Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | v-ets avian erythroblastosis virus E26 oncogene homolog | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | fli-1 protein | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Brugia malayi | Fli-1 protein | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Schistosoma japonicum | ko:K09435 transcriptional regulator ERG, putative | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Schistosoma mansoni | ets-related | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase eta, putative | 0.0042 | 0.0303 | 0.2601 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0087 | 0.228 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (probably LuxR/UhpA-family) | 0.0153 | 0.5107 | 0.6267 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0062 | 0.1164 | 0.1164 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0036 | 0.0037 | 0.0161 |
Schistosoma mansoni | DNA polymerase eta | 0.0042 | 0.0303 | 0.0303 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0153 | 0.5107 | 1 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0153 | 0.5107 | 1 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0087 | 0.228 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0042 | 0.0303 | 0.1328 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.815 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0062 | 0.1164 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.173 | 0.173 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0062 | 0.1164 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0042 | 0.0303 | 0.0303 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0036 | 0.0037 | 0.0161 |
Mycobacterium ulcerans | putative regulatory protein | 0.0153 | 0.5107 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0303 | 0.0303 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.228 | 0.228 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (LuxR-family) | 0.0153 | 0.5107 | 0.6267 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0042 | 0.0303 | 0.2601 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0062 | 0.1164 | 0.1164 |
Schistosoma mansoni | gabp alpha | 0.0087 | 0.228 | 0.228 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0062 | 0.1164 | 0.1164 |
Mycobacterium tuberculosis | Possible transcriptional regulatory protein | 0.0153 | 0.5107 | 0.6267 |
Echinococcus multilocularis | dna polymerase eta | 0.0042 | 0.0303 | 0.1328 |
Brugia malayi | Ets-domain containing protein | 0.0087 | 0.228 | 0.228 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0062 | 0.1164 | 1 |
Mycobacterium tuberculosis | Possible two component transcriptional regulatory protein (probably LuxR-family) | 0.0153 | 0.5107 | 0.6267 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0062 | 0.1164 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0062 | 0.1164 | 0.5105 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0153 | 0.5107 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0062 | 0.1164 | 0.5105 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0062 | 0.1164 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0042 | 0.0303 | 0.2601 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.0153 | 0.5107 | 0.6267 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0153 | 0.5107 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0153 | 0.5107 | 1 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0087 | 0.228 | 0.228 |
Mycobacterium tuberculosis | Possible nitrate/nitrite response transcriptional regulatory protein NarL | 0.0153 | 0.5107 | 0.6267 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.