Detailed information for compound 1395816

Basic information

Technical information
  • TDR Targets ID: 1395816
  • Name: N-[4-(methoxymethyl)-2-oxochromen-7-yl]-4-met hylbenzenesulfonamide
  • MW: 359.396 | Formula: C18H17NO5S
  • H donors: 1 H acceptors: 3 LogP: 2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1cc(=O)oc2c1ccc(c2)NS(=O)(=O)c1ccc(cc1)C
  • InChi: 1S/C18H17NO5S/c1-12-3-6-15(7-4-12)25(21,22)19-14-5-8-16-13(11-23-2)9-18(20)24-17(16)10-14/h3-10,19H,11H2,1-2H3
  • InChiKey: OBEUUKBLPWLARH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-(methoxymethyl)-2-oxo-chromen-7-yl]-4-methyl-benzenesulfonamide
  • N-[4-(methoxymethyl)-2-oxo-7-chromenyl]-4-methylbenzenesulfonamide
  • N-[2-keto-4-(methoxymethyl)chromen-7-yl]-4-methyl-benzenesulfonamide
  • Maybridge3_005360
  • RJF 01162
  • MLS000850758
  • N1-[4-(methoxymethyl)-2-oxo-2H-chromen-7-yl]-4-methylbenzene-1-sulfonamide
  • SMR000456775
  • ZINC01044779

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus expressed protein 0.001 0.0181 0.019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.4055 0.4055
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.9545 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0788 0.0788
Brugia malayi Bromodomain containing protein 0.0095 0.5137 0.5137
Echinococcus multilocularis expressed protein 0.001 0.0181 0.0181
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.001 0.0181 0.5
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.1176 0.1232
Echinococcus multilocularis bloom syndrome protein 0.0029 0.1279 0.1279
Schistosoma mansoni ferritin 0.001 0.0181 0.0181
Trichomonas vaginalis ferritin, putative 0.001 0.0181 0.0655
Loa Loa (eye worm) hypothetical protein 0.0053 0.2714 0.2714
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.2763 1
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.0181 0.5
Trypanosoma cruzi ISWI complex protein 0.0018 0.0663 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.1176 0.1176
Schistosoma mansoni zinc finger protein 0.0028 0.1217 0.1217
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0788 0.0825
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.0181 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.2295 0.2295
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.2345 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0788 0.0788
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0008 0.0036 0.0131
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0282 0.1204
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0788 0.0825
Schistosoma mansoni ferritin 0.001 0.0181 0.0181
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.1176 0.1176
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.2763 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.2126 0.2126
Entamoeba histolytica hypothetical protein 0.0043 0.2126 0.8821
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.1279 0.4629
Brugia malayi Bromodomain containing protein 0.0051 0.2541 0.2541
Mycobacterium ulcerans bacterioferritin BfrA 0.001 0.0181 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.2126 0.8821
Schistosoma mansoni zinc finger protein 0.0018 0.0663 0.0663
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0146 0.8128 0.8128
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.2123 0.2123
Schistosoma mansoni ferritin light chain 0.001 0.0181 0.0181
Schistosoma mansoni ferritin 0.001 0.0181 0.0181
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.4055 0.4248
Echinococcus granulosus zinc finger protein 0.0028 0.1217 0.1275
Schistosoma mansoni hypothetical protein 0.0043 0.2126 0.2126
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0788 0.0788
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.2123 0.2224
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0008 0.0036 0.0131
Entamoeba histolytica hypothetical protein 0.0043 0.2126 0.8821
Schistosoma mansoni ferritin 0.001 0.0181 0.0181
Leishmania major hypothetical protein, conserved 0.0018 0.0663 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0282 0.0296
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0282 0.0296
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.2345 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.4583 0.4583
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0716 0.259
Schistosoma mansoni DNA helicase recq5 0.0012 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0056 0.2849 0.2849
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0282 0.0282
Echinococcus granulosus bloom syndrome protein 0.0029 0.1279 0.134
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0282 0.1021
Schistosoma mansoni ferritin light chain 0.001 0.0181 0.0181
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.2126 0.2227
Brugia malayi PHD-finger family protein 0.0034 0.1594 0.1594
Schistosoma mansoni DNA helicase recq1 0.0012 0.0282 0.0282
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.2763 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0282 0.0282
Loa Loa (eye worm) RecQ helicase 0.0029 0.1279 0.1279
Treponema pallidum bacterioferrin (TpF1) 0.001 0.0181 0.5
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.1279 0.4629
Schistosoma mansoni bromodomain containing protein 0.0009 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0021 0.0788 0.0788
Trypanosoma cruzi ISWI complex protein 0.0018 0.0663 1
Schistosoma mansoni hypothetical protein 0.0025 0.1041 0.1041
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0282 0.0282
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0922 0.0922
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.2763 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.2345 1
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.1082 0.1082
Loa Loa (eye worm) hypothetical protein 0.0012 0.0282 0.0282
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0282 0.0282
Schistosoma mansoni bromodomain containing protein 0.0081 0.4308 0.4308
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.0181 0.5
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.1073 0.3834
Echinococcus multilocularis zinc finger protein 0.0028 0.1217 0.1217
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0488 0.1768
Echinococcus multilocularis ferritin 0.001 0.0181 0.0181
Brugia malayi hypothetical protein 0.0043 0.2126 0.2126
Mycobacterium ulcerans bacterioferritin BfrB 0.001 0.0181 0.5
Schistosoma mansoni apoferritin-2 0.001 0.0181 0.0181
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0788 0.0788
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.2763 0.2895
Entamoeba histolytica hypothetical protein 0.0043 0.2126 0.8821
Loa Loa (eye worm) hypothetical protein 0.0009 0.0135 0.0135
Trypanosoma brucei ISWI complex protein 0.0018 0.0663 1
Schistosoma mansoni apoferritin-2 0.001 0.0181 0.0181
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0788 0.0788
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.1041 0.1041
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0788 0.0788
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0282 0.1021
Schistosoma mansoni hypothetical protein 0.0018 0.0663 0.0663
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.1279 0.1279
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.2763 1
Echinococcus granulosus ferritin 0.001 0.0181 0.019
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.2126 0.2126

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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