Detailed information for compound 1396356

Basic information

Technical information
  • TDR Targets ID: 1396356
  • Name: 2,3-dihydroindol-1-yl-(2-methylfuran-3-yl)met hanone
  • MW: 227.259 | Formula: C14H13NO2
  • H donors: 0 H acceptors: 1 LogP: 2.44 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1occc1C(=O)N1CCc2c1cccc2
  • InChi: 1S/C14H13NO2/c1-10-12(7-9-17-10)14(16)15-8-6-11-4-2-3-5-13(11)15/h2-5,7,9H,6,8H2,1H3
  • InChiKey: PKPFQDAFJVTRES-UHFFFAOYSA-N  

Network

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Synonyms

  • indolin-1-yl-(2-methyl-3-furyl)methanone
  • 1-indolinyl-(2-methyl-3-furyl)methanone
  • MLS000109962
  • SMR000105895
  • BIM-0031106.P001
  • CBMicro_031127
  • Oprea1_430658
  • A2669/0113695
  • MixCom6_001431
  • ZINC00090853

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Echinococcus multilocularis dna polymerase eta 0.0054 0.583 0.583
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0074 0.9481 0.9481
Echinococcus granulosus somatostatin receptor 0.0074 0.9481 0.9481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.9481 0.9481
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.011 1
Onchocerca volvulus 0.0074 0.9481 0.5
Echinococcus granulosus g protein coupled receptor 0.0074 0.9481 0.9481
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.011 1
Brugia malayi AKH receptor 0.0074 0.9481 0.9481
Echinococcus multilocularis g protein coupled receptor 0.0074 0.9481 0.9481
Brugia malayi hypothetical protein 0.0074 0.9481 0.9481
Brugia malayi hypothetical protein 0.0074 0.9481 0.9481
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.9481 0.9481
Schistosoma mansoni DNA polymerase eta 0.0054 0.583 0.583
Onchocerca volvulus 0.0074 0.9481 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.9481 0.9481
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.011 0.0189
Echinococcus granulosus neuropeptide s receptor 0.0074 0.9481 0.9481
Echinococcus granulosus G protein coupled receptor 139 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.011 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0074 0.9481 0.9481
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.9481 0.9481
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.9481 0.9481
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0074 0.9481 0.9481
Echinococcus granulosus g protein coupled receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0074 0.9481 0.9481
Echinococcus multilocularis dna polymerase kappa 0.0023 0.011 0.011
Schistosoma mansoni neuropeptide receptor 0.0074 0.9481 0.9481
Schistosoma mansoni hypothetical protein 0.0074 0.9481 0.9481
Onchocerca volvulus 0.0074 0.9481 0.5
Brugia malayi hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.011 0.0189
Onchocerca volvulus 0.0074 0.9481 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.6048 0.6048
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0074 0.9481 0.5
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.583 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.9481 0.9481
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.9481 0.9481
Brugia malayi hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0074 0.9481 0.9481
Brugia malayi hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni opsin-like receptor 0.0074 0.9481 0.9481
Schistosoma mansoni neuropeptide receptor 0.0074 0.9481 0.9481
Schistosoma mansoni neuropeptide f receptor 76f 0.0074 0.9481 0.9481
Echinococcus granulosus orexin receptor type 2 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.6048 0.6048
Echinococcus multilocularis neuropeptide receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0074 0.9481 0.9481
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.6048 0.6048
Brugia malayi neuropeptide F receptor 0.0074 0.9481 0.9481
Brugia malayi hypothetical protein 0.0074 0.9481 0.9481
Brugia malayi hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0074 0.9481 0.9481
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.011 0.0189
Echinococcus granulosus dna polymerase kappa 0.0023 0.011 0.011
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) melatonin receptor type 1A 0.0074 0.9481 0.9481
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0074 0.9481 0.9481
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni myosin xvIII 0.0074 0.9481 0.9481
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.011 0.011
Echinococcus multilocularis orexin receptor type 2 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Echinococcus multilocularis dro:myosuppressin receptor 0.0074 0.9481 0.9481
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.9481 0.9481
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Echinococcus granulosus fmrfamide receptor 0.0074 0.9481 0.9481
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.6048 0.6048
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.9481 0.9481
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0074 0.9481 0.9481
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0074 0.9481 0.9481
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Leishmania major DNA polymerase eta, putative 0.0054 0.583 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.011 0.0189
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.583 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0074 0.9481 0.9481
Schistosoma mansoni biogenic amine receptor 0.0074 0.9481 0.9481
Echinococcus multilocularis fmrfamide receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0074 0.9481 0.9481
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.011 0.0189
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.9481 0.9481
Echinococcus multilocularis fmrfamide receptor 0.0074 0.9481 0.9481
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.011 0.0189
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Leishmania major DNA polymerase eta, putative 0.0038 0.2842 0.4874
Echinococcus multilocularis G-protein coupled receptor, putative 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni opsin-like receptor 0.0074 0.9481 0.9481
Onchocerca volvulus 0.0074 0.9481 0.5
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) TYRA-2 protein 0.0074 0.9481 0.9481
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0074 0.9481 0.9481
Brugia malayi Dopamine receptor protein 2 0.0074 0.9481 0.9481
Brugia malayi ORL1-like opioid receptor 0.0074 0.9481 0.9481
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.6048 0.6048
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Onchocerca volvulus 0.0074 0.9481 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0074 0.9481 0.9481
Echinococcus granulosus peptide allatostatin:somatostatin 0.0074 0.9481 0.9481
Brugia malayi Serotonin receptor 0.0074 0.9481 0.9481
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.9481 0.9481
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.9481 0.9481
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.2842 0.4874
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.9481 0.9481
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0074 0.9481 0.9481
Echinococcus multilocularis somatostatin receptor 0.0074 0.9481 0.9481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.9481 0.9481
Brugia malayi Dopamine receptor protein 1 0.0074 0.9481 0.9481
Brugia malayi putative neuropeptide receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Brugia malayi Melatonin receptor type 1A 0.0074 0.9481 0.9481
Onchocerca volvulus 0.0074 0.9481 0.5
Brugia malayi G-protein coupled receptor 0.0074 0.9481 0.9481
Brugia malayi hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Schistosoma mansoni hypothetical protein 0.0074 0.9481 0.9481
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.2842 1
Echinococcus granulosus neuropeptide receptor 0.0074 0.9481 0.9481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.9481 0.9481
Brugia malayi G-protein coupled receptor 0.0074 0.9481 0.9481
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.011 0.0189
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni adenoreceptor 0.0074 0.9481 0.9481
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.583 0.583
Schistosoma mansoni amine GPCR 0.0074 0.9481 0.9481
Brugia malayi hypothetical protein 0.0074 0.9481 0.9481
Echinococcus granulosus 7tm_1 domain containing protein 0.0074 0.9481 0.9481
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.9481 0.9481
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.9481 0.9481
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.011 1
Echinococcus granulosus hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0054 0.583 0.583
Brugia malayi larval opioid receptor 0.0074 0.9481 0.9481
Echinococcus granulosus tachykinin peptides receptor 99D 0.0074 0.9481 0.9481
Echinococcus granulosus g protein coupled receptor 0.0074 0.9481 0.9481
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0074 0.9481 0.9481
Echinococcus granulosus sex peptide receptor 0.0074 0.9481 0.9481
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Brugia malayi neuropeptide F receptor 0.0074 0.9481 0.9481
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.011 0.0189
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0074 0.9481 0.9481
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.9481 0.9481
Echinococcus granulosus g-protein coupled receptor 0.0074 0.9481 0.9481
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.9481 0.9481
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.011 1
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.9481 0.9481
Onchocerca volvulus 0.0074 0.9481 0.5
Schistosoma mansoni amine GPCR 0.0074 0.9481 0.9481
Echinococcus granulosus neuropeptide receptor A26 0.0074 0.9481 0.9481
Echinococcus granulosus dna polymerase eta 0.0054 0.583 0.583
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.9481 0.9481
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.9481 0.9481
Echinococcus granulosus allatostatin A receptor 0.0074 0.9481 0.9481
Brugia malayi hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.011 0.011
Onchocerca volvulus 0.0074 0.9481 0.5
Echinococcus granulosus neuropeptide receptor 0.0074 0.9481 0.9481
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Onchocerca volvulus 0.0074 0.9481 0.5
Brugia malayi G protein-coupled receptor 0.0074 0.9481 0.9481
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0074 0.9481 0.9481
Onchocerca volvulus 0.0074 0.9481 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.9481 0.9481
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0074 0.9481 0.9481
Schistosoma mansoni hypothetical protein 0.0074 0.9481 0.9481
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.9481 0.9481
Schistosoma mansoni growth hormone secretagogue receptor 0.0074 0.9481 0.9481
Schistosoma mansoni alpha-1 adrenergic receptor 0.0074 0.9481 0.9481
Schistosoma mansoni histamine h1 receptor 0.0074 0.9481 0.9481
Echinococcus granulosus 7TM GPCR rhodopsin 0.0074 0.9481 0.9481
Schistosoma mansoni hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.011 0.0189
Trypanosoma brucei unspecified product 0.0023 0.011 0.0189
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0074 0.9481 0.9481
Echinococcus multilocularis neuropeptide s receptor 0.0074 0.9481 0.9481
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0074 0.9481 0.9481
Echinococcus multilocularis g-protein coupled receptor 0.0074 0.9481 0.9481
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.011 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.9481 0.9481
Echinococcus multilocularis neuropeptide receptor 0.0074 0.9481 0.9481
Brugia malayi G protein-coupled receptor F59B2.13 0.0074 0.9481 0.9481
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.011 0.0189
Schistosoma mansoni neuropeptide receptor 0.0074 0.9481 0.9481
Echinococcus multilocularis g protein coupled receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Giardia lamblia DINP protein human, muc B family 0.0023 0.011 1
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.9481 0.9481
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.011 0.0189
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.011 0.0189
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.011 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Onchocerca volvulus 0.0074 0.9481 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.9481 0.9481
Schistosoma mansoni opsin-like receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0074 0.9481 0.9481
Echinococcus granulosus serotonin receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Echinococcus multilocularis serotonin receptor 0.0074 0.9481 0.9481
Schistosoma mansoni biogenic amine receptor 0.0074 0.9481 0.9481
Brugia malayi sulfakinin receptor protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.011 0.0189
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.9481 0.9481
Onchocerca volvulus 0.0074 0.9481 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0074 0.9481 0.9481
Onchocerca volvulus 0.0074 0.9481 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.011 0.0189
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Brugia malayi Tachykinin-like peptides receptor 99D 0.0074 0.9481 0.9481
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.6048 0.6048
Brugia malayi putative neuropeptide receptor NPR1 0.0074 0.9481 0.9481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.9481 0.9481
Brugia malayi GnHR receptor homolog 0.0074 0.9481 0.9481
Leishmania major DNA polymerase kappa, putative 0.0023 0.011 0.0189
Brugia malayi Dopamine receptor 0.0074 0.9481 0.9481
Onchocerca volvulus 0.0074 0.9481 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Brugia malayi Serotonin receptor 0.0074 0.9481 0.9481
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.011 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.9481 0.9481
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.9481 0.9481
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.011 0.011
Echinococcus multilocularis neuropeptide FF receptor 2 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni neuropeptide receptor 0.0074 0.9481 0.9481
Brugia malayi RE15519p 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Schistosoma mansoni amine GPCR 0.0074 0.9481 0.9481
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.6048 0.6048
Schistosoma mansoni biogenic amine receptor 0.0074 0.9481 0.9481
Onchocerca volvulus 0.0074 0.9481 0.5
Echinococcus multilocularis serotonin receptor 0.0074 0.9481 0.9481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.9481 0.9481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.9481 0.9481
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.011 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.011 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.9481 0.9481
Echinococcus granulosus dro:myosuppressin receptor 0.0074 0.9481 0.9481
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0074 0.9481 0.9481
Echinococcus multilocularis sex peptide receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.6048 0.6048
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.9481 0.9481
Echinococcus multilocularis allatostatin A receptor 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Onchocerca volvulus 0.0074 0.9481 0.5
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.011 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.9481 0.9481
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0074 0.9481 0.9481
Loa Loa (eye worm) hypothetical protein 0.0074 0.9481 0.9481
Echinococcus multilocularis neuropeptide receptor A26 0.0074 0.9481 0.9481
Onchocerca volvulus Neuropeptide F receptor homolog 0.0074 0.9481 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0074 0.9481 0.9481
Schistosoma mansoni amine GPCR 0.0074 0.9481 0.9481
Brugia malayi follicle stimulating hormone receptor 0.0074 0.9481 0.9481
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0074 0.9481 0.9481
Schistosoma mansoni amine GPCR 0.0074 0.9481 0.9481
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0074 0.9481 0.9481
Echinococcus granulosus neuropeptide FF receptor 2 0.0074 0.9481 0.9481
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.6048 0.6048

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0045 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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