Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0136 | 0.1055 | 0.2831 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0618 | 0.7801 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0557 | 0.6944 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | thioredoxin reductase | 0.0166 | 0.1474 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0618 | 0.7801 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0557 | 0.6944 | 0.8837 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0557 | 0.6944 | 0.8646 |
Mycobacterium tuberculosis | Probable reductase | 0.0557 | 0.6944 | 0.8837 |
Echinococcus multilocularis | acetylcholinesterase | 0.0136 | 0.1055 | 0.2831 |
Treponema pallidum | thioredoxin reductase (trxB) | 0.0166 | 0.1474 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0249 | 0.2632 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0557 | 0.6944 | 0.8837 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0166 | 0.1474 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0136 | 0.1055 | 0.2831 |
Echinococcus multilocularis | acetylcholinesterase | 0.0136 | 0.1055 | 0.2831 |
Brugia malayi | Carboxylesterase family protein | 0.0136 | 0.1055 | 0.4008 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0557 | 0.6944 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0618 | 0.7801 | 1 |
Chlamydia trachomatis | thioredoxin reductase | 0.0166 | 0.1474 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0557 | 0.6944 | 0.8837 |
Trypanosoma brucei | trypanothione reductase | 0.0249 | 0.2632 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0249 | 0.2632 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0249 | 0.2632 | 1 |
Giardia lamblia | Thioredoxin reductase | 0.0166 | 0.1474 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0249 | 0.2632 | 1 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0166 | 0.1474 | 1 |
Entamoeba histolytica | thioredoxin reductase, putative | 0.0166 | 0.1474 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0136 | 0.1055 | 0.0651 |
Plasmodium falciparum | thioredoxin reductase | 0.0249 | 0.2632 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0136 | 0.1055 | 0.4008 |
Echinococcus granulosus | acetylcholinesterase | 0.0136 | 0.1055 | 0.2831 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0618 | 0.7801 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0249 | 0.2632 | 1 |
Leishmania major | trypanothione reductase | 0.0249 | 0.2632 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0249 | 0.2632 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0092 | 0.0432 | 0.1642 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0249 | 0.2632 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0249 | 0.2632 | 1 |
Brugia malayi | glutathione reductase | 0.0249 | 0.2632 | 1 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0166 | 0.1474 | 1 |
Mycobacterium tuberculosis | Probable thioredoxin reductase TrxB2 (TRXR) (TR) | 0.0166 | 0.1474 | 0.1414 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0249 | 0.2632 | 0.2985 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0166 | 0.1474 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0249 | 0.2632 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0249 | 0.2632 | 1 |
Mycobacterium ulcerans | thioredoxin reductase TrxB2 | 0.0166 | 0.1474 | 1 |
Trichomonas vaginalis | dihydrolipoamide dehydrogenase, putative | 0.0166 | 0.1474 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0136 | 0.1055 | 0.2831 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 112.219 um | PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 1663 (Primary HTS), 1678 (Summary of Project)] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.