Detailed information for compound 1396801

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 173.468 | Formula: C5H7Cl3
  • H donors: 0 H acceptors: 0 LogP: 3.47 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cl/C=C\Cl.C/C=C\Cl
  • InChi: 1S/C3H5Cl.C2H2Cl2/c1-2-3-4;3-1-2-4/h2-3H,1H3;1-2H/b3-2-;2-1-
  • InChiKey: UKDOTCFNLHHKOF-FGRDZWBJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.1169 0.4189 0.4186
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0012 0.0006 0.0007
Echinococcus multilocularis jumonji domain containing protein 0.0026 0.0057 0.0065
Schistosoma mansoni jumonji domain containing protein 0.0048 0.0138 0.0156
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0017 0.0025 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0028
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0031 0.0025
Schistosoma mansoni ap endonuclease 0.0012 0.0006 0.0007
Echinococcus multilocularis PHD finger protein rhinoceros 0.0019 0.0031 0.0035
Brugia malayi hypothetical protein 0.1169 0.4189 0.4732
Brugia malayi Dihydrofolate reductase 0.0835 0.2983 0.3367
Loa Loa (eye worm) jmjC domain-containing protein 0.0022 0.0045 0.0044
Schistosoma mansoni ap endonuclease 0.0012 0.0006 0.0007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0012 0.0006 0.0007
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0835 0.2983 0.3367
Brugia malayi thymidylate synthase 0.2457 0.8846 1
Schistosoma mansoni hypothetical protein 0.0019 0.0031 0.0035
Echinococcus multilocularis thymidylate synthase 0.2457 0.8846 1
Echinococcus granulosus jumonji domain containing protein 0.0026 0.0057 0.0065
Echinococcus granulosus tm gpcr rhodopsin 0.0137 0.0459 0.0519
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0183 0.0207
Echinococcus multilocularis peregrin 0.0019 0.0031 0.0035
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0082
Loa Loa (eye worm) dihydrofolate reductase 0.0835 0.2983 0.3367
Brugia malayi jmjC domain containing protein 0.0061 0.0183 0.02
Mycobacterium ulcerans thymidylate synthase 0.2457 0.8846 1
Echinococcus granulosus lysine specific demethylase 5A 0.0022 0.0045 0.0051
Echinococcus granulosus peregrin 0.0019 0.0031 0.0035
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0012 0.0006 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0074 0.023 0.0254
Plasmodium falciparum phd finger protein, putative 0.0019 0.0031 0.0025
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0137 0.0459 0.0519
Mycobacterium tuberculosis Hypothetical protein 0.1169 0.4189 0.4732
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0017 0.0025 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0022 0.0045 0.0051
Brugia malayi PHD-finger family protein 0.0019 0.0031 0.0028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0022 0.0045 0.0051
Echinococcus multilocularis nmda type glutamate receptor 0.0023 0.0049 0.0055
Echinococcus granulosus thymidylate synthase 0.2457 0.8846 1
Chlamydia trachomatis dihydrofolate reductase 0.0835 0.2983 1
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0017 0.0025 0.0022
Brugia malayi jmjC domain containing protein 0.0022 0.0045 0.0044
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0023 0.0049 0.0055
Echinococcus granulosus PHD finger protein rhinoceros 0.0019 0.0031 0.0035
Echinococcus multilocularis dihydrofolate reductase 0.0835 0.2983 0.3372
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.2457 0.8846 1
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.2457 0.8846 1
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0031 0.0025
Loa Loa (eye worm) thymidylate synthase 0.2457 0.8846 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0074 0.023 0.0254
Onchocerca volvulus 0.2457 0.8846 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0012 0.0006 0.5
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0031 0.0028
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0183 0.0207
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.2457 0.8846 1
Echinococcus granulosus nmda type glutamate receptor 0.0023 0.0049 0.0055
Brugia malayi Bromodomain containing protein 0.0019 0.0031 0.0028
Schistosoma mansoni dihydrofolate reductase 0.0835 0.2983 0.3372
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0835 0.2983 0.3367
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0128 0.0428 0.0477
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0017 0.0025 1
Brugia malayi dihydrofolate reductase family protein 0.0835 0.2983 0.3367
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0019 0.0031 0.0035
Giardia lamblia PHD finger protein 15 0.0019 0.0031 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0022 0.0045 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.1169 0.4189 1
Brugia malayi MH2 domain containing protein 0.0074 0.023 0.0254
Mycobacterium ulcerans epoxide hydrolase EphA 0.0128 0.0428 0.0477
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0102 0.0109
Echinococcus granulosus dihydrofolate reductase 0.0835 0.2983 0.3372

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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