Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3774 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0115 | 0.3774 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0115 | 0.3774 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0115 | 0.3774 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0115 | 0.3774 | 0.5 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0027 | 0.0073 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0027 | 0.0073 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0115 | 0.3774 | 0.3757 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0115 | 0.3774 | 0.3757 |
Schistosoma mansoni | coup transcription factor | 0.0115 | 0.3774 | 0.3757 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0115 | 0.3774 | 0.3757 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0115 | 0.3774 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0115 | 0.3774 | 0.3757 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0027 | 0.0073 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0115 | 0.3774 | 0.3757 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0115 | 0.3774 | 0.3757 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0115 | 0.3774 | 0.3757 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0061 | 0.0027 | 0.0073 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0115 | 0.3774 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0115 | 0.3774 | 0.3757 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0115 | 0.3774 | 0.3757 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0115 | 0.3774 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0061 | 0.0027 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0027 | 0.0073 |
Brugia malayi | nuclear receptor RXR | 0.0061 | 0.0027 | 0.0073 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0115 | 0.3774 | 0.3757 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0115 | 0.3774 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0115 | 0.3774 | 0.3757 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0115 | 0.3774 | 0.3757 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0115 | 0.3774 | 0.3757 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0115 | 0.3774 | 0.3757 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0115 | 0.3774 | 0.3757 |
Schistosoma mansoni | nuclear hormone receptor | 0.0115 | 0.3774 | 0.3757 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0115 | 0.3774 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0115 | 0.3774 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0115 | 0.3774 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0027 | 0.0073 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0115 | 0.3774 | 0.3757 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0115 | 0.3774 | 0.3757 |
Onchocerca volvulus | 0.0115 | 0.3774 | 0.5 | |
Brugia malayi | nuclear hormone receptor | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3774 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0115 | 0.3774 | 0.3757 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0115 | 0.3774 | 0.3757 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0115 | 0.3774 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0027 | 0.0073 |
Schistosoma mansoni | thyroid hormone receptor | 0.0115 | 0.3774 | 0.3757 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0115 | 0.3774 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0115 | 0.3774 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0115 | 0.3774 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0115 | 0.3774 | 0.3757 |
Brugia malayi | steroid hormone receptor | 0.0115 | 0.3774 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0115 | 0.3774 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0115 | 0.3774 | 0.3757 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.3774 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0115 | 0.3774 | 0.3757 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0115 | 0.3774 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0115 | 0.3774 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0115 | 0.3774 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0115 | 0.3774 | 0.3757 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0115 | 0.3774 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0115 | 0.3774 | 0.3757 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0115 | 0.3774 | 0.3757 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0061 | 0.0027 | 0.0073 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0115 | 0.3774 | 0.3757 |
Echinococcus granulosus | FTZ F1 alpha | 0.0115 | 0.3774 | 0.3757 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0027 | 0.0073 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0115 | 0.3774 | 0.3757 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.206 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 37.6505 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.