Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.052 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4498 | 0.4498 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0917 | 0.0311 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.052 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0625 | 0.0625 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.052 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4225 | 0.3655 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.851 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4225 | 0.3642 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.9595 | 0.9595 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4498 | 0.4498 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4498 | 0.4131 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0122 | 0.0122 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4498 | 0.4131 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.052 | 1 |
Onchocerca volvulus | 0.0035 | 0.4225 | 0.5 | |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0917 | 0.0311 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.052 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.052 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4225 | 0.4225 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.