Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidase homolog | 0.0142 | 0.2713 | 1 |
Brugia malayi | Peroxidasin | 0.0142 | 0.2713 | 1 |
Brugia malayi | hypothetical protein | 0.0142 | 0.2713 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0142 | 0.2713 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0142 | 0.2713 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0142 | 0.2713 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0142 | 0.2713 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0142 | 0.2713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Onchocerca volvulus | 0.0142 | 0.2713 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0142 | 0.2713 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0142 | 0.2713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Onchocerca volvulus | 0.0142 | 0.2713 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0142 | 0.2713 | 1 |
Schistosoma mansoni | peroxidasin | 0.0142 | 0.2713 | 0.2713 |
Brugia malayi | Animal haem peroxidase family protein | 0.0142 | 0.2713 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.7287 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0142 | 0.2713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0142 | 0.2713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Schistosoma mansoni | peroxidasin | 0.0142 | 0.2713 | 0.2713 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Echinococcus granulosus | peroxidasin | 0.0142 | 0.2713 | 0.2713 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0142 | 0.2713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0326 | 0.8902 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0142 | 0.2713 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0142 | 0.2713 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0142 | 0.2713 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0142 | 0.2713 | 0.3047 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2713 | 1 |
Onchocerca volvulus | 0.0142 | 0.2713 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0142 | 0.2713 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.2239 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (binding) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.