Detailed information for compound 1397042

Basic information

Technical information
  • TDR Targets ID: 1397042
  • Name: 2-[[3-[(3,4-dimethoxyphenyl)methyl]-4-oxo-[1, 3,4]thiadiazolo[5,4-c][1,2,4]triazin-7-yl]sul fanyl]-N-phenylacetamide
  • MW: 469.537 | Formula: C21H19N5O4S2
  • H donors: 1 H acceptors: 2 LogP: 3.66 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)Cc1nnc2n(c1=O)nc(s2)SCC(=O)Nc1ccccc1
  • InChi: 1S/C21H19N5O4S2/c1-29-16-9-8-13(11-17(16)30-2)10-15-19(28)26-20(24-23-15)32-21(25-26)31-12-18(27)22-14-6-4-3-5-7-14/h3-9,11H,10,12H2,1-2H3,(H,22,27)
  • InChiKey: BJOJDURDOKWMLD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[3-[(3,4-dimethoxyphenyl)methyl]-4-oxo-[1,3,4]thiadiazolo[5,4-c][1,2,4]triazin-7-yl]sulfanyl]-N-phenyl-acetamide
  • 2-[[3-[(3,4-dimethoxyphenyl)methyl]-4-oxo-[1,3,4]thiadiazolo[5,4-c][1,2,4]triazin-7-yl]thio]-N-phenylacetamide
  • 2-[[3-(3,4-dimethoxybenzyl)-4-keto-[1,3,4]thiadiazolo[5,4-c][1,2,4]triazin-7-yl]thio]-N-phenyl-acetamide
  • 2-[[3-[(3,4-dimethoxyphenyl)methyl]-4-oxo-[1,3,4]thiadiazolo[5,4-c][1,2,4]triazin-7-yl]sulfanyl]-N-phenyl-ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0218 0.0347 0.0347
Brugia malayi coiled-coil like protein 1 0.0072 0.0065 0.0065
Brugia malayi hypothetical protein 0.0051 0.0024 0.0024
Echinococcus granulosus pdz domain containing protein 0.0051 0.0024 0.0024
Brugia malayi RNA, U transporter 1 0.0099 0.0116 0.0116
Echinococcus multilocularis endonuclease reverse transcriptase 0.0077 0.0074 0.0074
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0218 0.0347 0.5
Echinococcus granulosus sphingomyelin synthase protein 1 0.0051 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0051 0.0024 0.0024
Brugia malayi Nuclear hormone receptor-like 1 0.0179 0.0272 0.0272
Schistosoma mansoni hypothetical protein 0.0077 0.0074 0.0074
Plasmodium vivax lysine--tRNA ligase, putative 0.0218 0.0347 1
Plasmodium vivax cysteine repeat modular protein 2, putative 0.0077 0.0074 0.1048
Brugia malayi cask-interacting protein 2 0.0051 0.0024 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0074 0.1048
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0074 0.0067 0.0067
Schistosoma mansoni spingomyelin synthetase-related 0.0051 0.0024 0.0024
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0072 0.0065 0.0065
Onchocerca volvulus 0.0051 0.0024 0.0024
Brugia malayi ephrin receptor 1 precursor 0.0457 0.0812 0.0812
Schistosoma mansoni lysyl-tRNA synthetase 0.0218 0.0347 0.0347
Giardia lamblia CEGP1 protein 0.0077 0.0074 0.1541
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0045 0.0011 0.0011
Schistosoma mansoni ephrin receptor 0.0927 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.0051 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0051 0.0024 0.0024
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0072 0.0065 0.0065
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0074 0.0067 0.0067
Brugia malayi Nuclear hormone receptor-like 1 0.0161 0.0236 0.0236
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0218 0.0347 1
Echinococcus granulosus liprin alpha 2 0.0051 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0158 0.0232 0.0232
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0024 0.0024
Onchocerca volvulus 0.0077 0.0074 0.0074
Onchocerca volvulus Tankyrase homolog 0.0051 0.0024 0.0024
Brugia malayi lysyl-tRNA synthetase 0.0218 0.0347 0.0347
Brugia malayi Sphingomyelin synthase-related 1 0.0051 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0051 0.0024 0.0024
Brugia malayi GCC2 and GCC3 family protein 0.0077 0.0074 0.0074
Loa Loa (eye worm) tnks protein 0.0051 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0051 0.0024 0.0024
Echinococcus multilocularis polyhomeotic protein 2 0.0051 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0051 0.0024 0.0024
Brugia malayi AIDA-1b 0.0051 0.0024 0.0024
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0051 0.0024 0.0024
Brugia malayi Shank2E 0.0051 0.0024 0.0024
Echinococcus multilocularis snurportin 1 0.0372 0.0646 0.0646
Echinococcus multilocularis Sterile alpha motif SAM 0.0051 0.0024 0.0024
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0051 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0072 0.0065 0.0065
Echinococcus multilocularis lysyl tRNA synthetase 0.0218 0.0347 0.0347
Echinococcus multilocularis pdz domain containing protein 0.0051 0.0024 0.0024
Echinococcus granulosus Sterile alpha motif type 0.0051 0.0024 0.0024
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0218 0.0347 1
Echinococcus multilocularis liprin alpha 2 0.0051 0.0024 0.0024
Echinococcus granulosus lysyl tRNA synthetase 0.0218 0.0347 0.0347
Echinococcus multilocularis histone acetyltransferase myst3 0.0051 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0051 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0077 0.0074 0.0074
Schistosoma mansoni lysyl-tRNA synthetase 0.0218 0.0347 0.0347
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0191 0.0295 0.8388
Schistosoma mansoni thyroid hormone receptor 0.0113 0.0143 0.0143
Brugia malayi Liprin-alpha 2 0.0072 0.0065 0.0065
Brugia malayi GCC2 and GCC3 family protein 0.0077 0.0074 0.0074
Schistosoma mansoni ephrin receptor 0.0045 0.0011 0.0011
Echinococcus granulosus endonuclease reverse transcriptase 0.0077 0.0074 0.0074
Entamoeba histolytica hypothetical protein 0.0218 0.0347 1
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0051 0.0024 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0074 0.1048
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0024 0.0024
Loa Loa (eye worm) TK/EPH protein kinase 0.1122 0.2103 0.2103
Onchocerca volvulus 0.0077 0.0074 0.0074
Echinococcus multilocularis ephrin type A receptor 4 A 0.1004 0.1875 0.1875
Loa Loa (eye worm) hypothetical protein 0.0918 0.1707 0.1707
Schistosoma mansoni Protein aveugle 0.0051 0.0024 0.0024
Brugia malayi bicaudal-C 0.0051 0.0024 0.0024
Echinococcus granulosus polyhomeotic protein 2 0.0051 0.0024 0.0024
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0074 0.0067 0.0067
Onchocerca volvulus 0.0051 0.0024 0.0024
Schistosoma mansoni Protein aveugle 0.0051 0.0024 0.0024
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0024 0.0024
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0072 0.0065 0.0065
Echinococcus multilocularis thyroid hormone receptor alpha 0.0113 0.0143 0.0143
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0161 0.0236 0.0236
Schistosoma mansoni lip-related protein (liprin) alpha 0.0072 0.0065 0.0065
Onchocerca volvulus 0.0051 0.0024 0.0024
Onchocerca volvulus 0.0051 0.0024 0.0024
Schistosoma mansoni sodium-bile acid cotransporter related 0.2104 0.401 0.401
Loa Loa (eye worm) hypothetical protein 0.0072 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0072 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0372 0.0646 0.0646
Leishmania major lysyl-tRNA synthetase, putative 0.0218 0.0347 0.5
Loa Loa (eye worm) hypothetical protein 0.0077 0.0074 0.0074
Chlamydia trachomatis lysine--tRNA ligase 0.0218 0.0347 0.5
Echinococcus multilocularis Sterile alpha motif type 0.0051 0.0024 0.0024
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0218 0.0347 1
Echinococcus granulosus ephrin type A receptor 4 A 0.1004 0.1875 0.1875
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0185 0.0284 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0161 0.0236 0.0236
Schistosoma mansoni polyhomeotic 0.0051 0.0024 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0113 0.0143 0.0143
Schistosoma mansoni phd finger protein 0.0051 0.0024 0.0024
Giardia lamblia Lysyl-tRNA synthetase 0.0218 0.0347 1
Loa Loa (eye worm) hypothetical protein 0.0484 0.0863 0.0863
Plasmodium falciparum lysine--tRNA ligase 0.0218 0.0347 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0045 0.0011 0.0011
Schistosoma mansoni DNAj-like protein 0.0051 0.0024 0.0024
Onchocerca volvulus 0.0051 0.0024 0.0024
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0218 0.0347 0.5
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0072 0.0065 0.0065
Loa Loa (eye worm) AIDA-1b 0.0051 0.0024 0.0024
Brugia malayi hypothetical protein 0.0051 0.0024 0.0024
Echinococcus granulosus snurportin 1 0.0372 0.0646 0.0646
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0077 0.0074 0.1048
Brugia malayi GCC2 and GCC3 family protein 0.0077 0.0074 0.0074
Echinococcus granulosus histone acetyltransferase myst3 0.0051 0.0024 0.0024
Toxoplasma gondii lysine-tRNA ligase 0.0218 0.0347 1
Onchocerca volvulus 0.0051 0.0024 0.0024
Echinococcus multilocularis liprin alpha 2 0.0072 0.0065 0.0065
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0218 0.0347 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0074 0.0074
Onchocerca volvulus 0.0051 0.0024 0.0024
Plasmodium vivax cysteine repeat modular protein 3, putative 0.0077 0.0074 0.1048
Onchocerca volvulus 0.0918 0.1707 0.1707
Loa Loa (eye worm) hypothetical protein 0.0077 0.0074 0.0074
Brugia malayi GCC2 and GCC3 family protein 0.0077 0.0074 0.0074
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0185 0.0284 0.5
Schistosoma mansoni sodium-bile acid cotransporter 0.3084 0.5914 0.5914
Echinococcus granulosus Sterile alpha motif SAM 0.0072 0.0065 0.0065
Echinococcus granulosus liprin alpha 2 0.0072 0.0065 0.0065
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0024 0.0024
Giardia lamblia Hypothetical protein 0.0077 0.0074 0.1541
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0072 0.0065 0.0065

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3109 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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