Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | mixed-lineage leukemia protein mll | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Neospora caninum | Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma japonicum | ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0571 | 0.1229 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4355 | 0.5403 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0461 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0571 | 0.1229 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.2085 | 0.2587 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.806 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.2085 | 0.2587 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.2085 | 0.4492 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.806 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4642 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.806 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0461 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.2085 | 0.2587 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2085 | 0.2085 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0571 | 0.0571 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2085 | 0.2085 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0878 | 0.1891 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0461 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.5295 | 0.5295 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.2085 | 0.4492 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0042 | 0.0042 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0461 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.2085 | 0.2587 |
Onchocerca volvulus | 0.0035 | 0.4355 | 1 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0461 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.2085 | 0.4492 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4642 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4355 | 0.4355 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0461 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.4381 | 0.9437 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.4381 | 0.9437 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2085 | 0.2085 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.5295 | 0.6569 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.0858 | 0.1064 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4381 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0461 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.4381 | 0.4381 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.806 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4381 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4642 | 0.4642 |
Brugia malayi | hypothetical protein | 0.0035 | 0.4381 | 0.5435 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0461 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0461 | 0.5 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0009 | 0.0571 | 0.1229 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4381 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0461 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4642 | 0.4642 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0878 | 0.1891 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0009 | 0.0571 | 0.1229 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.2085 | 0.4492 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4355 | 0.5403 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0878 | 0.1089 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0461 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0461 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.2085 | 0.2085 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.2085 | 0.4492 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8859 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0461 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0461 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.5295 | 0.6569 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0461 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.2085 | 0.4492 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.4381 | 0.4381 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0461 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4381 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0461 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0461 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.5849 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.