Detailed information for compound 1397928

Basic information

Technical information
  • TDR Targets ID: 1397928
  • Name: 4-[3-(azepan-1-yl)propylamino]-N-(3,5-difluor ophenyl)-3-nitrobenzamide hydrochloride
  • MW: 468.925 | Formula: C22H27ClF2N4O3
  • H donors: 2 H acceptors: 3 LogP: 5.72 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cc(cc(c1)F)NC(=O)c1ccc(c(c1)[N+](=O)[O-])NCCCN1CCCCCC1.Cl
  • InChi: 1S/C22H26F2N4O3.ClH/c23-17-13-18(24)15-19(14-17)26-22(29)16-6-7-20(21(12-16)28(30)31)25-8-5-11-27-9-3-1-2-4-10-27;/h6-7,12-15,25H,1-5,8-11H2,(H,26,29);1H
  • InChiKey: HSDVEEMECKBKEA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[3-(azepan-1-yl)propylamino]-N-(3,5-difluorophenyl)-3-nitro-benzamide hydrochloride
  • 4-[3-(1-azepanyl)propylamino]-N-(3,5-difluorophenyl)-3-nitrobenzamide hydrochloride
  • 4-[(3-azepan-1-ylpropyl)amino]-N-(3,5-difluorophenyl)-3-nitrobenzamide
  • MLS000689414
  • SMR000311213

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0078 0.0432 0.2624
Mycobacterium ulcerans hypothetical protein 0.0171 0.1107 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0375 0.061
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.023 0.1691
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.005 0.023 0.1691
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0037 0.0135 0.0131
Echinococcus multilocularis muscleblind protein 0.018 0.1172 0.1169
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0086 0.1042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0375 0.0582
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.023 0.1691
Schistosoma mansoni nuclear hormone receptor 0.007 0.0375 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.007 0.0375 0.061
Brugia malayi hypothetical protein 0.003 0.0086 0.0129
Loa Loa (eye worm) hypothetical protein 0.0078 0.0432 0.0703
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0191 0.1699
Brugia malayi MH2 domain containing protein 0.0126 0.0775 0.1209
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0172
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.023 0.1691
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0432 0.123
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.007 0.0375 0.0372
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0139 0.0136
Loa Loa (eye worm) AMP-binding enzyme family protein 0.005 0.023 0.0374
Trypanosoma brucei acetyl-CoA synthetase, putative 0.005 0.023 0.5316
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0191 0.0294
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0033 0.0106 0.0102
Entamoeba histolytica acyl-CoA synthetase, putative 0.0171 0.1107 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.007 0.0375 0.0372
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0019 0.0435
Mycobacterium tuberculosis Conserved protein 0.0078 0.0432 0.123
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0432 1
Echinococcus granulosus tar DNA binding protein 0.0063 0.0324 0.0321
Loa Loa (eye worm) hypothetical protein 0.0205 0.1349 0.2194
Echinococcus multilocularis ferritin 0.0026 0.0051 0.0048
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0086 0.1921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0191 0.3839
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.1704
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0051 0.0137
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.005 0.023 0.1691
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0033 0.0106 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0324 0.0321
Schistosoma mansoni microtubule-associated protein tau 0.1397 0.9985 1
Onchocerca volvulus 0.005 0.023 0.0998
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0432 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.2134
Schistosoma mansoni acetyl-CoA synthetase 0.005 0.023 0.0227
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1579 0.1576
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0191 0.4415
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.007 0.0375 0.061
Loa Loa (eye worm) hypothetical protein 0.0037 0.0135 0.0219
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0432 0.123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.007 0.0375 0.061
Giardia lamblia GTOR 0.0045 0.0191 0.5
Onchocerca volvulus 0.005 0.023 0.0998
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.007 0.0375 0.0372
Schistosoma mansoni bromodomain containing protein 0.0067 0.0348 0.0345
Loa Loa (eye worm) hypothetical protein 0.003 0.0086 0.014
Brugia malayi nuclear receptor RXR 0.0037 0.0135 0.0205
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0438 0.3039 0.3037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.2134
Loa Loa (eye worm) hypothetical protein 0.0171 0.1107 0.1801
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0324 0.0503
Brugia malayi Nuclear hormone receptor-like 1 0.0867 0.6146 0.9623
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.023 0.065
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0432 0.0671
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.007 0.0375 0.061
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.032 0.0317
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0086 0.1921
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.007 0.0375 0.0372
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.005 0.023 0.065
Brugia malayi Muscleblind-like protein 0.018 0.1172 0.183
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.018 0.1172 0.1906
Schistosoma mansoni thyroid hormone receptor 0.0509 0.3549 0.3552
Brugia malayi Nuclear hormone receptor family member nhr-1 0.007 0.0375 0.0582
Loa Loa (eye worm) hypothetical protein 0.0078 0.0432 0.0703
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0324 0.0321
Brugia malayi nuclear receptor NHR-88 0.007 0.0375 0.0582
Loa Loa (eye worm) hypothetical protein 0.007 0.0375 0.061
Brugia malayi AMP-binding enzyme family protein 0.005 0.023 0.0355
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0125 0.2876
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0432 0.0703
Loa Loa (eye worm) beta-lactamase 0.0078 0.0432 0.0703
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0432 0.123
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0191 0.0188
Schistosoma mansoni zinc finger protein 0.0021 0.0015 0.0011
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0023 0.0037
Mycobacterium leprae Probable lipase LipE 0.0078 0.0432 0.3605
Loa Loa (eye worm) hypothetical protein 0.0128 0.0793 0.129
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.005 0.023 0.0355
Loa Loa (eye worm) hypothetical protein 0.0078 0.0432 0.0703
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0215 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0375 0.0582
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.007 0.0375 0.0372
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.007 0.0375 0.0372
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0033 0.0106 0.0102
Entamoeba histolytica acyl-coA synthetase, putative 0.0171 0.1107 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0139 0.0136
Onchocerca volvulus 0.0078 0.0432 0.2624
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.005 0.023 0.1691
Onchocerca volvulus 0.005 0.023 0.0998
Schistosoma mansoni apoferritin-2 0.0026 0.0051 0.0048
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0171 0.1107 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.007 0.0375 0.0372
Entamoeba histolytica acyl-CoA synthetase, putative 0.0171 0.1107 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0215 0.0212
Echinococcus granulosus nuclear receptor nhr 48 0.0033 0.0106 0.0102
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0432 0.3605
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0106 0.0102
Loa Loa (eye worm) hypothetical protein 0.0078 0.0432 0.0703
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.006 0.0486
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0106 0.0102
Loa Loa (eye worm) hypothetical protein 0.007 0.0375 0.061
Brugia malayi Nuclear hormone receptor family member nhr-40 0.007 0.0375 0.0582
Echinococcus multilocularis microtubule associated protein 2 0.1397 0.9985 0.9985
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0121 0.0742 0.2122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.007 0.0375 0.061
Echinococcus multilocularis FTZ F1 alpha 0.007 0.0375 0.0372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.1704
Schistosoma mansoni steroid hormone receptor ad4bp 0.007 0.0375 0.0372
Brugia malayi Nuclear hormone receptor family member nhr-31 0.007 0.0375 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0084 0.1096
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0191 0.4415
Brugia malayi nuclear hormone receptor 0.007 0.0375 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-49 0.007 0.0375 0.0582
Schistosoma mansoni ferritin light chain 0.0026 0.0051 0.0048
Schistosoma mansoni ferritin 0.0026 0.0051 0.0048
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.005 0.023 0.065
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0432 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0172
Loa Loa (eye worm) hypothetical protein 0.0037 0.0135 0.0219
Leishmania major acetyl-CoA synthetase, putative 0.005 0.023 0.2051
Brugia malayi Nuclear hormone receptor-like 1 0.0901 0.6387 1
Toxoplasma gondii propionate-CoA ligase 0.005 0.023 0.5284
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0432 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0172
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0171 0.1107 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0775 0.1261
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0432 0.0429
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.005 0.023 0.1691
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0004 0.0068
Plasmodium vivax acetyl-CoA synthetase, putative 0.005 0.023 0.2867
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0086 0.1975
Loa Loa (eye worm) steroid hormone receptor 0.007 0.0375 0.061
Mycobacterium ulcerans acyl-CoA synthetase 0.0171 0.1107 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0033 0.0106 0.0102
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0033 0.0106 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.2134
Leishmania major 4-coumarate:coa ligase-like protein 0.0171 0.1107 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0191 0.0188
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0051 0.0137
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.005 0.023 0.0226
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0191 0.0188
Loa Loa (eye worm) nuclear receptor NHR-67 0.0033 0.0106 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0375 0.0582
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.007 0.0375 0.0372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.2134
Loa Loa (eye worm) hypothetical protein 0.0128 0.0793 0.129
Brugia malayi steroid hormone receptor 0.007 0.0375 0.0582
Brugia malayi beta-lactamase family protein 0.0078 0.0432 0.0671
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.007 0.0375 0.061
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0172
Loa Loa (eye worm) DR-78 0.0033 0.0106 0.0172
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0432 0.123
Mycobacterium ulcerans lipase LipD 0.0078 0.0432 0.3605
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.007 0.0375 0.0372
Schistosoma mansoni ferritin 0.0026 0.0051 0.0048
Schistosoma mansoni hypothetical protein 0.0022 0.0023 0.0019
Loa Loa (eye worm) RNA binding protein 0.0063 0.0324 0.0528
Brugia malayi AMP-binding enzyme family protein 0.005 0.023 0.0355
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0172
Onchocerca volvulus 0.0171 0.1107 0.8053
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.005 0.023 0.0226
Loa Loa (eye worm) hypothetical protein 0.007 0.0375 0.061
Mycobacterium ulcerans acyl-CoA synthetase 0.0171 0.1107 1
Schistosoma mansoni ferritin 0.0026 0.0051 0.0048
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.005 0.023 0.1691
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0043 0.0179 0.0505
Loa Loa (eye worm) hypothetical protein 0.0078 0.0432 0.0703
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0245 0.0379
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0106 0.0102
Loa Loa (eye worm) hypothetical protein 0.007 0.0375 0.061
Loa Loa (eye worm) hypothetical protein 0.0045 0.019 0.031
Mycobacterium ulcerans acyl-CoA synthetase 0.0171 0.1107 1
Echinococcus granulosus ecdysone induced protein 78C 0.007 0.0375 0.0372
Loa Loa (eye worm) hypothetical protein 0.0128 0.0793 0.129
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.005 0.023 0.5284
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0086 0.1921
Onchocerca volvulus 0.0205 0.1349 1
Echinococcus multilocularis zinc finger protein 0.0021 0.0015 0.0011
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0867 0.6146 1
Leishmania major hypothetical protein, conserved 0.003 0.0086 0.0746
Loa Loa (eye worm) hypothetical protein 0.005 0.023 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-14 0.007 0.0375 0.0582
Schistosoma mansoni apoferritin-2 0.0026 0.0051 0.0048
Trichomonas vaginalis esterase, putative 0.0078 0.0432 1
Brugia malayi AMP-binding enzyme family protein 0.005 0.023 0.0355
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.005 0.023 0.2051
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.1704
Onchocerca volvulus Bile acid receptor homolog 0.007 0.0375 0.2166
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.007 0.0375 0.0372
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0432 0.0429
Schistosoma mansoni hypothetical protein 0.0438 0.3039 0.3041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0375 0.0372
Brugia malayi conserved hypotetical protein 0.0033 0.0106 0.016
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0171 0.1107 1
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.023 0.1691
Loa Loa (eye worm) hypothetical protein 0.0052 0.0245 0.0399
Brugia malayi acetyl-Coenzyme A synthetase 2 0.005 0.023 0.0355
Schistosoma mansoni zinc finger protein 0.0033 0.0106 0.0102
Loa Loa (eye worm) hypothetical protein 0.0171 0.1107 0.1801
Leishmania major hypothetical protein, conserved 0.0078 0.0432 0.3882
Brugia malayi Nuclear hormone receptor family member nhr-25 0.007 0.0375 0.0582
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0106 0.0102
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.005 0.023 0.5284
Loa Loa (eye worm) hypothetical protein 0.018 0.1172 0.1906
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0106 0.0102
Echinococcus granulosus expressed protein 0.0026 0.0051 0.0048
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.005 0.023 0.065
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0086 0.1042
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0128 0.0793 0.2268
Loa Loa (eye worm) hypothetical protein 0.0078 0.0432 0.0703
Echinococcus multilocularis thyroid hormone receptor alpha 0.0509 0.3549 0.3547
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.007 0.0375 0.0372
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0033 0.0106 0.0172
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.005 0.023 0.5284
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0432 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.007 0.0375 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.006 0.0486
Brugia malayi orphan nuclear receptor NR2E1 0.0033 0.0106 0.016
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0108 0.2429
Loa Loa (eye worm) hypothetical protein 0.004 0.0158 0.0257
Brugia malayi hypothetical protein 0.0037 0.0135 0.0205
Brugia malayi Bromodomain containing protein 0.0079 0.0437 0.0679
Mycobacterium ulcerans beta-lactamase 0.0078 0.0432 0.3605
Schistosoma mansoni nuclear receptor 0.0033 0.0106 0.0102
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0191 0.4377
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0432 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.005 0.023 0.5316
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.007 0.0375 0.0372
Loa Loa (eye worm) hypothetical protein 0.007 0.0375 0.061
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.023 0.1691
Loa Loa (eye worm) nuclear hormone receptor 0.0033 0.0106 0.0172
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0004 0.0006
Plasmodium vivax acyl-CoA synthetase, putative 0.0128 0.0793 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.005 0.023 0.1691
Brugia malayi ecdysone receptor 0.0033 0.0106 0.016
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.005 0.023 0.065
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0172
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0203
Onchocerca volvulus 0.0078 0.0432 0.2624
Brugia malayi ecdysteroid receptor 0.007 0.0375 0.0582
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0324 0.0528
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.023 0.1691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.2134
Loa Loa (eye worm) hypothetical protein 0.007 0.0375 0.061
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0171 0.1107 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.007 0.0375 0.0372
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.005 0.023 0.065
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0125 0.1098
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0037 0.0135 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.007 0.0375 0.061
Brugia malayi AMP-binding enzyme family protein 0.0171 0.1107 0.1728
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.023 0.065
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0033 0.0106 0.0102
Brugia malayi nuclear hormone receptor 0.0033 0.0106 0.016
Brugia malayi beta-lactamase family protein 0.0078 0.0432 0.0671
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0171 0.1107 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.023 0.065
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0172
Mycobacterium tuberculosis Conserved protein 0.0078 0.0432 0.123
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0172
Schistosoma mansoni ferritin 0.0026 0.0051 0.0048
Brugia malayi hypothetical protein 0.0037 0.0135 0.0205
Echinococcus granulosus thyroid hormone receptor alpha 0.0033 0.0106 0.0102
Schistosoma mansoni coup transcription factor 0.007 0.0375 0.0372
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.023 0.1691
Loa Loa (eye worm) hypothetical protein 0.0128 0.0793 0.129
Brugia malayi nuclear receptor NHR-88 0.0033 0.0106 0.016
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.005 0.023 0.1691
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0058 0.0437
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0432 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0324 0.0321
Echinococcus granulosus muscleblind protein 0.018 0.1172 0.1169
Echinococcus granulosus zinc finger protein 0.0021 0.0015 0.0011
Brugia malayi nuclear hormone receptor family member odr-7 0.0033 0.0106 0.016
Loa Loa (eye worm) oxidoreductase 0.005 0.023 0.0374
Brugia malayi beta-lactamase 0.0078 0.0432 0.0671
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0125 0.019
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0324 0.0528
Brugia malayi TAR-binding protein 0.0063 0.0324 0.0503
Brugia malayi nuclear receptor NHR-67 0.0033 0.0106 0.016
Brugia malayi AMP-binding enzyme family protein 0.0171 0.1107 0.1728
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0106 0.016
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.005 0.023 0.065
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.023 0.1691
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.005 0.023 0.5284
Brugia malayi Steroid receptor seven-up type 2 0.007 0.0375 0.0582
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0128 0.0793 0.7026
Brugia malayi AMP-binding enzyme family protein 0.005 0.023 0.0355
Schistosoma mansoni retinoid-x-receptor (RXR) 0.007 0.0375 0.0372
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.007 0.0375 0.2166
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0245 0.0399
Brugia malayi Nuclear hormone receptor-like 1 0.0867 0.6146 0.9623
Loa Loa (eye worm) hypothetical protein 0.0237 0.1579 0.2569
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0171 0.1107 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.032 0.0317
Onchocerca volvulus Protein ultraspiracle homolog 0.007 0.0375 0.2166
Mycobacterium tuberculosis Possible penicillin-binding protein 0.05 0.3485 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.1704
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.023 0.1691
Brugia malayi hypothetical protein 0.002 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0135 0.0219
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0106 0.0102
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0432 0.123
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0051 0.5
Brugia malayi nuclear hormone receptor family member nhr-6 0.0033 0.0106 0.016
Plasmodium falciparum acyl-CoA synthetase 0.0128 0.0793 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0121 0.0742 0.2122
Echinococcus granulosus FTZ F1 alpha 0.007 0.0375 0.0372
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.005 0.023 0.5284
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0286
Leishmania major 4-coumarate:coa ligase-like protein 0.0171 0.1107 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0058 0.0437
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1579 0.1576
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.007 0.0375 0.0582
Onchocerca volvulus 0.0048 0.0215 0.0878
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0191 0.1699
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.005 0.023 0.5284
Echinococcus granulosus ferritin 0.0026 0.0051 0.0048
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.023 0.1691
Schistosoma mansoni thyroid hormone receptor 0.0509 0.3549 0.3552
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0171 0.1107 0.3169
Loa Loa (eye worm) hypothetical protein 0.0171 0.1107 0.1801
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0121 0.0742 0.2122
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.005 0.023 0.065
Brugia malayi hypothetical protein 0.0033 0.0106 0.016
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0106 0.016
Mycobacterium ulcerans hypothetical protein 0.0078 0.0432 0.3605
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0432 0.0428
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.023 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.1704
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.005 0.023 0.0424
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0191 0.4377
Brugia malayi photoreceptor-specific nuclear receptor 0.007 0.0375 0.0582
Loa Loa (eye worm) hypothetical protein 0.0037 0.0135 0.0219
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0004 0.0068
Trichomonas vaginalis ferritin, putative 0.0026 0.0051 0.0268
Onchocerca volvulus 0.007 0.0375 0.2166
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0191 0.0311
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0324 0.0321
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.007 0.0375 0.0372
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0375 0.0372
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0033 0.0106 0.0102
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0432 0.0428
Loa Loa (eye worm) hypothetical protein 0.0863 0.6118 0.9953
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0106 0.0102
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0037 0.0135 0.0131
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0324 0.0321
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.005 0.023 0.1691
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0037 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0432 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0432 0.3605
Brugia malayi nuclear receptor RXR 0.0033 0.0106 0.016
Schistosoma mansoni hypothetical protein 0.0048 0.0215 0.0212
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0037 0.0034
Leishmania major acetyl-CoA synthetase, putative 0.005 0.023 0.2051
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0172
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0432 0.123
Schistosoma mansoni retinoic acid receptor RXR 0.007 0.0375 0.0372
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0125 0.2827
Trichomonas vaginalis antibiotic synthetase, putative 0.005 0.023 0.4833
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0432 0.123
Schistosoma mansoni RAR-like nuclear receptor 0.007 0.0375 0.0372
Loa Loa (eye worm) hypothetical protein 0.0128 0.0793 0.129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0041 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.007 0.0375 0.0582
Leishmania major 4-coumarate:coa ligase-like protein 0.0171 0.1107 1
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0432 0.5426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0191 0.3839
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0041 0.0007
Echinococcus multilocularis ecdysone induced protein 78C 0.007 0.0375 0.0372
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0128 0.0793 0.5
Echinococcus granulosus microtubule associated protein 2 0.1397 0.9985 0.9985
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.005 0.023 0.1691
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0432 0.3605
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0245 0.0379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0077 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.1704
Brugia malayi tailless protein 0.0033 0.0106 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0041 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0041 0.0007
Brugia malayi hypothetical protein 0.0237 0.1579 0.2468
Brugia malayi hypothetical protein 0.0033 0.0106 0.016
Plasmodium falciparum acetyl-CoA synthetase, putative 0.005 0.023 0.2867
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0106 0.0102
Toxoplasma gondii ABC1 family protein 0.0078 0.0432 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0135 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-3 0.007 0.0375 0.0582
Brugia malayi RNA binding protein 0.0063 0.0324 0.0503
Echinococcus granulosus retinoic acid receptor rxr beta a 0.007 0.0375 0.0372
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0171 0.1107 0.3169
Brugia malayi PHD-finger family protein 0.0026 0.0055 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0108 0.1704
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0775 0.1261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.006 0.0486
Echinococcus granulosus nuclear receptor 2DBD gamma 0.007 0.0375 0.0372
Mycobacterium ulcerans acetyl-CoA synthetase 0.005 0.023 0.1691
Onchocerca volvulus 0.005 0.023 0.0998
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0051 0.5
Loa Loa (eye worm) AMP-binding enzyme family protein 0.005 0.023 0.0374
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0172
Loa Loa (eye worm) hypothetical protein 0.0037 0.0135 0.0219
Trichomonas vaginalis antibiotic synthetase, putative 0.005 0.023 0.4833
Schistosoma mansoni nuclear receptor 0.0033 0.0106 0.0102
Loa Loa (eye worm) hypothetical protein 0.0033 0.0106 0.0172
Echinococcus multilocularis muscleblind protein 1 0.018 0.1172 0.1169
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0086 0.1042
Schistosoma mansoni nuclear receptor nhr-48 0.0033 0.0106 0.0102
Loa Loa (eye worm) hypothetical protein 0.005 0.023 0.0374
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0121 0.0742 0.2122
Schistosoma mansoni hypothetical protein 0.0036 0.0125 0.0122
Brugia malayi AMP-binding enzyme family protein 0.0171 0.1107 0.1728
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0143 0.2621
Brugia malayi Bromodomain containing protein 0.004 0.0157 0.0241
Schistosoma mansoni ferritin light chain 0.0026 0.0051 0.0048
Mycobacterium tuberculosis Conserved protein 0.0078 0.0432 0.123
Schistosoma mansoni cellular tumor antigen P53 0.0205 0.1349 0.1348
Loa Loa (eye worm) hypothetical protein 0.0074 0.0404 0.0658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0191 0.3839
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0438 0.3039 0.3037
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0324 0.0321
Echinococcus multilocularis expressed protein 0.0026 0.0051 0.0048
Loa Loa (eye worm) hypothetical protein 0.007 0.0375 0.061

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 160 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
Potency (functional) 0.2119 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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