Detailed information for compound 1395781

Basic information

Technical information
  • TDR Targets ID: 1395781
  • Name: 1-(2-diethylaminoethylamino)-3-methylpyrido[1 ,2-a]benzimidazole-4-carbonitrile
  • MW: 321.419 | Formula: C19H23N5
  • H donors: 1 H acceptors: 2 LogP: 4.36 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNc1cc(C)c(c2n1c1ccccc1n2)C#N)CC
  • InChi: 1S/C19H23N5/c1-4-23(5-2)11-10-21-18-12-14(3)15(13-20)19-22-16-8-6-7-9-17(16)24(18)19/h6-9,12,21H,4-5,10-11H2,1-3H3
  • InChiKey: MIKCSNKEGXOTPE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(2-diethylaminoethylamino)-3-methyl-pyrido[1,2-a]benzimidazole-4-carbonitrile
  • 1-(2-diethylaminoethylamino)-3-methyl-4-pyrido[1,2-a]benzimidazolecarbonitrile
  • AG-205/33671059
  • Oprea1_331181
  • Oprea1_231293
  • BAS 01047493
  • STOCK4S-82866
  • Benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile, 1-(2-diethylaminoethylamino)-3-methyl-
  • 1-{[2-(diethylamino)ethyl]amino}-3-methylpyrido[1,2-a]benzimidazole-4-carbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0066 0.1588 0.1537
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.065 0.065
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0024
Plasmodium falciparum heat shock protein 90, putative 0.0168 0.4697 1
Echinococcus granulosus heat shock protein 90 0.0047 0.1031 0.0977
Schistosoma mansoni endoplasmin 0.0047 0.1031 0.1031
Schistosoma mansoni RAR-like nuclear receptor 0.0066 0.1588 0.1588
Toxoplasma gondii exonuclease III APE 0.002 0.0197 0.0294
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0197 0.0294
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0017
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0066 0.1588 0.1537
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0985 0.1995
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0026 0.0397 0.0462
Echinococcus multilocularis heat shock protein 90 0.0047 0.1031 0.0977
Loa Loa (eye worm) hypothetical protein 0.0035 0.065 0.0625
Trypanosoma brucei heat shock protein, putative 0.0047 0.1031 0.1331
Loa Loa (eye worm) hypothetical protein 0.0035 0.0649 0.0624
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0197 0.0132
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0985 0.093
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0078 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0066 0.1588 0.1537
Brugia malayi Steroid receptor seven-up type 2 0.0066 0.1588 0.1537
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0576 0.0519
Trypanosoma brucei trypanothione reductase 0.0046 0.0985 0.1268
Entamoeba histolytica DNA topoisomerase II, putative 0.0073 0.1804 0.7391
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.1031 0.3838
Brugia malayi Synaptic glycoprotein SC2 0.0046 0.1 0.0945
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.086 0.0911
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0337 0.0379
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0078
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0046 0.1 0.1288
Schistosoma mansoni ap endonuclease 0.002 0.0197 0.0197
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0026 0.0397 0.0462
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0046 0.1 0.3693
Leishmania major cytochrome P450 reductase, putative 0.0023 0.0306 0.0337
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0046 0.1 0.0945
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.3118 0.3484
Loa Loa (eye worm) hypothetical protein 0.0035 0.065 0.0625
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0035 0.065 0.0635
Trichomonas vaginalis heat shock protein, putative 0.0047 0.1031 0.1059
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.1 0.1288
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0337 0.0379
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0029 0.0491 0.0433
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0342 1 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0058 0.1365 0.1312
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5818 0.6377
Echinococcus multilocularis methionine synthase reductase 0.0016 0.0091 0.0031
Echinococcus granulosus FTZ F1 alpha 0.0066 0.1588 0.1537
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0066 0.1588 0.1537
Schistosoma mansoni ap endonuclease 0.002 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0511
Toxoplasma gondii heat shock protein HSP90 0.0047 0.1031 0.2094
Brugia malayi MH2 domain containing protein 0.0115 0.3103 0.3061
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.1031 0.1331
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0066 0.1588 0.1537
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.086 0.1096
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.6153 0.675
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0078 0.0024
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0058 0.1365 0.1312
Echinococcus multilocularis carbonic anhydrase 0.0058 0.1365 0.1312
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0078 0.0024
Echinococcus multilocularis para nitrobenzyl esterase 0.0035 0.065 0.0593
Brugia malayi hypothetical protein 0.0024 0.0337 0.0278
Loa Loa (eye worm) hypothetical protein 0.007 0.1713 0.1691
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0058 0.1365 0.1312
Echinococcus multilocularis carbonic anhydrase II 0.0255 0.7353 0.7337
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0576 0.0519
Trypanosoma brucei heat shock protein, putative 0.0047 0.1031 0.1331
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0026 0.0397 0.0462
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0337 0.0596
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.3118 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.065 0.0625
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0066 0.1588 0.1537
Brugia malayi Carboxylesterase family protein 0.0035 0.065 0.0593
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.3118 0.3484
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0649 0.0592
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0536 0.0478
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0029 0.0491 0.0433
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0026 0.0397 0.0462
Brugia malayi Thioredoxin reductase 0.0046 0.0985 0.093
Toxoplasma gondii DNA topoisomerase 2, putative 0.0073 0.1804 0.376
Brugia malayi FAD binding domain containing protein 0.0016 0.0091 0.0031
Loa Loa (eye worm) hypothetical protein 0.0066 0.1588 0.1566
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0302 0.0249
Loa Loa (eye worm) hypothetical protein 0.0035 0.065 0.0625
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0078 0.0024
Onchocerca volvulus 0.0035 0.065 0.0281
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Schistosoma mansoni gliotactin 0.0035 0.065 0.065
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0046 0.1 0.1024
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0031 0.0536 0.0478
Loa Loa (eye worm) heat shock protein 75 0.0029 0.0491 0.0465
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0066 0.1588 0.1537
Schistosoma mansoni coup transcription factor 0.0066 0.1588 0.1588
Loa Loa (eye worm) hypothetical protein 0.0044 0.0947 0.0923
Schistosoma mansoni DNA topoisomerase II 0.0073 0.1804 0.1804
Schistosoma mansoni hypothetical protein 0.0342 0.9984 0.9984
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0748 0.0692
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0026 0.0397 0.0462
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0066 0.1588 0.1943
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0058 0.1365 0.1342
Loa Loa (eye worm) hypothetical protein 0.0046 0.1 0.0976
Plasmodium falciparum endoplasmin, putative 0.0035 0.0662 0.1298
Trypanosoma brucei heat shock protein, putative 0.0047 0.1031 0.1331
Plasmodium vivax heat shock protein 86, putative 0.0047 0.1031 0.2094
Schistosoma mansoni thyroid hormone receptor 0.0189 0.535 0.535
Schistosoma mansoni heat shock protein 0.0047 0.1031 0.1031
Onchocerca volvulus 0.0035 0.065 0.0281
Plasmodium vivax DNA topoisomerase II, putative 0.0073 0.1804 0.376
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.2371 0.3168
Echinococcus multilocularis thyroid hormone receptor alpha 0.0189 0.535 0.5322
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.1 0.1024
Trypanosoma cruzi Heat shock protein 83, putative 0.0047 0.1031 0.1331
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.9078 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.065 0.0671
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0066 0.1588 0.1566
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0066 0.1588 0.1566
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0536 0.0478
Brugia malayi tailless protein 0.0031 0.0536 0.0478
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.1 0.1024
Plasmodium falciparum thioredoxin reductase 0.0016 0.0078 0.0037
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0023 0.0306 0.0254
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0197 0.1524
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.1 0.1288
Loa Loa (eye worm) glutathione reductase 0.0046 0.0985 0.0961
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5818 0.6377
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0511
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0255 0.7353 0.7337
Brugia malayi nuclear hormone receptor family member odr-7 0.0031 0.0536 0.0478
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.1031 0.4158
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.086 1
Echinococcus multilocularis carboxylesterase 5A 0.0035 0.065 0.0593
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1093 0.1093
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.1 0.1288
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0066 0.1588 0.1588
Plasmodium vivax endoplasmin, putative 0.0047 0.1031 0.2094
Chlamydia trachomatis DNA gyrase subunit B 0.0042 0.0883 1
Echinococcus granulosus carbonic anhydrase 0.0058 0.1365 0.1312
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0337 0.0596
Loa Loa (eye worm) hypothetical protein 0.0066 0.1588 0.1566
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0054 0.125 0.1345
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0511
Echinococcus granulosus acetylcholinesterase 0.0035 0.065 0.0593
Brugia malayi glutathione reductase 0.0046 0.0985 0.093
Trypanosoma brucei Heat shock protein 83, putative 0.0047 0.1031 0.1331
Trichomonas vaginalis spcc417.12 protein, putative 0.0035 0.065 0.0635
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0536 0.0478
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0197 0.0187
Schistosoma mansoni heat shock protein 0.0047 0.1031 0.1031
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.3103 0.3085
Brugia malayi nuclear receptor NHR-67 0.0031 0.0536 0.0478
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0031 0.0536 0.0478
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0066 0.1588 0.1537
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0511
Brugia malayi photoreceptor-specific nuclear receptor 0.0066 0.1588 0.1537
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0024
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0255 0.7353 0.7346
Loa Loa (eye worm) acetylcholinesterase 1 0.0035 0.065 0.0625
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0302 0.0243
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0078 0.0024
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0058 0.1374 0.1801
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0255 0.7353 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0511
Echinococcus granulosus neuroligin 0.0035 0.065 0.0593
Echinococcus granulosus BC026374 protein S09 family 0.0035 0.065 0.0593
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0066 0.1588 0.1537
Giardia lamblia Nitric oxide synthase, inducible 0.0023 0.0306 0.0997
Brugia malayi flavodoxin family protein 0.0026 0.0397 0.0339
Brugia malayi nuclear receptor NHR-88 0.0031 0.0536 0.0478
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0985 0.1054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1093 0.1039
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0066 0.1588 0.1537
Mycobacterium ulcerans DNA gyrase subunit B 0.0028 0.0453 0.0429
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0046 0.1 0.3693
Loa Loa (eye worm) nuclear hormone receptor 0.0031 0.0536 0.0511
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0576 0.0519
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Leishmania major trypanothione reductase 0.0046 0.0985 0.1268
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.2765 0.3081
Leishmania major heat shock protein, putative 0.0029 0.0491 0.059
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0026 0.0397 0.0339
Schistosoma mansoni hypothetical protein 0.0058 0.1365 0.1365
Loa Loa (eye worm) nuclear receptor NHR-67 0.0031 0.0536 0.0511
Loa Loa (eye worm) DR-78 0.0031 0.0536 0.0511
Toxoplasma gondii thioredoxin reductase 0.0046 0.0985 0.1995
Echinococcus granulosus carbonic anhydrase 0.0058 0.1365 0.1312
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0066 0.1588 0.1537
Plasmodium falciparum carbonic anhydrase 0.0058 0.1365 0.2813
Loa Loa (eye worm) hypothetical protein 0.0066 0.1588 0.1566
Giardia lamblia DNA topoisomerase II 0.0063 0.152 0.6291
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.2692 0.2648
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0035 0.0649 0.0592
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0576 0.0519
Brugia malayi hypothetical protein 0.0031 0.0536 0.0478
Echinococcus multilocularis synaptic glycoprotein sc2 0.0046 0.1 0.0945
Echinococcus granulosus heat shock protein 90 0.0038 0.0748 0.0692
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.2371 0.2371
Giardia lamblia Grp94/Hsp90 0.0042 0.086 0.341
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0066 0.1588 0.1588
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5818 0.6377
Brugia malayi ecdysteroid receptor 0.0215 0.614 0.6117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0066 0.1588 0.1566
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0066 0.1588 0.1566
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0066 0.1588 0.1588
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0197 0.0187
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0748 0.0745
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0255 0.7353 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0985 0.093
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0985 0.0961
Giardia lamblia Synaptic glycoprotein SC2 0.0046 0.1 0.4021
Schistosoma mansoni hypothetical protein 0.0032 0.0576 0.0576
Chlamydia trachomatis sulfite reductase 0.0016 0.0091 0.0166
Brugia malayi conserved hypotetical protein 0.0031 0.0536 0.0478
Mycobacterium ulcerans hypothetical protein 0.0046 0.1 0.1053
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0073 0.1804 0.1754
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0066 0.1588 0.1566
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0066 0.1601 0.2113
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.1031 0.1331
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0255 0.7353 0.7353
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0078 0.0017
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0197 0.0187
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0058 0.1374 0.1801
Echinococcus granulosus carboxylesterase 5A 0.0035 0.065 0.0593
Schistosoma mansoni endoplasmin 0.0047 0.1031 0.1031
Brugia malayi Carboxylesterase family protein 0.0035 0.065 0.0593
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0058 0.1365 0.1312
Trypanosoma brucei heat shock protein, putative 0.0047 0.1031 0.1331
Brugia malayi nuclear hormone receptor 0.0066 0.1588 0.1537
Loa Loa (eye worm) hypothetical protein 0.0046 0.1 0.0976
Schistosoma mansoni BC026374 protein (S09 family) 0.0035 0.065 0.065
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0197 0.0137
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0046 0.1 0.1
Onchocerca volvulus Bile acid receptor homolog 0.0215 0.614 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.065 0.0625
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.5818 0.9429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0066 0.1588 0.1566
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0536 0.0478
Brugia malayi hypothetical protein 0.0035 0.0649 0.0592
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Loa Loa (eye worm) hypothetical protein 0.0044 0.0947 0.0923
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0031 0.0536 0.0536
Brugia malayi Probable DNA topoisomerase II 0.0073 0.1804 0.1754
Brugia malayi Carboxylesterase family protein 0.0035 0.065 0.0593
Schistosoma mansoni zinc finger protein 0.0031 0.0536 0.0536
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0066 0.1588 0.1537
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0066 0.1588 0.1537
Brugia malayi orphan nuclear receptor NR2E1 0.0031 0.0536 0.0478
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0511
Echinococcus multilocularis ecdysone induced protein 78C 0.0066 0.1588 0.1537
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0066 0.1588 0.1537
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0035 0.0649 0.0624
Echinococcus multilocularis nuclear receptor nhr 48 0.0031 0.0536 0.0478
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0511
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.3359 0.3318
Plasmodium falciparum thioredoxin reductase 0.0046 0.0985 0.1995
Brugia malayi hypothetical protein 0.0035 0.0649 0.0592
Trypanosoma brucei carbonic anhydrase-like protein 0.0255 0.7353 1
Plasmodium vivax DNA gyrase subunit B, putative 0.0028 0.0453 0.0847
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0078 0.0024
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0078 0.002
Schistosoma mansoni heat shock protein 0.0029 0.0491 0.0491
Trichomonas vaginalis sulfite reductase, putative 0.0026 0.0397 0.0355
Loa Loa (eye worm) hypothetical protein 0.0035 0.065 0.0625
Schistosoma mansoni hypothetical protein 0.0342 0.9984 0.9984
Loa Loa (eye worm) FAD binding domain-containing protein 0.0016 0.0091 0.0065
Schistosoma mansoni nuclear receptor nhr-48 0.0031 0.0536 0.0536
Schistosoma mansoni hypothetical protein 0.0035 0.0653 0.0653
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.9078 0.9076
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.065 0.0671
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.3103 0.3085
Plasmodium falciparum polyprenol reductase, putative 0.0046 0.1 0.2026
Echinococcus multilocularis acetylcholinesterase 0.0035 0.065 0.0593
Plasmodium falciparum DNA gyrase subunit B 0.0028 0.0453 0.0847
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0379 0.0335
Onchocerca volvulus Protein ultraspiracle homolog 0.0066 0.1588 0.1943
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0748 0.0943
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0197 0.0136
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0197 0.0187
Onchocerca volvulus 0.0035 0.065 0.0281
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.3359 0.3318
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0073 0.0027
Loa Loa (eye worm) hypothetical protein 0.0058 0.1365 0.1342
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0078 0.0037
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.1031 0.1331
Loa Loa (eye worm) hypothetical protein 0.0035 0.065 0.0625
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0066 0.1588 0.1537
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0026 0.0397 0.0462
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0029 0.0491 0.1351
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0653 0.0596
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0066 0.1588 0.1588
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0249 0.0258
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0026 0.0397 0.0339
Loa Loa (eye worm) carboxylesterase 0.0035 0.065 0.0625
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0255 0.7353 0.7337
Echinococcus granulosus thyroid hormone receptor alpha 0.0031 0.0536 0.0478
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0337 0.0379
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0536 0.0081
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.3118 0.3484
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0536 0.0478
Trypanosoma cruzi heat shock protein, putative 0.0029 0.0491 0.059
Trichomonas vaginalis heat shock protein, putative 0.0042 0.086 0.0869
Loa Loa (eye worm) carboxylesterase 0.0035 0.065 0.0625
Trichomonas vaginalis heat shock protein, putative 0.0042 0.086 0.0869
Brugia malayi Nuclear hormone receptor-like 1 0.0066 0.1588 0.1537
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0337 0.0596
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5818 0.6377
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0748 0.0943
Echinococcus multilocularis acetylcholinesterase 0.0035 0.065 0.0593
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0536 0.0536
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0046 0.1 0.2026
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5818 0.6377
Echinococcus granulosus carbonic anhydrase 0.0058 0.1365 0.1312
Trypanosoma brucei heat shock protein, putative 0.0047 0.1031 0.1331
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0197 0.0294
Schistosoma mansoni nuclear receptor 0.0031 0.0536 0.0536
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0031 0.0536 0.0536
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0016 0.0091 0.0091
Plasmodium vivax polyprenol reductase, putative 0.0046 0.1 0.2026
Brugia malayi steroid hormone receptor 0.0066 0.1588 0.1537
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0066 0.1588 0.1537
Schistosoma mansoni carbonic anhydrase-related 0.0058 0.1365 0.1365
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0028 0.0453 0.0847
Loa Loa (eye worm) hypothetical protein 0.0026 0.0397 0.0372
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.2765 0.3081
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0216 0.0335
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1093 0.1039
Brugia malayi nuclear receptor RXR 0.0031 0.0536 0.0478
Loa Loa (eye worm) hypothetical protein 0.0035 0.0649 0.0624
Brugia malayi heat shock protein 90 0.0047 0.1031 0.0977
Plasmodium vivax heat shock protein 90, putative 0.0029 0.0491 0.0928
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.2692 0.2673
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0028 0.0453 0.0447
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.2371 0.2548
Treponema pallidum heat shock protein 90 0.0042 0.086 1
Entamoeba histolytica hypothetical protein 0.0035 0.0653 0.2099
Onchocerca volvulus 0.0031 0.0536 0.0081
Echinococcus granulosus synaptic glycoprotein sc2 0.0046 0.1 0.0945
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.9078 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0066 0.1588 0.1537
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5818 0.6377
Brugia malayi Carboxylesterase family protein 0.0035 0.065 0.0593
Loa Loa (eye worm) RecQ helicase 0.0023 0.0302 0.0276
Loa Loa (eye worm) hypothetical protein 0.0102 0.2692 0.2673
Leishmania major DNA topoisomerase ii 0.0066 0.1601 0.2113
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0078 0.0037
Brugia malayi Endoplasmin precursor 0.0047 0.1031 0.0977
Schistosoma mansoni hypothetical protein 0.007 0.1713 0.1713
Entamoeba histolytica hypothetical protein 0.0035 0.0653 0.2099
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0024
Trypanosoma brucei heat shock protein 84, putative 0.0029 0.0491 0.059
Echinococcus multilocularis GPCR, family 2 0.0032 0.0576 0.0519
Echinococcus multilocularis heat shock protein 90 0.0038 0.0748 0.0692
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0054 0.125 0.1345
Mycobacterium ulcerans carboxylesterase, LipT 0.0304 0.8837 1
Trypanosoma cruzi p450 reductase, putative 0.0026 0.0397 0.0462
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.9078 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0066 0.1588 0.1537
Schistosoma mansoni hypothetical protein 0.0032 0.0576 0.0576
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.1031 0.1331
Leishmania major hypothetical protein, conserved 0.0024 0.0337 0.0379
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0026 0.0397 0.0339
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0302 0.0243
Onchocerca volvulus 0.0035 0.065 0.0281
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0046 0.1 0.0945
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.2371 0.3168
Loa Loa (eye worm) hypothetical protein 0.0035 0.065 0.0625
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0024
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0046 0.1 0.2026
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0748 0.2922
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.2371 0.2351
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0046 0.1 0.3693
Toxoplasma gondii heat shock protein 75, putative 0.0029 0.0491 0.0928
Echinococcus granulosus GPCR family 2 0.0032 0.0576 0.0519
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0028 0.0453 0.4802
Schistosoma mansoni nuclear hormone receptor 0.0066 0.1588 0.1588
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0066 0.1588 0.1537
Loa Loa (eye worm) hypothetical protein 0.0117 0.3146 0.3127
Trypanosoma brucei heat shock protein, putative 0.0047 0.1031 0.1331
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0197 0.0155
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1093 0.1039
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1713 0.1662
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0302 0.0249
Loa Loa (eye worm) hypothetical protein 0.0066 0.1588 0.1566
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0078 0.0037
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.2371 0.2324
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.1 0.1024
Echinococcus granulosus para nitrobenzyl esterase 0.0035 0.065 0.0593
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0066 0.1588 0.1566
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0511
Loa Loa (eye worm) hypothetical protein 0.0058 0.1365 0.1342
Onchocerca volvulus 0.0046 0.1 0.0901
Schistosoma mansoni carbonic anhydrase 0.0058 0.1365 0.1365
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0046 0.1 0.1288
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0576 0.0551
Loa Loa (eye worm) hypothetical protein 0.0035 0.0649 0.0624
Mycobacterium tuberculosis Probable reductase 0.0104 0.2765 0.3081
Echinococcus multilocularis BC026374 protein (S09 family) 0.0035 0.065 0.0593
Giardia lamblia Hypothetical protein 0.0023 0.0306 0.0997
Loa Loa (eye worm) FAD binding domain-containing protein 0.0026 0.0397 0.0372
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.9078 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.065 0.065
Schistosoma mansoni carbonic anhydrase-related 0.0058 0.1365 0.1365
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0026 0.0397 0.0462
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0255 0.7353 0.7353
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0066 0.1588 0.1537
Entamoeba histolytica hypothetical protein 0.0035 0.0653 0.2099
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.1 0.1024
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.2692 0.2648
Plasmodium vivax flavodoxin domain containing protein 0.0023 0.0306 0.053
Brugia malayi Carboxylesterase family protein 0.0035 0.065 0.0593
Chlamydia trachomatis DNA gyrase subunit B 0.0028 0.0453 0.4661
Loa Loa (eye worm) hypothetical protein 0.0036 0.0681 0.0656
Loa Loa (eye worm) hypothetical protein 0.0024 0.0337 0.0311
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0046 0.1 0.2026
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0197 0.0132
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0026 0.0397 0.0339
Brugia malayi hypothetical protein 0.0035 0.065 0.0593
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0035 0.065 0.0593
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.1031 0.1331
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0197 0.0137
Plasmodium vivax heat shock protein, putative 0.0168 0.4697 1
Trichomonas vaginalis endoplasmin, putative 0.0035 0.0662 0.0649
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.2765 0.3081
Loa Loa (eye worm) hypothetical protein 0.0036 0.0681 0.0656
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.2371 0.3328
Mycobacterium tuberculosis Carboxylesterase LipT 0.0304 0.8837 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0035 0.065 0.0593
Schistosoma mansoni neuroligin 3 (S09 family) 0.0035 0.065 0.065
Echinococcus granulosus acetylcholinesterase 0.0035 0.065 0.0593
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0035 0.0649 0.0649
Plasmodium falciparum glutathione reductase 0.0016 0.0078 0.0037
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0026 0.0397 0.0462
Brugia malayi nuclear hormone receptor 0.0031 0.0536 0.0478
Onchocerca volvulus 0.0035 0.065 0.0281
Schistosoma mansoni cytochrome P450 reductase 0.0026 0.0397 0.0397
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0054 0.125 0.1345
Trypanosoma brucei polo-like protein kinase 0.0091 0.2371 0.3168
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0536 0.0478
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0342 1 1
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0046 0.1 0.1024
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Brugia malayi nuclear receptor NHR-88 0.0066 0.1588 0.1537
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.1 0.2026
Loa Loa (eye worm) hypothetical protein 0.0046 0.1 0.0976
Toxoplasma gondii hypothetical protein 0.0058 0.1365 0.2813
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.1 0.2026
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0197 0.0137
Brugia malayi Carboxylesterase family protein 0.0035 0.065 0.0593
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.097 0.0991
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0337 0.0596
Schistosoma mansoni carbonic anhydrase-related 0.0058 0.1365 0.1365
Loa Loa (eye worm) hypothetical protein 0.0066 0.1588 0.1566
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0342 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0068 0.0015
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0046 0.1 0.0945
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.6153 0.675
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0031 0.0536 0.0511
Schistosoma mansoni hypothetical protein 0.0032 0.0576 0.0576
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0066 0.1588 0.1537
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0078 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0066 0.1588 0.1537
Echinococcus multilocularis endoplasmin 0.0042 0.086 0.0804
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0024
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0576 0.0519
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0197 0.052
Loa Loa (eye worm) steroid hormone receptor 0.0066 0.1588 0.1566
Brugia malayi nuclear receptor RXR 0.0035 0.0649 0.0592
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.2371 0.2548
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0662 0.0649
Schistosoma mansoni steroid hormone receptor ad4bp 0.0066 0.1588 0.1588
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0536 0.0478
Echinococcus granulosus nuclear receptor nhr 48 0.0031 0.0536 0.0478
Loa Loa (eye worm) heat shock protein 90 0.0047 0.1031 0.1007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0653 0.0596
Leishmania major carbonic anhydrase-like protein 0.0255 0.7353 1
Leishmania major mitochondrial DNA topoisomerase II 0.0058 0.1374 0.1801
Trypanosoma brucei heat shock protein, putative 0.0047 0.1031 0.1331
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.1031 0.1331
Brugia malayi ecdysone receptor 0.0031 0.0536 0.0478
Loa Loa (eye worm) hypothetical protein 0.0215 0.614 0.613
Onchocerca volvulus 0.0066 0.1588 0.1943
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0066 0.1588 0.1537
Brugia malayi FAD binding domain containing protein 0.0026 0.0397 0.0339
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0653 0.0653
Entamoeba histolytica hypothetical protein 0.0046 0.1 0.3693
Echinococcus multilocularis carbonic anhydrase 0.0058 0.1365 0.1312
Leishmania major p450 reductase, putative 0.0026 0.0397 0.0462
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0536 0.0536
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.097 0.0991
Echinococcus multilocularis geminin 0.0342 0.9984 0.9983
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0066 0.1588 0.1588
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0536 0.0081
Echinococcus multilocularis FTZ F1 alpha 0.0066 0.1588 0.1537
Onchocerca volvulus 0.0031 0.0536 0.0081
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0073 0.1804 0.1754
Brugia malayi hypothetical protein 0.0016 0.0074 0.0014
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0035 0.0649 0.0592
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0078 0.0024
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.1031 0.3838
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.065 0.065
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0379 0.0686
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.2371 0.2548
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.1 0.1288
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.2765 0.8435
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.2371 0.3168
Loa Loa (eye worm) hypothetical protein 0.0066 0.1588 0.1566
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0649 0.0592
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.006 0.006
Plasmodium falciparum DNA topoisomerase 2 0.0073 0.1804 0.376
Schistosoma mansoni retinoic acid receptor RXR 0.0066 0.1588 0.1588
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0511
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.9078 1
Brugia malayi hypothetical protein 0.0031 0.0536 0.0478
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0066 0.1601 0.2113
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.2371 0.2548
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0031 0.0536 0.0478
Echinococcus granulosus carbonic anhydrase II 0.0255 0.7353 0.7337
Trypanosoma cruzi DNA topoisomerase II, putative 0.0066 0.1601 0.2113
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0511
Schistosoma mansoni hypothetical protein 0.0124 0.3359 0.3359
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0342 1 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.2371 0.2324
Echinococcus multilocularis carbonic anhydrase 0.0058 0.1365 0.1312
Loa Loa (eye worm) hypothetical protein 0.0058 0.1365 0.1342
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.9078 0.9073
Brugia malayi Hsp90 protein 0.0029 0.0491 0.0433
Brugia malayi hypothetical protein 0.0035 0.0653 0.0596
Echinococcus granulosus heat shock protein 0.0047 0.1031 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.1 0.1024
Schistosoma mansoni nuclear receptor 0.0031 0.0536 0.0536
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0073 0.1804 0.1754
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0017
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0058 0.1365 0.1312
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.2371 0.2548
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0066 0.1588 0.1537
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.2371 0.2324
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0026 0.0397 0.0727
Echinococcus multilocularis neuroligin 0.0035 0.065 0.0593
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0536 0.0478
Plasmodium vivax glutathione reductase, putative 0.0046 0.0985 0.1995
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.2765 0.3081
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0046 0.1 0.1024
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0046 0.1 0.1024
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.065 0.065
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0066 0.1588 0.1588
Echinococcus granulosus methionine synthase reductase 0.0016 0.0091 0.0031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0649 0.0624
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0046 0.1 0.1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0576 0.0519
Echinococcus multilocularis heat shock protein 0.0047 0.1031 0.0977
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0197 0.1524
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0028 0.0453 0.4802
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.5818 0.6377
Loa Loa (eye worm) hypothetical protein 0.0035 0.0649 0.0624
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.2765 0.3081
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0073 0.1804 0.1754
Loa Loa (eye worm) endoplasmin 0.0047 0.1031 0.1007
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Giardia lamblia Kinase, PLK 0.0091 0.2371 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0078 0.0037
Leishmania major heat shock protein 83-1 0.0047 0.1031 0.1331
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.2371 1
Schistosoma mansoni kinase 0.0046 0.1007 0.1007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1093 0.1039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0649 0.0649
Entamoeba histolytica hypothetical protein 0.0035 0.0653 0.2099
Echinococcus granulosus bloom syndrome protein 0.0023 0.0302 0.0243
Echinococcus granulosus ecdysone induced protein 78C 0.0066 0.1588 0.1537
Echinococcus granulosus endoplasmin 0.0042 0.086 0.0804
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.2371 0.2548
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0024
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0026 0.0397 0.0365
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.2371 0.2548
Trypanosoma brucei DNA topoisomerase ii 0.0058 0.1374 0.1801
Plasmodium falciparum nitric oxide synthase, putative 0.0026 0.0397 0.0727
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1093 0.1093
Loa Loa (eye worm) hypothetical protein 0.0035 0.065 0.0625
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0078 0.0037
Loa Loa (eye worm) carbonic anhydrase 3 0.0255 0.7353 0.7346
Mycobacterium ulcerans heat shock protein 90 0.0042 0.086 0.0893
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1093 0.1039
Brugia malayi nuclear hormone receptor family member nhr-6 0.0031 0.0536 0.0478
Plasmodium falciparum heat shock protein 90 0.0047 0.1031 0.2094
Schistosoma mansoni thyroid hormone receptor 0.0189 0.535 0.535
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0066 0.1588 0.1537
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0197 0.0171
Trypanosoma brucei heat shock protein, putative 0.0047 0.1031 0.1331
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0024
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.006 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0066 0.1588 0.1537
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.9078 1
Trichomonas vaginalis DNA topoisomerase II, putative 0.0073 0.1804 0.1918
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0511
Loa Loa (eye worm) carboxylesterase 0.0035 0.065 0.0625
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0031 0.0536 0.0478
Schistosoma mansoni acetylcholinesterase 0.0035 0.065 0.065
Loa Loa (eye worm) TOPoisomerase family member 0.0073 0.1804 0.1782
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0985 0.1268
Schistosoma mansoni hypothetical protein 0.0032 0.0576 0.0576
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1093 0.1093
Echinococcus granulosus geminin 0.0342 0.9984 0.9983
Loa Loa (eye worm) hypothetical protein 0.0032 0.0576 0.0551
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0024
Toxoplasma gondii heat shock protein 90, putative 0.0047 0.1031 0.2094
Loa Loa (eye worm) hypothetical protein 0.0066 0.1588 0.1566
Plasmodium falciparum glutathione reductase 0.0046 0.0985 0.1995
Toxoplasma gondii Hsp90 domain-containing protein 0.0168 0.4697 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0066 0.1601 0.2113
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1093 0.107

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.