Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Muscarinic acetylcholine receptor | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, muscarinic 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 0.0317 | 0.5 | 0.5 | |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0317 | 0.5 | 0.5 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0317 | 0.5 | 0.5 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0317 | 0.5 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0317 | 0.5 | 0.5 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0317 | 0.5 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0317 | 0.5 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0317 | 0.5 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0317 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CCh (functional) | % | Stimulations of inositol phosphate(PI) accumulation in transfected CHO cells in Muscarinic acetylcholine receptor M1. values are the maximal response obtained from the compound tested at 100 uM normalized to the effect of carbachol; Not tested | ChEMBL. | 9651157 |
CCh (functional) | % | Stimulations of inositol phosphate(PI) accumulation in transfected CHO cells in Muscarinic acetylcholine receptor M3. values are the maximal response obtained from the compound tested at 100 uM normalized to the effect of carbachol; Not tested | ChEMBL. | 9651157 |
CCh (functional) | % | Stimulations of inositol phosphate(PI) accumulation in transfected CHO cells in Muscarinic acetylcholine receptor M5 values are the maximal response obtained from the compound tested at 100 uM normalized to the effect of carbachol; Not tested | ChEMBL. | 9651157 |
CCh (functional) | 0 % | Stimulations of inositol phosphate(PI) accumulation in transfected CHO cells in Muscarinic acetylcholine receptor M1. values are the maximal response obtained from the compound tested at 100 uM normalized to the effect of carbachol; Not tested | ChEMBL. | 9651157 |
CCh (functional) | 0 % | Stimulations of inositol phosphate(PI) accumulation in transfected CHO cells in Muscarinic acetylcholine receptor M3. values are the maximal response obtained from the compound tested at 100 uM normalized to the effect of carbachol; Not tested | ChEMBL. | 9651157 |
CCh (functional) | 0 % | Stimulations of inositol phosphate(PI) accumulation in transfected CHO cells in Muscarinic acetylcholine receptor M5 values are the maximal response obtained from the compound tested at 100 uM normalized to the effect of carbachol; Not tested | ChEMBL. | 9651157 |
IC50 (binding) | = 218 nM | Muscarinic acetylcholine receptor binding assay was conducted using [3H]-cis-methyldioxolane (CMD) to label agonist sites in membrane preparations from rat neocortex | ChEMBL. | 9651157 |
IC50 (binding) | = 218 nM | Muscarinic acetylcholine receptor binding assay was conducted using [3H]-cis-methyldioxolane (CMD) to label agonist sites in membrane preparations from rat neocortex | ChEMBL. | 9651157 |
IC50 (binding) | = 219 nM | Binding affinity towards muscarinic receptor using [3H]-cis-methyldioxolane (CMD) to label agonist sites in membrane preparations from rat neocortex | ChEMBL. | No reference |
IC50 (binding) | = 219 nM | Binding affinity towards muscarinic receptor using [3H]-cis-methyldioxolane (CMD) to label agonist sites in membrane preparations from rat neocortex | ChEMBL. | No reference |
IC50 (binding) | = 17600 nM | Muscarinic acetylcholine receptor binding assay was conducted using [3H]-quinuclidinyl benzilate (QNB) to label antagonist sites in membrane preparations from rat neocortex | ChEMBL. | 9651157 |
IC50 (binding) | = 17600 nM | Muscarinic acetylcholine receptor binding assay was conducted using [3H]-quinuclidinyl benzilate (QNB) to label antagonist sites in membrane preparations from rat neocortex | ChEMBL. | 9651157 |
IC50 (binding) | = 17658 nM | Binding affinity towards muscarinic receptor using [3H]-quinuclidinyl benzilate (QNB) to label antagonist sites in membrane preparations from rat neocortex | ChEMBL. | No reference |
IC50 (binding) | = 17658 nM | Binding affinity towards muscarinic receptor using [3H]-quinuclidinyl benzilate (QNB) to label antagonist sites in membrane preparations from rat neocortex | ChEMBL. | No reference |
IC50 (binding) | = 16.6 uM | Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M1 | ChEMBL. | 9651157 |
IC50 (binding) | = 16.6 uM | Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M1 | ChEMBL. | 9651157 |
IC50 (binding) | = 69.3 uM | Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2 | ChEMBL. | 9651157 |
IC50 (binding) | = 69.3 uM | Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2 | ChEMBL. | 9651157 |
Ratio (binding) | = 80.7 | Ratio of QNB binding to CMD binding was evaluated | ChEMBL. | 9651157 |
Ratio (binding) | = 81 | Ratio of QNB/CMD binding affinities to predict agonistic efficacy at muscarinic receptor | ChEMBL. | No reference |
Ratio (binding) | = 4.17 | Inhibitory ratio of QNB binding to m1 vs m2 receptor [IC50(m1)/IC50(m2)] was evaluated | ChEMBL. | 9651157 |
Ratio (binding) | = 4.2 | Ratio of binding affinity against m1 over m2 muscarinic subtypes was determined using labelled [3H]-QNB in CHO cells | ChEMBL. | No reference |
Ratio (binding) | = 80.7 | Ratio of QNB binding to CMD binding was evaluated | ChEMBL. | 9651157 |
Ratio (binding) | = 81 | Ratio of QNB/CMD binding affinities to predict agonistic efficacy at muscarinic receptor | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.