Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | elastase, neutrophil expressed | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | transmembrane protease serine 3 | elastase, neutrophil expressed | 267 aa | 236 aa | 27.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hexokinase | 0.0079 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0079 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0079 | 1 | 1 |
Giardia lamblia | MRP-like ABC transporter | 0.0018 | 0.0616 | 1 |
Plasmodium falciparum | hexokinase | 0.0079 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0079 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0073 | 0.9101 | 0.9042 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0018 | 0.0616 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0079 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0079 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0073 | 0.9101 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.6142 | 0.6142 |
Treponema pallidum | hexokinase (hxk) | 0.0079 | 1 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0073 | 0.9101 | 0.9042 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0073 | 0.9101 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0073 | 0.9101 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0079 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0616 | 0.0616 |
Brugia malayi | hypothetical protein | 0.0035 | 0.3211 | 0.2765 |
Loa Loa (eye worm) | hexokinase | 0.005 | 0.5479 | 0.5479 |
Brugia malayi | hexokinase type II | 0.0025 | 0.1724 | 0.1181 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0073 | 0.9101 | 0.9042 |
Giardia lamblia | ABC transporter, putative | 0.0018 | 0.0616 | 1 |
Echinococcus granulosus | hexokinase | 0.0079 | 1 | 1 |
Onchocerca volvulus | 0.0079 | 1 | 1 | |
Brugia malayi | Hexokinase family protein | 0.005 | 0.5479 | 0.5182 |
Leishmania major | hexokinase, putative | 0.0079 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0079 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0594 | 0.0594 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.3211 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0073 | 0.9101 | 0.9042 |
Echinococcus multilocularis | hexokinase | 0.0079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0616 | 0.0616 |
Loa Loa (eye worm) | hexokinase | 0.0024 | 0.1621 | 0.1621 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0073 | 0.9101 | 0.9042 |
Loa Loa (eye worm) | hexokinase type II | 0.0079 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0079 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0079 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0079 | 1 | 1 |
Onchocerca volvulus | 0.0079 | 1 | 1 | |
Onchocerca volvulus | 0.0073 | 0.9101 | 0.8012 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0035 | 0.3211 | 0.2765 |
Trypanosoma brucei | hexokinase, putative | 0.0079 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0024 | 0.1621 | 0.1071 |
Brugia malayi | Hexokinase family protein | 0.0079 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0079 | 1 | 1 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.0018 | 0.0616 | 0.0616 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1724 | 0.1724 |
Loa Loa (eye worm) | thymidylate synthase | 0.0073 | 0.9101 | 0.9101 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.0018 | 0.0616 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0079 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0073 | 0.9101 | 0.9042 |
Brugia malayi | thymidylate synthase | 0.0073 | 0.9101 | 0.9042 |
Leishmania major | hexokinase, putative | 0.0079 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1724 | 0.1724 |
Onchocerca volvulus | 0.0079 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0079 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0079 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0073 | 0.9101 | 0.9042 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.4 uM | In vitro inhibitory activity against human leukocyte elastase (HLE) | ChEMBL. | 2391693 |
IC50 (binding) | = 2.4 uM | In vitro inhibitory activity against human leukocyte elastase (HLE) | ChEMBL. | 2391693 |
k obs / 1 (binding) | = 3500 M-1 s-1 | Second-order rate constant for time-dependent inactivation of Human Leukocyte Elastase for 15 min | ChEMBL. | 2391693 |
k obs / 1 (binding) | = 3500 M-1 s-1 | Second-order rate constant for time-dependent inactivation of Human Leukocyte Elastase for 15 min | ChEMBL. | 2391693 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.