Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 13 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 13 | 365 aa | 366 aa | 30.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1115 | 0.1279 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0041 | 0.0612 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0612 | 0.0396 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0041 | 0.0612 | 0.0612 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.4601 | 0.5276 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0041 | 0.0612 | 0.0702 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.8721 | 0.8691 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0612 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.8721 | 0.8691 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0041 | 0.0612 | 0.0702 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0067 | 0.2517 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0096 | 0.4601 | 0.4919 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0067 | 0.2517 | 0.2349 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0041 | 0.0612 | 0.0612 |
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0041 | 0.0612 | 0.5 |
Echinococcus multilocularis | geminin | 0.017 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.8721 | 0.8691 |
Echinococcus multilocularis | dna polymerase eta | 0.0096 | 0.4601 | 0.4477 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0041 | 0.0612 | 0.0396 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0612 | 0.0396 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0096 | 0.4601 | 0.4919 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0225 | 0.0258 |
Echinococcus granulosus | dna polymerase eta | 0.0096 | 0.4601 | 0.4477 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0041 | 0.0612 | 0.5 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0.8721 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.8721 | 0.8691 |
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0612 | 0.5 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0.8721 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0152 | 0.8721 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0225 | 0.0225 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0041 | 0.0612 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.8721 | 0.8691 |
Giardia lamblia | DINP protein human, muc B family | 0.0041 | 0.0612 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0067 | 0.2517 | 0.2349 |
Leishmania major | DNA polymerase eta, putative | 0.0096 | 0.4601 | 0.4919 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1115 | 0.1279 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0041 | 0.0612 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.8721 | 0.8691 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1115 | 0.1279 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0096 | 0.4601 | 0.5276 |
Brugia malayi | P38 map kinase family protein 2 | 0.0152 | 0.8721 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0096 | 0.4601 | 0.4601 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0041 | 0.0612 | 0.0396 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1115 | 0.1279 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0225 | 0.0225 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.8721 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.8721 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 280 nM | Evaluated for inhibition of human mitogen-activated protein kinase p38 | ChEMBL. | 15115396 |
Kd (binding) | = 280 nM | Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluorescent binding assay | ChEMBL. | 12086485 |
Kd (binding) | = 280 nM | Evaluated for inhibition of human mitogen-activated protein kinase p38 | ChEMBL. | 15115396 |
Kd (binding) | = 280 nM | Binding affinity for human recombinant Mitogen-activated protein kinase p38 in a fluorescent binding assay | ChEMBL. | 12086485 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.