Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA helicase recq1 | 0.0019 | 0.1545 | 0.1495 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0019 | 0.1545 | 0.5359 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0882 | 0.2315 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.3615 | 0.2925 |
Onchocerca volvulus | 0.0033 | 0.3615 | 0.5 | |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.1545 | 0.1262 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0019 | 0.1545 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.3615 | 0.3577 |
Echinococcus multilocularis | musashi | 0.0033 | 0.3615 | 0.2925 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.3615 | 0.2925 |
Treponema pallidum | ATP-dependent DNA helicase | 0.001 | 0.0059 | 0.5 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0019 | 0.1545 | 0.0631 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0028 | 0.2833 | 0.1523 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0028 | 0.2833 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.3615 | 1 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0028 | 0.2833 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.3615 | 0.3577 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0882 | 0.2315 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0028 | 0.2833 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0019 | 0.1545 | 0.5455 |
Giardia lamblia | Rrm3p helicase | 0.0028 | 0.2833 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.3522 | 0.9738 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0019 | 0.1545 | 0.0631 |
Echinococcus multilocularis | lamin | 0.0033 | 0.3615 | 0.2925 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0028 | 0.2833 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.1545 | 0.1545 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.3615 | 1 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0028 | 0.2833 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0019 | 0.1545 | 0.1262 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.1246 | 0.3339 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0059 | 0.0059 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.2833 | 0.279 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0028 | 0.2833 | 1 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0028 | 0.2833 | 0.1523 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0028 | 0.2833 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0019 | 0.1545 | 0.1495 |
Echinococcus granulosus | lamin | 0.0033 | 0.3615 | 0.2925 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0028 | 0.2833 | 0.2058 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0019 | 0.1545 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.3615 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.1545 | 0.1262 |
Loa Loa (eye worm) | RecQ helicase | 0.0019 | 0.1545 | 0.418 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0059 | 0.0208 |
Echinococcus granulosus | bloom syndrome protein | 0.0019 | 0.1545 | 0.0631 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.3615 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.3615 | 0.3577 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0028 | 0.2833 | 0.2058 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0976 | 0.2578 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0059 | 0.0000000035153 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0019 | 0.1545 | 0.418 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.3615 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0059 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.3615 | 0.2925 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.1545 | 0.418 |
Onchocerca volvulus | 0.0033 | 0.3615 | 0.5 | |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0019 | 0.1545 | 0.0631 |
Echinococcus multilocularis | bloom syndrome protein | 0.0019 | 0.1545 | 0.0631 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0019 | 0.1545 | 0.0631 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.2833 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.