brugia malayi | Carboxylesterase family protein | 0.1002 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0154 | 0.0154 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0169 | 0.1542 | 0.141 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0154 | 0.0154 |
Onchocerca volvulus | 0.0169 | 0.1542 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1542 | 0.1542 |
Onchocerca volvulus | 0.0169 | 0.1542 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1542 | 0.1542 |
Brugia malayi | Carboxylesterase family protein | 0.0169 | 0.1542 | 0.1542 |
Echinococcus granulosus | acetylcholinesterase | 0.1002 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1002 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0169 | 0.1542 | 0.141 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1542 | 0.1542 |
Brugia malayi | Carboxylesterase family protein | 0.0169 | 0.1542 | 0.1542 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0169 | 0.1542 | 0.141 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0169 | 0.1542 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0169 | 0.1542 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0169 | 0.1542 | 0.141 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0154 | 0.0154 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.8288 | 0.8262 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0169 | 0.1542 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1002 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1542 | 0.1542 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0169 | 0.1542 | 0.141 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.1542 | 0.1542 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0148 | 0.0148 |
Loa Loa (eye worm) | carboxylesterase | 0.0169 | 0.1542 | 0.1542 |
Echinococcus granulosus | carboxylesterase 5A | 0.1002 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0169 | 0.1542 | 0.141 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1002 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0169 | 0.1542 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0169 | 0.1542 | 0.1542 |
Echinococcus multilocularis | neuroligin | 0.0169 | 0.1542 | 0.141 |
Onchocerca volvulus | 0.0169 | 0.1542 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0169 | 0.1542 | 0.141 |
Brugia malayi | Carboxylesterase family protein | 0.0169 | 0.1542 | 0.1542 |
Onchocerca volvulus | 0.0169 | 0.1542 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0169 | 0.1542 | 0.141 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1002 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0169 | 0.1542 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1002 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1002 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0169 | 0.1542 | 0.141 |
Schistosoma mansoni | acetylcholinesterase | 0.0169 | 0.1542 | 0.141 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0169 | 0.1542 | 0.141 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0154 | 0.0154 |
Echinococcus granulosus | acetylcholinesterase | 0.1002 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.8288 | 0.8262 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.0787 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.