Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 0.354 | 0.354 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0.354 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.354 | 0.354 |
Onchocerca volvulus | 0.0012 | 0.354 | 0.5 | |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | ecdysteroid receptor | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.354 | 0.354 |
Brugia malayi | steroid hormone receptor | 0.0012 | 0.354 | 0.354 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0.354 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0.354 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 0.354 | 0.354 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 0.354 | 0.354 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 0.354 | 0.354 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 0.354 | 0.354 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 0.354 | 0.354 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 0.354 | 0.354 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.