TDR Targets

Basic information

Technical information

TDR Targets ID: 1396323
Name: 3-ethyl-1-[(4-oxo-1H-quinazolin-2-yl)methyl]- 1-(phenylmethyl)thiourea
MW: 352.453 | Formula: C19H20N4OS
H donors: 1 H acceptors: 3 LogP: 3.41 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCN=C(N(Cc1nc(O)c2c(n1)cccc2)Cc1ccccc1)S
InChi: 1S/C19H20N4OS/c1-2-20-19(25)23(12-14-8-4-3-5-9-14)13-17-21-16-11-7-6-10-15(16)18(24)22-17/h3-11H,2,12-13H2,1H3,(H,20,25)(H,21,22,24)
InChiKey: RQNOMOCBZIQAHH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(benzyl)-3-ethyl-1-[(4-keto-1H-quinazolin-2-yl)methyl]thiourea
ASN 05384580
ZINC04848119
MLS000548366
SMR000171052
1-Benzyl-3-ethyl-1-(4-oxo-3,4-dihydro-quinazolin-2-ylmethyl)-thiourea

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	multiple endocrine neoplasia I		No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Bacillus subtilis (strain 168)	ATP-dependent Clp protease proteolytic subunit	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127187	All targets in OG5_127187
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Probable ClpP-like protease	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Neospora caninum	ATP-dependent Clp protease proteolytic subunit, related	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	peptidase Clp S14 family	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K06275 parvin, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Babesia bovis	ATP-dependent Clp protease proteolytic subunit 1, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Plasmodium yoelii	ATP-dependent Clp protease, proteolytic subunit ClpP, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	186 aa	40.3 %
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	36.0 %
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	35.5 %
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	180 aa	36.7 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Plasmodium yoelii	Clp protease	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.6 %
Chlamydia trachomatis	hypothetical protein	ATP-dependent Clp protease proteolytic subunit	197 aa	171 aa	22.8 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.1 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	ATP-dependent Clp protease proteolytic subunit	197 aa	172 aa	57.0 %
Onchocerca volvulus	Putative V-type proton ATPase subunit F	ATP-dependent Clp protease proteolytic subunit	197 aa	194 aa	54.1 %
Schistosoma mansoni	neuropeptide receptor	ATP-dependent Clp protease proteolytic subunit	197 aa	174 aa	20.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	pregnancy-associated plasma protein-E	0.0035	0.01	0.01
Brugia malayi	Armadillo/beta-catenin-like repeat family protein	0.0095	0.0688	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0285	0.2563	0.2563
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Brugia malayi	hypothetical protein	0.0151	0.1237	0.1237
Onchocerca volvulus		0.0034	0.0093	0.0093
Schistosoma mansoni	twik family of potassium channels-related	0.0031	0.0059	0.0069
Onchocerca volvulus		0.0035	0.0096	0.0096
Echinococcus granulosus	integrin alpha 3	0.0237	0.209	0.209
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0031	0.0059	0.0059
Echinococcus multilocularis	integrin alpha ps	0.0139	0.112	0.112
Brugia malayi	hypothetical protein	0.0151	0.1237	0.1237
Loa Loa (eye worm)	hypothetical protein	0.0306	0.2771	0.2771
Loa Loa (eye worm)	hypothetical protein	0.0171	0.1436	0.1436
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0039	0.0138	0.0163
Brugia malayi	hypothetical protein	0.0286	0.2566	0.2566
Echinococcus granulosus	cyclins	0.0035	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1486	0.1486
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0151	0.1237	0.1237
Echinococcus multilocularis	enteropeptidase	0.0034	0.0093	0.0093
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0327	0.2969	0.2969
Brugia malayi	Sushi domain	0.0035	0.01	0.01
Brugia malayi	Trypsin family protein	0.0034	0.0093	0.0093
Brugia malayi	hypothetical protein	0.0151	0.1237	0.1237
Toxoplasma gondii	subtilisin SUB7	0.0038	0.0127	0.1629
Onchocerca volvulus		0.0027	0.002	0.002
Plasmodium falciparum	potassium channel	0.0031	0.0059	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Onchocerca volvulus	Cirhin homolog	0.0094	0.0682	0.0682
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0038	0.0127	0.015
Plasmodium vivax	SET domain protein, putative	0.0067	0.041	0.5644
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0035	0.0103	0.0103
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0059	0.0086
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0327	0.2969	0.2969
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0327	0.2969	0.2969
Brugia malayi	hypothetical protein	0.003	0.0054	0.0054
Onchocerca volvulus		0.0035	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0243	0.2147	0.2147
Trichomonas vaginalis	cyclin B, putative	0.0085	0.059	0.1063
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0035	0.01	0.01
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.0096	0.0096
Loa Loa (eye worm)	trypsin family protein	0.0034	0.0093	0.0093
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0327	0.2969	0.2969
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0092	0.0665	0.0665
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.1441	0.2767
Onchocerca volvulus		0.0031	0.0059	0.0059
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0476	0.6677
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0031	0.0059	0.0059
Schistosoma mansoni	hypothetical protein	0.014	0.1134	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0127	0.0137
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0209	0.1814	0.3513
Mycobacterium leprae	Possible secreted protease	0.0038	0.0127	0.0859
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0171	0.1441	0.2767
Loa Loa (eye worm)	hypothetical protein	0.0681	0.6457	0.6457
Onchocerca volvulus		0.0176	0.1486	0.1486
Echinococcus granulosus	GPCR family 2	0.0048	0.0225	0.0225
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Loa Loa (eye worm)	DOMON domain-containing protein	0.0027	0.002	0.002
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0033	0.0075	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Schistosoma mansoni	hypothetical protein	0.0067	0.0409	0.0483
Onchocerca volvulus		0.0151	0.1237	0.1237
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0151	0.1237	0.146
Loa Loa (eye worm)	WD40 repeat protein	0.014	0.1134	0.1134
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0176	0.1486	0.1486
Schistosoma mansoni	cpg binding protein	0.0035	0.0096	0.0113
Trichomonas vaginalis	cyclin B3, putative	0.0035	0.0103	0.0088
Schistosoma mansoni	cpg binding protein	0.0037	0.0115	0.0136
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0151	0.1237	0.1237
Loa Loa (eye worm)	hypothetical protein	0.0035	0.01	0.01
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Toxoplasma gondii	subtilisin SUB11	0.0038	0.0127	0.1629
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0093	0.0093
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0031	0.0059	0.0059
Schistosoma mansoni	integrin alpha-ps	0.0072	0.0466	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Schistosoma mansoni	hypothetical protein	0.0034	0.0093	0.011
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.1441	0.2767
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0171	0.1441	0.2767
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.0225	0.0225
Schistosoma mansoni	hypothetical protein	0.0048	0.0225	0.0265
Echinococcus multilocularis	cyclin b3	0.0035	0.0103	0.0103
Onchocerca volvulus		0.0681	0.6457	0.6457
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0038	0.0127	0.1093
Trypanosoma cruzi	ion transport protein, putative	0.0031	0.0059	0.0086
Brugia malayi	hypothetical protein	0.0035	0.01	0.01
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0151	0.1241	0.1241
Echinococcus multilocularis	cyclins	0.0035	0.0103	0.0103
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0176	0.1486	0.1486
Onchocerca volvulus		0.0031	0.0059	0.0059
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0039	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0039	0.0138	0.0163
Plasmodium falciparum	apical sushi protein	0.0035	0.01	0.0732
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0476	0.0562
Schistosoma mansoni	hypothetical protein	0.0058	0.0328	0.0387
Echinococcus granulosus	twik family of potassium channels	0.0031	0.0059	0.0059
Schistosoma mansoni	serine-type protease inhibitor	0.0869	0.8314	0.9811
Plasmodium vivax	subtilisin-like protease 2, putative	0.0038	0.0127	0.1158
Schistosoma mansoni	cyclin B3	0.0035	0.0103	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0151	0.1241	0.1241
Plasmodium vivax	apical sushi protein, putative	0.0035	0.01	0.0732
Echinococcus granulosus	cyclins	0.0035	0.0103	0.0103
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0031	0.0059	0.0059
Leishmania major	potassium channel subunit-like protein	0.0031	0.0059	0.0086
Leishmania major	hypothetical protein, conserved	0.0031	0.0059	0.0086
Trichomonas vaginalis	cyclins, putative	0.0085	0.059	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1486	0.1486
Trypanosoma brucei	mitotic cyclin 6	0.0085	0.059	1
Echinococcus multilocularis	cyclins	0.0035	0.0103	0.0103
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0327	0.2969	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.1441	0.2767
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0031	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0031	0.0059	0.0059
Echinococcus granulosus	potassium channel subfamily K 8	0.0031	0.0059	0.0059
Onchocerca volvulus		0.0272	0.2432	0.2432
Echinococcus granulosus	cyclins	0.0035	0.0103	0.0103
Toxoplasma gondii	subtilisin SUB1	0.0038	0.0127	0.1629
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0327	0.2969	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1486	0.1486
Echinococcus multilocularis	potassium channel subfamily K	0.0031	0.0059	0.0059
Echinococcus multilocularis	C type lectin domian containing protein	0.0035	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Schistosoma mansoni	cercarial elastase (S01 family)	0.0034	0.0093	0.011
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Echinococcus multilocularis	potassium channel subfamily K 8	0.0031	0.0059	0.0059
Echinococcus multilocularis	twik family of potassium channels	0.0031	0.0059	0.0059
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0327	0.2969	0.2969
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.1441	0.2767
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0327	0.2969	0.2969
Loa Loa (eye worm)	TWK-28 protein	0.0031	0.0059	0.0059
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.0225	0.0225
Brugia malayi	hypothetical protein	0.0031	0.0059	0.0059
Echinococcus multilocularis	integrin alpha 3	0.0237	0.209	0.209
Onchocerca volvulus		0.0035	0.01	0.01
Echinococcus multilocularis	cyclin B	0.0085	0.059	0.059
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0327	0.2969	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0327	0.2969	0.2969
Loa Loa (eye worm)	integrin alpha pat-2	0.0477	0.4452	0.4452
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.0665	0.0784
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0684	0.5
Trichomonas vaginalis	cyclins, putative	0.0085	0.059	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1241	0.1241
Schistosoma mansoni	hypothetical protein	0.0494	0.4618	0.5449
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0151	0.1241	0.1241
Brugia malayi	endoprotease bli-4 precursor	0.0886	0.8474	0.8474
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0684	0.5
Leishmania major	ion transport protein-like protein	0.0031	0.0059	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Brugia malayi	GCC2 and GCC3 family protein	0.0035	0.01	0.01
Onchocerca volvulus		0.0327	0.2969	0.2969
Plasmodium falciparum	subtilisin-like protease 2	0.0038	0.0127	0.1158
Echinococcus granulosus	Mastin	0.0034	0.0093	0.0093
Onchocerca volvulus		0.0035	0.01	0.01
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Toxoplasma gondii	rhoptry neck protein RON1	0.0035	0.01	0.1225
Schistosoma mansoni	cpg binding protein	0.0037	0.0115	0.0136
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0476	0.788
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0298	0.0298
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0151	0.1237	0.1237
Brugia malayi	excitatory GABA receptor EXP-1A	0.0327	0.2969	0.2969
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0038	0.0127	0.1637
Echinococcus granulosus	glycoprotein Antigen 5	0.0034	0.0093	0.0093
Entamoeba histolytica	hypothetical protein	0.0043	0.0182	0.0865
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0038	0.0127	0.015
Toxoplasma gondii	ion channel protein	0.0031	0.0059	0.0602
Schistosoma mansoni	nAChR subunit	0.0151	0.1237	0.146
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0327	0.2969	0.2969
Brugia malayi	Protein set-1	0.0067	0.041	0.041
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0038	0.0127	0.1093
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.002
Echinococcus multilocularis	cyclins	0.0035	0.0103	0.0103
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0209	0.1814	0.3513
Onchocerca volvulus		0.0034	0.0093	0.0093
Echinococcus multilocularis	cyclin B3 1	0.0035	0.0103	0.0103
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0327	0.2969	0.2969
Schistosoma mansoni	histone-lysine n-methyltransferase seto7	0.0067	0.041	0.0483
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0038	0.0127	0.1362
Echinococcus multilocularis	small conductance calcium activated potassium	0.0859	0.8216	0.8216
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0034	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0094	0.0684	1
Schistosoma mansoni	hypothetical protein	0.0205	0.1769	0.2087
Onchocerca volvulus		0.0031	0.0059	0.0059
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Onchocerca volvulus		0.0034	0.0093	0.0093
Schistosoma mansoni	twik family of potassium channels-related	0.0031	0.0059	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0859	0.8216	0.8216
Onchocerca volvulus		0.0058	0.0328	0.0328
Brugia malayi	Pre-SET motif family protein	0.0254	0.2258	0.2258
Toxoplasma gondii	histone lysine methyltransferase SET8	0.0067	0.041	0.5876
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0038	0.0127	0.1637
Echinococcus granulosus	C type lectin domian containing protein	0.0035	0.01	0.01
Brugia malayi	hypothetical protein	0.0035	0.01	0.01
Toxoplasma gondii	subtilisin SUB9	0.0038	0.0127	0.1629
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0085	0.059	0.059
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0298	0.0298
Onchocerca volvulus		0.0047	0.022	0.022
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0034	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.004	0.0148	0.0148
Trichomonas vaginalis	cyclin B, putative	0.0085	0.059	0.1063
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0031	0.0059	0.0059
Brugia malayi	latrophilin 2 splice variant baaae	0.0103	0.0771	0.0771
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0062	0.0364	0.7307
Echinococcus granulosus	geminin	0.0205	0.1769	0.1769
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.1441	0.2767
Schistosoma mansoni	twik family of potassium channels-related	0.0031	0.0059	0.0069
Echinococcus granulosus	enteropeptidase	0.0034	0.0093	0.0093
Brugia malayi	hypothetical protein	0.0035	0.01	0.01
Trichomonas vaginalis	cyclin B, putative	0.0085	0.059	0.1063
Trichomonas vaginalis	cyclins, putative	0.0058	0.0326	0.0534
Giardia lamblia	High cysteine membrane protein Group 2	0.0329	0.2995	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0034	0.0093	0.011
Onchocerca volvulus		0.0681	0.6457	0.6457
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Echinococcus multilocularis	protein will die slowly	0.014	0.1134	0.1134
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0234	0.2059	0.2059
Onchocerca volvulus		0.0034	0.0093	0.0093
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Onchocerca volvulus		0.0327	0.2969	0.2969
Loa Loa (eye worm)	acetylcholine receptor protein	0.0151	0.1237	0.1237
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0033	0.0075	0.0328
Toxoplasma gondii	rhoptry neck protein RON9	0.0035	0.01	0.1225
Brugia malayi	Trypsin-like protease protein 5	0.0034	0.0093	0.0093
Echinococcus multilocularis	neuroendocrine convertase 2	0.0557	0.5234	0.5234
Echinococcus granulosus	protein will die slowly	0.014	0.1134	0.1134
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0094	0.0684	0.0684
Schistosoma mansoni	calcium-activated potassium channel	0.0031	0.0059	0.0069
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0038	0.0127	0.0127
Onchocerca volvulus		0.0034	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0234	0.2059	0.2059
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0127	0.0127
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0327	0.2969	0.2969
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0327	0.2969	0.2969
Echinococcus multilocularis	twik family of potassium channels	0.0031	0.0059	0.0059
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0031	0.0059	0.0059
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0035	0.0103	0.0103
Echinococcus multilocularis	nAChR subunit	0.0176	0.1486	0.1486
Echinococcus granulosus	integrin alpha ps	0.0139	0.112	0.112
Schistosoma mansoni	calcium-activated potassium channel	0.0031	0.0059	0.0069
Echinococcus granulosus	beta catenin	0.0095	0.0688	0.0688
Onchocerca volvulus		0.0031	0.0059	0.0059
Brugia malayi	Probable ClpP-like protease	0.0094	0.0684	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0031	0.0059	0.0059
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Echinococcus granulosus	Furin 1	0.0209	0.1814	0.1814
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0093	0.0093
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0327	0.2969	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0684	0.0684
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0209	0.1814	0.3513
Loa Loa (eye worm)	proprotein convertase 2	0.0209	0.1814	0.1814
Echinococcus granulosus	c4b binding protein beta chain	0.0035	0.01	0.01
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0077	0.0513	0.0605
Brugia malayi	Cation transporter family protein	0.0327	0.2969	0.2969
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Echinococcus granulosus	histone lysine methyltransferase setb	0.0039	0.0138	0.0138
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Echinococcus multilocularis	calcium activated potassium channel variant	0.0031	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Leishmania major	cyclin	0.0085	0.059	1
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0085	0.059	1
Schistosoma mansoni	cyclin B	0.0085	0.059	0.0696
Echinococcus granulosus	cpg binding protein	0.0037	0.0115	0.0115
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0327	0.2969	0.2969
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0039	0.0138	0.1794
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0038	0.0127	0.1637
Schistosoma mansoni	twik family of potassium channels-related	0.0031	0.0059	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0476	0.6877
Mycobacterium ulcerans	hypothetical protein	0.0034	0.0093	0.0558
Trichomonas vaginalis	WD repeat domain, putative	0.014	0.1134	0.2152
Echinococcus granulosus	dnaJ subfamily B	0.0494	0.4618	0.4618
Echinococcus multilocularis	glycine receptor subunit beta	0.0327	0.2969	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0306	0.2771	0.2771
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0031	0.0059	0.0059
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0094	0.0684	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Schistosoma mansoni	nAChR subunit	0.0327	0.2969	0.3504
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0318	0.2884	0.2884
Schistosoma mansoni	neurotransmitter gated ion channel	0.0151	0.1237	0.146
Schistosoma mansoni	cercarial elastase (S01 family)	0.0034	0.0093	0.011
Schistosoma mansoni	furin-1 (S08 family)	0.0385	0.3547	0.4186
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0327	0.2969	0.3504
Trichomonas vaginalis	set domain proteins, putative	0.0289	0.2599	0.5086
Toxoplasma gondii	subtilisin SUB6	0.0038	0.0127	0.1629
Loa Loa (eye worm)	HMP-2 protein	0.0095	0.0688	0.0688
Toxoplasma gondii	subtilisin SUB4	0.0038	0.0127	0.1629
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Brugia malayi	Will die slowly protein	0.014	0.1134	0.1134
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0328	0.0387
Schistosoma mansoni	cercarial elastase (S01 family)	0.0034	0.0093	0.011
Brugia malayi	Subtilase family protein	0.0038	0.0127	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.1441	0.2767
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Trypanosoma brucei	subtilisin peptidase	0.0038	0.0127	0.1362
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0466	0.0466
Entamoeba histolytica	hypothetical protein	0.0176	0.1486	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0151	0.1237	0.1237
Schistosoma mansoni	nAChR subunit	0.0151	0.1237	0.146
Onchocerca volvulus		0.0035	0.01	0.01
Giardia lamblia	G2/mitotic-specific cyclin B	0.0085	0.059	0.1809
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0034	0.0093	0.011
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0038	0.0127	0.1362
Brugia malayi	hypothetical protein	0.0151	0.1237	0.1237
Echinococcus multilocularis	histone lysine n methyltransferase setd8	0.0067	0.041	0.041
Onchocerca volvulus		0.0031	0.0059	0.0059
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0085	0.059	0.059
Schistosoma mansoni	cercarial elastase (S01 family)	0.0034	0.0093	0.011
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Echinococcus granulosus	nAChR subunit	0.0176	0.1486	0.1486
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0176	0.1486	0.1754
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0127	0.0137
Echinococcus multilocularis	potassium channel subfamily K 8	0.0031	0.0059	0.0059
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0538	0.5054	1
Trypanosoma cruzi	subtilisin peptidase	0.0038	0.0127	0.1362
Plasmodium vivax	subtilisin-like protease 1	0.0038	0.0127	0.1158
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0684	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0311	0.2819	0.3327
Schistosoma mansoni	hypothetical protein	0.0171	0.1441	0.17
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0034	0.0093	0.0093
Echinococcus granulosus	histone lysine n methyltransferase setd8	0.0067	0.041	0.041
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0034	0.0093	0.011
Plasmodium falciparum	SET domain protein, putative	0.0067	0.041	0.5644
Schistosoma mansoni	cercarial elastase (S01 family)	0.0034	0.0093	0.011
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.1441	0.2767
Onchocerca volvulus		0.0027	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0409	0.0409
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0038	0.0127	0.0127
Onchocerca volvulus		0.0289	0.2599	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Brugia malayi	hypothetical protein	0.0151	0.1237	0.1237
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0327	0.2969	0.2969
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0538	0.5054	0.5054
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Schistosoma mansoni	hypothetical protein	0.0205	0.1769	0.2087
Loa Loa (eye worm)	hypothetical protein	0.0035	0.01	0.01
Trichomonas vaginalis	cyclins, putative	0.0085	0.059	0.1063
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0127	0.0137
Schistosoma mansoni	cercarial elastase (S01 family)	0.0034	0.0093	0.011
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1486	0.1486
Leishmania major	hypothetical protein, conserved	0.0031	0.0059	0.0086
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0031	0.0059	0.0059
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0298	0.0298
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0031	0.0059	0.0059
Schistosoma mansoni	hypothetical protein	0.0027	0.002	0.0023
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0476	0.0476
Onchocerca volvulus		0.0039	0.0138	0.0138
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0039	0.0138	0.0163
Brugia malayi	hypothetical protein	0.0031	0.0059	0.0059
Plasmodium vivax	SET domain protein, putative	0.0039	0.0138	0.1333
Brugia malayi	Cation transporter family protein	0.0327	0.2969	0.2969
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0038	0.0127	0.1362
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0031	0.0059	0.0086
Schistosoma mansoni	twik family of potassium channels-related	0.0031	0.0059	0.0069
Onchocerca volvulus		0.0035	0.01	0.01
Brugia malayi	neuroendocrine convertase 1 precursor	0.0557	0.5234	0.5234
Schistosoma mansoni	cercarial elastase (S01 family)	0.0034	0.0093	0.011
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0094	0.0684	1
Echinococcus multilocularis	integrin alpha ps	0.0139	0.112	0.112
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0083	0.057	0.057
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0182	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0027	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Entamoeba histolytica	hypothetical protein	0.0043	0.0182	0.0865
Echinococcus multilocularis	Furin 1	0.0209	0.1814	0.1814
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.1441	0.2767
Schistosoma mansoni	twik family of potassium channels-related	0.0031	0.0059	0.0069
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Schistosoma mansoni	nAChR subunit	0.0327	0.2969	0.3504
Echinococcus multilocularis	cpg binding protein	0.0037	0.0115	0.0115
Schistosoma mansoni	cercarial elastase (S01 family)	0.0034	0.0093	0.011
Echinococcus granulosus	furin	0.0886	0.8474	0.8474
Brugia malayi	Pre-SET motif family protein	0.0039	0.0138	0.0138
Leishmania major	calcium/potassium channel (CAKC), putative	0.0031	0.0059	0.0086
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0035	0.0103	0.0103
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.0225	0.0225
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0327	0.2969	0.2969
Loa Loa (eye worm)	uncoordinated protein 58	0.0031	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0035	0.01	0.01
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0684	0.5
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Schistosoma mansoni	calcium-activated potassium channel	0.0859	0.8216	0.9696
Echinococcus multilocularis	cyclins	0.0035	0.0103	0.0103
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0476	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0031	0.0059	0.0059
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0031	0.0059	0.0059
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0538	0.5054	0.5054
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0034	0.0093	0.011
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0151	0.1237	0.1237
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.2566	0.2566
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0038	0.0127	0.1093
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.1441	0.2767
Onchocerca volvulus		0.0035	0.01	0.01
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0151	0.1237	0.1237
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.0684	1
Echinococcus granulosus	twik family of potassium channels	0.0031	0.0059	0.0059
Echinococcus multilocularis	nAChR subunit	0.0327	0.2969	0.2969
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0327	0.2969	0.2969
Onchocerca volvulus		0.014	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0327	0.2969	0.2969
Trichomonas vaginalis	cyclin A, putative	0.0085	0.059	0.1063
Echinococcus multilocularis	geminin	0.0205	0.1769	0.1769
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Toxoplasma gondii	subtilisin SUB12	0.0053	0.0271	0.3797
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1486	0.1486
Trichomonas vaginalis	cyclin D, putative	0.0035	0.0103	0.0088
Giardia lamblia	Furin precursor putative serine protease	0.0171	0.1441	0.4709
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0327	0.2969	0.2969
Echinococcus multilocularis	c4b binding protein beta chain	0.0035	0.01	0.01
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0085	0.059	1
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.1441	0.2767
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Trypanosoma cruzi	cyclin, putative	0.0085	0.059	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0034	0.0093	0.0093
Brugia malayi	Trypsin family protein	0.0306	0.2771	0.2771
Echinococcus granulosus	integrin alpha ps	0.0067	0.0409	0.0409
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0254	0.2258	0.2258
Schistosoma mansoni	hypothetical protein	0.0043	0.0182	0.0215
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0327	0.2969	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0347	0.3175	0.3175
Brugia malayi	Cation transporter family protein	0.0681	0.6457	0.6457
Echinococcus granulosus	small conductance calcium activated potassium	0.0859	0.8216	0.8216
Echinococcus granulosus	nAChR subunit	0.0327	0.2969	0.2969
Onchocerca volvulus		0.0031	0.0059	0.0059
Onchocerca volvulus		0.0327	0.2969	0.2969
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0038	0.0127	0.015
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0176	0.1486	0.1486
Brugia malayi	Trypsin family protein	0.0034	0.0093	0.0093
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0327	0.2969	0.2969
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0031	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Loa Loa (eye worm)	subtilase	0.0038	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0085	0.059	0.059
Echinococcus granulosus	cyclin b3	0.0035	0.0103	0.0103
Echinococcus granulosus	potassium channel subfamily K 8	0.0031	0.0059	0.0059
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0038	0.0127	0.1362
Echinococcus multilocularis		0.0714	0.6788	0.6788
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0171	0.1441	0.2767
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0298	0.0352
Schistosoma mansoni	hypothetical protein	0.0103	0.0771	0.0909
Schistosoma mansoni	peptidase Clp (S14 family)	0.0094	0.0684	0.0807
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0038	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0035	0.01	0.01
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0031	0.0059	0.0059
Schistosoma mansoni	nAChR subunit	0.0327	0.2969	0.3504
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0886	0.8474	1
Echinococcus multilocularis	GPCR, family 2	0.0048	0.0225	0.0225
Loa Loa (eye worm)	ACC-1 protein	0.0327	0.2969	0.2969
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0031	0.0059	0.0059
Onchocerca volvulus		0.0306	0.2771	0.2771
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0327	0.2969	0.2969
Plasmodium falciparum	cyclin	0.0035	0.0103	0.0771
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0476	0.6677
Echinococcus granulosus	cyclin B	0.0085	0.059	0.059
Toxoplasma gondii	hypothetical protein	0.0033	0.0075	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0225	0.0225
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0062	0.0364	0.7307
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0327	0.2969	0.2969
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0681	0.6457	0.7619
Onchocerca volvulus		0.0035	0.01	0.01
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0684	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Entamoeba histolytica	cyclin family protein	0.0035	0.0103	0.0308
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0681	0.6457	0.7619
Echinococcus granulosus	membrane bound transcription factor site 1	0.0038	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0771	0.0771
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0327	0.2969	0.3504
Brugia malayi	hypothetical protein	0.0043	0.0182	0.0182
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0039	0.0138	0.0163
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0034	0.0093	0.011
Echinococcus granulosus	peptidase Clp S14 family	0.0062	0.0364	0.0364
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0182	0.0215
Toxoplasma gondii	ion channel protein	0.0031	0.0059	0.0602
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.0665	0.0784
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0684	1
Entamoeba histolytica	cyclin family protein	0.0035	0.0103	0.0308
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0054	0.0533
Giardia lamblia	Cyclin A	0.0035	0.0103	0.015
Loa Loa (eye worm)	hypothetical protein	0.003	0.0054	0.0054
Brugia malayi	hypothetical protein	0.0035	0.01	0.01
Loa Loa (eye worm)	cyclin domain-containing protein	0.0035	0.0103	0.0103
Brugia malayi	pregnancy-associated plasma protein-A	0.0035	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0151	0.1237	0.1237
Schistosoma mansoni	cercarial elastase (S01 family)	0.0034	0.0093	0.011
Onchocerca volvulus		0.0085	0.059	0.059
Trichomonas vaginalis	cyclin B, putative	0.0035	0.0103	0.0088
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0096	0.0096
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0151	0.1237	0.1237
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0031	0.0059	0.0086
Entamoeba histolytica	hypothetical protein	0.0043	0.0182	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.0225	0.0225
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0034	0.0093	0.0093
Trichomonas vaginalis	cyclins, putative	0.0035	0.0103	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0093	0.0093
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0039	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0327	0.2969	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0306	0.2771	0.327
Loa Loa (eye worm)	hypothetical protein	0.0035	0.01	0.01
Onchocerca volvulus		0.0031	0.0059	0.0059
Schistosoma mansoni	neurotransmitter gated ion channel	0.0151	0.1237	0.146
Echinococcus multilocularis	cyclins	0.0035	0.0103	0.0103
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0069	0.0435	0.6265
Schistosoma mansoni	cercarial elastase (S01 family)	0.0034	0.0093	0.011
Schistosoma mansoni	nAChR subunit	0.0327	0.2969	0.3504
Loa Loa (eye worm)	hypothetical protein	0.053	0.4974	0.4974
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0038	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Plasmodium falciparum	subtilisin-like protease 3	0.0038	0.0127	0.1158
Plasmodium vivax	potassium channel, putative	0.0031	0.0059	0.0073
Echinococcus multilocularis	cyclins	0.0035	0.0103	0.0103
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0031	0.0059	0.0059
Echinococcus multilocularis	dnaJ subfamily B	0.0494	0.4618	0.4618
Toxoplasma gondii	subtilisin SUB5	0.0038	0.0127	0.1629
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0031	0.0059	0.0059
Onchocerca volvulus		0.0038	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0067	0.041	0.041
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0327	0.2969	0.2969
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0298	0.0298
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0327	0.2969	0.3504
Loa Loa (eye worm)	hypothetical protein	0.0286	0.2566	0.2566
Schistosoma mansoni	twik family of potassium channels-related	0.0031	0.0059	0.0069
Onchocerca volvulus		0.0035	0.01	0.01
Onchocerca volvulus		0.0151	0.1237	0.1237
Loa Loa (eye worm)	hypothetical protein	0.0886	0.8474	0.8474
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Schistosoma mansoni	serine-type protease inhibitor	0.0869	0.8314	0.9811
Brugia malayi	hypothetical protein	0.0034	0.0093	0.0093
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0062	0.0364	0.0364
Brugia malayi	Trypsin family protein	0.0034	0.0093	0.0093
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0298	0.0352
Echinococcus multilocularis	transmembrane protease serine 3	0.0034	0.0093	0.0093
Trypanosoma cruzi	cyclin 6, putative	0.0085	0.059	1
Trichomonas vaginalis	cyclin D, putative	0.0035	0.0103	0.0088
Leishmania major	subtilisin-like serine peptidase	0.0038	0.0127	0.1362
Trypanosoma cruzi	cyclin, putative	0.0085	0.059	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0327	0.2969	0.2969
Loa Loa (eye worm)	hypothetical protein	0.0035	0.01	0.01
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0327	0.2969	0.2969
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0298	0.0298
Entamoeba histolytica	hypothetical protein	0.0043	0.0182	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1486	0.1486
Echinococcus granulosus	neuroendocrine convertase 2	0.0557	0.5234	0.5234
Echinococcus granulosus	calcium activated potassium channel variant	0.0031	0.0059	0.0059
Echinococcus multilocularis	glycoprotein Antigen 5	0.0034	0.0093	0.0093
Onchocerca volvulus		0.0681	0.6457	0.6457
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0092	0.0665	0.0665
Echinococcus granulosus	glycine receptor subunit beta	0.0327	0.2969	0.2969
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0038	0.0127	0.015
Schistosoma mansoni	nAChR subunit	0.0327	0.2969	0.3504
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0092	0.0665	0.0665
Plasmodium falciparum	potassium channel	0.0031	0.0059	0.0073
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0085	0.059	0.059
Brugia malayi	proprotein convertase 2	0.0557	0.5234	0.5234
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0327	0.2969	0.2969
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0031	0.0059	0.0059
Onchocerca volvulus		0.0035	0.01	0.01
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0038	0.0127	0.1637
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0031	0.0059	0.0059
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0059	0.0086
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0209	0.1814	0.3513
Echinococcus granulosus	cyclins	0.0035	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0031	0.0059	0.0086
Loa Loa (eye worm)	TWK-7 protein	0.0031	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0681	0.6457	0.6457
Brugia malayi	hypothetical protein	0.0035	0.01	0.01
Echinococcus multilocularis	cyclins	0.0035	0.0103	0.0103
Brugia malayi	hypothetical protein	0.0035	0.01	0.01
Schistosoma mansoni	acetylcholine receptor-related	0.0151	0.1237	0.146
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0151	0.1237	0.1237
Plasmodium vivax	potassium channel, putative	0.0031	0.0059	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0093	0.0093
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0209	0.1814	0.3513
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0151	0.1237	0.1237
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0096	0.0096
Echinococcus multilocularis	integrin alpha ps	0.0067	0.0409	0.0409
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0151	0.1237	0.1237
Schistosoma mansoni	hypothetical protein	0.0048	0.0225	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1486	0.1486
Loa Loa (eye worm)	ACC-1 protein	0.0327	0.2969	0.2969
Plasmodium falciparum	subtilisin-like protease 1	0.0038	0.0127	0.1158
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0038	0.0127	0.0137
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.0225	0.0225
Schistosoma mansoni	nAChR subunit	0.0327	0.2969	0.3504
Schistosoma mansoni	hypothetical protein	0.0034	0.0093	0.011
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0538	0.5054	1
Schistosoma mansoni	beta-catenin	0.0095	0.0688	0.0812
Echinococcus granulosus	transmembrane protease serine 3	0.0034	0.0093	0.0093
Toxoplasma gondii	subtilisin SUB8	0.0038	0.0127	0.1629
Toxoplasma gondii	subtilisin SUB10	0.0038	0.0127	0.1629
Schistosoma mansoni	hypothetical protein	0.0031	0.0059	0.0069
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0031	0.0059	0.0086
Onchocerca volvulus		0.0027	0.002	0.002
Brugia malayi	Muscle positioning protein 4	0.0027	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0327	0.2969	0.2969
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0151	0.1237	0.1237
Schistosoma mansoni	hypothetical protein	0.0048	0.0225	0.0265
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0476	0.0562
Brugia malayi	Integrin alpha pat-2 precursor	0.031	0.2802	0.2802
Trichomonas vaginalis	cyclin B, putative	0.0085	0.059	0.1063
Schistosoma mansoni	integrin alpha	0.031	0.2802	0.3306
Schistosoma mansoni	integrin alpha-ps	0.0139	0.112	0.1322
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1486	0.1486
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0038	0.0127	0.0859
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0031	0.0059	0.0059
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0209	0.1814	0.3513
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0327	0.2969	0.2969
Schistosoma mansoni	hypothetical protein	0.0859	0.8216	0.9696
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0062	0.0364	0.4744
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.0684	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0327	0.2969	0.3504
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0298	0.0352
Entamoeba histolytica	cyclin, putative	0.0085	0.059	0.3721
Echinococcus multilocularis	glycine receptor subunit beta	0.0327	0.2969	0.2969
Echinococcus granulosus	glycine receptor subunit beta	0.0327	0.2969	0.2969
Schistosoma mansoni	calcium-activated potassium channel	0.0603	0.5692	0.6717
Echinococcus granulosus	cyclin B3 1	0.0035	0.0103	0.0103
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.2566	0.2566
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0083	0.057	0.057
Schistosoma mansoni	twik family of potassium channels-related	0.0031	0.0059	0.0069
Onchocerca volvulus		0.0031	0.0059	0.0059
Schistosoma mansoni	nAChR subunit	0.0327	0.2969	0.3504
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0476	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Echinococcus granulosus	potassium channel subfamily K	0.0031	0.0059	0.0059
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0327	0.2969	0.2969
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0176	0.1486	0.1486
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0034	0.0093	0.011
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0327	0.2969	0.2969
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0031	0.0059	0.0059
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0684	1
Trichomonas vaginalis	cyclins, putative	0.0085	0.059	0.1063
Trichomonas vaginalis	hypothetical protein	0.0171	0.1441	0.2767
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.1441	0.2767
Brugia malayi	hypothetical protein	0.0035	0.01	0.01
Onchocerca volvulus		0.0027	0.002	0.002
Schistosoma mansoni	neurotransmitter gated ion channel	0.0176	0.1486	0.1754
Onchocerca volvulus		0.0151	0.1237	0.1237
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0151	0.1237	0.1237
Trypanosoma cruzi	ion transport protein, putative	0.0031	0.0059	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0103	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0035	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Onchocerca volvulus		0.0035	0.01	0.01
Brugia malayi	celfurPC protein	0.0714	0.6788	0.6788
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0031	0.0059	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0225	0.1974	0.1974
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0031	0.0059	0.0086
Brugia malayi	SEA domain containing protein	0.0027	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1237	0.1237
Toxoplasma gondii	subtilisin SUB2	0.0038	0.0127	0.1629
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0038	0.0127	0.0127
Schistosoma mansoni	hypothetical protein	0.0048	0.0225	0.0265
Schistosoma mansoni	cercarial elastase (S01 family)	0.0034	0.0093	0.011
Echinococcus multilocularis	beta catenin	0.0095	0.0688	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0327	0.2969	0.2969
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0038	0.0127	0.0859
Loa Loa (eye worm)	endoprotease bli-4	0.0886	0.8474	0.8474
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0059	0.0059
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0127	0.0137
Giardia lamblia	Hypothetical protein	0.0035	0.0103	0.015
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0176	0.1486	0.1754
Schistosoma mansoni	c4b-binding protein beta chain	0.0035	0.01	0.0118
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0476	0.6677
Plasmodium vivax	subtilisin-like serine protease, putative	0.0038	0.0127	0.1158
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0031	0.0059	0.0059
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.0225	0.0225
Entamoeba histolytica	cyclin, putative	0.0035	0.0103	0.0308
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0182	0.0182
Onchocerca volvulus		0.0176	0.1486	0.1486
Schistosoma mansoni	cyclins	0.0035	0.0103	0.0121
Echinococcus multilocularis	Mastin	0.0034	0.0093	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0127	0.0137
Loa Loa (eye worm)	GABA receptor subunit	0.0176	0.1486	0.1486
Echinococcus granulosus	cyclins	0.0035	0.0103	0.0103
Loa Loa (eye worm)	LGC-31 protein	0.0327	0.2969	0.2969
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0209	0.1814	0.214
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0327	0.2969	0.2969

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1636 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 0.2512 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.3162 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.7943 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.8913 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	2.9093 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 7.0795 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 7.0795 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1519202

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1396323