TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 459.537 | Formula: C27H29N3O4
H donors: 2 H acceptors: 3 LogP: 3.79 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: CCN(C(=O)COc1ccccc1Cc1ccccc1)CC(=O)Nc1ccc(cc1)NC(=O)C
InChi: 1S/C27H29N3O4/c1-3-30(18-26(32)29-24-15-13-23(14-16-24)28-20(2)31)27(33)19-34-25-12-8-7-11-22(25)17-21-9-5-4-6-10-21/h4-16H,3,17-19H2,1-2H3,(H,28,31)(H,29,32)
InChiKey: JLEQYKJTRNGXDF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	gabp alpha	0.0071	0.0595	0.0512
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.013	0.1261	0.1261
Giardia lamblia	PHD finger protein 15	0.0032	0.0159	0.5
Brugia malayi	nuclear hormone receptor family member odr-7	0.0025	0.0088	0.0023
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0053	0.0402	0.0317
Echinococcus multilocularis	jumonji domain containing protein	0.0044	0.0297	0.0211
Echinococcus multilocularis	FTZ F1 alpha	0.0053	0.0402	0.0317
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0065	0.1394
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0402	0.0402
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0468	0.0383
Echinococcus granulosus	peregrin	0.0032	0.0159	0.0072
Brugia malayi	tailless protein	0.0025	0.0088	0.0023
Echinococcus multilocularis	peregrin	0.0032	0.0159	0.0072
Brugia malayi	Steroid receptor seven-up type 2	0.0053	0.0402	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0065	0.0065
Toxoplasma gondii	hypothetical protein	0.0114	0.1082	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0025	0.0088	0.0023
Echinococcus granulosus	carbonic anhydrase	0.0114	0.1082	0.1003
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0053	0.0402	0.0339
Onchocerca volvulus	Alhambra homolog	0.0032	0.0159	0.0094
Trypanosoma brucei	carbonic anhydrase-like protein	0.0211	0.2161	0.5
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0114	0.1082	0.1023
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0053	0.0402	0.0402
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0053	0.0402	0.0339
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0211	0.2161	0.2161
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0053	0.0402	0.0339
Brugia malayi	RNA binding protein	0.013	0.1261	0.1203
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0053	0.0402	0.0317
Brugia malayi	photoreceptor-specific nuclear receptor	0.0053	0.0402	0.0339
Onchocerca volvulus	Bile acid receptor homolog	0.0053	0.0402	0.0339
Brugia malayi	conserved hypotetical protein	0.0025	0.0088	0.0023
Schistosoma mansoni	carbonic anhydrase-related	0.0114	0.1082	0.1003
Echinococcus multilocularis	carbonic anhydrase	0.0114	0.1082	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0402	0.0402
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0065	0.5
Schistosoma mansoni	tar DNA-binding protein	0.013	0.1261	0.1183
Echinococcus multilocularis	carbonic anhydrase II	0.0211	0.2161	0.2091
Loa Loa (eye worm)	DR-78	0.0025	0.0088	0.0088
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0025	0.0088	0.0023
Brugia malayi	Ets-domain containing protein	0.0071	0.0595	0.0533
Loa Loa (eye worm)	TAR-binding protein	0.013	0.1261	0.1261
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0053	0.0402	0.0317
Brugia malayi	nuclear receptor RXR	0.0028	0.0122	0.0057
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0061	0.0492	0.0408
Plasmodium vivax	SET domain protein, putative	0.0061	0.0492	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0468	0.3347
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0053	0.0402	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0402	0.0402
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0061	0.0492	0.0408
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0053	0.0402	0.0317
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0053	0.0402	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0088
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0065	0.1394
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0468	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0065	0.1394
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0402	0.0402
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0053	0.0402	0.0317
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0032	0.0159	0.0072
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0468	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0028	0.0122	0.0034
Echinococcus multilocularis	carbonic anhydrase	0.0114	0.1082	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1082	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0088
Brugia malayi	RNA recognition motif domain containing protein	0.013	0.1261	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0492	0.0492
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0053	0.0402	0.0317
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0053	0.0402	0.0339
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0065	0.1394
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0065	0.1394
Schistosoma mansoni	tar DNA-binding protein	0.013	0.1261	0.1183
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0065	0.0065
Echinococcus multilocularis	tar DNA binding protein	0.013	0.1261	0.1183
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0468	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0053	0.0402	0.0339
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0053	0.0402	0.0317
Brugia malayi	hypothetical protein	0.0028	0.0122	0.0057
Echinococcus granulosus	jumonji domain containing protein	0.0044	0.0297	0.0211
Brugia malayi	Nuclear hormone receptor E75	0.0025	0.0088	0.0023
Schistosoma mansoni	tar DNA-binding protein	0.013	0.1261	0.1183
Loa Loa (eye worm)	RNA binding protein	0.013	0.1261	0.1261
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0233	0.0146
Brugia malayi	nuclear receptor NHR-88	0.0053	0.0402	0.0339
Brugia malayi	jmjC domain containing protein	0.0103	0.0959	0.09
Brugia malayi	nuclear hormone receptor	0.0025	0.0088	0.0023
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0233	0.0146
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0468	0.0383
Onchocerca volvulus		0.0053	0.0402	0.0339
Schistosoma mansoni	retinoic acid receptor RXR	0.0053	0.0402	0.0317
Echinococcus granulosus	PHD finger protein rhinoceros	0.0032	0.0159	0.0072
Brugia malayi	ecdysone receptor	0.0025	0.0088	0.0023
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0053	0.0402	0.0317
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0103	0.0959	0.0879
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0053	0.0402	0.0317
Onchocerca volvulus		0.0488	0.5242	0.5211
Loa Loa (eye worm)	hypothetical protein	0.0054	0.041	0.041
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0114	0.1082	0.1023
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0088
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0065	0.5
Brugia malayi	Pre-SET motif family protein	0.0429	0.4582	0.4547
Schistosoma mansoni	tar DNA-binding protein	0.013	0.1261	0.1183
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0065	0.1394
Echinococcus granulosus	lysine specific demethylase 5A	0.0038	0.0233	0.0146
Loa Loa (eye worm)	jmjC domain-containing protein	0.0065	0.0534	0.0534
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0103	0.0959	0.0879
Schistosoma mansoni	sodium-bile acid cotransporter	0.0544	0.5867	0.583
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0065	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0053	0.0402	0.0317
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0468	1
Brugia malayi	hypothetical protein	0.0025	0.0088	0.0023
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0114	0.1082	0.1023
Echinococcus multilocularis	GA binding protein alpha chain	0.0071	0.0595	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0216	0.2214	0.2214
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0053	0.0402	0.0339
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0032	0.0159	0.0072
Schistosoma mansoni	nuclear hormone receptor	0.0053	0.0402	0.0317
Loa Loa (eye worm)	steroid hormone receptor	0.0053	0.0402	0.0402
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0053	0.0402	0.0402
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0053	0.0402	0.0402
Echinococcus multilocularis	ecdysone induced protein 78C	0.0053	0.0402	0.0317
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0065	0.5
Onchocerca volvulus		0.0025	0.0088	0.0023
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0053	0.0402	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0088
Echinococcus granulosus	tar DNA binding protein	0.013	0.1261	0.1183
Schistosoma mansoni	carbonic anhydrase	0.0114	0.1082	0.1003
Brugia malayi	nuclear hormone receptor	0.0053	0.0402	0.0339
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.0233	0.0233
Echinococcus granulosus	carbonic anhydrase II	0.0211	0.2161	0.2091
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0053	0.0402	0.0402
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0053	0.0402	0.0339
Echinococcus multilocularis	carbonic anhydrase	0.0114	0.1082	0.1003
Leishmania major	carbonic anhydrase-like protein	0.0211	0.2161	1
Schistosoma mansoni	sodium-bile acid cotransporter related	0.0371	0.394	0.3887
Brugia malayi	orphan nuclear receptor NR2E1	0.0025	0.0088	0.0023
Loa Loa (eye worm)	nuclear hormone receptor	0.0025	0.0088	0.0088
Brugia malayi	Nuclear hormone receptor-like 1	0.0219	0.2248	0.2197
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0492	0.0408
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0053	0.0402	0.0339
Schistosoma mansoni	jumonji domain containing protein	0.0082	0.0723	0.064
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0053	0.0402	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0088
Plasmodium falciparum	carbonic anhydrase	0.0114	0.1082	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0038	0.0233	0.0146
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0025	0.0088	0.0088
Brugia malayi	TAR-binding protein	0.013	0.1261	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0088
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0053	0.0402	0.0317
Brugia malayi	jmjC domain containing protein	0.0038	0.0233	0.0169
Echinococcus granulosus	carbonic anhydrase	0.0114	0.1082	0.1003
Plasmodium falciparum	phd finger protein, putative	0.0032	0.0159	0.147
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0088
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0492	0.0408
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0211	0.2161	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0122	0.0122
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0065	0.5
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0211	0.2161	0.2109
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0402	0.0402
Brugia malayi	nuclear receptor NHR-67	0.0025	0.0088	0.0023
Schistosoma mansoni	RAR-like nuclear receptor	0.0053	0.0402	0.0317
Brugia malayi	Nuclear hormone receptor E75	0.0025	0.0088	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1082	0.1082
Brugia malayi	nuclear receptor RXR	0.0025	0.0088	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0122	0.0122
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0211	0.2161	0.2091
Brugia malayi	hypothetical protein	0.0028	0.0122	0.0057
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0053	0.0402	0.0339
Loa Loa (eye worm)	carbonic anhydrase 3	0.0211	0.2161	0.2161
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0101	0.093	0.085
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0468	0.1921
Brugia malayi	N-terminal motif family protein	0.0176	0.1771	0.1717
Brugia malayi	Bromodomain containing protein	0.0032	0.0159	0.0094
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0025	0.0088	0.0023
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0053	0.0402	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0122	0.0122
Loa Loa (eye worm)	fli-1 protein	0.0215	0.2199	0.2199
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0053	0.0402	0.0317
Brugia malayi	Pre-SET motif family protein	0.0061	0.0492	0.043
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0053	0.0402	0.0402
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0053	0.0402	0.0339
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0053	0.0402	0.0317
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0053	0.0402	0.0402
Brugia malayi	hypothetical protein	0.0025	0.0088	0.0023
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0053	0.0402	0.0339
Schistosoma mansoni	hypothetical protein	0.0032	0.0159	0.0072
Onchocerca volvulus		0.0025	0.0088	0.0023
Loa Loa (eye worm)	hypothetical protein	0.006	0.0481	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0088
Schistosoma mansoni	tar DNA-binding protein	0.013	0.1261	0.1183
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0429	0.4582	0.4582
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0053	0.0402	0.0339
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0028	0.0122	0.0034
Schistosoma mansoni	thyroid hormone receptor	0.0154	0.1525	0.145
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0065	0.1394
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0025	0.0088	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0088
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0211	0.2161	0.5
Echinococcus granulosus	GA binding protein alpha chain	0.0071	0.0595	0.0512
Brugia malayi	Fli-1 protein	0.0215	0.2199	0.2148
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0114	0.1082	0.1023
Schistosoma mansoni	thyroid hormone receptor	0.0154	0.1525	0.145
Echinococcus granulosus	FTZ F1 alpha	0.0053	0.0402	0.0317
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0061	0.0492	0.3611
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0101	0.093	0.085
Brugia malayi	Ets-domain containing protein	0.0071	0.0595	0.0533
Trichomonas vaginalis	set domain proteins, putative	0.0488	0.5242	0.5
Onchocerca volvulus		0.0061	0.0492	0.043
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0061	0.0492	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0402	0.0402
Onchocerca volvulus	Protein ultraspiracle homolog	0.0053	0.0402	0.0339
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0053	0.0402	0.0317
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0053	0.0402	0.0317
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0468	0.0383
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0065	0.1394
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0492	0.0408
Brugia malayi	PHD-finger family protein	0.0032	0.0159	0.0094
Schistosoma mansoni	ets-related	0.0215	0.2199	0.213
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0402	0.0402
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0053	0.0402	0.0317
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0053	0.0402	0.0339
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0065	0.1394
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0219	0.2248	0.2248
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0114	0.1082	0.1082
Schistosoma mansoni	carbonic anhydrase-related	0.0114	0.1082	0.1003
Brugia malayi	ecdysteroid receptor	0.0053	0.0402	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0122	0.0122
Echinococcus granulosus	carbonic anhydrase	0.0114	0.1082	0.1003
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0028	0.0122	0.0034
Schistosoma mansoni	carbonic anhydrase-related	0.0114	0.1082	0.1003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0053	0.0402	0.0402
Schistosoma mansoni	hypothetical protein	0.0101	0.093	0.085
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0122	0.0122
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0025	0.0088	0.0088
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0159	0.3231
Echinococcus granulosus	ecdysone induced protein 78C	0.0053	0.0402	0.0317
Brugia malayi	Nuclear hormone receptor-like 1	0.0244	0.2529	0.248
Echinococcus granulosus	histone lysine methyltransferase setb	0.0061	0.0492	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0065	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0114	0.1082	0.1082
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0154	0.1525	0.145
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0402	0.0402
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0065	0.1394
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1771	0.1771
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0114	0.1082	0.1023
Schistosoma mansoni	hypothetical protein	0.0114	0.1082	0.1003
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0211	0.2161	0.2091
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0059	0.0467	0.0382
Brugia malayi	steroid hormone receptor	0.0053	0.0402	0.0339
Brugia malayi	nuclear receptor NHR-88	0.0025	0.0088	0.0023
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0071	0.0595	0.0595
Loa Loa (eye worm)	PHD-finger family protein	0.0032	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0088	0.0088
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0176	0.1771	0.1717
Brugia malayi	Nuclear hormone receptor-like 1	0.0219	0.2248	0.2197
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0468	0.0383
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0028	0.0122	0.0034
Schistosoma mansoni	coup transcription factor	0.0053	0.0402	0.0317
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0211	0.2161	0.2109

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1533960

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1397188